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The map label for this gene is mdh [H]

Identifier: 89056614

GI number: 89056614

Start: 4230809

End: 4231897

Strand: Direct

Name: mdh [H]

Synonym: Jann_4123

Alternate gene names: 89056614

Gene position: 4230809-4231897 (Clockwise)

Preceding gene: 89056613

Following gene: 89056615

Centisome position: 97.98

GC content: 62.17

Gene sequence:

>1089_bases
ATGAATCAGACGATTGTGATGACCAATGTAGACCGGGAACAGTTGCGGACCTTCGTGGCAGAGGGGTTTCGAGCCCTCGG
ATTGACGGAGGAAGACGCGGGCATTTTCGCCAATGCGCTGATCTTCTCGGAACTGCGTTTTCATCCCGGTCAAGGGCAAG
GCGTCGCCCGTCTGCGCAGGTATCACGAGCGGATCGGGAATGGAGAGGTCAACCCCCGCGCTGGATGGTCCATCGTCAAG
GAAGGGCCCGCTTTGGCACTGGTCGATGCCCACAATGGGATCGGGACCGTTGCCGCATCAAAAGCGATGGCGCTGGCAAT
CAAAAAGGCGAAAGAGGGTGGGATCGGCACCGTTGTCGTCCGCAACTCTACCCACTACGGCTCCAGCGCGGTTCATGCCT
GTCAGGCGCTGGAGCATGGGTGTATCGGTGTGGCCTTCACCAACGCGGGCCCAGAAATGGCGCCTTGGGGTGGGCGCGAA
GGCGTGACCGGCACCAACCCCTGGTCCATCGCCGCGCCATCGGATCAAGGCTTCCCCACCGTCCTCGACATCGCGATCAC
GACAGCGGGCAAGGGCATGATGAACTGGCTGATCCGCGAAGGGAAGAAAATGCCGCTGGATTGGGCGATCACACCCGACG
GCGACGAAACGGACGATCCCGCCGCCGCATTGAAGGGGCCGTTGTTGGGAATCGGCGGGCATAAGGGCTATGGGCTGGCC
TTCATGACAGAGGCTTTGACCGGCGTCCTGTCGGGTGGCGGCTTTGGCCTGACCCCCTATTCCGATCCGCAAAAACTGGA
CGTCTCGCACTACTTTCAGGCCATTGATATCGAATGGTTCATGGACCCGGACGATTACGCCACGCGCATGGGCGCGTTCG
TGCAGATGGCCAAGACCCGCGCGCTGCGCCCCGGGTTTGACGAGATCCTCGTGCCCGGCGAACAGGAGGCGCGCCGGACT
GCCGCGAAGGCTGAAAACGGCGTGCCGATTGATGATGTCGTACTGGCGGACATGCAGGCGCTGGGGCGAGAGCTCGGGTT
GAAAACGCCGCTGGACGGACTTGGTCCCTACACGGGCAGCACGCTGTGA

Upstream 100 bases:

>100_bases
ACGGCCCCGGCATGACGGTGGTGATGACCGCCCCCGCAGGCCAACTTGGCAGCTACGACGCGCCGGGCACGAATATCGCC
GACATTCTGGGGCTATCCGC

Downstream 100 bases:

>100_bases
CACCGCTGGAGCCCACTTTCTTCGCCCGCGCGCGAGATCGGCTACGTGCCCGCGCGATGAATGCAGGGCTCGACGGATTG
CTTCTGCTGCGTGCCCCCAA

Product: malate dehydrogenase (NAD)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MNQTIVMTNVDREQLRTFVAEGFRALGLTEEDAGIFANALIFSELRFHPGQGQGVARLRRYHERIGNGEVNPRAGWSIVK
EGPALALVDAHNGIGTVAASKAMALAIKKAKEGGIGTVVVRNSTHYGSSAVHACQALEHGCIGVAFTNAGPEMAPWGGRE
GVTGTNPWSIAAPSDQGFPTVLDIAITTAGKGMMNWLIREGKKMPLDWAITPDGDETDDPAAALKGPLLGIGGHKGYGLA
FMTEALTGVLSGGGFGLTPYSDPQKLDVSHYFQAIDIEWFMDPDDYATRMGAFVQMAKTRALRPGFDEILVPGEQEARRT
AAKAENGVPIDDVVLADMQALGRELGLKTPLDGLGPYTGSTL

Sequences:

>Translated_362_residues
MNQTIVMTNVDREQLRTFVAEGFRALGLTEEDAGIFANALIFSELRFHPGQGQGVARLRRYHERIGNGEVNPRAGWSIVK
EGPALALVDAHNGIGTVAASKAMALAIKKAKEGGIGTVVVRNSTHYGSSAVHACQALEHGCIGVAFTNAGPEMAPWGGRE
GVTGTNPWSIAAPSDQGFPTVLDIAITTAGKGMMNWLIREGKKMPLDWAITPDGDETDDPAAALKGPLLGIGGHKGYGLA
FMTEALTGVLSGGGFGLTPYSDPQKLDVSHYFQAIDIEWFMDPDDYATRMGAFVQMAKTRALRPGFDEILVPGEQEARRT
AAKAENGVPIDDVVLADMQALGRELGLKTPLDGLGPYTGSTL
>Mature_362_residues
MNQTIVMTNVDREQLRTFVAEGFRALGLTEEDAGIFANALIFSELRFHPGQGQGVARLRRYHERIGNGEVNPRAGWSIVK
EGPALALVDAHNGIGTVAASKAMALAIKKAKEGGIGTVVVRNSTHYGSSAVHACQALEHGCIGVAFTNAGPEMAPWGGRE
GVTGTNPWSIAAPSDQGFPTVLDIAITTAGKGMMNWLIREGKKMPLDWAITPDGDETDDPAAALKGPLLGIGGHKGYGLA
FMTEALTGVLSGGGFGLTPYSDPQKLDVSHYFQAIDIEWFMDPDDYATRMGAFVQMAKTRALRPGFDEILVPGEQEARRT
AAKAENGVPIDDVVLADMQALGRELGLKTPLDGLGPYTGSTL

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=348, Percent_Identity=31.6091954022989, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786727, Length=331, Percent_Identity=29.0030211480363, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790000, Length=331, Percent_Identity=27.7945619335347, Blast_Score=125, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17507179, Length=306, Percent_Identity=34.9673202614379, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17536633, Length=356, Percent_Identity=33.4269662921348, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45553211, Length=315, Percent_Identity=31.7460317460317, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24667912, Length=315, Percent_Identity=31.7460317460317, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24667908, Length=315, Percent_Identity=31.7460317460317, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24667904, Length=315, Percent_Identity=31.7460317460317, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24648360, Length=349, Percent_Identity=29.2263610315186, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24658010, Length=306, Percent_Identity=27.1241830065359, Blast_Score=111, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 38402; Mature: 38402

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTIVMTNVDREQLRTFVAEGFRALGLTEEDAGIFANALIFSELRFHPGQGQGVARLRR
CCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
YHERIGNGEVNPRAGWSIVKEGPALALVDAHNGIGTVAASKAMALAIKKAKEGGIGTVVV
HHHHHCCCCCCCCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEE
RNSTHYGSSAVHACQALEHGCIGVAFTNAGPEMAPWGGREGVTGTNPWSIAAPSDQGFPT
ECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCE
VLDIAITTAGKGMMNWLIREGKKMPLDWAITPDGDETDDPAAALKGPLLGIGGHKGYGLA
EEEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHCCCEEEECCCCCCCHH
FMTEALTGVLSGGGFGLTPYSDPQKLDVSHYFQAIDIEWFMDPDDYATRMGAFVQMAKTR
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHEEEEEEEEECCHHHHHHHHHHHHHHHHH
ALRPGFDEILVPGEQEARRTAAKAENGVPIDDVVLADMQALGRELGLKTPLDGLGPYTGS
CCCCCHHHEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
TL
CC
>Mature Secondary Structure
MNQTIVMTNVDREQLRTFVAEGFRALGLTEEDAGIFANALIFSELRFHPGQGQGVARLRR
CCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
YHERIGNGEVNPRAGWSIVKEGPALALVDAHNGIGTVAASKAMALAIKKAKEGGIGTVVV
HHHHHCCCCCCCCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEE
RNSTHYGSSAVHACQALEHGCIGVAFTNAGPEMAPWGGREGVTGTNPWSIAAPSDQGFPT
ECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCE
VLDIAITTAGKGMMNWLIREGKKMPLDWAITPDGDETDDPAAALKGPLLGIGGHKGYGLA
EEEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHCCCEEEECCCCCCCHH
FMTEALTGVLSGGGFGLTPYSDPQKLDVSHYFQAIDIEWFMDPDDYATRMGAFVQMAKTR
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHEEEEEEEEECCHHHHHHHHHHHHHHHHH
ALRPGFDEILVPGEQEARRTAAKAENGVPIDDVVLADMQALGRELGLKTPLDGLGPYTGS
CCCCCHHHEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
TL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]