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The map label for this gene is ydgK [H]

Identifier: 89055866

GI number: 89055866

Start: 3428006

End: 3429223

Strand: Direct

Name: ydgK [H]

Synonym: Jann_3375

Alternate gene names: 89055866

Gene position: 3428006-3429223 (Clockwise)

Preceding gene: 89055860

Following gene: 89055867

Centisome position: 79.39

GC content: 63.71

Gene sequence:

>1218_bases
ATGATGACGGCTTCCCCGGCGCGGTTTCTGGATCGCACCACACCCCCGCATATCTTCACCTTGATCCTCGTCACAGGCCT
TGGCGCGCTGTCGATGAACATCTTCCTGCCGTCTCTGCCGGCGATGGCGGATTATTTTGACACCGATTACCGCCTGATGC
AGCTGTCGGTGTCGCTCTATCTCTTCGTCAATGCCGGGCTTCAGGTGATCATCGGGCCGATCTCGGATCGCTACGGGCGC
AGACCCGTCATTCTCGGCGGCTGCGCGATCTTCCTTCTCGCAACCCTCGGGTGCCTTCTGGCCAACACCATCGAGGTCTT
CCTCGTCTTCCGCATGGTCCAGGCCGTCATCGTCACGGGCCTCGTTCTGGGCCGGGCGGTCGTGCGCGACATGTATGACG
ACCGGGAAGCCGCGTCGCAGATCGGCTACGTCACCATGGGCATGGCCGTGGTCCCGATGATCGGCCCCGGCATCGGCGGC
GTCTTGGAAGAGAGTTTCAGCTGGCACGCCAATTTCGTCCTCCTCTTCATCCTCGGGGCCGCGATCATGGCACTGGTCTG
GGCCGACCTCGGCGAAACGGCACGCACCCAAAGCACCAGCCTCCGCGCACAGATCCGGGAATATCCCGAACTTCTCGCCT
CCCGCCGCTTCTGGGGCTATTGCCTGACAGCCTCCTTCGCGTCGGGCGCGTTCTTCTCCTATCTCGGCGGGGCACCCTAT
GTGGGGTCCGAGGTCTTCGGTCTGTCGGCGGCCAAGGTCGGCCTCTACTTCGGCGCGCCGGCCCTCGGCTACTTCTTTGG
CAATTGGATATCGGGGCGATACTCCATGCGTGTCGGCATCAATGGGATGATCCTGTGGGGCTCCATTGCGTCGGCCATCG
GGATGGGGCTGTCCCTTGGCCTGTCACTCCTTGGCTGGCAAACCGCGATCACCTTCTTCGGGTTCATGACCTCCGTGGGT
CTGGGCAACGGGATGGTCCTGCCGAACGCGACCTCGGGTATGCTATCGGTGCGCCCGCATCTGGCGGGCAGCGCGTCGGG
CCTTGGCGGCGCAATCATGCTGGCAGGCGGTGGCGCGATGTCCCTTCTGGCCGCAGCGGTCCTGACCGGCGACCGGGGGG
AATTGCCGCTTCTGGTGATCATGTTTGCCACAGCCATCGCAGCGGTCGTGGCGATTGGCTATACGATCCGCAGAGAGGCG
ACGCTCACCTCCGATTGA

Upstream 100 bases:

>100_bases
ATTACTTAGCGAGCTGAACCCACATTCTGCAAAGTTGCATAACTTGTATACTTCTCCGACCCCTCTGGACGGCGCGACCG
ATGGGGCGTAGGCAAACGTA

Downstream 100 bases:

>100_bases
CCGCGCAACCTTCACCGGGACGCACCCTGCGGGACGGTGGGAGGGGCGAGGCCTCCGGGTTTTCGCATCGCGAAAATCGG
GGCCAGCGTCTCCCCCGGCC

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MMTASPARFLDRTTPPHIFTLILVTGLGALSMNIFLPSLPAMADYFDTDYRLMQLSVSLYLFVNAGLQVIIGPISDRYGR
RPVILGGCAIFLLATLGCLLANTIEVFLVFRMVQAVIVTGLVLGRAVVRDMYDDREAASQIGYVTMGMAVVPMIGPGIGG
VLEESFSWHANFVLLFILGAAIMALVWADLGETARTQSTSLRAQIREYPELLASRRFWGYCLTASFASGAFFSYLGGAPY
VGSEVFGLSAAKVGLYFGAPALGYFFGNWISGRYSMRVGINGMILWGSIASAIGMGLSLGLSLLGWQTAITFFGFMTSVG
LGNGMVLPNATSGMLSVRPHLAGSASGLGGAIMLAGGGAMSLLAAAVLTGDRGELPLLVIMFATAIAAVVAIGYTIRREA
TLTSD

Sequences:

>Translated_405_residues
MMTASPARFLDRTTPPHIFTLILVTGLGALSMNIFLPSLPAMADYFDTDYRLMQLSVSLYLFVNAGLQVIIGPISDRYGR
RPVILGGCAIFLLATLGCLLANTIEVFLVFRMVQAVIVTGLVLGRAVVRDMYDDREAASQIGYVTMGMAVVPMIGPGIGG
VLEESFSWHANFVLLFILGAAIMALVWADLGETARTQSTSLRAQIREYPELLASRRFWGYCLTASFASGAFFSYLGGAPY
VGSEVFGLSAAKVGLYFGAPALGYFFGNWISGRYSMRVGINGMILWGSIASAIGMGLSLGLSLLGWQTAITFFGFMTSVG
LGNGMVLPNATSGMLSVRPHLAGSASGLGGAIMLAGGGAMSLLAAAVLTGDRGELPLLVIMFATAIAAVVAIGYTIRREA
TLTSD
>Mature_405_residues
MMTASPARFLDRTTPPHIFTLILVTGLGALSMNIFLPSLPAMADYFDTDYRLMQLSVSLYLFVNAGLQVIIGPISDRYGR
RPVILGGCAIFLLATLGCLLANTIEVFLVFRMVQAVIVTGLVLGRAVVRDMYDDREAASQIGYVTMGMAVVPMIGPGIGG
VLEESFSWHANFVLLFILGAAIMALVWADLGETARTQSTSLRAQIREYPELLASRRFWGYCLTASFASGAFFSYLGGAPY
VGSEVFGLSAAKVGLYFGAPALGYFFGNWISGRYSMRVGINGMILWGSIASAIGMGLSLGLSLLGWQTAITFFGFMTSVG
LGNGMVLPNATSGMLSVRPHLAGSASGLGGAIMLAGGGAMSLLAAAVLTGDRGELPLLVIMFATAIAAVVAIGYTIRREA
TLTSD

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=340, Percent_Identity=30, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI48994889, Length=374, Percent_Identity=26.7379679144385, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI87082312, Length=353, Percent_Identity=29.1784702549575, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1790146, Length=232, Percent_Identity=26.2931034482759, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787065, Length=267, Percent_Identity=25.8426966292135, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790794, Length=239, Percent_Identity=25.5230125523013, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790195, Length=161, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324264, Length=176, Percent_Identity=26.1363636363636, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42781; Mature: 42781

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTASPARFLDRTTPPHIFTLILVTGLGALSMNIFLPSLPAMADYFDTDYRLMQLSVSLY
CCCCCCHHHHCCCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHE
LFVNAGLQVIIGPISDRYGRRPVILGGCAIFLLATLGCLLANTIEVFLVFRMVQAVIVTG
EEEECCCEEEEECCHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLGRAVVRDMYDDREAASQIGYVTMGMAVVPMIGPGIGGVLEESFSWHANFVLLFILGA
HHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHH
AIMALVWADLGETARTQSTSLRAQIREYPELLASRRFWGYCLTASFASGAFFSYLGGAPY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEHHHHCCHHHHHHCCCCC
VGSEVFGLSAAKVGLYFGAPALGYFFGNWISGRYSMRVGINGMILWGSIASAIGMGLSLG
CCCHHHCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCEEEEHHHHHHHHHHHHHHH
LSLLGWQTAITFFGFMTSVGLGNGMVLPNATSGMLSVRPHLAGSASGLGGAIMLAGGGAM
HHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEECCCCCCCCCCCCCEEEEECCCHH
SLLAAAVLTGDRGELPLLVIMFATAIAAVVAIGYTIRREATLTSD
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MMTASPARFLDRTTPPHIFTLILVTGLGALSMNIFLPSLPAMADYFDTDYRLMQLSVSLY
CCCCCCHHHHCCCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHE
LFVNAGLQVIIGPISDRYGRRPVILGGCAIFLLATLGCLLANTIEVFLVFRMVQAVIVTG
EEEECCCEEEEECCHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLGRAVVRDMYDDREAASQIGYVTMGMAVVPMIGPGIGGVLEESFSWHANFVLLFILGA
HHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHH
AIMALVWADLGETARTQSTSLRAQIREYPELLASRRFWGYCLTASFASGAFFSYLGGAPY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEHHHHCCHHHHHHCCCCC
VGSEVFGLSAAKVGLYFGAPALGYFFGNWISGRYSMRVGINGMILWGSIASAIGMGLSLG
CCCHHHCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCEEEEHHHHHHHHHHHHHHH
LSLLGWQTAITFFGFMTSVGLGNGMVLPNATSGMLSVRPHLAGSASGLGGAIMLAGGGAM
HHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEECCCCCCCCCCCCCEEEEECCCHH
SLLAAAVLTGDRGELPLLVIMFATAIAAVVAIGYTIRREATLTSD
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]