Click here to switch to the map view.

The map label for this gene is glmU

Identifier: 89055676

GI number: 89055676

Start: 3226484

End: 3227848

Strand: Direct

Name: glmU

Synonym: Jann_3185

Alternate gene names: 89055676

Gene position: 3226484-3227848 (Clockwise)

Preceding gene: 89055673

Following gene: 89055677

Centisome position: 74.72

GC content: 64.4

Gene sequence:

>1365_bases
ATGCAGGCCACTCCACGCCCCCTTGCCCTGATTGTTCTGGCGGCAGGTGCCGGCACTCGGATGAACTCCGATTTGCCCAA
GCCGTTGCACACCTTGGGATCTGCGCCGCTTGTCGCCCATACGATTGCGGCGGGCGCATCGCTGGAGCCCGCGCGTCTGG
TGGTGATCACCGGCCACGGCGCGGATGAGGTCGAGGCCGTCTTGCAGGATATCGCGCCCGAGGCCGTCACCGCGCGGCAA
ACTCCACAACTGGGCACCGGCCATGCGGTTTTGCAGGCGGCGGCGGCGCTGGAGGGGTTCGAGGGCGACGCGATGGTCCT
CTACGGGGACAGTCCTTTCTTCACATCTGAGACGTTGCAAGCCATGCGCATTGCCCGCGCCGCCCATGATGTGGTGATGT
TGGGGTTCCGCCCGGCAGATCCCGGTCGCTACGGGCGGCTGGTGATGGACGGCGACACGTTGCGCAAGATCGTTGAGTTC
AAGGATGCGACGCCCGAGGAACGAGAGATCACGTTCTGCAATTCCGGCGTTCTGTGTGCAGACGCGGCGACCCTGATGAC
GCTTCTGGCGCAACTCACCAACGACAATGCGGCGGGCGAGTATTATCTGACGGACGTGCCGGAACTGGCAGGCAACGCCG
GTTTGACAGCCACCGCCATTGCCTGTGATGAGGCCGAGACGATTGGCATCAACTCGCGCGCAGAGCTTGTCCGCGCGGAG
GCGCAGTTTCAGTCCCAGCGCCGGGCCGCGTTGATTGAAGCGGGCGTCACCATGCAGGCCCCGGATAGCGTGCACTTTGC
GCTCGACACCCATATCGGGCGCGATGCGGTGATCGAGCCTTATGTGGTGTTTGGCGCGGACGTGACCGTTGAATCCGGTG
CGCAGATCCGCGCCTTCAGCCATCTGGAGGGTTGCCATATCAGCGCGGGGGCCATCGTCGGTCCCTACGCGCGCCTGCGG
CCCGGGGCGGAGATTGGCAACAATGCCAAGGTCGGCAATTTCGTCGAGGTCAAAGCCGCGGACATCGCCGAGGGCGCGAA
GGTCAATCACCTCAGCTACATCGGGGACGCCACCGTGGGCGAGCGGGCCAATATCGGGGCGGGCACGGTGACCTGCAACT
ACGATGGCGTCATGAAGCACCGCACGGATATCGGGGCAGATGCCTTCATCGGGTCGGACACCATGTTGGTGGCCCCGGTC
ACGGTCGGCGCAGGGGCCATGACGGCCAGCGGATCGACGATCACCGAAGACGTCCCCGACGGCGCACTGGCCCTGGGCCG
TGCCAAGCAAGTCAACAAGCCCGGTCTTGCCACGAAGTTACGTGCGCGCCTGAAGGCGATTAAAGATGCAAAATCAAAGG
ACTAG

Upstream 100 bases:

>100_bases
CCACCGCTATTACAGCTTGTCGGCCAAATTGAACGTATCCGGGGTTTGCCCCGGCCCCGTGCAGCGTTAATAGGCAACAA
ACGCGAAGGAAAGACGTTTC

Downstream 100 bases:

>100_bases
ACCATGTGTGGAATCATCGGCGTTCTGGGCGATCACGAGGTTGCGCCGATCCTGGTCGAAGCGCTGAAGCGGCTGGAATA
TCGTGGCTATGACAGCGCCG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MQATPRPLALIVLAAGAGTRMNSDLPKPLHTLGSAPLVAHTIAAGASLEPARLVVITGHGADEVEAVLQDIAPEAVTARQ
TPQLGTGHAVLQAAAALEGFEGDAMVLYGDSPFFTSETLQAMRIARAAHDVVMLGFRPADPGRYGRLVMDGDTLRKIVEF
KDATPEEREITFCNSGVLCADAATLMTLLAQLTNDNAAGEYYLTDVPELAGNAGLTATAIACDEAETIGINSRAELVRAE
AQFQSQRRAALIEAGVTMQAPDSVHFALDTHIGRDAVIEPYVVFGADVTVESGAQIRAFSHLEGCHISAGAIVGPYARLR
PGAEIGNNAKVGNFVEVKAADIAEGAKVNHLSYIGDATVGERANIGAGTVTCNYDGVMKHRTDIGADAFIGSDTMLVAPV
TVGAGAMTASGSTITEDVPDGALALGRAKQVNKPGLATKLRARLKAIKDAKSKD

Sequences:

>Translated_454_residues
MQATPRPLALIVLAAGAGTRMNSDLPKPLHTLGSAPLVAHTIAAGASLEPARLVVITGHGADEVEAVLQDIAPEAVTARQ
TPQLGTGHAVLQAAAALEGFEGDAMVLYGDSPFFTSETLQAMRIARAAHDVVMLGFRPADPGRYGRLVMDGDTLRKIVEF
KDATPEEREITFCNSGVLCADAATLMTLLAQLTNDNAAGEYYLTDVPELAGNAGLTATAIACDEAETIGINSRAELVRAE
AQFQSQRRAALIEAGVTMQAPDSVHFALDTHIGRDAVIEPYVVFGADVTVESGAQIRAFSHLEGCHISAGAIVGPYARLR
PGAEIGNNAKVGNFVEVKAADIAEGAKVNHLSYIGDATVGERANIGAGTVTCNYDGVMKHRTDIGADAFIGSDTMLVAPV
TVGAGAMTASGSTITEDVPDGALALGRAKQVNKPGLATKLRARLKAIKDAKSKD
>Mature_454_residues
MQATPRPLALIVLAAGAGTRMNSDLPKPLHTLGSAPLVAHTIAAGASLEPARLVVITGHGADEVEAVLQDIAPEAVTARQ
TPQLGTGHAVLQAAAALEGFEGDAMVLYGDSPFFTSETLQAMRIARAAHDVVMLGFRPADPGRYGRLVMDGDTLRKIVEF
KDATPEEREITFCNSGVLCADAATLMTLLAQLTNDNAAGEYYLTDVPELAGNAGLTATAIACDEAETIGINSRAELVRAE
AQFQSQRRAALIEAGVTMQAPDSVHFALDTHIGRDAVIEPYVVFGADVTVESGAQIRAFSHLEGCHISAGAIVGPYARLR
PGAEIGNNAKVGNFVEVKAADIAEGAKVNHLSYIGDATVGERANIGAGTVTCNYDGVMKHRTDIGADAFIGSDTMLVAPV
TVGAGAMTASGSTITEDVPDGALALGRAKQVNKPGLATKLRARLKAIKDAKSKD

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=454, Percent_Identity=41.6299559471366, Blast_Score=337, Evalue=7e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_JANSC (Q28MG0)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_511127.1
- ProteinModelPortal:   Q28MG0
- SMR:   Q28MG0
- STRING:   Q28MG0
- GeneID:   3935656
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_3185
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q28MG0
- ProtClustDB:   PRK14353
- BioCyc:   JSP290400:JANN_3185-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 47156; Mature: 47156

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 350-350 BINDING 80-80 BINDING 145-145 BINDING 159-159 BINDING 174-174 BINDING 374-374 BINDING 392-392 BINDING 427-427

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQATPRPLALIVLAAGAGTRMNSDLPKPLHTLGSAPLVAHTIAAGASLEPARLVVITGHG
CCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCEEEEEEECCC
ADEVEAVLQDIAPEAVTARQTPQLGTGHAVLQAAAALEGFEGDAMVLYGDSPFFTSETLQ
HHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
AMRIARAAHDVVMLGFRPADPGRYGRLVMDGDTLRKIVEFKDATPEEREITFCNSGVLCA
HHHHHHHHCCEEEEEEECCCCCCCCEEEECCHHHHHHHHHCCCCCCCCEEEEECCCEEEH
DAATLMTLLAQLTNDNAAGEYYLTDVPELAGNAGLTATAIACDEAETIGINSRAELVRAE
HHHHHHHHHHHHHCCCCCCEEEECCCHHHCCCCCCEEEEEEECCCCEECCCCHHHHHHHH
AQFQSQRRAALIEAGVTMQAPDSVHFALDTHIGRDAVIEPYVVFGADVTVESGAQIRAFS
HHHHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCEEEEECCEEECCCCEEEEEC
HLEGCHISAGAIVGPYARLRPGAEIGNNAKVGNFVEVKAADIAEGAKVNHLSYIGDATVG
CCCCCEEECCCEECCHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCCEEEECCCCCCC
ERANIGAGTVTCNYDGVMKHRTDIGADAFIGSDTMLVAPVTVGAGAMTASGSTITEDVPD
CCCCCCCCEEEECCCCCCHHCCCCCCCEEECCCCEEEEEEEECCCCEECCCCEECCCCCC
GALALGRAKQVNKPGLATKLRARLKAIKDAKSKD
CHHHHCCHHCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQATPRPLALIVLAAGAGTRMNSDLPKPLHTLGSAPLVAHTIAAGASLEPARLVVITGHG
CCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCEEEEEEECCC
ADEVEAVLQDIAPEAVTARQTPQLGTGHAVLQAAAALEGFEGDAMVLYGDSPFFTSETLQ
HHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
AMRIARAAHDVVMLGFRPADPGRYGRLVMDGDTLRKIVEFKDATPEEREITFCNSGVLCA
HHHHHHHHCCEEEEEEECCCCCCCCEEEECCHHHHHHHHHCCCCCCCCEEEEECCCEEEH
DAATLMTLLAQLTNDNAAGEYYLTDVPELAGNAGLTATAIACDEAETIGINSRAELVRAE
HHHHHHHHHHHHHCCCCCCEEEECCCHHHCCCCCCEEEEEEECCCCEECCCCHHHHHHHH
AQFQSQRRAALIEAGVTMQAPDSVHFALDTHIGRDAVIEPYVVFGADVTVESGAQIRAFS
HHHHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCEEEEECCEEECCCCEEEEEC
HLEGCHISAGAIVGPYARLRPGAEIGNNAKVGNFVEVKAADIAEGAKVNHLSYIGDATVG
CCCCCEEECCCEECCHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCCEEEECCCCCCC
ERANIGAGTVTCNYDGVMKHRTDIGADAFIGSDTMLVAPVTVGAGAMTASGSTITEDVPD
CCCCCCCCEEEECCCCCCHHCCCCCCCEEECCCCEEEEEEEECCCCEECCCCEECCCCCC
GALALGRAKQVNKPGLATKLRARLKAIKDAKSKD
CHHHHCCHHCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA