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The map label for this gene is glmS [H]

Identifier: 89055677

GI number: 89055677

Start: 3227852

End: 3229660

Strand: Direct

Name: glmS [H]

Synonym: Jann_3186

Alternate gene names: 89055677

Gene position: 3227852-3229660 (Clockwise)

Preceding gene: 89055676

Following gene: 89055678

Centisome position: 74.75

GC content: 63.07

Gene sequence:

>1809_bases
ATGTGTGGAATCATCGGCGTTCTGGGCGATCACGAGGTTGCGCCGATCCTGGTCGAAGCGCTGAAGCGGCTGGAATATCG
TGGCTATGACAGCGCCGGGATCGCCACGGTGCAGAACGGTGTGCTGGATCGCAGGCGCGCGGTGGGCAAGTTGGTGAACC
TGTCTGACACGCTGGTCCATGATCCGCTGGCTGGCAAATCCGGCATCGGCCACACCCGGTGGGCGACCCATGGGGGGCCG
ACGGTCACCAACGCCCATCCCCATCAAGCAGGCCGCGTCGCGGTGGTGCACAACGGTATTATCGAGAATTACAAAGAGTT
GCGCGACCGGCTGAGCCACCGGACCTTCGTGACCGACACGGATACAGAGACCGTCGCACAATTATGCGAGGACTTCCTTG
ATCAGGGCCTGCCCCCACGCGAGGCCGCGGTTGAAACGCTGAAGCATCTGGACGGGGCCTATGCGTTGGCCTTCCTGTTC
CACGGTGAGGAAGACCTGATCGTCGCCGCGCGCATGGGGTCGCCTTTAGCCATCGGGCACGGCGACGGAGAGATGTTCGT
GGGCTCAGACGCCATCGCGCTCGGCCCCATGACAGACCGGATCACCTACCTAGAAGAGGGCGATTATGCCTTCGTCACCC
GCGCAGGCGCCGAGATCCGAGAGGCCCATGGCGCGCTGGCCAACCGGGAAACGTTACACGTCCCCGCCCAGGCCATTCAG
CTGGACAAGGGCGGCCATAAACACTTCATGGCGAAGGAAATCTTCGAACAGCCCGTGGTGCTGGCCGATTGCCTGAAATC
CTATTCCGGGGACGGTCGCGTCGCGCTGCCCGAACCGCTTGATTTCACGCAAACCGACCGATTGATTTTCGTCGCCTGTG
GCACCGCCTTTTACGCCTGCGCCGTGGCGAAATATTGGTTCGAGCAATTGGCAGGCATCCCCTGCGACGTCGATATCGCG
TCTGAATTCCGCTACCGTGAACCGCCCGTGTCCTCGGACGCGACTGCGCTTTTCGTCAGCCAATCCGGCGAAACCGCGGA
CACGCTCGCCGCCCTGCGTTACGTGCAGGAGAAGGCCGCGCGTGTCGTGTCGGTCGTCAACGTCCCCGGATCGTCGATCG
CGCGCGAATCAGATCTGGCCTTGCCGATCCTGGCGGGGGTTGAGGTCGGCGTGGCCTCCACCAAGGCATTCATGAACCAA
TTGGGGGTGCTGGCCAACCTCGCCATTCTCGCCGCGCGCCAAAGGGGCCGGATCGACGCGGACCGGGAGGCCGAGCTGCT
GGAAACCCTGCGCGGGATGCCGGGCCTGATCAATCAGGCGCTGGCGCTGGAAGGCAAGATCGCCAAACGCACCGCCAAGC
TGGCCGAGGCGAAATCCGTCCTTTTCCTAGGGCGCGGCGCGATGTACCCGCTGGCCATGGAAGGTGCGCTGAAGCTCAAG
GAAATCAGCTATATCCACGCTGAAGGGTATGCGTCTGGCGAGTTGAAGCACGGCCCCATCGCCTTGATCGACAAATCCGT
CCCGGTGATCGTCTTCGCCCCCCGCGATGCGCTCTTCGACAAGACGGTCTCCAACATGCAGGAGGTCATGGCCCGCGATG
GAAAGGTCTGGCTGATCACCGATGCCGATGGCGCGGCGCAGGCAGGCGACGGCACATGGGATACGCTGGTCATGCCAAAG
GTGGACCCGATCCTGGCCCCGATGCTCTACGCGGTCGCGGCGCAGCTGATCGCCTACCATACGGCGATCCATAAGGGCAC
GGATGTGGACCAACCCCGCAACCTGGCAAAATCGGTGACCGTTGAATGA

Upstream 100 bases:

>100_bases
GGCCCTGGGCCGTGCCAAGCAAGTCAACAAGCCCGGTCTTGCCACGAAGTTACGTGCGCGCCTGAAGGCGATTAAAGATG
CAAAATCAAAGGACTAGACC

Downstream 100 bases:

>100_bases
CCCTGGACCTGCATGATCTGACCCTGACCGGCACCCATGTCAGCCTGGTCCCGCTGAGCCAGGCCCACCACGATGCCTTG
GCCGCTGCCAGCGATGCGGG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MCGIIGVLGDHEVAPILVEALKRLEYRGYDSAGIATVQNGVLDRRRAVGKLVNLSDTLVHDPLAGKSGIGHTRWATHGGP
TVTNAHPHQAGRVAVVHNGIIENYKELRDRLSHRTFVTDTDTETVAQLCEDFLDQGLPPREAAVETLKHLDGAYALAFLF
HGEEDLIVAARMGSPLAIGHGDGEMFVGSDAIALGPMTDRITYLEEGDYAFVTRAGAEIREAHGALANRETLHVPAQAIQ
LDKGGHKHFMAKEIFEQPVVLADCLKSYSGDGRVALPEPLDFTQTDRLIFVACGTAFYACAVAKYWFEQLAGIPCDVDIA
SEFRYREPPVSSDATALFVSQSGETADTLAALRYVQEKAARVVSVVNVPGSSIARESDLALPILAGVEVGVASTKAFMNQ
LGVLANLAILAARQRGRIDADREAELLETLRGMPGLINQALALEGKIAKRTAKLAEAKSVLFLGRGAMYPLAMEGALKLK
EISYIHAEGYASGELKHGPIALIDKSVPVIVFAPRDALFDKTVSNMQEVMARDGKVWLITDADGAAQAGDGTWDTLVMPK
VDPILAPMLYAVAAQLIAYHTAIHKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_602_residues
MCGIIGVLGDHEVAPILVEALKRLEYRGYDSAGIATVQNGVLDRRRAVGKLVNLSDTLVHDPLAGKSGIGHTRWATHGGP
TVTNAHPHQAGRVAVVHNGIIENYKELRDRLSHRTFVTDTDTETVAQLCEDFLDQGLPPREAAVETLKHLDGAYALAFLF
HGEEDLIVAARMGSPLAIGHGDGEMFVGSDAIALGPMTDRITYLEEGDYAFVTRAGAEIREAHGALANRETLHVPAQAIQ
LDKGGHKHFMAKEIFEQPVVLADCLKSYSGDGRVALPEPLDFTQTDRLIFVACGTAFYACAVAKYWFEQLAGIPCDVDIA
SEFRYREPPVSSDATALFVSQSGETADTLAALRYVQEKAARVVSVVNVPGSSIARESDLALPILAGVEVGVASTKAFMNQ
LGVLANLAILAARQRGRIDADREAELLETLRGMPGLINQALALEGKIAKRTAKLAEAKSVLFLGRGAMYPLAMEGALKLK
EISYIHAEGYASGELKHGPIALIDKSVPVIVFAPRDALFDKTVSNMQEVMARDGKVWLITDADGAAQAGDGTWDTLVMPK
VDPILAPMLYAVAAQLIAYHTAIHKGTDVDQPRNLAKSVTVE
>Mature_602_residues
MCGIIGVLGDHEVAPILVEALKRLEYRGYDSAGIATVQNGVLDRRRAVGKLVNLSDTLVHDPLAGKSGIGHTRWATHGGP
TVTNAHPHQAGRVAVVHNGIIENYKELRDRLSHRTFVTDTDTETVAQLCEDFLDQGLPPREAAVETLKHLDGAYALAFLF
HGEEDLIVAARMGSPLAIGHGDGEMFVGSDAIALGPMTDRITYLEEGDYAFVTRAGAEIREAHGALANRETLHVPAQAIQ
LDKGGHKHFMAKEIFEQPVVLADCLKSYSGDGRVALPEPLDFTQTDRLIFVACGTAFYACAVAKYWFEQLAGIPCDVDIA
SEFRYREPPVSSDATALFVSQSGETADTLAALRYVQEKAARVVSVVNVPGSSIARESDLALPILAGVEVGVASTKAFMNQ
LGVLANLAILAARQRGRIDADREAELLETLRGMPGLINQALALEGKIAKRTAKLAEAKSVLFLGRGAMYPLAMEGALKLK
EISYIHAEGYASGELKHGPIALIDKSVPVIVFAPRDALFDKTVSNMQEVMARDGKVWLITDADGAAQAGDGTWDTLVMPK
VDPILAPMLYAVAAQLIAYHTAIHKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=694, Percent_Identity=36.1671469740634, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI205277386, Length=692, Percent_Identity=35.6936416184971, Blast_Score=370, Evalue=1e-102,
Organism=Escherichia coli, GI1790167, Length=611, Percent_Identity=48.6088379705401, Blast_Score=553, Evalue=1e-159,
Organism=Escherichia coli, GI1788651, Length=239, Percent_Identity=29.7071129707113, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87082251, Length=311, Percent_Identity=22.508038585209, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=430, Percent_Identity=39.5348837209302, Blast_Score=288, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=39.5348837209302, Blast_Score=288, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI17539970, Length=433, Percent_Identity=38.1062355658199, Blast_Score=285, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6322745, Length=446, Percent_Identity=40.3587443946188, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6323731, Length=428, Percent_Identity=30.607476635514, Blast_Score=197, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=35.7487922705314, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21357745, Length=693, Percent_Identity=35.6421356421356, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI28573187, Length=202, Percent_Identity=33.1683168316832, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 64693; Mature: 64693

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGVLGDHEVAPILVEALKRLEYRGYDSAGIATVQNGVLDRRRAVGKLVNLSDTLVH
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHC
DPLAGKSGIGHTRWATHGGPTVTNAHPHQAGRVAVVHNGIIENYKELRDRLSHRTFVTDT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCEEEECC
DTETVAQLCEDFLDQGLPPREAAVETLKHLDGAYALAFLFHGEEDLIVAARMGSPLAIGH
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCEEEEC
GDGEMFVGSDAIALGPMTDRITYLEEGDYAFVTRAGAEIREAHGALANRETLHVPAQAIQ
CCCCEEECCCCEEECCCCCCEEEEECCCEEEEEECCHHHHHHHHHHCCCCEEECCHHHEE
LDKGGHKHFMAKEIFEQPVVLADCLKSYSGDGRVALPEPLDFTQTDRLIFVACGTAFYAC
ECCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEECCCCCCCCCCCCEEEEEHHHHHHHH
AVAKYWFEQLAGIPCDVDIASEFRYREPPVSSDATALFVSQSGETADTLAALRYVQEKAA
HHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
RVVSVVNVPGSSIARESDLALPILAGVEVGVASTKAFMNQLGVLANLAILAARQRGRIDA
HHEEEEECCCHHHCCCCCCCCEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DREAELLETLRGMPGLINQALALEGKIAKRTAKLAEAKSVLFLGRGAMYPLAMEGALKLK
CHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCCEECCCCEEHH
EISYIHAEGYASGELKHGPIALIDKSVPVIVFAPRDALFDKTVSNMQEVMARDGKVWLIT
HEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEE
DADGAAQAGDGTWDTLVMPKVDPILAPMLYAVAAQLIAYHTAIHKGTDVDQPRNLAKSVT
CCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCC
VE
CC
>Mature Secondary Structure
MCGIIGVLGDHEVAPILVEALKRLEYRGYDSAGIATVQNGVLDRRRAVGKLVNLSDTLVH
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHC
DPLAGKSGIGHTRWATHGGPTVTNAHPHQAGRVAVVHNGIIENYKELRDRLSHRTFVTDT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCEEEECC
DTETVAQLCEDFLDQGLPPREAAVETLKHLDGAYALAFLFHGEEDLIVAARMGSPLAIGH
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCEEEEC
GDGEMFVGSDAIALGPMTDRITYLEEGDYAFVTRAGAEIREAHGALANRETLHVPAQAIQ
CCCCEEECCCCEEECCCCCCEEEEECCCEEEEEECCHHHHHHHHHHCCCCEEECCHHHEE
LDKGGHKHFMAKEIFEQPVVLADCLKSYSGDGRVALPEPLDFTQTDRLIFVACGTAFYAC
ECCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEECCCCCCCCCCCCEEEEEHHHHHHHH
AVAKYWFEQLAGIPCDVDIASEFRYREPPVSSDATALFVSQSGETADTLAALRYVQEKAA
HHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
RVVSVVNVPGSSIARESDLALPILAGVEVGVASTKAFMNQLGVLANLAILAARQRGRIDA
HHEEEEECCCHHHCCCCCCCCEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DREAELLETLRGMPGLINQALALEGKIAKRTAKLAEAKSVLFLGRGAMYPLAMEGALKLK
CHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCCEECCCCEEHH
EISYIHAEGYASGELKHGPIALIDKSVPVIVFAPRDALFDKTVSNMQEVMARDGKVWLIT
HEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEE
DADGAAQAGDGTWDTLVMPKVDPILAPMLYAVAAQLIAYHTAIHKGTDVDQPRNLAKSVT
CCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCC
VE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA