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The map label for this gene is mdmC [H]

Identifier: 89255531

GI number: 89255531

Start: 85149

End: 85565

Strand: Direct

Name: mdmC [H]

Synonym: FTL_0091

Alternate gene names: 89255531

Gene position: 85149-85565 (Clockwise)

Preceding gene: 89255530

Following gene: 89255535

Centisome position: 4.49

GC content: 34.05

Gene sequence:

>417_bases
ATGCTTAGCTCACCTAACCAGTTACAGTTACTTAGCCTTTTGCTAAAAATCATTAATGTTAAAAGGGTTTTAGAAATAGG
AGTTTTTCGTGGTTTTTCTACTTTAGTAATGGCACAAGTTTTAGCTGATGATGCTACTATTGAAGCCTGTGATATTGGCT
ATGAGTATCTTAAGCCATATGAGCATTTTTGGCAGCAGGCAAAAGTTGAACATAAGATTAACCTAAATATTGCACCAGCT
CTTGAGACACTTGATAGATTTTTACAGCAACAGCTAAAATTTGATTTTGTTTATATCGATGCTGATAAGCCAAACTACAT
AAATTATTATGAAAAAGCTTTAGCTCTAATGGATTCTGGTGGGCTTATTGCTATAGATAATGTGCTTTGGTCAGGTCGGG
TTGCTGATAAAAAATAA

Upstream 100 bases:

>100_bases
GAGTTCAAGTCTTGACGATTATATTGATACTAATTCAGTTAAGTTAGATGTTATTGCACAGCAACTTTTTAATAAAGCAA
AAAATGATAAACTAAGTCAT

Downstream 100 bases:

>100_bases
TGAGGTAAACACGCTTGTAATAAGACAGCTAAATAACTTAATTCATGATGATAAGCGCGTAGACGCTTGTATAATACCGA
TTGGAGATGGTATAAATTTA

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MLSSPNQLQLLSLLLKIINVKRVLEIGVFRGFSTLVMAQVLADDATIEACDIGYEYLKPYEHFWQQAKVEHKINLNIAPA
LETLDRFLQQQLKFDFVYIDADKPNYINYYEKALALMDSGGLIAIDNVLWSGRVADKK

Sequences:

>Translated_138_residues
MLSSPNQLQLLSLLLKIINVKRVLEIGVFRGFSTLVMAQVLADDATIEACDIGYEYLKPYEHFWQQAKVEHKINLNIAPA
LETLDRFLQQQLKFDFVYIDADKPNYINYYEKALALMDSGGLIAIDNVLWSGRVADKK
>Mature_138_residues
MLSSPNQLQLLSLLLKIINVKRVLEIGVFRGFSTLVMAQVLADDATIEACDIGYEYLKPYEHFWQQAKVEHKINLNIAPA
LETLDRFLQQQLKFDFVYIDADKPNYINYYEKALALMDSGGLIAIDNVLWSGRVADKK

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=131, Percent_Identity=40.4580152671756, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17565612, Length=140, Percent_Identity=37.8571428571429, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI72001127, Length=140, Percent_Identity=35, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI25148771, Length=145, Percent_Identity=35.8620689655172, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI72001028, Length=140, Percent_Identity=35.7142857142857, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 15782; Mature: 15782

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSSPNQLQLLSLLLKIINVKRVLEIGVFRGFSTLVMAQVLADDATIEACDIGYEYLKPY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHCCHHHHHHH
EHFWQQAKVEHKINLNIAPALETLDRFLQQQLKFDFVYIDADKPNYINYYEKALALMDSG
HHHHHHHCCCCEECCEEHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHHCCC
GLIAIDNVLWSGRVADKK
CEEEECCEEECCCCCCCC
>Mature Secondary Structure
MLSSPNQLQLLSLLLKIINVKRVLEIGVFRGFSTLVMAQVLADDATIEACDIGYEYLKPY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHCCHHHHHHH
EHFWQQAKVEHKINLNIAPALETLDRFLQQQLKFDFVYIDADKPNYINYYEKALALMDSG
HHHHHHHCCCCEECCEEHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHHCCC
GLIAIDNVLWSGRVADKK
CEEEECCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]