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The map label for this gene is tyrA [H]

Identifier: 89255495

GI number: 89255495

Start: 49873

End: 50535

Strand: Reverse

Name: tyrA [H]

Synonym: FTL_0048

Alternate gene names: 89255495

Gene position: 50535-49873 (Counterclockwise)

Preceding gene: 89255496

Following gene: 89255494

Centisome position: 2.67

GC content: 33.48

Gene sequence:

>663_bases
ATGCAAAAAAGAATTTGTATAATTGGTGGTAATGGTGAAATGGGTCAGATGACTCAAAATATTTTTAGCAAATTTCTGCC
TGAATATATATTAACTATTTTTGATGAAAATGATTGGCAAACTCCCGAGCAAAAACTTGCTAATCAAGACATTGTAATAC
TATCCGTACCTATATATCTAACAACGGAAATTATCAAAAGAACTATACCATATCTTTCTAAAGGCACTATCTTAGCTGAC
TATACCAGTATTAAAAAAGAACCTCTAGACTGTATGTTAGCTAATTATGACGGTCCTGTAGTTGGACTACACCCAATATT
TGGACCCACTATCAGCTCACCTGAAAATCAAGTAATCGTAGTCTGTGATGGTAAGCAACAAGACAAGTATCAATACTTTA
TCGATGACCTAGCTAGAATTGGTTTTAGTATCGAGAAAATGACAGCCGAAGCACATGATGAAGCAATGACTTTTATCCAA
GGCATTGAGCATTTTAGTGTTTATTGTTTGGGAATGTTTCTTAAGCATAAAAATATTGATATTCACAAGATGCTAAAGCT
TGCTAGTCCAGTTTATAAAATGGAGTTAAACATCGTAGGTAGGCTTTTTAGTCAAGGTCCCGGATTATATGCTGATATTA
TTATGTCAGATAAACAAAGATAA

Upstream 100 bases:

>100_bases
TACCTGTTCCTGAGCGAGGTCGAGGGGCTGCCATGAAAAAAGTATGTCGCTATAGCTTACAGAGTAAGCAGCGGAAAAAT
TAAAATTAAGGAACCTTAAA

Downstream 100 bases:

>100_bases
CAAATGATTGTTGAGTTTGCTGAGTTTGTAAACTCTAATGCTAAAAAAGTCTCTGAAGGTGACAAACAAACTTTTATTGA
AAATTTCAAAGCGGTAAAAG

Product: prephenate dehydrogenase.

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MQKRICIIGGNGEMGQMTQNIFSKFLPEYILTIFDENDWQTPEQKLANQDIVILSVPIYLTTEIIKRTIPYLSKGTILAD
YTSIKKEPLDCMLANYDGPVVGLHPIFGPTISSPENQVIVVCDGKQQDKYQYFIDDLARIGFSIEKMTAEAHDEAMTFIQ
GIEHFSVYCLGMFLKHKNIDIHKMLKLASPVYKMELNIVGRLFSQGPGLYADIIMSDKQR

Sequences:

>Translated_220_residues
MQKRICIIGGNGEMGQMTQNIFSKFLPEYILTIFDENDWQTPEQKLANQDIVILSVPIYLTTEIIKRTIPYLSKGTILAD
YTSIKKEPLDCMLANYDGPVVGLHPIFGPTISSPENQVIVVCDGKQQDKYQYFIDDLARIGFSIEKMTAEAHDEAMTFIQ
GIEHFSVYCLGMFLKHKNIDIHKMLKLASPVYKMELNIVGRLFSQGPGLYADIIMSDKQR
>Mature_220_residues
MQKRICIIGGNGEMGQMTQNIFSKFLPEYILTIFDENDWQTPEQKLANQDIVILSVPIYLTTEIIKRTIPYLSKGTILAD
YTSIKKEPLDCMLANYDGPVVGLHPIFGPTISSPENQVIVVCDGKQQDKYQYFIDDLARIGFSIEKMTAEAHDEAMTFIQ
GIEHFSVYCLGMFLKHKNIDIHKMLKLASPVYKMELNIVGRLFSQGPGLYADIIMSDKQR

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=215, Percent_Identity=40.9302325581395, Blast_Score=197, Evalue=5e-52,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 25006; Mature: 25006

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKRICIIGGNGEMGQMTQNIFSKFLPEYILTIFDENDWQTPEQKLANQDIVILSVPIYL
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEHHHH
TTEIIKRTIPYLSKGTILADYTSIKKEPLDCMLANYDGPVVGLHPIFGPTISSPENQVIV
HHHHHHHHCCCCCCCCEEEEHHHHCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCEEE
VCDGKQQDKYQYFIDDLARIGFSIEKMTAEAHDEAMTFIQGIEHFSVYCLGMFLKHKNID
EECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IHKMLKLASPVYKMELNIVGRLFSQGPGLYADIIMSDKQR
HHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
>Mature Secondary Structure
MQKRICIIGGNGEMGQMTQNIFSKFLPEYILTIFDENDWQTPEQKLANQDIVILSVPIYL
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEHHHH
TTEIIKRTIPYLSKGTILADYTSIKKEPLDCMLANYDGPVVGLHPIFGPTISSPENQVIV
HHHHHHHHCCCCCCCCEEEEHHHHCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCEEE
VCDGKQQDKYQYFIDDLARIGFSIEKMTAEAHDEAMTFIQGIEHFSVYCLGMFLKHKNID
EECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IHKMLKLASPVYKMELNIVGRLFSQGPGLYADIIMSDKQR
HHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]