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The map label for this gene is pyrC [H]

Identifier: 89255480

GI number: 89255480

Start: 34297

End: 35643

Strand: Direct

Name: pyrC [H]

Synonym: FTL_0033

Alternate gene names: 89255480

Gene position: 34297-35643 (Clockwise)

Preceding gene: 89255478

Following gene: 89255482

Centisome position: 1.81

GC content: 38.38

Gene sequence:

>1347_bases
ATGTCAAATCAAAGTTTACTTATCAAAAATGCTACGGTCGTAAATGAGGGCAAAACATTTAAATCAGATGTTCTGGTAGA
GAATGGTAGAATTGCCAAAGTTGCTGCAAATATAGACAAATCAGCAGATAAAATCTTAGATGCTACAGGGCTTCATCTAC
TACCAGGTATGATTGATGATCAGGTGCATTTTAGAGAGCCTGGGCTTATGCACAAAGGTGATATCGAGTCAGAATCTCGT
GCTGCTGTAATGGGCGGTATCACATCATATATGGAGATGCCAAATGTAAATCCAGCTACTACAGTAGTTGAGCGACTAGA
TGAGAAAAAAGAGCGTGCAGCTGCTAGATCTCATGCAAACTATGCTTTTTATATTGGTGCGACTAATGATAATGTTGAGG
AGCTAAAGCGCCTAAAACCAAATGATGCTTGTGCTATCAAAATATTTATGGGAGCATCGACCGGTAATATGCTGGTGAAT
AATCCTGAAACTCTCGAAGGCTTTTTTAGAGATAGTCCACTACTTATCGTGACACACTGTGAAGATACGCCAATGATTAC
AGAGCTTGAGAATAAAGCCCGTCAAAAATATGGCGAAAATGTGCCATTTGATTTACATCCGGAAATTCGCTCGAGGGAAG
CATGTTTTAAATCATCAGATTTAGCTGTTTCACTAGCAAAGAAATATAACTCAAGATTACATGTGCTACATCTAACGACA
GCTGAAGAGATGGTACATTTTGATAATACTATCCCGTTAGAAGAGAAGCGTATTACAGCCGAGGTTTGTGCTCACCACTT
GTTTTTCTCACGTAAAGATTATGCTGATAAGGGCTCACGTATCAAATGTAATCCCGCAATTAAAGAAGAGAGCGATCGTC
TAAAGTTACTAGAGTGTGTAGCTAATGATACTATTGATGTAATTGCTACAGATCATGCGCCACATACTTGGGAAGAAAAG
CAGGGCACTTACTTCAAAACTCCAGCTGGTTTACCACTTGTTGAGCAGGCACTTATTTCAATTTTAGAGCATTATCATAA
GGGTTTCTTAACTCTTGAGCAGGTAGTACAAAAGACAGCACATGCTCCGGCAATTGTCTACAAAGTAAAAGAGCGTGGTT
TTATCCGTGAAGGCTATCATGCTGACTTGGTATTAGTAGATCTTAATGATCCACATACTGTGACAGATGAATGTTGTCAT
TATAAATGTGGTTGGACTCCATTTGATGGCATCACTTTCCAATCAAAAGTTCAGACAACAATTGTAAATGGTGTAGTTAA
ATATCATAAAGGTAAAATAGTAAGCGATCAAAGAGGACAATGTTTAGAGTTTAATCATGAGTTTTGA

Upstream 100 bases:

>100_bases
AAACATATTAACATGAACGATCAGATAAATATTATTTTTTAAATGTGGCGATTTATACTATGGTTCATTATAATTTGGGT
AGATTGTAAAGGAGGAAAAA

Downstream 100 bases:

>100_bases
TAAAGCTAAAATTTAGAAAATAATTAATTATTTATGATTTAAAGCTCTAAGAATCATTTTTTCAATATCAGAGTTTATAT
TAACGTATTCTAATTTTATG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSNQSLLIKNATVVNEGKTFKSDVLVENGRIAKVAANIDKSADKILDATGLHLLPGMIDDQVHFREPGLMHKGDIESESR
AAVMGGITSYMEMPNVNPATTVVERLDEKKERAAARSHANYAFYIGATNDNVEELKRLKPNDACAIKIFMGASTGNMLVN
NPETLEGFFRDSPLLIVTHCEDTPMITELENKARQKYGENVPFDLHPEIRSREACFKSSDLAVSLAKKYNSRLHVLHLTT
AEEMVHFDNTIPLEEKRITAEVCAHHLFFSRKDYADKGSRIKCNPAIKEESDRLKLLECVANDTIDVIATDHAPHTWEEK
QGTYFKTPAGLPLVEQALISILEHYHKGFLTLEQVVQKTAHAPAIVYKVKERGFIREGYHADLVLVDLNDPHTVTDECCH
YKCGWTPFDGITFQSKVQTTIVNGVVKYHKGKIVSDQRGQCLEFNHEF

Sequences:

>Translated_448_residues
MSNQSLLIKNATVVNEGKTFKSDVLVENGRIAKVAANIDKSADKILDATGLHLLPGMIDDQVHFREPGLMHKGDIESESR
AAVMGGITSYMEMPNVNPATTVVERLDEKKERAAARSHANYAFYIGATNDNVEELKRLKPNDACAIKIFMGASTGNMLVN
NPETLEGFFRDSPLLIVTHCEDTPMITELENKARQKYGENVPFDLHPEIRSREACFKSSDLAVSLAKKYNSRLHVLHLTT
AEEMVHFDNTIPLEEKRITAEVCAHHLFFSRKDYADKGSRIKCNPAIKEESDRLKLLECVANDTIDVIATDHAPHTWEEK
QGTYFKTPAGLPLVEQALISILEHYHKGFLTLEQVVQKTAHAPAIVYKVKERGFIREGYHADLVLVDLNDPHTVTDECCH
YKCGWTPFDGITFQSKVQTTIVNGVVKYHKGKIVSDQRGQCLEFNHEF
>Mature_447_residues
SNQSLLIKNATVVNEGKTFKSDVLVENGRIAKVAANIDKSADKILDATGLHLLPGMIDDQVHFREPGLMHKGDIESESRA
AVMGGITSYMEMPNVNPATTVVERLDEKKERAAARSHANYAFYIGATNDNVEELKRLKPNDACAIKIFMGASTGNMLVNN
PETLEGFFRDSPLLIVTHCEDTPMITELENKARQKYGENVPFDLHPEIRSREACFKSSDLAVSLAKKYNSRLHVLHLTTA
EEMVHFDNTIPLEEKRITAEVCAHHLFFSRKDYADKGSRIKCNPAIKEESDRLKLLECVANDTIDVIATDHAPHTWEEKQ
GTYFKTPAGLPLVEQALISILEHYHKGFLTLEQVVQKTAHAPAIVYKVKERGFIREGYHADLVLVDLNDPHTVTDECCHY
KCGWTPFDGITFQSKVQTTIVNGVVKYHKGKIVSDQRGQCLEFNHEF

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=385, Percent_Identity=28.3116883116883, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI4503375, Length=451, Percent_Identity=24.1685144124169, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI19923821, Length=457, Percent_Identity=23.6323851203501, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4503051, Length=458, Percent_Identity=21.3973799126638, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI62422571, Length=453, Percent_Identity=21.6335540838852, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI190194363, Length=459, Percent_Identity=22.8758169934641, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4503379, Length=455, Percent_Identity=22.1978021978022, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4503377, Length=452, Percent_Identity=21.6814159292035, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=27.4599542334096, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI87082175, Length=459, Percent_Identity=23.5294117647059, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI193204318, Length=388, Percent_Identity=29.639175257732, Blast_Score=168, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71989490, Length=449, Percent_Identity=25.3897550111359, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17539558, Length=456, Percent_Identity=23.9035087719298, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322218, Length=411, Percent_Identity=27.2506082725061, Blast_Score=122, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24642586, Length=382, Percent_Identity=29.5811518324607, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI221377917, Length=459, Percent_Identity=24.1830065359477, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17137462, Length=453, Percent_Identity=26.0485651214128, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18859883, Length=426, Percent_Identity=22.7699530516432, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24644287, Length=250, Percent_Identity=27.2, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644289, Length=198, Percent_Identity=28.2828282828283, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 50303; Mature: 50172

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQSLLIKNATVVNEGKTFKSDVLVENGRIAKVAANIDKSADKILDATGLHLLPGMIDD
CCCCEEEEEEEEEEECCCCCCCCEEEECCCEEEEEECCCHHHHHHHHCCCHHHCCCCCCC
QVHFREPGLMHKGDIESESRAAVMGGITSYMEMPNVNPATTVVERLDEKKERAAARSHAN
CEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
YAFYIGATNDNVEELKRLKPNDACAIKIFMGASTGNMLVNNPETLEGFFRDSPLLIVTHC
EEEEEECCCCCHHHHHHCCCCCCEEEEEEEECCCCCEEECCCHHHHHHHCCCCEEEEEEC
EDTPMITELENKARQKYGENVPFDLHPEIRSREACFKSSDLAVSLAKKYNSRLHVLHLTT
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCEEEEEEECC
AEEMVHFDNTIPLEEKRITAEVCAHHLFFSRKDYADKGSRIKCNPAIKEESDRLKLLECV
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHH
ANDTIDVIATDHAPHTWEEKQGTYFKTPAGLPLVEQALISILEHYHKGFLTLEQVVQKTA
CCCCEEEEEECCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
HAPAIVYKVKERGFIREGYHADLVLVDLNDPHTVTDECCHYKCGWTPFDGITFQSKVQTT
CCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHCCCCCCCCCCCCEEHHHHHHH
IVNGVVKYHKGKIVSDQRGQCLEFNHEF
HHHHHHHHHCCCEECCCCCCEEECCCCC
>Mature Secondary Structure 
SNQSLLIKNATVVNEGKTFKSDVLVENGRIAKVAANIDKSADKILDATGLHLLPGMIDD
CCCEEEEEEEEEEECCCCCCCCEEEECCCEEEEEECCCHHHHHHHHCCCHHHCCCCCCC
QVHFREPGLMHKGDIESESRAAVMGGITSYMEMPNVNPATTVVERLDEKKERAAARSHAN
CEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
YAFYIGATNDNVEELKRLKPNDACAIKIFMGASTGNMLVNNPETLEGFFRDSPLLIVTHC
EEEEEECCCCCHHHHHHCCCCCCEEEEEEEECCCCCEEECCCHHHHHHHCCCCEEEEEEC
EDTPMITELENKARQKYGENVPFDLHPEIRSREACFKSSDLAVSLAKKYNSRLHVLHLTT
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCEEEEEEECC
AEEMVHFDNTIPLEEKRITAEVCAHHLFFSRKDYADKGSRIKCNPAIKEESDRLKLLECV
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHH
ANDTIDVIATDHAPHTWEEKQGTYFKTPAGLPLVEQALISILEHYHKGFLTLEQVVQKTA
CCCCEEEEEECCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
HAPAIVYKVKERGFIREGYHADLVLVDLNDPHTVTDECCHYKCGWTPFDGITFQSKVQTT
CCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHCCCCCCCCCCCCEEHHHHHHH
IVNGVVKYHKGKIVSDQRGQCLEFNHEF
HHHHHHHHHCCCEECCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]