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The map label for this gene is acsA [H]

Identifier: 89056194

GI number: 89056194

Start: 3786505

End: 3788442

Strand: Direct

Name: acsA [H]

Synonym: Jann_3703

Alternate gene names: 89056194

Gene position: 3786505-3788442 (Clockwise)

Preceding gene: 89056193

Following gene: 89056195

Centisome position: 87.69

GC content: 62.38

Gene sequence:

>1938_bases
GTGCCCAAAGATCAACTGCCGCCCCTGTTGCCTGACGCCCATATCGACGCTGCCCGCTATGACGAGATGTACGCGGCCTC
CGTTGCGGACCCGGAGGCTTTCTGGGACGAGCATGGCAAGCGCATCGACTGGATCAAGCCCTATACAAAGGTGAAAGACA
CGTCTTTCGCCCATGACGATGTGCATATCCGCTGGTTTGAAGACGGCACCCTGAACGTCAGCGCCAACTGCATCGACCGT
CATCTGGCGGAGCGTGGCGACCAGACCGCGATCCTGTTTGAGCCCGATGAGCCGACAGATCCCGCACAGCATATCACCTA
CAACCAGCTTCATGTCGAAGTCAGCAAATTCGCCAACGTCCTGAAGGGCCTGGGCGTGGGGCGCGGCGACCGTGTGGTCC
TTTACATGCCGATGATCCCGGAGGCGGCCTACGCGATGCTGGCCTGCACGCGCATCGGGGCGGTGCATTCCATCGTCTTC
GCGGGCTTCTCTCCCGATGCGCTGTCCGCCCGGATCAATGGCTGTGACGCCAAGCTGGTGATCACCTCTGACGGGGCCCC
GCGCGGGGGTCGGGTGACGGAGCTGAAAGACAACGTCAACAAGGCGCTCTTGCACAACCAGATCAAGACCCAGTGCCTCG
TTGTGAAGCGCACCGGCGGGCAGGTTGCCTGGATCGCGGACCGGGACCATTGGTATCACGAGCTGGCCGAAACCGTTTCA
GCCGATTGCCCGCCCGAAGAGATGGGGGCCGAAGACCCGCTGTTCATTCTTTACACGTCCGGCTCCACCGGCATGCCCAA
GGGCGTGGTGCATACGACGGGCGGCTACATCGTCTATGCCTCCATGACCCACGAATACACGTTTGACTACAAGGACGGCG
ACGTCTTCTGGTGCACGGCGGATGTGGGCTGGGTCACGGGCCACAGCTATATCGTCTATGGCCCGCTGGCCAATGGCGGC
ACCACGCTGATGTTTGAGGGCGTGCCCACCTACCCCGACGCGGGCCGGTTCTGGGAAGTCTGCGAGAAACACAAGGTCAA
CCAGTTCTACACCGCCCCCACCGCCATCCGCGCGTTGATGGGTAAGGGGACGTCCTTTGTGGAGAAGTACGACCTGAGCA
GTCTGAAATTGCTGGGAACGGTCGGCGAAAACATCAACCCTGAGGCCTGGAACTGGTACAACGAGAATGTCGGTAAGGGC
CGCTGCCCCATCGTCGACACGTGGTGGCAGACGGAAACGGGCGGCCACATGATGACCCCCCTGCCCGGCGCGCATACGTT
GAAGCCCGGATCGGCGCAGAAGCCGTTCTTTGGCGTGCAACCGCTGGTGCTGGACCCGACGAGCGCGGAGGTTATTGAGG
GCAATGACGTGGAAGGCGTGCTGGTCATCGCCGACAGCTGGCCCGGCCAGATGCGCACCGTCTGGGGCGACCATGAGCGG
TTCGTGGCCACCTATTTCAGCGACTACAAGGGCTACTACTTCAGCGGCGACGGCTGCAAACGCGACGCGGACGGTGAGTA
TTGGATCACGGGCCGCGTGGACGATGTGATCAACGTATCGGGCCACCGCATGGGCACGCCCGAGATCGAGAGCGCGCTGG
TCGCCCATGAAACCGTGTCCGAGGCCGCCGTGGTCGGCTACCCGCATCCGGTCAAAGGCCAGGGCATCTATTGCTACGTG
ACCCTGATGAATGATGAGACGCCGTCCGATGAATTGAAGGCCACGTTGCAGGCCTGGGTCCGGCAAGAGATTGGCCCAAT
CGCCAAGCCGGACGTCATCCAATGGGCGCCGGGCCTGCCCAAGACCCGCTCCGGCAAGATCATGCGGCGCATCCTGCGCA
AGATCGCCGAGAATGATTACGGCGCGCTTGGCGATACGTCCACATTGGCCGATCCATCGGTGGTGGACGATCTGATCGCC
AACCGCGCGGACACCTGA

Upstream 100 bases:

>100_bases
TCTGATCCGCACATTCCCTGCCATGCTTGAAGGGACTGCGAGACGCACGCAATCGGCCGGGAGGGCCGCGCGCCGCTGAC
ACGACGGAGGAGAGACACCC

Downstream 100 bases:

>100_bases
CGCCGCTTTGCCACCGTCCTTGCACATGGGGCGGTGGCGGGTTGCGGAAAATGCTGCGCTGCGGCATAATCGGAACGTAA
CCCTCCGGAGCGCAACAATG

Product: acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MPKDQLPPLLPDAHIDAARYDEMYAASVADPEAFWDEHGKRIDWIKPYTKVKDTSFAHDDVHIRWFEDGTLNVSANCIDR
HLAERGDQTAILFEPDEPTDPAQHITYNQLHVEVSKFANVLKGLGVGRGDRVVLYMPMIPEAAYAMLACTRIGAVHSIVF
AGFSPDALSARINGCDAKLVITSDGAPRGGRVTELKDNVNKALLHNQIKTQCLVVKRTGGQVAWIADRDHWYHELAETVS
ADCPPEEMGAEDPLFILYTSGSTGMPKGVVHTTGGYIVYASMTHEYTFDYKDGDVFWCTADVGWVTGHSYIVYGPLANGG
TTLMFEGVPTYPDAGRFWEVCEKHKVNQFYTAPTAIRALMGKGTSFVEKYDLSSLKLLGTVGENINPEAWNWYNENVGKG
RCPIVDTWWQTETGGHMMTPLPGAHTLKPGSAQKPFFGVQPLVLDPTSAEVIEGNDVEGVLVIADSWPGQMRTVWGDHER
FVATYFSDYKGYYFSGDGCKRDADGEYWITGRVDDVINVSGHRMGTPEIESALVAHETVSEAAVVGYPHPVKGQGIYCYV
TLMNDETPSDELKATLQAWVRQEIGPIAKPDVIQWAPGLPKTRSGKIMRRILRKIAENDYGALGDTSTLADPSVVDDLIA
NRADT

Sequences:

>Translated_645_residues
MPKDQLPPLLPDAHIDAARYDEMYAASVADPEAFWDEHGKRIDWIKPYTKVKDTSFAHDDVHIRWFEDGTLNVSANCIDR
HLAERGDQTAILFEPDEPTDPAQHITYNQLHVEVSKFANVLKGLGVGRGDRVVLYMPMIPEAAYAMLACTRIGAVHSIVF
AGFSPDALSARINGCDAKLVITSDGAPRGGRVTELKDNVNKALLHNQIKTQCLVVKRTGGQVAWIADRDHWYHELAETVS
ADCPPEEMGAEDPLFILYTSGSTGMPKGVVHTTGGYIVYASMTHEYTFDYKDGDVFWCTADVGWVTGHSYIVYGPLANGG
TTLMFEGVPTYPDAGRFWEVCEKHKVNQFYTAPTAIRALMGKGTSFVEKYDLSSLKLLGTVGENINPEAWNWYNENVGKG
RCPIVDTWWQTETGGHMMTPLPGAHTLKPGSAQKPFFGVQPLVLDPTSAEVIEGNDVEGVLVIADSWPGQMRTVWGDHER
FVATYFSDYKGYYFSGDGCKRDADGEYWITGRVDDVINVSGHRMGTPEIESALVAHETVSEAAVVGYPHPVKGQGIYCYV
TLMNDETPSDELKATLQAWVRQEIGPIAKPDVIQWAPGLPKTRSGKIMRRILRKIAENDYGALGDTSTLADPSVVDDLIA
NRADT
>Mature_644_residues
PKDQLPPLLPDAHIDAARYDEMYAASVADPEAFWDEHGKRIDWIKPYTKVKDTSFAHDDVHIRWFEDGTLNVSANCIDRH
LAERGDQTAILFEPDEPTDPAQHITYNQLHVEVSKFANVLKGLGVGRGDRVVLYMPMIPEAAYAMLACTRIGAVHSIVFA
GFSPDALSARINGCDAKLVITSDGAPRGGRVTELKDNVNKALLHNQIKTQCLVVKRTGGQVAWIADRDHWYHELAETVSA
DCPPEEMGAEDPLFILYTSGSTGMPKGVVHTTGGYIVYASMTHEYTFDYKDGDVFWCTADVGWVTGHSYIVYGPLANGGT
TLMFEGVPTYPDAGRFWEVCEKHKVNQFYTAPTAIRALMGKGTSFVEKYDLSSLKLLGTVGENINPEAWNWYNENVGKGR
CPIVDTWWQTETGGHMMTPLPGAHTLKPGSAQKPFFGVQPLVLDPTSAEVIEGNDVEGVLVIADSWPGQMRTVWGDHERF
VATYFSDYKGYYFSGDGCKRDADGEYWITGRVDDVINVSGHRMGTPEIESALVAHETVSEAAVVGYPHPVKGQGIYCYVT
LMNDETPSDELKATLQAWVRQEIGPIAKPDVIQWAPGLPKTRSGKIMRRILRKIAENDYGALGDTSTLADPSVVDDLIAN
RADT

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=671, Percent_Identity=52.3099850968703, Blast_Score=688, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=684, Percent_Identity=51.1695906432749, Blast_Score=682, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=625, Percent_Identity=49.12, Blast_Score=617, Evalue=1e-177,
Organism=Homo sapiens, GI13375727, Length=631, Percent_Identity=38.9857369255151, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI122937307, Length=514, Percent_Identity=27.6264591439689, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI38505220, Length=516, Percent_Identity=28.6821705426357, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI42544132, Length=515, Percent_Identity=27.1844660194175, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI31982927, Length=633, Percent_Identity=24.6445497630332, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI115511026, Length=517, Percent_Identity=25.531914893617, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI58082049, Length=513, Percent_Identity=26.5107212475634, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI157311624, Length=516, Percent_Identity=25.968992248062, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI157311622, Length=516, Percent_Identity=25.968992248062, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI42544134, Length=334, Percent_Identity=25.4491017964072, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI187761345, Length=405, Percent_Identity=26.1728395061728, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI187761343, Length=405, Percent_Identity=26.1728395061728, Blast_Score=94, Evalue=6e-19,
Organism=Escherichia coli, GI1790505, Length=630, Percent_Identity=61.5873015873016, Blast_Score=806, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=630, Percent_Identity=38.2539682539683, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI145693145, Length=543, Percent_Identity=24.6777163904236, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1788107, Length=575, Percent_Identity=23.8260869565217, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71983001, Length=654, Percent_Identity=48.6238532110092, Blast_Score=598, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI71982997, Length=654, Percent_Identity=48.6238532110092, Blast_Score=598, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI17569507, Length=643, Percent_Identity=22.8615863141524, Blast_Score=149, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17558820, Length=553, Percent_Identity=23.1464737793852, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17557194, Length=576, Percent_Identity=23.7847222222222, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538037, Length=131, Percent_Identity=33.587786259542, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=639, Percent_Identity=48.8262910798122, Blast_Score=622, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6319264, Length=658, Percent_Identity=46.5045592705167, Blast_Score=580, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6319699, Length=373, Percent_Identity=23.8605898123324, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24667955, Length=660, Percent_Identity=52.7272727272727, Blast_Score=678, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=565, Percent_Identity=57.1681415929203, Blast_Score=640, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=523, Percent_Identity=57.9349904397706, Blast_Score=601, Evalue=1e-172,
Organism=Drosophila melanogaster, GI21355225, Length=639, Percent_Identity=34.7417840375587, Blast_Score=354, Evalue=1e-97,
Organism=Drosophila melanogaster, GI21355181, Length=543, Percent_Identity=23.0202578268877, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71172; Mature: 71041

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKDQLPPLLPDAHIDAARYDEMYAASVADPEAFWDEHGKRIDWIKPYTKVKDTSFAHDD
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCEECCCCCCHHCCCCCCCCCC
VHIRWFEDGTLNVSANCIDRHLAERGDQTAILFEPDEPTDPAQHITYNQLHVEVSKFANV
EEEEEEECCEEEEEHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCEEHHEEEEHHHHHHH
LKGLGVGRGDRVVLYMPMIPEAAYAMLACTRIGAVHSIVFAGFSPDALSARINGCDAKLV
HHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCHHHEEEECCCCEEEE
ITSDGAPRGGRVTELKDNVNKALLHNQIKTQCLVVKRTGGQVAWIADRDHWYHELAETVS
EECCCCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCHHHHHHHHHHHC
ADCPPEEMGAEDPLFILYTSGSTGMPKGVVHTTGGYIVYASMTHEYTFDYKDGDVFWCTA
CCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEEEEEEEEECCCCEEEEEC
DVGWVTGHSYIVYGPLANGGTTLMFEGVPTYPDAGRFWEVCEKHKVNQFYTAPTAIRALM
CCCEEECCCEEEEEECCCCCCEEEECCCCCCCCCCHHHHHHHHCCCCEEECCHHHHHHHH
GKGTSFVEKYDLSSLKLLGTVGENINPEAWNWYNENVGKGRCPIVDTWWQTETGGHMMTP
CCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEECC
LPGAHTLKPGSAQKPFFGVQPLVLDPTSAEVIEGNDVEGVLVIADSWPGQMRTVWGDHER
CCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCCCCEEEEEECCCCCCEEEECCCCHH
FVATYFSDYKGYYFSGDGCKRDADGEYWITGRVDDVINVSGHRMGTPEIESALVAHETVS
HHEEEHHHCCCEEECCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHH
EAAVVGYPHPVKGQGIYCYVTLMNDETPSDELKATLQAWVRQEIGPIAKPDVIQWAPGLP
CCEEECCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCC
KTRSGKIMRRILRKIAENDYGALGDTSTLADPSVVDDLIANRADT
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
PKDQLPPLLPDAHIDAARYDEMYAASVADPEAFWDEHGKRIDWIKPYTKVKDTSFAHDD
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCEECCCCCCHHCCCCCCCCCC
VHIRWFEDGTLNVSANCIDRHLAERGDQTAILFEPDEPTDPAQHITYNQLHVEVSKFANV
EEEEEEECCEEEEEHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCEEHHEEEEHHHHHHH
LKGLGVGRGDRVVLYMPMIPEAAYAMLACTRIGAVHSIVFAGFSPDALSARINGCDAKLV
HHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCHHHEEEECCCCEEEE
ITSDGAPRGGRVTELKDNVNKALLHNQIKTQCLVVKRTGGQVAWIADRDHWYHELAETVS
EECCCCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCHHHHHHHHHHHC
ADCPPEEMGAEDPLFILYTSGSTGMPKGVVHTTGGYIVYASMTHEYTFDYKDGDVFWCTA
CCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEEEEEEEEECCCCEEEEEC
DVGWVTGHSYIVYGPLANGGTTLMFEGVPTYPDAGRFWEVCEKHKVNQFYTAPTAIRALM
CCCEEECCCEEEEEECCCCCCEEEECCCCCCCCCCHHHHHHHHCCCCEEECCHHHHHHHH
GKGTSFVEKYDLSSLKLLGTVGENINPEAWNWYNENVGKGRCPIVDTWWQTETGGHMMTP
CCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEECC
LPGAHTLKPGSAQKPFFGVQPLVLDPTSAEVIEGNDVEGVLVIADSWPGQMRTVWGDHER
CCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCCCCEEEEEECCCCCCEEEECCCCHH
FVATYFSDYKGYYFSGDGCKRDADGEYWITGRVDDVINVSGHRMGTPEIESALVAHETVS
HHEEEHHHCCCEEECCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHH
EAAVVGYPHPVKGQGIYCYVTLMNDETPSDELKATLQAWVRQEIGPIAKPDVIQWAPGLP
CCEEECCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCC
KTRSGKIMRRILRKIAENDYGALGDTSTLADPSVVDDLIANRADT
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9256491 [H]