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The map label for this gene is tpm [H]

Identifier: 89255479

GI number: 89255479

Start: 33485

End: 34165

Strand: Reverse

Name: tpm [H]

Synonym: FTL_0032

Alternate gene names: 89255479

Gene position: 34165-33485 (Counterclockwise)

Preceding gene: 89255481

Following gene: 89255477

Centisome position: 1.8

GC content: 30.4

Gene sequence:

>681_bases
ATGAATAAGCTTGAAACTAATAATAATCAATATTGGCTAGATAGATGGCAAAATGATGATGTAGGTTTTTGTCAAGAATC
ACCAAATGAGTTTCTAGTTAAGCATTTTTCTAAACTAAACATAAATGATTCATCGGTATGCTTAATACCAATGTGTGGCT
GTAGTATAGATATGTTATTTTTCTTATCTAAGGGGGTTAAAGTAATTGGTATTGAGCTATCAGAAAAAGCTGTCTTATCA
TTTTTTAGCCAAAATACTATCAATTATGAAGTTATACATGGCAATGACTATAAACTCTATAAAGGCGATGATATTGAGAT
ATATGTAGCAGATATTTTTAACTTACCAAAGATAGCAAACAATTTACCAGTATTTGATATTTGGTATGATAGAGGTGCTT
ATATCGCTTTGCCTAATGACCTTAGGACTAATTATGCAAAAATGATGCTAGAAGTATGCTCTAATAATACTCAAATACTC
TTATTAGTAATGGAACATGACAAGAAATCCCAGACTCCTCCTTATAGTGTTACTCAATCTGAGCTGATAAAGAACTTCTC
TACTAAGATCAAATTTGAACTAATTGATAGTAAACAAAGAGATAATATCCCAGACTATCGAAAGGCTGAAGGAATGACTG
AACAATATTACACAACTTATCTAAGAAAAAAGCAATATTAG

Upstream 100 bases:

>100_bases
AATGAACCATAGTATAAATCGCCACATTTAAAAAATAATATTTATCTGATCGTTCATGTTAATATGTTTAGTTAGTTAAT
AACTGTAGATTACAAACAAT

Downstream 100 bases:

>100_bases
AAAAACTAGTAAAATAGTTAATCATAATACTTTTCGGATTTAGTATGTTTTAGAATTTGAATGTTAGTAATGTTTTTAAT
GTGAAATTCTGAAACAAGTT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNKLETNNNQYWLDRWQNDDVGFCQESPNEFLVKHFSKLNINDSSVCLIPMCGCSIDMLFFLSKGVKVIGIELSEKAVLS
FFSQNTINYEVIHGNDYKLYKGDDIEIYVADIFNLPKIANNLPVFDIWYDRGAYIALPNDLRTNYAKMMLEVCSNNTQIL
LLVMEHDKKSQTPPYSVTQSELIKNFSTKIKFELIDSKQRDNIPDYRKAEGMTEQYYTTYLRKKQY

Sequences:

>Translated_226_residues
MNKLETNNNQYWLDRWQNDDVGFCQESPNEFLVKHFSKLNINDSSVCLIPMCGCSIDMLFFLSKGVKVIGIELSEKAVLS
FFSQNTINYEVIHGNDYKLYKGDDIEIYVADIFNLPKIANNLPVFDIWYDRGAYIALPNDLRTNYAKMMLEVCSNNTQIL
LLVMEHDKKSQTPPYSVTQSELIKNFSTKIKFELIDSKQRDNIPDYRKAEGMTEQYYTTYLRKKQY
>Mature_226_residues
MNKLETNNNQYWLDRWQNDDVGFCQESPNEFLVKHFSKLNINDSSVCLIPMCGCSIDMLFFLSKGVKVIGIELSEKAVLS
FFSQNTINYEVIHGNDYKLYKGDDIEIYVADIFNLPKIANNLPVFDIWYDRGAYIALPNDLRTNYAKMMLEVCSNNTQIL
LLVMEHDKKSQTPPYSVTQSELIKNFSTKIKFELIDSKQRDNIPDYRKAEGMTEQYYTTYLRKKQY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

Organism=Homo sapiens, GI4507653, Length=184, Percent_Identity=30.9782608695652, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 26432; Mature: 26432

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLETNNNQYWLDRWQNDDVGFCQESPNEFLVKHFSKLNINDSSVCLIPMCGCSIDMLF
CCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHH
FLSKGVKVIGIELSEKAVLSFFSQNTINYEVIHGNDYKLYKGDDIEIYVADIFNLPKIAN
HHHCCCEEEEEEECHHHHHHHHHCCCEEEEEEECCCEEEEECCCCEEEEECHHCCCHHHC
NLPVFDIWYDRGAYIALPNDLRTNYAKMMLEVCSNNTQILLLVMEHDKKSQTPPYSVTQS
CCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHH
ELIKNFSTKIKFELIDSKQRDNIPDYRKAEGMTEQYYTTYLRKKQY
HHHHHHCCEEEEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKLETNNNQYWLDRWQNDDVGFCQESPNEFLVKHFSKLNINDSSVCLIPMCGCSIDMLF
CCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHH
FLSKGVKVIGIELSEKAVLSFFSQNTINYEVIHGNDYKLYKGDDIEIYVADIFNLPKIAN
HHHCCCEEEEEEECHHHHHHHHHCCCEEEEEEECCCEEEEECCCCEEEEECHHCCCHHHC
NLPVFDIWYDRGAYIALPNDLRTNYAKMMLEVCSNNTQILLLVMEHDKKSQTPPYSVTQS
CCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHH
ELIKNFSTKIKFELIDSKQRDNIPDYRKAEGMTEQYYTTYLRKKQY
HHHHHHCCEEEEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA