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The map label for this gene is guaD [H]

Identifier: 89055215

GI number: 89055215

Start: 2734788

End: 2736065

Strand: Direct

Name: guaD [H]

Synonym: Jann_2724

Alternate gene names: 89055215

Gene position: 2734788-2736065 (Clockwise)

Preceding gene: 89055213

Following gene: 89055218

Centisome position: 63.33

GC content: 62.91

Gene sequence:

>1278_bases
TTGATTTTAGGACAGCTTCTTGCGTTTGAAGGGGACCCGCGCGCGTTGGGTCCGGGTGCGGCGCGCCATGATACGTTCGG
CGCTGTGCTGGTTCGCGACGGTCTGATCGCCCGTGTCGGGGATGCAGCGTCCTTGCGCGCGGACCATCCGGGCGTGCCAG
TGACCGATCACGGGGATGATCTGATCCTGCCGGGCTTCATCGACGCCCACGTCCATTATCCCCAAACGGCGATGATCGCG
TCCTGGGGCAAGCGGCTGATCGACTGGCTCAACACCTACACTTTCCCTGAGGAGGCACGGTTCCACGACCCGGACTATGC
CACTGATATCGCGGGACGGTATCTGGATTTAGTGACGTCGAACGGCACCACGACGGTGGCCAGCTATTGCACGATCCACC
CAACTTCTGTGGACGCATTTTTCGCGGCGGCTCAAGCCAAGCGCATGCGGGTTCTGGCGGGCAAGACCTGCATGGACCGC
AATGCGCCGGACGATCTGCGCGACACGGCGCAATCGGCCTATGATGACAGCCGCGCGCTTCTGCGCAAATGGCACGGGGT
CGACCGCCTTGGCTATGTGATCACGCCCCGGTTTTCGCCGACCTCCACGCCCGAGCAGCTGTCGGCCCTTGGCGCGCTTT
GGGCAGAGCATCCTGATTGCCTCATGCAGACGCACCTGAGCGAGCAGCTCGATGAGATCGCCTGGGTCCGGGATCTGTAC
CCAAACGCGCGCGATTATCTTGATACTTATGAGGCCCACGGACTTCTGGGATCGCGCGGCGTATATGGCCACGCGATCCA
TCTGGAGCCGCGCGAAACAACCCGCCTGGCGGAGGTCGGCGCGGCGCTGGTCCACTGTCCGACGTCCAACACGTTCATCG
GTTCGGGTCTGTTCGACATGGGGCTGGCGAACACAATTTCGGTGGGTCTGGCGACAGATACCGGCGGCGGGTCCAGTTTT
TCAATGTTGCGCACGATGGCCGCAGCTTACGAGGTGGCGCAACTGCGCGGACATGCCGTGCACCCGTCCGAGTTGATCTG
GCGTGCAACGGGCGGCTCCGCTCAAGCCCTTCATCTAGAAGACAAAATCGGGCGGCTGGCCCCCGGGTTCGAGGCAGATC
TCTGCATTCTGAACCTGGCGTCTACCCCTGCGATTTCACAACGCCACGCCCGCGCGAGCGATATTTGGGAGGCCGTGTTC
CCGACCATCATGATGGGTGACGACCGGGCGGTGACCCAGACCTATGTGGCCGGGGTCCCGGTCAAAACGGGCCGGTAA

Upstream 100 bases:

>100_bases
GATATCCCCTGTTCTGCGCGTGCAAAGGGCCTAACATGAGGCGGCGGTAAGGGCTATCACCCGCGTTGTAAAAAACCCGG
AGGTGTCGGTGACCGAGCGT

Downstream 100 bases:

>100_bases
CGGGATCAGACAGCGTCTTCGACGGCGCCGACAATATCGTCGACCACGGCCGTCATCAGCGCCTCATCCTCGGCTTCGGC
CATGACGCGGATCAAAGGCT

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MILGQLLAFEGDPRALGPGAARHDTFGAVLVRDGLIARVGDAASLRADHPGVPVTDHGDDLILPGFIDAHVHYPQTAMIA
SWGKRLIDWLNTYTFPEEARFHDPDYATDIAGRYLDLVTSNGTTTVASYCTIHPTSVDAFFAAAQAKRMRVLAGKTCMDR
NAPDDLRDTAQSAYDDSRALLRKWHGVDRLGYVITPRFSPTSTPEQLSALGALWAEHPDCLMQTHLSEQLDEIAWVRDLY
PNARDYLDTYEAHGLLGSRGVYGHAIHLEPRETTRLAEVGAALVHCPTSNTFIGSGLFDMGLANTISVGLATDTGGGSSF
SMLRTMAAAYEVAQLRGHAVHPSELIWRATGGSAQALHLEDKIGRLAPGFEADLCILNLASTPAISQRHARASDIWEAVF
PTIMMGDDRAVTQTYVAGVPVKTGR

Sequences:

>Translated_425_residues
MILGQLLAFEGDPRALGPGAARHDTFGAVLVRDGLIARVGDAASLRADHPGVPVTDHGDDLILPGFIDAHVHYPQTAMIA
SWGKRLIDWLNTYTFPEEARFHDPDYATDIAGRYLDLVTSNGTTTVASYCTIHPTSVDAFFAAAQAKRMRVLAGKTCMDR
NAPDDLRDTAQSAYDDSRALLRKWHGVDRLGYVITPRFSPTSTPEQLSALGALWAEHPDCLMQTHLSEQLDEIAWVRDLY
PNARDYLDTYEAHGLLGSRGVYGHAIHLEPRETTRLAEVGAALVHCPTSNTFIGSGLFDMGLANTISVGLATDTGGGSSF
SMLRTMAAAYEVAQLRGHAVHPSELIWRATGGSAQALHLEDKIGRLAPGFEADLCILNLASTPAISQRHARASDIWEAVF
PTIMMGDDRAVTQTYVAGVPVKTGR
>Mature_425_residues
MILGQLLAFEGDPRALGPGAARHDTFGAVLVRDGLIARVGDAASLRADHPGVPVTDHGDDLILPGFIDAHVHYPQTAMIA
SWGKRLIDWLNTYTFPEEARFHDPDYATDIAGRYLDLVTSNGTTTVASYCTIHPTSVDAFFAAAQAKRMRVLAGKTCMDR
NAPDDLRDTAQSAYDDSRALLRKWHGVDRLGYVITPRFSPTSTPEQLSALGALWAEHPDCLMQTHLSEQLDEIAWVRDLY
PNARDYLDTYEAHGLLGSRGVYGHAIHLEPRETTRLAEVGAALVHCPTSNTFIGSGLFDMGLANTISVGLATDTGGGSSF
SMLRTMAAAYEVAQLRGHAVHPSELIWRATGGSAQALHLEDKIGRLAPGFEADLCILNLASTPAISQRHARASDIWEAVF
PTIMMGDDRAVTQTYVAGVPVKTGR

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=379, Percent_Identity=32.4538258575198, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1789249, Length=395, Percent_Identity=43.0379746835443, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319963, Length=406, Percent_Identity=32.2660098522167, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24643849, Length=392, Percent_Identity=32.1428571428571, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 46029; Mature: 46029

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILGQLLAFEGDPRALGPGAARHDTFGAVLVRDGLIARVGDAASLRADHPGVPVTDHGDD
CCCCCEEEECCCCCCCCCCCCCCCCCCEEEECCCCCEECCCCHHCCCCCCCCCCCCCCCC
LILPGFIDAHVHYPQTAMIASWGKRLIDWLNTYTFPEEARFHDPDYATDIAGRYLDLVTS
EEECCEEECEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHEEEEEC
NGTTTVASYCTIHPTSVDAFFAAAQAKRMRVLAGKTCMDRNAPDDLRDTAQSAYDDSRAL
CCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHH
LRKWHGVDRLGYVITPRFSPTSTPEQLSALGALWAEHPDCLMQTHLSEQLDEIAWVRDLY
HHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
PNARDYLDTYEAHGLLGSRGVYGHAIHLEPRETTRLAEVGAALVHCPTSNTFIGSGLFDM
CCHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHCCEEEECCCCCCEECCCHHHH
GLANTISVGLATDTGGGSSFSMLRTMAAAYEVAQLRGHAVHPSELIWRATGGSAQALHLE
CCHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEECCCCCEEEEEH
DKIGRLAPGFEADLCILNLASTPAISQRHARASDIWEAVFPTIMMGDDRAVTQTYVAGVP
HHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHCCCC
VKTGR
CCCCC
>Mature Secondary Structure
MILGQLLAFEGDPRALGPGAARHDTFGAVLVRDGLIARVGDAASLRADHPGVPVTDHGDD
CCCCCEEEECCCCCCCCCCCCCCCCCCEEEECCCCCEECCCCHHCCCCCCCCCCCCCCCC
LILPGFIDAHVHYPQTAMIASWGKRLIDWLNTYTFPEEARFHDPDYATDIAGRYLDLVTS
EEECCEEECEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHEEEEEC
NGTTTVASYCTIHPTSVDAFFAAAQAKRMRVLAGKTCMDRNAPDDLRDTAQSAYDDSRAL
CCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHH
LRKWHGVDRLGYVITPRFSPTSTPEQLSALGALWAEHPDCLMQTHLSEQLDEIAWVRDLY
HHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
PNARDYLDTYEAHGLLGSRGVYGHAIHLEPRETTRLAEVGAALVHCPTSNTFIGSGLFDM
CCHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHCCEEEECCCCCCEECCCHHHH
GLANTISVGLATDTGGGSSFSMLRTMAAAYEVAQLRGHAVHPSELIWRATGGSAQALHLE
CCHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEECCCCCEEEEEH
DKIGRLAPGFEADLCILNLASTPAISQRHARASDIWEAVFPTIMMGDDRAVTQTYVAGVP
HHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHCCCC
VKTGR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]