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The map label for this gene is purK [H]

Identifier: 89055844

GI number: 89055844

Start: 3405002

End: 3406066

Strand: Direct

Name: purK [H]

Synonym: Jann_3353

Alternate gene names: 89055844

Gene position: 3405002-3406066 (Clockwise)

Preceding gene: 89055843

Following gene: 89055846

Centisome position: 78.86

GC content: 65.26

Gene sequence:

>1065_bases
ATGAGTGATCCGTTACCGGCTGGCAGCACCGTCGGCATTCTGGGTGGCGGTCAGTTGGGCCGCATGTTGGCTATGGCCGC
TGCGAACCTCGGCTACCGGGCCCACATCTTTGAGCCCGGCCCCGCCCCCGCCGCCGATGTGGCCCATGCCTGGACGCAAG
CCGGCTACGATGACCTCGACGCCCTGCGCAGCTTCGCGCAGGCCTGCGATGTCATCACCTTCGAGTTTGAGAATATCCCC
GCCGACGCCCTCCACGTCATCGCCAGCACCACACCCCTGTTCCCGGACCGCCGCGCGTTGGAAACCAGCCAGGACCGCCT
GATTGAGAAGGCCTTTCTCCGCGATATCGGCCTGAAAACAGCGCCCTATGCGCCGGTCAGCGGTGACATTCACGATGTGC
TGACCACGACGGGCACCCCCGCGATCCTGAAGACCCGCAGGTTCGGCTATGATGGCAAGGGACAGGCGCGCGTCATGGAC
ATGGGCGAGGCCGGGGCCGCCTTGGCCGCACTGGAAGGCGCGCCCGCGATTGCAGAGGGGTTCGTCGATTTCTCCACAGA
GATCAGCGTCATCGCGGCGCGCGGTCAAGATGGGTCCGTCGCGGCGTTTGACCCCGGCGAGAACGTCCATAAGGATGGCA
TCCTCGATACGACCACAGTGCCCGCCGCGATTCCGGCGTCCCTGCGCACCGACGCGGTGCTGATCGCATCGCAGATCCTC
ACTGCCCTCGACTATGTGGGCGTTCTGGGGGTGGAGTTGTTCGTCACGCCCGCAGGTCTGATCGTCAATGAAATCGCCCC
GCGCGTGCACAATTCCGGCCATTGGACCCAAGCGGGCTGCGCCGTGGACCAGTTTGAGCAACACATGCGGGCCGTCACCG
GCTGGCCGCTCGGGGACGGCAGCCGTCATGCCAACGTTGTGATGGAAAACCTCATCGGCGAGGACATCGCGCGCGCGTCA
AACCTGGCCAGTGAACCCGGCGTGCAGATCCACCTTTACGGCAAGGCTGAGACGCGGCAGGGGCGCAAGATGGGCCATAT
CAACCGCGTGACAGGTCCGGCGTAA

Upstream 100 bases:

>100_bases
ATGGCGGCAGCGATCCTGGCCAATGAAGACCCCGCCCTCGCCGCACGACTGGACCAGTGGCGCGCCGATCTGAGCGCCTC
AATCCCGGAGGCCCCCAGCG

Downstream 100 bases:

>100_bases
TCCCGTGACAGCGCCAAGATGGCCCTTTCATCTTGCCAAAAACGCGATTCCACCCTCTCCCCGCGCACCACCCACACAGA
TGAAGTGCATCTTGGGGGAG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSDPLPAGSTVGILGGGQLGRMLAMAAANLGYRAHIFEPGPAPAADVAHAWTQAGYDDLDALRSFAQACDVITFEFENIP
ADALHVIASTTPLFPDRRALETSQDRLIEKAFLRDIGLKTAPYAPVSGDIHDVLTTTGTPAILKTRRFGYDGKGQARVMD
MGEAGAALAALEGAPAIAEGFVDFSTEISVIAARGQDGSVAAFDPGENVHKDGILDTTTVPAAIPASLRTDAVLIASQIL
TALDYVGVLGVELFVTPAGLIVNEIAPRVHNSGHWTQAGCAVDQFEQHMRAVTGWPLGDGSRHANVVMENLIGEDIARAS
NLASEPGVQIHLYGKAETRQGRKMGHINRVTGPA

Sequences:

>Translated_354_residues
MSDPLPAGSTVGILGGGQLGRMLAMAAANLGYRAHIFEPGPAPAADVAHAWTQAGYDDLDALRSFAQACDVITFEFENIP
ADALHVIASTTPLFPDRRALETSQDRLIEKAFLRDIGLKTAPYAPVSGDIHDVLTTTGTPAILKTRRFGYDGKGQARVMD
MGEAGAALAALEGAPAIAEGFVDFSTEISVIAARGQDGSVAAFDPGENVHKDGILDTTTVPAAIPASLRTDAVLIASQIL
TALDYVGVLGVELFVTPAGLIVNEIAPRVHNSGHWTQAGCAVDQFEQHMRAVTGWPLGDGSRHANVVMENLIGEDIARAS
NLASEPGVQIHLYGKAETRQGRKMGHINRVTGPA
>Mature_353_residues
SDPLPAGSTVGILGGGQLGRMLAMAAANLGYRAHIFEPGPAPAADVAHAWTQAGYDDLDALRSFAQACDVITFEFENIPA
DALHVIASTTPLFPDRRALETSQDRLIEKAFLRDIGLKTAPYAPVSGDIHDVLTTTGTPAILKTRRFGYDGKGQARVMDM
GEAGAALAALEGAPAIAEGFVDFSTEISVIAARGQDGSVAAFDPGENVHKDGILDTTTVPAAIPASLRTDAVLIASQILT
ALDYVGVLGVELFVTPAGLIVNEIAPRVHNSGHWTQAGCAVDQFEQHMRAVTGWPLGDGSRHANVVMENLIGEDIARASN
LASEPGVQIHLYGKAETRQGRKMGHINRVTGPA

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=340, Percent_Identity=38.8235294117647, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI1788155, Length=359, Percent_Identity=28.6908077994429, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324702, Length=360, Percent_Identity=32.7777777777778, Blast_Score=201, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 37174; Mature: 37043

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPLPAGSTVGILGGGQLGRMLAMAAANLGYRAHIFEPGPAPAADVAHAWTQAGYDDLD
CCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHH
ALRSFAQACDVITFEFENIPADALHVIASTTPLFPDRRALETSQDRLIEKAFLRDIGLKT
HHHHHHHHHCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
APYAPVSGDIHDVLTTTGTPAILKTRRFGYDGKGQARVMDMGEAGAALAALEGAPAIAEG
CCCCCCCCCHHHHHHCCCCCHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHCCCCHHHHH
FVDFSTEISVIAARGQDGSVAAFDPGENVHKDGILDTTTVPAAIPASLRTDAVLIASQIL
HHCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TALDYVGVLGVELFVTPAGLIVNEIAPRVHNSGHWTQAGCAVDQFEQHMRAVTGWPLGDG
HHHHHHHHHHHHHEECCHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHCCCCCCC
SRHANVVMENLIGEDIARASNLASEPGVQIHLYGKAETRQGRKMGHINRVTGPA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDPLPAGSTVGILGGGQLGRMLAMAAANLGYRAHIFEPGPAPAADVAHAWTQAGYDDLD
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHH
ALRSFAQACDVITFEFENIPADALHVIASTTPLFPDRRALETSQDRLIEKAFLRDIGLKT
HHHHHHHHHCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
APYAPVSGDIHDVLTTTGTPAILKTRRFGYDGKGQARVMDMGEAGAALAALEGAPAIAEG
CCCCCCCCCHHHHHHCCCCCHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHCCCCHHHHH
FVDFSTEISVIAARGQDGSVAAFDPGENVHKDGILDTTTVPAAIPASLRTDAVLIASQIL
HHCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TALDYVGVLGVELFVTPAGLIVNEIAPRVHNSGHWTQAGCAVDQFEQHMRAVTGWPLGDG
HHHHHHHHHHHHHEECCHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHCCCCCCC
SRHANVVMENLIGEDIARASNLASEPGVQIHLYGKAETRQGRKMGHINRVTGPA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]