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The map label for this gene is csgA [H]

Identifier: 89055681

GI number: 89055681

Start: 3232070

End: 3232723

Strand: Direct

Name: csgA [H]

Synonym: Jann_3190

Alternate gene names: 89055681

Gene position: 3232070-3232723 (Clockwise)

Preceding gene: 89055679

Following gene: 89055682

Centisome position: 74.85

GC content: 60.4

Gene sequence:

>654_bases
ATGACAACCCTGATCACGGGCGCGAACCGGGGACTCGGCCTGGGCCTGGCAGAGCATTATCGCACCGCAGGAGAGACGGT
GATCGGCACGTCGCGCGATGGCGAGGCCGGTGTGCGGCTGGACGTGACGGATACGACGTCACTTGCCAACCTGAGCGAAA
CACTGGGCGACGACCCCATAGACACGCTGATCTGTAACGCAGGCGTTTTTCTGGACCGCCACGAGAAAACTGAGACCGGG
TATGCGGCAAAGCTGTGGAAGCGGACCTTCGCCACCAATGTCATGGGCGTCTTCCTGACAATTCAGACCGTGCTCCCCAA
CCTCAAGACCGCCAAGACCGCCAAGACCCCGAAGATCGTCATTATCTCAAGTCAAATGGGCTCTTCGGCAAAAGCGGGCG
GCAATGCGCTGATCTACCGGGCGTCCAAGGCGGCAGCCCTGAACCTTGGCCGCAACCTGGCCGTGGATCTTGAACTGGAC
GGGATCGCCGTTGGCATCTACCACCCGGGCTGGGTGCGCACGGATATGGGCGGTGGTGGGGCAGCAATCTCGGTCTACAC
GTCGGTCAAGGGTCTCTCCCATCAAATTGAGGCGCTTAGCCTGGAGACAACAGGATGCTTCCTGAACTGGGACGGCAATC
CGCAGGATTACTAA

Upstream 100 bases:

>100_bases
CCTCCTGATGTGCGGCACCCTAGACCAGCGCAAAGCGCTTGCAAACGGCCCTGTCCATGGCACTATTTGAACCGGACCAA
CAGGTGAGGGAGTGGCCCCA

Downstream 100 bases:

>100_bases
GCGTCCCTTGCCCCCGCGTCCGCCCCCGGGTAAGTCCGGGCGCGACTGAACAACGGGATCCTCCATGCCCCTCCTGGTGA
TGAAATTCGGCGGCACATCC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MTTLITGANRGLGLGLAEHYRTAGETVIGTSRDGEAGVRLDVTDTTSLANLSETLGDDPIDTLICNAGVFLDRHEKTETG
YAAKLWKRTFATNVMGVFLTIQTVLPNLKTAKTAKTPKIVIISSQMGSSAKAGGNALIYRASKAAALNLGRNLAVDLELD
GIAVGIYHPGWVRTDMGGGGAAISVYTSVKGLSHQIEALSLETTGCFLNWDGNPQDY

Sequences:

>Translated_217_residues
MTTLITGANRGLGLGLAEHYRTAGETVIGTSRDGEAGVRLDVTDTTSLANLSETLGDDPIDTLICNAGVFLDRHEKTETG
YAAKLWKRTFATNVMGVFLTIQTVLPNLKTAKTAKTPKIVIISSQMGSSAKAGGNALIYRASKAAALNLGRNLAVDLELD
GIAVGIYHPGWVRTDMGGGGAAISVYTSVKGLSHQIEALSLETTGCFLNWDGNPQDY
>Mature_216_residues
TTLITGANRGLGLGLAEHYRTAGETVIGTSRDGEAGVRLDVTDTTSLANLSETLGDDPIDTLICNAGVFLDRHEKTETGY
AAKLWKRTFATNVMGVFLTIQTVLPNLKTAKTAKTPKIVIISSQMGSSAKAGGNALIYRASKAAALNLGRNLAVDLELDG
IAVGIYHPGWVRTDMGGGGAAISVYTSVKGLSHQIEALSLETTGCFLNWDGNPQDY

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Homo sapiens, GI10190746, Length=219, Percent_Identity=30.5936073059361, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=192, Percent_Identity=28.6458333333333, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559962, Length=241, Percent_Identity=31.5352697095436, Blast_Score=93, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17558990, Length=248, Percent_Identity=31.8548387096774, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17558994, Length=248, Percent_Identity=29.0322580645161, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17532177, Length=243, Percent_Identity=30.8641975308642, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17558992, Length=248, Percent_Identity=31.8548387096774, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193207563, Length=248, Percent_Identity=28.6290322580645, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17559964, Length=241, Percent_Identity=30.7053941908714, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17542178, Length=240, Percent_Identity=31.25, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17541382, Length=247, Percent_Identity=33.1983805668016, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI72001658, Length=239, Percent_Identity=26.3598326359833, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322779, Length=251, Percent_Identity=28.2868525896414, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24640547, Length=244, Percent_Identity=29.9180327868852, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 22859; Mature: 22728

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLITGANRGLGLGLAEHYRTAGETVIGTSRDGEAGVRLDVTDTTSLANLSETLGDDPI
CCEEEECCCCCCCCCHHHHHHCCCCEEEECCCCCCCCEEEEECCCCCHHHHHHHHCCCCH
DTLICNAGVFLDRHEKTETGYAAKLWKRTFATNVMGVFLTIQTVLPNLKTAKTAKTPKIV
HHHEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCCCCCCCCEEE
IISSQMGSSAKAGGNALIYRASKAAALNLGRNLAVDLELDGIAVGIYHPGWVRTDMGGGG
EEECCCCCCCCCCCCEEEEECCCCEEEECCCCEEEEEEECCEEEEEECCCEEEEECCCCC
AAISVYTSVKGLSHQIEALSLETTGCFLNWDGNPQDY
EEEEEEEECCCCCCEEEEEEEEECEEEEEECCCCCCC
>Mature Secondary Structure 
TTLITGANRGLGLGLAEHYRTAGETVIGTSRDGEAGVRLDVTDTTSLANLSETLGDDPI
CEEEECCCCCCCCCHHHHHHCCCCEEEECCCCCCCCEEEEECCCCCHHHHHHHHCCCCH
DTLICNAGVFLDRHEKTETGYAAKLWKRTFATNVMGVFLTIQTVLPNLKTAKTAKTPKIV
HHHEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCCCCCCCCEEE
IISSQMGSSAKAGGNALIYRASKAAALNLGRNLAVDLELDGIAVGIYHPGWVRTDMGGGG
EEECCCCCCCCCCCCEEEEECCCCEEEECCCCEEEEEEECCEEEEEECCCEEEEECCCCC
AAISVYTSVKGLSHQIEALSLETTGCFLNWDGNPQDY
EEEEEEEECCCCCCEEEEEEEEECEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]