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The map label for this gene is flhA

Identifier: 89056677

GI number: 89056677

Start: 4295698

End: 4297779

Strand: Direct

Name: flhA

Synonym: Jann_4186

Alternate gene names: 89056677

Gene position: 4295698-4297779 (Clockwise)

Preceding gene: 89056676

Following gene: 89056678

Centisome position: 99.48

GC content: 57.25

Gene sequence:

>2082_bases
ATGATCTCCGCGAAAGCTCTGTTCCAGCCGACGATCCTGTTCGCCTTGGCGTTGATGGCTGTCATCATCATGATGATCCT
GCCGGTGCCCTCGTTCATACTCGATATTGGCCTGGCCGCCTCATTTGGCTTGGCCATCTTGATCTTCACCGTCACACTTT
TTATCGAGCGTCCCTTAGATTTCTCTGCATTTCCGACTGTTCTGCTCGCGTCCTTGATGTTGCGTCTGTCGCTGAATGTG
TCGTCTACAAAACTGATAATCGGTCAAGGCCATACTGGCACTGACGCCGCAGGCAGTGTGATCGAAGGCTTCGCGATGTT
CGTGATCGACGGCTCGGTCGTCATGGGTCTCGTCATTTTCTGCGTTCTTTTGATCGTTAACTTTATCGTCATCAACAAAG
GCGCCGCTCGTATGGCGGAGGTCGGGGCTCGTTTCGCCTTGGACGGGATGCCTGGCAAACAGCTCGCAATCGACAGCGAT
ATGGCGGCGGGCGCCATCGATCACGAGGAAGCCAAAACCCGGAGAGAGCGAGAGCAAGCAGAAACGACTTTCTTTGGATC
GCTCGACGGTGCGTCGAAATTTGTGAAAGGGGACGCAATCGCCGGTCTTCTGATCACCATGCTGAACCTTGTCGTCGGCC
TGATCATCGGCACGACGATGCACGGAATGCCGATTGGGCAAGCCTTTGAAACGTATTCAATTTTAACGATCGGGGATGGC
CTCGTCAGTCAGATACCGTCGGTCATTATCGCCATTGCATCCGCCCTTCTTCTGGCGCGGGGCGGGGCCAGTGGCGCGAC
CGATACCGCGCTTTTCGCACAGCTTGGCAAGCACCCGTCTGCCTTGATCGCCGTATCCCTTCTCATGGCGATCTTCGCGC
TGGTCCCCGGCCTTCCTGCCGCACCTTTCCTTCTAGGAGCCGCCGCCTTGGGCTTTGCCGCCTGGCGACGCATGAAGACG
CTGGACGAGCAAGCAGAGCCGGAGGACGCGTCAAGTCCTGAAGCGCTGGAAGCCCCCAAAGAAACGAGCGGGGACTTGCT
GGATGTGGATGATATCCATGTCGAATTCTCACCAGACCTCGTCAGTTTGGCGTTGGATCCCGCAACCGGCCTAGACGCTC
GGATCAAGAACATGCGCGAACATGTGGCGCGATCTTTCGGCGTTCTCCTTCCGGAAATGCGCCTCACAGATCGCGGGGAT
TTGCCACCCGGGACCTATTCCATAAGGCTTTTGGGCGTGGAGCATGCAACGGCACAACTCAACCCCGCCCGGGTATTGAT
GCTGACGCAAGATGGTGCCGTTGACTTGCCAGACGGGGAAGAGACCTCTGAACCCGTCTACGGCGCGCCTGCTCGATGGA
TCGACCCCAGAGATCGTGAGCGCGCCGGGCTTGCGGGCATGACGGTCGTCACACCGTCGGAGGTTTTGGCGACGCATCTT
TTAGAAGTTCTCAAGCGTAACCTGTCCCGGTTGATGACGTTCAAAACGCTTCAACGACAGTTGGACGCCTTTATCGCTCT
GAGCGATGGCGCGCGATCTGAAGAGAACCGCCGGCTCCTCAATGAACTTGTTCCCGACAAGGTGCCCTTGGATCTGCTTC
ATGCCATCCTTCGCCTGCTGCTGGCCGAACAGGTCTCCATCCGCAATCTTCCATTGATCCTGGAGGCCATTGCTGAATCG
CGAGGTACAACCACTCAGCCGGAGATGATTTGCGAACATGTACGCCAGCGTCTCGGGTTCCAACTGATCGCCGACATGAA
GCGCAGTGATGGAACGTTACCGCTCATCCAATTGGCAAGTGAGTGGGAGGACGTGTTCCTGCGGTTTCAAATTGGCGGCG
ACGGTGGCCTGCCAGAGATCGCGCTGCCACCGGATGAGTTCAACGCGCTTGCCAAATCAGTCAGTGAGAAAGTCGCAACC
GCCAGCGAGAAGGGCACATTTCCTGCCATCGTGACCTCGTCCCTAAGGCGGCGTTTCCTCCGCACCGTCCTGTCCGCCCG
AGGTATCCCCAACCCAGTATTTTCATTTGAAGAAATCGGGCTAGAGGCAAAGCCAGCACTTGTCGGACTGGCCGCTCCAT
GA

Upstream 100 bases:

>100_bases
GTCCATCGGGTTCCGAGCATTCATACCAGACGTCAGACTGCCGCCCCGCTCCCTGCGCGACGGGCCCAATCACCACACCT
GTATCAATCGGAGCTTCATC

Downstream 100 bases:

>100_bases
TCGACCTGTTGGCCCAGCTTCTTGATCTTTCGGAGATCTGGCTTGCAACTGGTATCGCTGTTTTTCTACGGGTCGGTGCC
TGTTTTCTTGTGCTTCCGGG

Product: flagellar biosynthesis protein FlhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 693; Mature: 693

Protein sequence:

>693_residues
MISAKALFQPTILFALALMAVIIMMILPVPSFILDIGLAASFGLAILIFTVTLFIERPLDFSAFPTVLLASLMLRLSLNV
SSTKLIIGQGHTGTDAAGSVIEGFAMFVIDGSVVMGLVIFCVLLIVNFIVINKGAARMAEVGARFALDGMPGKQLAIDSD
MAAGAIDHEEAKTRREREQAETTFFGSLDGASKFVKGDAIAGLLITMLNLVVGLIIGTTMHGMPIGQAFETYSILTIGDG
LVSQIPSVIIAIASALLLARGGASGATDTALFAQLGKHPSALIAVSLLMAIFALVPGLPAAPFLLGAAALGFAAWRRMKT
LDEQAEPEDASSPEALEAPKETSGDLLDVDDIHVEFSPDLVSLALDPATGLDARIKNMREHVARSFGVLLPEMRLTDRGD
LPPGTYSIRLLGVEHATAQLNPARVLMLTQDGAVDLPDGEETSEPVYGAPARWIDPRDRERAGLAGMTVVTPSEVLATHL
LEVLKRNLSRLMTFKTLQRQLDAFIALSDGARSEENRRLLNELVPDKVPLDLLHAILRLLLAEQVSIRNLPLILEAIAES
RGTTTQPEMICEHVRQRLGFQLIADMKRSDGTLPLIQLASEWEDVFLRFQIGGDGGLPEIALPPDEFNALAKSVSEKVAT
ASEKGTFPAIVTSSLRRRFLRTVLSARGIPNPVFSFEEIGLEAKPALVGLAAP

Sequences:

>Translated_693_residues
MISAKALFQPTILFALALMAVIIMMILPVPSFILDIGLAASFGLAILIFTVTLFIERPLDFSAFPTVLLASLMLRLSLNV
SSTKLIIGQGHTGTDAAGSVIEGFAMFVIDGSVVMGLVIFCVLLIVNFIVINKGAARMAEVGARFALDGMPGKQLAIDSD
MAAGAIDHEEAKTRREREQAETTFFGSLDGASKFVKGDAIAGLLITMLNLVVGLIIGTTMHGMPIGQAFETYSILTIGDG
LVSQIPSVIIAIASALLLARGGASGATDTALFAQLGKHPSALIAVSLLMAIFALVPGLPAAPFLLGAAALGFAAWRRMKT
LDEQAEPEDASSPEALEAPKETSGDLLDVDDIHVEFSPDLVSLALDPATGLDARIKNMREHVARSFGVLLPEMRLTDRGD
LPPGTYSIRLLGVEHATAQLNPARVLMLTQDGAVDLPDGEETSEPVYGAPARWIDPRDRERAGLAGMTVVTPSEVLATHL
LEVLKRNLSRLMTFKTLQRQLDAFIALSDGARSEENRRLLNELVPDKVPLDLLHAILRLLLAEQVSIRNLPLILEAIAES
RGTTTQPEMICEHVRQRLGFQLIADMKRSDGTLPLIQLASEWEDVFLRFQIGGDGGLPEIALPPDEFNALAKSVSEKVAT
ASEKGTFPAIVTSSLRRRFLRTVLSARGIPNPVFSFEEIGLEAKPALVGLAAP
>Mature_693_residues
MISAKALFQPTILFALALMAVIIMMILPVPSFILDIGLAASFGLAILIFTVTLFIERPLDFSAFPTVLLASLMLRLSLNV
SSTKLIIGQGHTGTDAAGSVIEGFAMFVIDGSVVMGLVIFCVLLIVNFIVINKGAARMAEVGARFALDGMPGKQLAIDSD
MAAGAIDHEEAKTRREREQAETTFFGSLDGASKFVKGDAIAGLLITMLNLVVGLIIGTTMHGMPIGQAFETYSILTIGDG
LVSQIPSVIIAIASALLLARGGASGATDTALFAQLGKHPSALIAVSLLMAIFALVPGLPAAPFLLGAAALGFAAWRRMKT
LDEQAEPEDASSPEALEAPKETSGDLLDVDDIHVEFSPDLVSLALDPATGLDARIKNMREHVARSFGVLLPEMRLTDRGD
LPPGTYSIRLLGVEHATAQLNPARVLMLTQDGAVDLPDGEETSEPVYGAPARWIDPRDRERAGLAGMTVVTPSEVLATHL
LEVLKRNLSRLMTFKTLQRQLDAFIALSDGARSEENRRLLNELVPDKVPLDLLHAILRLLLAEQVSIRNLPLILEAIAES
RGTTTQPEMICEHVRQRLGFQLIADMKRSDGTLPLIQLASEWEDVFLRFQIGGDGGLPEIALPPDEFNALAKSVSEKVAT
ASEKGTFPAIVTSSLRRRFLRTVLSARGIPNPVFSFEEIGLEAKPALVGLAAP

Specific function: Required for formation of the rod structure of the flagellar apparatus. May constitute the export apparatus of flagellin. The flagellum is required to cause a persistent disease in a murine model of infection [H]

COG id: COG1298

COG function: function code NU; Flagellar biosynthesis pathway, component FlhA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family [H]

Homologues:

Organism=Escherichia coli, GI1788187, Length=653, Percent_Identity=37.9785604900459, Blast_Score=394, Evalue=1e-110,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006301
- InterPro:   IPR001712 [H]

Pfam domain/function: PF00771 FHIPEP [H]

EC number: NA

Molecular weight: Translated: 74132; Mature: 74132

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISAKALFQPTILFALALMAVIIMMILPVPSFILDIGLAASFGLAILIFTVTLFIERPLD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FSAFPTVLLASLMLRLSLNVSSTKLIIGQGHTGTDAAGSVIEGFAMFVIDGSVVMGLVIF
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
CVLLIVNFIVINKGAARMAEVGARFALDGMPGKQLAIDSDMAAGAIDHEEAKTRREREQA
HHHHHHHHHHHCCCHHHHHHHCCHHEECCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
ETTFFGSLDGASKFVKGDAIAGLLITMLNLVVGLIIGTTMHGMPIGQAFETYSILTIGDG
HHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCH
LVSQIPSVIIAIASALLLARGGASGATDTALFAQLGKHPSALIAVSLLMAIFALVPGLPA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCH
APFLLGAAALGFAAWRRMKTLDEQAEPEDASSPEALEAPKETSGDLLDVDDIHVEFSPDL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCEEECCCEEEEECCCE
VSLALDPATGLDARIKNMREHVARSFGVLLPEMRLTDRGDLPPGTYSIRLLGVEHATAQL
EEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEHHCCCC
NPARVLMLTQDGAVDLPDGEETSEPVYGAPARWIDPRDRERAGLAGMTVVTPSEVLATHL
CCEEEEEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCEEEECHHHHHHHHH
LEVLKRNLSRLMTFKTLQRQLDAFIALSDGARSEENRRLLNELVPDKVPLDLLHAILRLL
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
LAEQVSIRNLPLILEAIAESRGTTTQPEMICEHVRQRLGFQLIADMKRSDGTLPLIQLAS
HHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
EWEDVFLRFQIGGDGGLPEIALPPDEFNALAKSVSEKVATASEKGTFPAIVTSSLRRRFL
HHCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RTVLSARGIPNPVFSFEEIGLEAKPALVGLAAP
HHHHHHCCCCCCCCCHHHCCCCCCCCEEECCCC
>Mature Secondary Structure
MISAKALFQPTILFALALMAVIIMMILPVPSFILDIGLAASFGLAILIFTVTLFIERPLD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FSAFPTVLLASLMLRLSLNVSSTKLIIGQGHTGTDAAGSVIEGFAMFVIDGSVVMGLVIF
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
CVLLIVNFIVINKGAARMAEVGARFALDGMPGKQLAIDSDMAAGAIDHEEAKTRREREQA
HHHHHHHHHHHCCCHHHHHHHCCHHEECCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
ETTFFGSLDGASKFVKGDAIAGLLITMLNLVVGLIIGTTMHGMPIGQAFETYSILTIGDG
HHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCH
LVSQIPSVIIAIASALLLARGGASGATDTALFAQLGKHPSALIAVSLLMAIFALVPGLPA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCH
APFLLGAAALGFAAWRRMKTLDEQAEPEDASSPEALEAPKETSGDLLDVDDIHVEFSPDL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCEEECCCEEEEECCCE
VSLALDPATGLDARIKNMREHVARSFGVLLPEMRLTDRGDLPPGTYSIRLLGVEHATAQL
EEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEHHCCCC
NPARVLMLTQDGAVDLPDGEETSEPVYGAPARWIDPRDRERAGLAGMTVVTPSEVLATHL
CCEEEEEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCEEEECHHHHHHHHH
LEVLKRNLSRLMTFKTLQRQLDAFIALSDGARSEENRRLLNELVPDKVPLDLLHAILRLL
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
LAEQVSIRNLPLILEAIAESRGTTTQPEMICEHVRQRLGFQLIADMKRSDGTLPLIQLAS
HHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
EWEDVFLRFQIGGDGGLPEIALPPDEFNALAKSVSEKVATASEKGTFPAIVTSSLRRRFL
HHCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RTVLSARGIPNPVFSFEEIGLEAKPALVGLAAP
HHHHHHCCCCCCCCCHHHCCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]