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The map label for this gene is mtaD [H]

Identifier: 89055729

GI number: 89055729

Start: 3285954

End: 3287288

Strand: Direct

Name: mtaD [H]

Synonym: Jann_3238

Alternate gene names: 89055729

Gene position: 3285954-3287288 (Clockwise)

Preceding gene: 89055728

Following gene: 89055730

Centisome position: 76.1

GC content: 63.75

Gene sequence:

>1335_bases
ATGAAGACGCTCCTCACCAACGCCTGGATCCTCGCGGTCGATGACGCGATGTCTGAATATCGCGACGGCTGGTTGTTGAT
AGAAAACAGCAAGATCGCAGCCCTTGGCGACGGCCCGCCGCCGGATACAAAGGGCGCAGAATTCTGCAATATGGGCGGTG
ACATCGTTATGCCCGGGATGGTGAACACCCATTGCCACATGGCGATGTCGCTGTTCCGAGGCTTGGGTGAGGACGTGGAT
GATCGCCTTTACCGCTACATGCTGCCGCTGGAACGCAAATTCGTCTCGGCCGACATGGTTCGCGTCGGCTCCACCCTGTC
GGCGCTGGAGATGATCATGGGCGGCGTCACCTGCGTCGCGGACATGTACTACCATGAAACGCAGGTCGCGGATGTCATCG
CGACCTCAGGCATGCGCGGCGTCGTGGGGCAAACGCTCGCCAATTTTGACCCGCCCGACCACACCAGTTTCGATGAGGGG
TTTGCGCTGTGCGACGCCTTGGTGGAGCATTGCGCGGGGATGCCGCGCGTGACTGCCTCCATCGCGCCGCACGCGCCCTA
TTCGACGGGCATGGACGTGATGGAGCGGGTGGCCGGCTGGCACGCCGATCACCCGGAAACCCGTATCCAGATTCATCTGG
CCGAGACGGAGGCCGAGGTCGCCTGGGCCCATGACACCCACGGCATGACCACCACGGCCGTCTGCGATGCAGCAGGCCTG
TTGAAGCCCGGCACAATCGCCGCCCATTGCCTGCTGATCAGTGACGCCGATATCGACATCCTCGCCCGAACCGATACCCG
CGTCGCCCACAACGCGCGCTCCAACGGCAAGGCCGGGCGCGGCATGGCGCGGGTGGAGGATATGCGCCGCGCGGGCATCC
CCGTGGGCCTCGCCACCGATGGCCCGATGAGCGGTAATACTCTTGATCTCTTCTCCCAGTTCGGCGTCGCCTCGATCTTC
GCCAAGGTTCTTGGCGGGTCCCGCAAGCCGCTGCCCACCCGCGACGTGATCCGCATGGCCACGATTGAGGGCGCGCGCGT
GCTGGGGCTGGAGGCGCAGACCGGCTCGCTAGAGGTCGGCAAGGCCGCCGATCTGATCCGCATCGACCTATCCGCGCCGC
GTATGCAGCCGATCTATGATCCCTACTCGGTCCTCGTTTTTGCCACGATGCCCACAGATGTGCGCGATGTCATGGTCGAT
GGCATCTGGCTGATGCGCGACCGGACGATTGAAACGCTGGAACCCGCGCGCGTACTGGCCGATGCCAATCAGGTGGCCGG
ACAATTCCGCACTGAGATTGCCGCCATAGATGCCGCGATGGCTGTCAAAGGATGA

Upstream 100 bases:

>100_bases
CGCATCTGGTGGCCAACGGCTCCCTCGCGACCCCGTTTGAGCCCGGAATGCGGGCCACGCTGGTCCCCAACCCGGACCAA
TGTGCGATCCTGGCTCCGGA

Downstream 100 bases:

>100_bases
TGCCATGACCCAATCGCCCGATCTGCAAGCCGTCCTCGACTATGCGGACGCGCACATGAACGACAGCCTTGCGCGGCTAT
TTGACCTCGTGCGCATACCG

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MKTLLTNAWILAVDDAMSEYRDGWLLIENSKIAALGDGPPPDTKGAEFCNMGGDIVMPGMVNTHCHMAMSLFRGLGEDVD
DRLYRYMLPLERKFVSADMVRVGSTLSALEMIMGGVTCVADMYYHETQVADVIATSGMRGVVGQTLANFDPPDHTSFDEG
FALCDALVEHCAGMPRVTASIAPHAPYSTGMDVMERVAGWHADHPETRIQIHLAETEAEVAWAHDTHGMTTTAVCDAAGL
LKPGTIAAHCLLISDADIDILARTDTRVAHNARSNGKAGRGMARVEDMRRAGIPVGLATDGPMSGNTLDLFSQFGVASIF
AKVLGGSRKPLPTRDVIRMATIEGARVLGLEAQTGSLEVGKAADLIRIDLSAPRMQPIYDPYSVLVFATMPTDVRDVMVD
GIWLMRDRTIETLEPARVLADANQVAGQFRTEIAAIDAAMAVKG

Sequences:

>Translated_444_residues
MKTLLTNAWILAVDDAMSEYRDGWLLIENSKIAALGDGPPPDTKGAEFCNMGGDIVMPGMVNTHCHMAMSLFRGLGEDVD
DRLYRYMLPLERKFVSADMVRVGSTLSALEMIMGGVTCVADMYYHETQVADVIATSGMRGVVGQTLANFDPPDHTSFDEG
FALCDALVEHCAGMPRVTASIAPHAPYSTGMDVMERVAGWHADHPETRIQIHLAETEAEVAWAHDTHGMTTTAVCDAAGL
LKPGTIAAHCLLISDADIDILARTDTRVAHNARSNGKAGRGMARVEDMRRAGIPVGLATDGPMSGNTLDLFSQFGVASIF
AKVLGGSRKPLPTRDVIRMATIEGARVLGLEAQTGSLEVGKAADLIRIDLSAPRMQPIYDPYSVLVFATMPTDVRDVMVD
GIWLMRDRTIETLEPARVLADANQVAGQFRTEIAAIDAAMAVKG
>Mature_444_residues
MKTLLTNAWILAVDDAMSEYRDGWLLIENSKIAALGDGPPPDTKGAEFCNMGGDIVMPGMVNTHCHMAMSLFRGLGEDVD
DRLYRYMLPLERKFVSADMVRVGSTLSALEMIMGGVTCVADMYYHETQVADVIATSGMRGVVGQTLANFDPPDHTSFDEG
FALCDALVEHCAGMPRVTASIAPHAPYSTGMDVMERVAGWHADHPETRIQIHLAETEAEVAWAHDTHGMTTTAVCDAAGL
LKPGTIAAHCLLISDADIDILARTDTRVAHNARSNGKAGRGMARVEDMRRAGIPVGLATDGPMSGNTLDLFSQFGVASIF
AKVLGGSRKPLPTRDVIRMATIEGARVLGLEAQTGSLEVGKAADLIRIDLSAPRMQPIYDPYSVLVFATMPTDVRDVMVD
GIWLMRDRTIETLEPARVLADANQVAGQFRTEIAAIDAAMAVKG

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=420, Percent_Identity=25, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1789249, Length=384, Percent_Identity=25, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI87082177, Length=410, Percent_Identity=26.8292682926829, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319963, Length=350, Percent_Identity=26.2857142857143, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24643849, Length=390, Percent_Identity=25.8974358974359, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 47759; Mature: 47759

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLLTNAWILAVDDAMSEYRDGWLLIENSKIAALGDGPPPDTKGAEFCNMGGDIVMPGM
CCCEECCCEEEEECHHHHHHCCCEEEEECCEEEEECCCCCCCCCCCHHHCCCCCEEECCC
VNTHCHMAMSLFRGLGEDVDDRLYRYMLPLERKFVSADMVRVGSTLSALEMIMGGVTCVA
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHH
DMYYHETQVADVIATSGMRGVVGQTLANFDPPDHTSFDEGFALCDALVEHCAGMPRVTAS
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEHC
IAPHAPYSTGMDVMERVAGWHADHPETRIQIHLAETEAEVAWAHDTHGMTTTAVCDAAGL
CCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHCCC
LKPGTIAAHCLLISDADIDILARTDTRVAHNARSNGKAGRGMARVEDMRRAGIPVGLATD
CCCCCCEEEEEEEECCCEEEEECCCCHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEECCC
GPMSGNTLDLFSQFGVASIFAKVLGGSRKPLPTRDVIRMATIEGARVLGLEAQTGSLEVG
CCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHEECCCEEEEEECCCCCEECC
KAADLIRIDLSAPRMQPIYDPYSVLVFATMPTDVRDVMVDGIWLMRDRTIETLEPARVLA
CCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHHCCEEEEECCCHHHCCHHHHHH
DANQVAGQFRTEIAAIDAAMAVKG
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTLLTNAWILAVDDAMSEYRDGWLLIENSKIAALGDGPPPDTKGAEFCNMGGDIVMPGM
CCCEECCCEEEEECHHHHHHCCCEEEEECCEEEEECCCCCCCCCCCHHHCCCCCEEECCC
VNTHCHMAMSLFRGLGEDVDDRLYRYMLPLERKFVSADMVRVGSTLSALEMIMGGVTCVA
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHH
DMYYHETQVADVIATSGMRGVVGQTLANFDPPDHTSFDEGFALCDALVEHCAGMPRVTAS
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEHC
IAPHAPYSTGMDVMERVAGWHADHPETRIQIHLAETEAEVAWAHDTHGMTTTAVCDAAGL
CCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHCCC
LKPGTIAAHCLLISDADIDILARTDTRVAHNARSNGKAGRGMARVEDMRRAGIPVGLATD
CCCCCCEEEEEEEECCCEEEEECCCCHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEECCC
GPMSGNTLDLFSQFGVASIFAKVLGGSRKPLPTRDVIRMATIEGARVLGLEAQTGSLEVG
CCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHEECCCEEEEEECCCCCEECC
KAADLIRIDLSAPRMQPIYDPYSVLVFATMPTDVRDVMVDGIWLMRDRTIETLEPARVLA
CCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHHCCEEEEECCCHHHCCHHHHHH
DANQVAGQFRTEIAAIDAAMAVKG
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA