Click here to switch to the map view.

The map label for this gene is uvrD [H]

Identifier: 89055268

GI number: 89055268

Start: 2791975

End: 2794428

Strand: Reverse

Name: uvrD [H]

Synonym: Jann_2777

Alternate gene names: 89055268

Gene position: 2794428-2791975 (Counterclockwise)

Preceding gene: 89055271

Following gene: 89055267

Centisome position: 64.72

GC content: 61.7

Gene sequence:

>2454_bases
ATGAGCCAATTCGACGATTCCGATGCCTTTGAGGCTGCCGCGACCTCTTCCCTCGCATCCCGGGCCATGGCCGCGCGACC
GCAGCCCTATATGGATGGCCTGAACCCGGCGCAGATCGCCGCTGTTAACCAGTTGGACGGCCCAGTGCTGATGCTGGCGG
GCGCGGGCACCGGCAAGACCCGGGCGCTCACGGCGCGGATCGCGCATCTCATGTCCACCGGCACGGCGCGCCCCAATGAG
ATCCTGGCCGTCACCTTCACCAACAAGGCCGCGAGAGAGATGAAGACGCGAGTTGGGCATCTGCTTGGTCAACCGGCGGA
GGGGATGCCGTGGCTTGGCACCTTCCATGCGATCTGCGTGAAACTGCTGCGCCGCCATGCTGAACTGGCGGGGCTCAAGT
CCAACTTCACCATCCTCGATACCGATGACCAGACCCGGCTGATGAAGCAACTGATCATCGCAGAAGAGATTGATGATAAG
CGCTGGCCCGCCCGTGCGCTGGGGTCAATTATCGACGGCTGGAAGAACCGCGCGCTGACGCCCGACAAGGTGCCAAGTGC
CGATCACGGGGCCTTCAACCATCAGGGTGTGAAACTGTACGCTCAATACCAGGCGCGCCTGAAGGCTTTGAATGCCTGCG
ATTTTGGCGATCTGCTGCTTCATGTCATACAGATTTTTCAGGATAATGATGACCTGCTGCAACAGTACCAGCGCTGGTTT
CGCTACATTTTGGTCGACGAGTATCAAGACACGAACGTGGCGCAGTATCTCTGGCTGCGGCTTCTGGCGGCGGGTCACAA
GAACATCTGCTGTGTGGGTGATGATGACCAGTCCATCTACGGCTGGCGTGGGGCCGAGGTGGGAAACATCCTGCGGTTTG
AGAAGGACTTCCCCGGCGCCCATGTGGTGCGGTTGGAGCAGAATTATCGCTCCACCGGGCATATCCTGGCCGCCGCATCT
GGCGTGATTGCGGGCAACACGGGGCGGCTTGGCAAGACGCTTTGGACGGATGGGGAGGACGGCGAGAAGGTGCGCCTCAT
CGGCCATTGGGACGGTGATGAAGAGGCCCGCTGGATCGGGGAAGAGATTGAGGCCATGGGCAAAGGCACCCGCGGCATGG
AGCCTATCGGGCCCAATTCCATCGCCATTCTGGTCCGCGCCTCTCACCAGATGCGCGCCTTTGAGGACCGGTTTCTGACC
ATCGGCCTGCCGTATCGCGTCATCGGAGGCCCGCGCTTTTACGAGCGGATGGAGATCCGCGACGCCATGGCGTATTTCCG
CGTCGTCGTCTCCCCCGATGACGATCTGGCGTTTGAGCGGATCGTGAATACCCCCAAGCGCGGCCTTGGCGACAAGGCGC
AGCAGACCATCCAGCGCATGGCGCGGTCCAACGGCGTCAGCCTTCTGGAGGGTGCGCGGCTTTGCGTCGAGACGCAGGCG
ATTGGAGGAAAAGGCGGGCGGGAGCTTCGCACGCTGGTGGACGGGTTGGCCCGGTGGCGCATTCAGTTGACCGGGGCCTT
GCGCGCAGCAGGGCCTTCCGATGATCTGATCGAAGAGGATGCGGATCCTTCCGAGGTGCCCAAAATATCCCACATCGAGC
TGGCTGAAATCATCCTCGATGAATCCGGCTACACTTCGCATTGGCAAAACGACAAGACCCCAGAGGGGCCGGGCCGGTTG
GAGAACCTCAAGGAACTGGTCAAAGCCCTGGAGAATTTCGAGAACCTGCAAGGATTTCTCGAACATGTCAGCCTGATCAT
GGACAATGAGCAGGACGATCAGGAGCCGAAGGTGACGTTGATGACGCTGCACGCCGCCAAGGGGTTGGAGTTTCCCGCCG
TGTTCCTACCCGGGTGGGAAGACGGGCTGTTTCCGTCCCAACGCTCGATGGACGAGTCGGGTCAGGCTGGCCTGGAAGAA
GAACGCCGCCTGGCCTACGTCGGCATCACGCGGGCGGAAGAGGTTTGCACGATCTCCTTTGCGGGCAACCGACGCGTTTA
TGGTCAATGGCAGTCCCAGATGCCGTCGCGCTTCATCGACGAATTGCCCGAAGATCACGTGGAGGTTCTGACGCCCCCGG
GGCTTTACGGGCACCAGGGGTCCGTCAGTGCCACCGCCAGCCCGGTCGAGCGGGAGATGGCAGGCTCCAATCTCCACGAA
AAGGCGGCCAGCGCCGACGTCTATAACTCGCCGGGCTGGAGGCGCCTGCAAGCACGCCAGGGCCAATACGGCACCCGCCA
GCCGTCGGAAGCCAAAGCCATGACCATCGATGCCGAGGCGATCAGTGCCTTTACGGTGGGCGATCGCGTCTTCCACCAGA
AGTTCGGTTATGGAGAGGTCGTGTCCGTCGAAGGTGACAAACTGGGGATCGAATTCGACAAGGCCGGTAGCAAGCATGTC
GTGGGCCGGTTCCTTGTGGCGGCGGGAGAAGAGGGGGGAGAGGTTCCCTTCTGA

Upstream 100 bases:

>100_bases
GCGGCGCGTCGGGCTGGCCCCCATTCGCAAACTCCGCATTGCAGGAACAATCTGCGAACATACCTTCCCCTCAAGCGTCC
GTCGCTCTATCTTTACGGCT

Downstream 100 bases:

>100_bases
TCACCTCTCGACCAAACCCCGTGCGCACACTAGGGTTGCCGTTCAAGCCCTTGATCTGACGCGGAGACATCTATGTTGCG
CCCCTTGACCGCCCTGGCCA

Product: ATP-dependent DNA helicase Rep

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 817; Mature: 816

Protein sequence:

>817_residues
MSQFDDSDAFEAAATSSLASRAMAARPQPYMDGLNPAQIAAVNQLDGPVLMLAGAGTGKTRALTARIAHLMSTGTARPNE
ILAVTFTNKAAREMKTRVGHLLGQPAEGMPWLGTFHAICVKLLRRHAELAGLKSNFTILDTDDQTRLMKQLIIAEEIDDK
RWPARALGSIIDGWKNRALTPDKVPSADHGAFNHQGVKLYAQYQARLKALNACDFGDLLLHVIQIFQDNDDLLQQYQRWF
RYILVDEYQDTNVAQYLWLRLLAAGHKNICCVGDDDQSIYGWRGAEVGNILRFEKDFPGAHVVRLEQNYRSTGHILAAAS
GVIAGNTGRLGKTLWTDGEDGEKVRLIGHWDGDEEARWIGEEIEAMGKGTRGMEPIGPNSIAILVRASHQMRAFEDRFLT
IGLPYRVIGGPRFYERMEIRDAMAYFRVVVSPDDDLAFERIVNTPKRGLGDKAQQTIQRMARSNGVSLLEGARLCVETQA
IGGKGGRELRTLVDGLARWRIQLTGALRAAGPSDDLIEEDADPSEVPKISHIELAEIILDESGYTSHWQNDKTPEGPGRL
ENLKELVKALENFENLQGFLEHVSLIMDNEQDDQEPKVTLMTLHAAKGLEFPAVFLPGWEDGLFPSQRSMDESGQAGLEE
ERRLAYVGITRAEEVCTISFAGNRRVYGQWQSQMPSRFIDELPEDHVEVLTPPGLYGHQGSVSATASPVEREMAGSNLHE
KAASADVYNSPGWRRLQARQGQYGTRQPSEAKAMTIDAEAISAFTVGDRVFHQKFGYGEVVSVEGDKLGIEFDKAGSKHV
VGRFLVAAGEEGGEVPF

Sequences:

>Translated_817_residues
MSQFDDSDAFEAAATSSLASRAMAARPQPYMDGLNPAQIAAVNQLDGPVLMLAGAGTGKTRALTARIAHLMSTGTARPNE
ILAVTFTNKAAREMKTRVGHLLGQPAEGMPWLGTFHAICVKLLRRHAELAGLKSNFTILDTDDQTRLMKQLIIAEEIDDK
RWPARALGSIIDGWKNRALTPDKVPSADHGAFNHQGVKLYAQYQARLKALNACDFGDLLLHVIQIFQDNDDLLQQYQRWF
RYILVDEYQDTNVAQYLWLRLLAAGHKNICCVGDDDQSIYGWRGAEVGNILRFEKDFPGAHVVRLEQNYRSTGHILAAAS
GVIAGNTGRLGKTLWTDGEDGEKVRLIGHWDGDEEARWIGEEIEAMGKGTRGMEPIGPNSIAILVRASHQMRAFEDRFLT
IGLPYRVIGGPRFYERMEIRDAMAYFRVVVSPDDDLAFERIVNTPKRGLGDKAQQTIQRMARSNGVSLLEGARLCVETQA
IGGKGGRELRTLVDGLARWRIQLTGALRAAGPSDDLIEEDADPSEVPKISHIELAEIILDESGYTSHWQNDKTPEGPGRL
ENLKELVKALENFENLQGFLEHVSLIMDNEQDDQEPKVTLMTLHAAKGLEFPAVFLPGWEDGLFPSQRSMDESGQAGLEE
ERRLAYVGITRAEEVCTISFAGNRRVYGQWQSQMPSRFIDELPEDHVEVLTPPGLYGHQGSVSATASPVEREMAGSNLHE
KAASADVYNSPGWRRLQARQGQYGTRQPSEAKAMTIDAEAISAFTVGDRVFHQKFGYGEVVSVEGDKLGIEFDKAGSKHV
VGRFLVAAGEEGGEVPF
>Mature_816_residues
SQFDDSDAFEAAATSSLASRAMAARPQPYMDGLNPAQIAAVNQLDGPVLMLAGAGTGKTRALTARIAHLMSTGTARPNEI
LAVTFTNKAAREMKTRVGHLLGQPAEGMPWLGTFHAICVKLLRRHAELAGLKSNFTILDTDDQTRLMKQLIIAEEIDDKR
WPARALGSIIDGWKNRALTPDKVPSADHGAFNHQGVKLYAQYQARLKALNACDFGDLLLHVIQIFQDNDDLLQQYQRWFR
YILVDEYQDTNVAQYLWLRLLAAGHKNICCVGDDDQSIYGWRGAEVGNILRFEKDFPGAHVVRLEQNYRSTGHILAAASG
VIAGNTGRLGKTLWTDGEDGEKVRLIGHWDGDEEARWIGEEIEAMGKGTRGMEPIGPNSIAILVRASHQMRAFEDRFLTI
GLPYRVIGGPRFYERMEIRDAMAYFRVVVSPDDDLAFERIVNTPKRGLGDKAQQTIQRMARSNGVSLLEGARLCVETQAI
GGKGGRELRTLVDGLARWRIQLTGALRAAGPSDDLIEEDADPSEVPKISHIELAEIILDESGYTSHWQNDKTPEGPGRLE
NLKELVKALENFENLQGFLEHVSLIMDNEQDDQEPKVTLMTLHAAKGLEFPAVFLPGWEDGLFPSQRSMDESGQAGLEEE
RRLAYVGITRAEEVCTISFAGNRRVYGQWQSQMPSRFIDELPEDHVEVLTPPGLYGHQGSVSATASPVEREMAGSNLHEK
AASADVYNSPGWRRLQARQGQYGTRQPSEAKAMTIDAEAISAFTVGDRVFHQKFGYGEVVSVEGDKLGIEFDKAGSKHVV
GRFLVAAGEEGGEVPF

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=789, Percent_Identity=39.9239543726236, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI48994965, Length=660, Percent_Identity=37.8787878787879, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1787196, Length=348, Percent_Identity=29.0229885057471, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6322369, Length=726, Percent_Identity=25.3443526170799, Blast_Score=184, Evalue=4e-47,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 90274; Mature: 90143

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFDDSDAFEAAATSSLASRAMAARPQPYMDGLNPAQIAAVNQLDGPVLMLAGAGTGKT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHEEEHHCCCCCEEEEEECCCCCH
RALTARIAHLMSTGTARPNEILAVTFTNKAAREMKTRVGHLLGQPAEGMPWLGTFHAICV
HHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
KLLRRHAELAGLKSNFTILDTDDQTRLMKQLIIAEEIDDKRWPARALGSIIDGWKNRALT
HHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
PDKVPSADHGAFNHQGVKLYAQYQARLKALNACDFGDLLLHVIQIFQDNDDLLQQYQRWF
CCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
RYILVDEYQDTNVAQYLWLRLLAAGHKNICCVGDDDQSIYGWRGAEVGNILRFEKDFPGA
HHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCEECCCCCCCCCCEEECCCCCCC
HVVRLEQNYRSTGHILAAASGVIAGNTGRLGKTLWTDGEDGEKVRLIGHWDGDEEARWIG
EEEEEECCCCCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHH
EEIEAMGKGTRGMEPIGPNSIAILVRASHQMRAFEDRFLTIGLPYRVIGGPRFYERMEIR
HHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHCCEEEECCCEEECCCCHHHHHHHHH
DAMAYFRVVVSPDDDLAFERIVNTPKRGLGDKAQQTIQRMARSNGVSLLEGARLCVETQA
HHHHHHEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCHHEEEEHH
IGGKGGRELRTLVDGLARWRIQLTGALRAAGPSDDLIEEDADPSEVPKISHIELAEIILD
CCCCCCHHHHHHHHHHHHEEEEEEEEHCCCCCCCHHHCCCCCHHHCCCCCCHHHHHHHCC
ESGYTSHWQNDKTPEGPGRLENLKELVKALENFENLQGFLEHVSLIMDNEQDDQEPKVTL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
MTLHAAKGLEFPAVFLPGWEDGLFPSQRSMDESGQAGLEEERRLAYVGITRAEEVCTISF
EEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHCEEEEEEEECCCCEEEEEE
AGNRRVYGQWQSQMPSRFIDELPEDHVEVLTPPGLYGHQGSVSATASPVEREMAGSNLHE
CCCCEEECCHHHCCHHHHHHHCCCCHHEEECCCCCCCCCCCCCCCCCHHHHHHCCCCHHH
KAASADVYNSPGWRRLQARQGQYGTRQPSEAKAMTIDAEAISAFTVGDRVFHQKFGYGEV
HHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCE
VSVEGDKLGIEFDKAGSKHVVGRFLVAAGEEGGEVPF
EEECCCEEEEEECCCCCHHHHHHHHEEECCCCCCCCC
>Mature Secondary Structure 
SQFDDSDAFEAAATSSLASRAMAARPQPYMDGLNPAQIAAVNQLDGPVLMLAGAGTGKT
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHEEEHHCCCCCEEEEEECCCCCH
RALTARIAHLMSTGTARPNEILAVTFTNKAAREMKTRVGHLLGQPAEGMPWLGTFHAICV
HHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
KLLRRHAELAGLKSNFTILDTDDQTRLMKQLIIAEEIDDKRWPARALGSIIDGWKNRALT
HHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
PDKVPSADHGAFNHQGVKLYAQYQARLKALNACDFGDLLLHVIQIFQDNDDLLQQYQRWF
CCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
RYILVDEYQDTNVAQYLWLRLLAAGHKNICCVGDDDQSIYGWRGAEVGNILRFEKDFPGA
HHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCEECCCCCCCCCCEEECCCCCCC
HVVRLEQNYRSTGHILAAASGVIAGNTGRLGKTLWTDGEDGEKVRLIGHWDGDEEARWIG
EEEEEECCCCCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHH
EEIEAMGKGTRGMEPIGPNSIAILVRASHQMRAFEDRFLTIGLPYRVIGGPRFYERMEIR
HHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHCCEEEECCCEEECCCCHHHHHHHHH
DAMAYFRVVVSPDDDLAFERIVNTPKRGLGDKAQQTIQRMARSNGVSLLEGARLCVETQA
HHHHHHEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCHHEEEEHH
IGGKGGRELRTLVDGLARWRIQLTGALRAAGPSDDLIEEDADPSEVPKISHIELAEIILD
CCCCCCHHHHHHHHHHHHEEEEEEEEHCCCCCCCHHHCCCCCHHHCCCCCCHHHHHHHCC
ESGYTSHWQNDKTPEGPGRLENLKELVKALENFENLQGFLEHVSLIMDNEQDDQEPKVTL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
MTLHAAKGLEFPAVFLPGWEDGLFPSQRSMDESGQAGLEEERRLAYVGITRAEEVCTISF
EEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHCEEEEEEEECCCCEEEEEE
AGNRRVYGQWQSQMPSRFIDELPEDHVEVLTPPGLYGHQGSVSATASPVEREMAGSNLHE
CCCCEEECCHHHCCHHHHHHHCCCCHHEEECCCCCCCCCCCCCCCCCHHHHHHCCCCHHH
KAASADVYNSPGWRRLQARQGQYGTRQPSEAKAMTIDAEAISAFTVGDRVFHQKFGYGEV
HHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCE
VSVEGDKLGIEFDKAGSKHVVGRFLVAAGEEGGEVPF
EEECCCEEEEEECCCCCHHHHHHHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]