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The map label for this gene is ypdF [H]

Identifier: 89055234

GI number: 89055234

Start: 2756307

End: 2758109

Strand: Direct

Name: ypdF [H]

Synonym: Jann_2743

Alternate gene names: 89055234

Gene position: 2756307-2758109 (Clockwise)

Preceding gene: 89055233

Following gene: 89055235

Centisome position: 63.83

GC content: 65.61

Gene sequence:

>1803_bases
ATGTTTCAGACCTTCACCGCGGCAACACGGCCCGACGATGGGCCACCTCGGTTGGCCGCCCTGCGGGCGCACCTGAAGTC
CGAGGGACTAGATGGGTTTCTGGTGCCCCGCGCGGACGCCCATCAGGGCGAGTATGTCGCCGATTGCGATGCGCGGCTGG
CGTGGTTGACGGGCTTCACCGGGTCGGCCGGGTTCGCGGCGATCCTTCCCGATGTGGCGGGCGTCTTCGTGGATGGACGC
TACCGCGTGCAGGTCCGCGCGCAGGTGGCCGACGTCTTCACACCCGTGCACTGGCCGGAAACCCAGTTGGCCGACTGGTT
GATCGACGCCCTGCCCCAAGGTGGCAAGGTTGGGTTCGACCCCTGGCTGCACACGGTTGATGAAATCGCGCGCCTGGAGG
CTGCCGTGGAGTCGCATCAGATCAGCCTTACACCCGTGGGCAATGCCGTGGATGCGATTTGGGCGAATCGGCCACCGCGC
CCGGACGCACCCGCGCGGACCTATCCTGACGCGCGCGCCGGAGCGTCCAGCGCCAGCAAACGCGCTGATGTGGCTGAGAT
CTTGGCAGAGAAGCAGCAGGCCGCTGCTGTCCTGACATTGCCGGACTCGATCAACTGGCTGCTCAACCTGCGCGGCGGGG
ATCTGCCACATCTGCCGGTGGTGCAGGCCTTTGCGATCATCCGCGCCTCAGGTGCCGTGGCTGTATTCACCGACCCCGCT
AAGTTCGATCAGATAGACCTTGGCCCGGACGTCACAATCGCCCCGTGGGAGGCCTTTGAGCCCGCCCTGGCTGACCTCAA
GGGCCCTGTCCGTCTGGATCCGGCCACTGCGCCCGATGCGGTCAGGCGGGCTCTGGAGCATGCTGGAGCAGAGATCGTCC
GCGCGACTGACCCTTGCCTGCTACCAAAAGCGCGCAAGAATGCGGCAGAGATCGCGGGCACCACGCAGGCGCACCTGCGC
GACGGGGTAGCTTTTGCGCGGTTCCTCCACTGGTTCGATGAGACCGCGCCAAGGGGCGGGCTGACCGAAATCGACGTCGC
CCAACAACTGGAAGCCTTCCGCGCCGAGACCGGAGCGCTCAGGGATATCTCCTTCGACACAATCGCCGGTGCCGGGCCCA
ATGGCGCGATTGTTCACTACCGCGTCACGGATGAGACGAATGCGCCCGTTCTTCCCGGTCAGCTATTCCTGATCGACAGC
GGCGGGCAGTATGAAGATGGCACGACCGACATCACCCGCACGCTGCCGGTCGGCACGTCCGACGCGGAGGCGCGCGACTG
CTTCACGCTGGTTCTGCAAGGGATGATCGCCGTCCATCGTGCCCGCTTTCCGAAAGGGGTTGCGGGGATGCATCTGGATG
CGTTGGCCCGCGCGCCACTTTGGGCGACCGGTCGGGACTATGACCACGGCACGGGGCACGGCGTGGGTGTCTACCTCAGC
GTCCATGAAGGGCCGCAAAGCCTGTCGCGCCGGGGGAAAGTGCCGCTGGAGCGCGGGATGATCCTGTCTAACGAGCCGGG
ATATTACCGCGAAGGGGCCTTTGGCATTCGGATCGAGAACCTGATCCATGTTGTCGATGCGCCCGAGGGGGCCGACGCGC
ATCGCGAGATGCTGGCCTTCGAAACGCTGACACTCGCGCCCATTGACCGCCGCCTGATCGTCGTCGACATGTTGAGCCCG
GCAGAGCGGGCTTGGCTCAATGGCTACCACGCCGAGGTTCTCGCAAAGATCGCCCCGCTGCTGGAGGCAGACGGCCATAC
CGATACGGCGGATTGGCTTACGCAGGCCTGCACACCGATCTGA

Upstream 100 bases:

>100_bases
GATGAAACGGGCGGGCTGACGGCCCCAAGATCCATTTGATGTGGCGCCCGCGCCTTCGGCTTGGGCGCGGTGGCAGCTGC
GCGGCGCAAAGGAGATCCGC

Downstream 100 bases:

>100_bases
GCGCCCCGATAGACAAGCGACATCAGACGTCTGTGGGACGTGCAACACCGGCGCACCTTGTGCCTGGAACACTGCGCAGG
GTACATAACGCGCATACACA

Product: peptidase M24

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MFQTFTAATRPDDGPPRLAALRAHLKSEGLDGFLVPRADAHQGEYVADCDARLAWLTGFTGSAGFAAILPDVAGVFVDGR
YRVQVRAQVADVFTPVHWPETQLADWLIDALPQGGKVGFDPWLHTVDEIARLEAAVESHQISLTPVGNAVDAIWANRPPR
PDAPARTYPDARAGASSASKRADVAEILAEKQQAAAVLTLPDSINWLLNLRGGDLPHLPVVQAFAIIRASGAVAVFTDPA
KFDQIDLGPDVTIAPWEAFEPALADLKGPVRLDPATAPDAVRRALEHAGAEIVRATDPCLLPKARKNAAEIAGTTQAHLR
DGVAFARFLHWFDETAPRGGLTEIDVAQQLEAFRAETGALRDISFDTIAGAGPNGAIVHYRVTDETNAPVLPGQLFLIDS
GGQYEDGTTDITRTLPVGTSDAEARDCFTLVLQGMIAVHRARFPKGVAGMHLDALARAPLWATGRDYDHGTGHGVGVYLS
VHEGPQSLSRRGKVPLERGMILSNEPGYYREGAFGIRIENLIHVVDAPEGADAHREMLAFETLTLAPIDRRLIVVDMLSP
AERAWLNGYHAEVLAKIAPLLEADGHTDTADWLTQACTPI

Sequences:

>Translated_600_residues
MFQTFTAATRPDDGPPRLAALRAHLKSEGLDGFLVPRADAHQGEYVADCDARLAWLTGFTGSAGFAAILPDVAGVFVDGR
YRVQVRAQVADVFTPVHWPETQLADWLIDALPQGGKVGFDPWLHTVDEIARLEAAVESHQISLTPVGNAVDAIWANRPPR
PDAPARTYPDARAGASSASKRADVAEILAEKQQAAAVLTLPDSINWLLNLRGGDLPHLPVVQAFAIIRASGAVAVFTDPA
KFDQIDLGPDVTIAPWEAFEPALADLKGPVRLDPATAPDAVRRALEHAGAEIVRATDPCLLPKARKNAAEIAGTTQAHLR
DGVAFARFLHWFDETAPRGGLTEIDVAQQLEAFRAETGALRDISFDTIAGAGPNGAIVHYRVTDETNAPVLPGQLFLIDS
GGQYEDGTTDITRTLPVGTSDAEARDCFTLVLQGMIAVHRARFPKGVAGMHLDALARAPLWATGRDYDHGTGHGVGVYLS
VHEGPQSLSRRGKVPLERGMILSNEPGYYREGAFGIRIENLIHVVDAPEGADAHREMLAFETLTLAPIDRRLIVVDMLSP
AERAWLNGYHAEVLAKIAPLLEADGHTDTADWLTQACTPI
>Mature_600_residues
MFQTFTAATRPDDGPPRLAALRAHLKSEGLDGFLVPRADAHQGEYVADCDARLAWLTGFTGSAGFAAILPDVAGVFVDGR
YRVQVRAQVADVFTPVHWPETQLADWLIDALPQGGKVGFDPWLHTVDEIARLEAAVESHQISLTPVGNAVDAIWANRPPR
PDAPARTYPDARAGASSASKRADVAEILAEKQQAAAVLTLPDSINWLLNLRGGDLPHLPVVQAFAIIRASGAVAVFTDPA
KFDQIDLGPDVTIAPWEAFEPALADLKGPVRLDPATAPDAVRRALEHAGAEIVRATDPCLLPKARKNAAEIAGTTQAHLR
DGVAFARFLHWFDETAPRGGLTEIDVAQQLEAFRAETGALRDISFDTIAGAGPNGAIVHYRVTDETNAPVLPGQLFLIDS
GGQYEDGTTDITRTLPVGTSDAEARDCFTLVLQGMIAVHRARFPKGVAGMHLDALARAPLWATGRDYDHGTGHGVGVYLS
VHEGPQSLSRRGKVPLERGMILSNEPGYYREGAFGIRIENLIHVVDAPEGADAHREMLAFETLTLAPIDRRLIVVDMLSP
AERAWLNGYHAEVLAKIAPLLEADGHTDTADWLTQACTPI

Specific function: Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is al

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24 family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=611, Percent_Identity=39.443535188216, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI264681565, Length=611, Percent_Identity=37.8068739770867, Blast_Score=381, Evalue=1e-105,
Organism=Homo sapiens, GI93141226, Length=600, Percent_Identity=34.3333333333333, Blast_Score=350, Evalue=3e-96,
Organism=Escherichia coli, GI1788728, Length=207, Percent_Identity=35.2657004830918, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17509539, Length=625, Percent_Identity=35.84, Blast_Score=339, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI25149105, Length=617, Percent_Identity=29.4975688816856, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6322999, Length=664, Percent_Identity=29.6686746987952, Blast_Score=290, Evalue=4e-79,
Organism=Drosophila melanogaster, GI17137632, Length=604, Percent_Identity=34.7682119205298, Blast_Score=331, Evalue=9e-91,
Organism=Drosophila melanogaster, GI161078230, Length=612, Percent_Identity=29.4117647058824, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI21357287, Length=612, Percent_Identity=29.4117647058824, Blast_Score=254, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 64500; Mature: 64500

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQTFTAATRPDDGPPRLAALRAHLKSEGLDGFLVPRADAHQGEYVADCDARLAWLTGFT
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEECCCCEEEEEECCC
GSAGFAAILPDVAGVFVDGRYRVQVRAQVADVFTPVHWPETQLADWLIDALPQGGKVGFD
CCCCHHHHHHHHHCEEECCEEEEEEEEEHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC
PWLHTVDEIARLEAAVESHQISLTPVGNAVDAIWANRPPRPDAPARTYPDARAGASSASK
HHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCHHCCCCCHHH
RADVAEILAEKQQAAAVLTLPDSINWLLNLRGGDLPHLPVVQAFAIIRASGAVAVFTDPA
HHHHHHHHHHHHHCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCC
KFDQIDLGPDVTIAPWEAFEPALADLKGPVRLDPATAPDAVRRALEHAGAEIVRATDPCL
CCCCEECCCCCEECCHHHCCHHHHHCCCCEEECCCCCHHHHHHHHHHCCCEEEECCCCCC
LPKARKNAAEIAGTTQAHLRDGVAFARFLHWFDETAPRGGLTEIDVAQQLEAFRAETGAL
CCHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCE
RDISFDTIAGAGPNGAIVHYRVTDETNAPVLPGQLFLIDSGGQYEDGTTDITRTLPVGTS
ECCCCHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCC
DAEARDCFTLVLQGMIAVHRARFPKGVAGMHLDALARAPLWATGRDYDHGTGHGVGVYLS
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEECCCCCCCCCCCCEEEEEE
VHEGPQSLSRRGKVPLERGMILSNEPGYYREGAFGIRIENLIHVVDAPEGADAHREMLAF
ECCCHHHHHHCCCCCHHHCEEECCCCCCCCCCCCEEEHHHEEEEECCCCCCHHHHHHHHH
ETLTLAPIDRRLIVVDMLSPAERAWLNGYHAEVLAKIAPLLEADGHTDTADWLTQACTPI
HHEEECCCCCEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MFQTFTAATRPDDGPPRLAALRAHLKSEGLDGFLVPRADAHQGEYVADCDARLAWLTGFT
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEECCCCEEEEEECCC
GSAGFAAILPDVAGVFVDGRYRVQVRAQVADVFTPVHWPETQLADWLIDALPQGGKVGFD
CCCCHHHHHHHHHCEEECCEEEEEEEEEHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC
PWLHTVDEIARLEAAVESHQISLTPVGNAVDAIWANRPPRPDAPARTYPDARAGASSASK
HHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCHHCCCCCHHH
RADVAEILAEKQQAAAVLTLPDSINWLLNLRGGDLPHLPVVQAFAIIRASGAVAVFTDPA
HHHHHHHHHHHHHCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCC
KFDQIDLGPDVTIAPWEAFEPALADLKGPVRLDPATAPDAVRRALEHAGAEIVRATDPCL
CCCCEECCCCCEECCHHHCCHHHHHCCCCEEECCCCCHHHHHHHHHHCCCEEEECCCCCC
LPKARKNAAEIAGTTQAHLRDGVAFARFLHWFDETAPRGGLTEIDVAQQLEAFRAETGAL
CCHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCE
RDISFDTIAGAGPNGAIVHYRVTDETNAPVLPGQLFLIDSGGQYEDGTTDITRTLPVGTS
ECCCCHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCC
DAEARDCFTLVLQGMIAVHRARFPKGVAGMHLDALARAPLWATGRDYDHGTGHGVGVYLS
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEECCCCCCCCCCCCEEEEEE
VHEGPQSLSRRGKVPLERGMILSNEPGYYREGAFGIRIENLIHVVDAPEGADAHREMLAF
ECCCHHHHHHCCCCCHHHCEEECCCCCCCCCCCCEEEHHHEEEEECCCCCCHHHHHHHHH
ETLTLAPIDRRLIVVDMLSPAERAWLNGYHAEVLAKIAPLLEADGHTDTADWLTQACTPI
HHEEECCCCCEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]