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The map label for this gene is cya [H]

Identifier: 89056522

GI number: 89056522

Start: 4135300

End: 4136691

Strand: Direct

Name: cya [H]

Synonym: Jann_4031

Alternate gene names: 89056522

Gene position: 4135300-4136691 (Clockwise)

Preceding gene: 89056517

Following gene: 89056528

Centisome position: 95.77

GC content: 62.72

Gene sequence:

>1392_bases
ATGATCGTCGCCGGAAGTGTACTTACTCTGCTCCTGATGGGGCTTGCCGTCGATGGGTTCGTGAACCCGGCCGATGAAGA
GCCGGACGATGATGCGGGCGTGCAGGAAGATGAACTGGACGGGGATGACCAATCAGGGTCCGGCGATGGTCTGACGGATC
TTCTGGACGCCGCGGGTAACGTGCCGGGCGAGCTGACCGCGTCGGCAAGCGCGGCACTGGCGTATACGCCCATAGACCAG
ATCGAACCCGACGAGGAAAACGATCTGTTGGCGCAGGCCGAAGCGGACGCCGATGAGGTCTGGGATATGGCCGAGGCCGA
GCAGTCCGAGTCGGATTTCATAGACATCCATTCCACCACCCATATCGGTGACGGGCAGGACGTGCCCTACGTGGCCACGT
TCGATCCCGAAACCGACACGCTCGTGCTTGAGTTTCTCGGCTTTGAGGAAGATGCCCCGGATATCGACGTCGCCTATGAC
GAGGACGAAGACGCCTCCATCGTGTCGGCCAATGGCTACCCGGTGACCATGGTCGAAGGGTCCAAGGATATGACAGCGGA
GCATGTCCGGGTTGTGATGGGCGGTGCGGACGAGGGCGAGGATCCGGATGCCCAACCCGACGGCACCGAGGGTGAGACGG
GAACCGGGCCAGATGATGCGGGCGCCGAAGGATCTAGCGGGTCGCAAGCCCAGGCCGACACCGCTGATCCAATGCCGCTG
GACCCGTCCGACATGCCCGACACCATGGATGAGGCCAGCGCAGACCGGATGAACAACATCTTCAATGGCGAGGGCGAAGA
GGTTGTGTCTGGCGACGGCGACGACGATGCGCTGACCGGCAGTGACGGCGATGACGTGATGGCTGGCGGCGCCGGAGATG
ACACCATTGATGGCGGCGACGATCGCGATCTGTTGTTCGGAGGGGACGGCGATGACGTACTCATGGGCGGCTCGGACGCG
GATTTCCTGCACGGCGGCCTTGGAGCGGACACGCTGGATGGCGGCGACGGTGACGATACTCTGGACGGCGTCGTCAGCAA
CGGCTCCACTGATGCCGATGAAGGTGACACGCTGTTTGGCGGAGACGGCGATGACCACATTATCCTGGGTCGGGGCGACA
TGGCCGAAGGCGGCGCGGGGGCGGACACGTTCACCAGCGGGTCTTATATCGAGACGGCAGAAGTGGCGGGCCACGTGTCC
GACTTCAACCCCACGGAGGACCGGATCGAGGTGATCTTTGATCCAGTGGAAAGCCCGGACCCCACTTTGGAAGTGCATGA
CTTTGAAGATGGCAGCGGCGCGGACATCGTCCTGGACGGTCAGATCATCCTGAGCGTGTCTGGTGCCCAGGGCCTGGATC
CAAACATGATCGAGCTGCAAGCCAGGGCATGA

Upstream 100 bases:

>100_bases
CTCCTGAACGCCCCAATTTTTACCGCCCGTTGTCAGGCCGCTGTCAAGGCGCTGTCAGACACTTGTCTGACACAGGCCGG
ACCAACCCGAGGGATCTGCC

Downstream 100 bases:

>100_bases
GGCGCTATTCCGGTGCGAAATGCGCCAGAACTGCCGCAAGGACCGGCTCGGGCACCTCTTCCATCATGAAGTGGCCCGTG
CCGTCGATTTCCTGCCCGTC

Product: type I secretion target repeat-containing protein

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MIVAGSVLTLLLMGLAVDGFVNPADEEPDDDAGVQEDELDGDDQSGSGDGLTDLLDAAGNVPGELTASASAALAYTPIDQ
IEPDEENDLLAQAEADADEVWDMAEAEQSESDFIDIHSTTHIGDGQDVPYVATFDPETDTLVLEFLGFEEDAPDIDVAYD
EDEDASIVSANGYPVTMVEGSKDMTAEHVRVVMGGADEGEDPDAQPDGTEGETGTGPDDAGAEGSSGSQAQADTADPMPL
DPSDMPDTMDEASADRMNNIFNGEGEEVVSGDGDDDALTGSDGDDVMAGGAGDDTIDGGDDRDLLFGGDGDDVLMGGSDA
DFLHGGLGADTLDGGDGDDTLDGVVSNGSTDADEGDTLFGGDGDDHIILGRGDMAEGGAGADTFTSGSYIETAEVAGHVS
DFNPTEDRIEVIFDPVESPDPTLEVHDFEDGSGADIVLDGQIILSVSGAQGLDPNMIELQARA

Sequences:

>Translated_463_residues
MIVAGSVLTLLLMGLAVDGFVNPADEEPDDDAGVQEDELDGDDQSGSGDGLTDLLDAAGNVPGELTASASAALAYTPIDQ
IEPDEENDLLAQAEADADEVWDMAEAEQSESDFIDIHSTTHIGDGQDVPYVATFDPETDTLVLEFLGFEEDAPDIDVAYD
EDEDASIVSANGYPVTMVEGSKDMTAEHVRVVMGGADEGEDPDAQPDGTEGETGTGPDDAGAEGSSGSQAQADTADPMPL
DPSDMPDTMDEASADRMNNIFNGEGEEVVSGDGDDDALTGSDGDDVMAGGAGDDTIDGGDDRDLLFGGDGDDVLMGGSDA
DFLHGGLGADTLDGGDGDDTLDGVVSNGSTDADEGDTLFGGDGDDHIILGRGDMAEGGAGADTFTSGSYIETAEVAGHVS
DFNPTEDRIEVIFDPVESPDPTLEVHDFEDGSGADIVLDGQIILSVSGAQGLDPNMIELQARA
>Mature_463_residues
MIVAGSVLTLLLMGLAVDGFVNPADEEPDDDAGVQEDELDGDDQSGSGDGLTDLLDAAGNVPGELTASASAALAYTPIDQ
IEPDEENDLLAQAEADADEVWDMAEAEQSESDFIDIHSTTHIGDGQDVPYVATFDPETDTLVLEFLGFEEDAPDIDVAYD
EDEDASIVSANGYPVTMVEGSKDMTAEHVRVVMGGADEGEDPDAQPDGTEGETGTGPDDAGAEGSSGSQAQADTADPMPL
DPSDMPDTMDEASADRMNNIFNGEGEEVVSGDGDDDALTGSDGDDVMAGGAGDDTIDGGDDRDLLFGGDGDDVLMGGSDA
DFLHGGLGADTLDGGDGDDTLDGVVSNGSTDADEGDTLFGGDGDDHIILGRGDMAEGGAGADTFTSGSYIETAEVAGHVS
DFNPTEDRIEVIFDPVESPDPTLEVHDFEDGSGADIVLDGQIILSVSGAQGLDPNMIELQARA

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 47423; Mature: 47423

Theoretical pI: Translated: 3.08; Mature: 3.08

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVAGSVLTLLLMGLAVDGFVNPADEEPDDDAGVQEDELDGDDQSGSGDGLTDLLDAAGN
CEECHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
VPGELTASASAALAYTPIDQIEPDEENDLLAQAEADADEVWDMAEAEQSESDFIDIHSTT
CCCCEECCCCCEEEECCHHHCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEECEE
HIGDGQDVPYVATFDPETDTLVLEFLGFEEDAPDIDVAYDEDEDASIVSANGYPVTMVEG
ECCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCEEEECCCCCCEEEECCCEEEEEEEC
SKDMTAEHVRVVMGGADEGEDPDAQPDGTEGETGTGPDDAGAEGSSGSQAQADTADPMPL
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DPSDMPDTMDEASADRMNNIFNGEGEEVVSGDGDDDALTGSDGDDVMAGGAGDDTIDGGD
CCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
DRDLLFGGDGDDVLMGGSDADFLHGGLGADTLDGGDGDDTLDGVVSNGSTDADEGDTLFG
CCEEEECCCCCCEEECCCCCHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEC
GDGDDHIILGRGDMAEGGAGADTFTSGSYIETAEVAGHVSDFNPTEDRIEVIFDPVESPD
CCCCCEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCCEEEEEECCCCCCC
PTLEVHDFEDGSGADIVLDGQIILSVSGAQGLDPNMIELQARA
CCEEEEECCCCCCCEEEECCEEEEEECCCCCCCCCEEEEEECC
>Mature Secondary Structure
MIVAGSVLTLLLMGLAVDGFVNPADEEPDDDAGVQEDELDGDDQSGSGDGLTDLLDAAGN
CEECHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
VPGELTASASAALAYTPIDQIEPDEENDLLAQAEADADEVWDMAEAEQSESDFIDIHSTT
CCCCEECCCCCEEEECCHHHCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEECEE
HIGDGQDVPYVATFDPETDTLVLEFLGFEEDAPDIDVAYDEDEDASIVSANGYPVTMVEG
ECCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCEEEECCCCCCEEEECCCEEEEEEEC
SKDMTAEHVRVVMGGADEGEDPDAQPDGTEGETGTGPDDAGAEGSSGSQAQADTADPMPL
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DPSDMPDTMDEASADRMNNIFNGEGEEVVSGDGDDDALTGSDGDDVMAGGAGDDTIDGGD
CCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
DRDLLFGGDGDDVLMGGSDADFLHGGLGADTLDGGDGDDTLDGVVSNGSTDADEGDTLFG
CCEEEECCCCCCEEECCCCCHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEC
GDGDDHIILGRGDMAEGGAGADTFTSGSYIETAEVAGHVSDFNPTEDRIEVIFDPVESPD
CCCCCEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCCEEEEEECCCCCCC
PTLEVHDFEDGSGADIVLDGQIILSVSGAQGLDPNMIELQARA
CCEEEEECCCCCCCEEEECCEEEEEECCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]