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The map label for this gene is hisE

Identifier: 89055287

GI number: 89055287

Start: 2811666

End: 2811974

Strand: Direct

Name: hisE

Synonym: Jann_2796

Alternate gene names: 89055287

Gene position: 2811666-2811974 (Clockwise)

Preceding gene: 89055286

Following gene: 89055288

Centisome position: 65.12

GC content: 61.49

Gene sequence:

>309_bases
ATGACCCCTCTTCAACAGCTGGCCGCCACGATTGAAGCCCGCAAAGGGGCCGATCCAGCGTCGTCTTGGACGGCAAAACT
TCTGTCCAAAGGCCCTGAGAAATGCGCGGAAAAGTTCGGGGAGGAGGCCGTGGAAGCCATCATCGAAGCCGTGAAGGGCG
ACCGCGACGCCCTGACATCCGAGGCCGCAGACGCCCTTTACCACCTGTTAGTGATGTGCGCCGCGCGGGACGTGAGCCTG
TCGGATATCGAAGCGGAACTTGAAAGCCGCCATGGCACGTCCGGGCTGACCGAGAAAGCAAACCGGTGA

Upstream 100 bases:

>100_bases
CGTCCGCCGTGCTGGCAGCCTCCATCTTCCACTTCGGCACCTATACGATCGGCGAGGCCAAGGCGCATATGGCCAAGGCC
GGAATTCCTGTGAGGCTGAC

Downstream 100 bases:

>100_bases
CGGGACCGCAATTAAACACAATCTATTTCTACGCCCAAACCGACGCCTATGCGGAATTCTCCAATTTCGCGCCCTTCGGG
GTCGAGATGGAGGGCGTCTA

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 102; Mature: 101

Protein sequence:

>102_residues
MTPLQQLAATIEARKGADPASSWTAKLLSKGPEKCAEKFGEEAVEAIIEAVKGDRDALTSEAADALYHLLVMCAARDVSL
SDIEAELESRHGTSGLTEKANR

Sequences:

>Translated_102_residues
MTPLQQLAATIEARKGADPASSWTAKLLSKGPEKCAEKFGEEAVEAIIEAVKGDRDALTSEAADALYHLLVMCAARDVSL
SDIEAELESRHGTSGLTEKANR
>Mature_101_residues
TPLQQLAATIEARKGADPASSWTAKLLSKGPEKCAEKFGEEAVEAIIEAVKGDRDALTSEAADALYHLLVMCAARDVSLS
DIEAELESRHGTSGLTEKANR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=88, Percent_Identity=43.1818181818182, Blast_Score=75, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_JANSC (Q28NJ9)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510738.1
- ProteinModelPortal:   Q28NJ9
- SMR:   Q28NJ9
- STRING:   Q28NJ9
- GeneID:   3935261
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2796
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   JSP290400:JANN_2796-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 10856; Mature: 10725

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLQQLAATIEARKGADPASSWTAKLLSKGPEKCAEKFGEEAVEAIIEAVKGDRDALTS
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EAADALYHLLVMCAARDVSLSDIEAELESRHGTSGLTEKANR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TPLQQLAATIEARKGADPASSWTAKLLSKGPEKCAEKFGEEAVEAIIEAVKGDRDALTS
CHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EAADALYHLLVMCAARDVSLSDIEAELESRHGTSGLTEKANR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA