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The map label for this gene is yeiA [H]

Identifier: 89055203

GI number: 89055203

Start: 2720807

End: 2722111

Strand: Reverse

Name: yeiA [H]

Synonym: Jann_2712

Alternate gene names: 89055203

Gene position: 2722111-2720807 (Counterclockwise)

Preceding gene: 89055204

Following gene: 89055202

Centisome position: 63.04

GC content: 62.22

Gene sequence:

>1305_bases
ATGGCTGACCTGACCTCCAACTTCATCGGCATCACTTCGCCCAACCCCTTCTGGCTCGCCTCCGCGCCGCCGACGGACAA
GGAATACAACGTCCGCCGCGCGTTTGAGGCGGGCTGGGGTGGCGTCGTCTGGAAAACGCTCGGCTCAGAGGGTCCGCCGG
TGGTGAACGTCAATGGCCCCCGGTACGGTGCGATCTACGGCGCGGACCGTCGGCTTCTGGGCCTCAACAATATCGAGCTG
ATCACCGACCGGGACCTCTACACCAACCTGGAAGAGATCAAGCGCGTGAAGGCAGACTACCCCGACCGCGCGATCATCGT
CTCCATCATGGTGCCGTGCGAGGAGGCGGCGTGGAAAGCCATCCTGCCGCTGGTGGAAGACACCGGCGCCGACGGGATCG
AGCTAAATTTCGGCTGCCCCCACGGCATGTCCGAGCGCGGCATGGGCGCGGCCGTGGGCCAGGTCCCCGAATACATCGAA
ATGGTGACGCGCTGGTGCAAGCAATATTACTCCAAGCCCGTCATTGTGAAGCTGACGCCCAACATCACGGACATCACCAA
ACCGGCGGCGGCGGCCAAGCGGGGCGGGGCGGATGCGGTGTCTTTGATCAACACGATCAACTCGATCACATCGGTCAATC
TGGACACAATGTCGCCCGAGCCGTCGATTGACGGGAAAGGATCGCACGGCGGCTATTGCGGCCCGGCGGTGAAACCCATT
GCCATGTCCATGGTGTCCGAGATTGCGCGCAGCCCGGAAACCCACGGCCTGCCAATCAGCGGCATCGGCGGTGTCACCAC
CTGGCGCGACGCGGCGGAGTTCATGACGCTGGGGGCGGGCAACGTGCAGGTCTGCACGGCGGCAATGACCTACGGGTTCA
AGATCGTAGAAGAAATGATCTCGGGCCTGTCGCAGTTTCTGGACGAGAAGGGCATGACACTGGATGATCTGGTGGGCCGT
GCGGTGCCGAATGTCACGGATTGGCAGTACCTGAACCTCAATTACGTCGCGAAAGCGCAGATCAATCAGGATGATTGCAT
CAAATGCGGGCGCTGCTATGCGGCCTGCGAAGACACGTCTCACCAGGCAATCTCCATGTCCGCCGATCGCGTGTTCGAGG
TGATCGACGCCGAATGCGTCGCCTGCAACCTTTGCGTGAACGTCTGCCCGGTGGAAAACTGCATCACCATGGTGGAAATG
GACGCCGGAGAGGTCGATCCACGCACCGGCAAACCCGTGGAGCCGGACTATGCCAACTGGACCACGCACCCCAACAATCC
GGGCCGTGTCGAGGCGGCGGAATGA

Upstream 100 bases:

>100_bases
TTGCGCGTCGGGCGGGGAAGACCTGACCGTGACCGCCGTGGCGGAAGGCCGCGACGCGGCGGAGGATATTCATATCGTAT
TGACAGGTAAGGAATAAATC

Downstream 100 bases:

>100_bases
TCACCGGGCTCGATCACATCAACCTGCAAACCGTCCAGCTTGCCGCGATGGTCAAATGGTACGATGAGGTCATGCACCTT
CATCCGGGGAAACGTCCGGC

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MADLTSNFIGITSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGSEGPPVVNVNGPRYGAIYGADRRLLGLNNIEL
ITDRDLYTNLEEIKRVKADYPDRAIIVSIMVPCEEAAWKAILPLVEDTGADGIELNFGCPHGMSERGMGAAVGQVPEYIE
MVTRWCKQYYSKPVIVKLTPNITDITKPAAAAKRGGADAVSLINTINSITSVNLDTMSPEPSIDGKGSHGGYCGPAVKPI
AMSMVSEIARSPETHGLPISGIGGVTTWRDAAEFMTLGAGNVQVCTAAMTYGFKIVEEMISGLSQFLDEKGMTLDDLVGR
AVPNVTDWQYLNLNYVAKAQINQDDCIKCGRCYAACEDTSHQAISMSADRVFEVIDAECVACNLCVNVCPVENCITMVEM
DAGEVDPRTGKPVEPDYANWTTHPNNPGRVEAAE

Sequences:

>Translated_434_residues
MADLTSNFIGITSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGSEGPPVVNVNGPRYGAIYGADRRLLGLNNIEL
ITDRDLYTNLEEIKRVKADYPDRAIIVSIMVPCEEAAWKAILPLVEDTGADGIELNFGCPHGMSERGMGAAVGQVPEYIE
MVTRWCKQYYSKPVIVKLTPNITDITKPAAAAKRGGADAVSLINTINSITSVNLDTMSPEPSIDGKGSHGGYCGPAVKPI
AMSMVSEIARSPETHGLPISGIGGVTTWRDAAEFMTLGAGNVQVCTAAMTYGFKIVEEMISGLSQFLDEKGMTLDDLVGR
AVPNVTDWQYLNLNYVAKAQINQDDCIKCGRCYAACEDTSHQAISMSADRVFEVIDAECVACNLCVNVCPVENCITMVEM
DAGEVDPRTGKPVEPDYANWTTHPNNPGRVEAAE
>Mature_433_residues
ADLTSNFIGITSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGSEGPPVVNVNGPRYGAIYGADRRLLGLNNIELI
TDRDLYTNLEEIKRVKADYPDRAIIVSIMVPCEEAAWKAILPLVEDTGADGIELNFGCPHGMSERGMGAAVGQVPEYIEM
VTRWCKQYYSKPVIVKLTPNITDITKPAAAAKRGGADAVSLINTINSITSVNLDTMSPEPSIDGKGSHGGYCGPAVKPIA
MSMVSEIARSPETHGLPISGIGGVTTWRDAAEFMTLGAGNVQVCTAAMTYGFKIVEEMISGLSQFLDEKGMTLDDLVGRA
VPNVTDWQYLNLNYVAKAQINQDDCIKCGRCYAACEDTSHQAISMSADRVFEVIDAECVACNLCVNVCPVENCITMVEMD
AGEVDPRTGKPVEPDYANWTTHPNNPGRVEAAE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=336, Percent_Identity=37.202380952381, Blast_Score=218, Evalue=1e-56,
Organism=Escherichia coli, GI87082059, Length=415, Percent_Identity=42.4096385542169, Blast_Score=331, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI71984108, Length=311, Percent_Identity=38.2636655948553, Blast_Score=210, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6322633, Length=327, Percent_Identity=27.217125382263, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640763, Length=312, Percent_Identity=41.025641025641, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI18858217, Length=312, Percent_Identity=41.025641025641, Blast_Score=230, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 46855; Mature: 46723

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLTSNFIGITSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGSEGPPVVNVNGP
CCCCCCCEEEECCCCCEEEECCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCEEEECCC
RYGAIYGADRRLLGLNNIELITDRDLYTNLEEIKRVKADYPDRAIIVSIMVPCEEAAWKA
CEEEEECCCCEEECCCCEEEEECCHHHCCHHHHHHHHCCCCCCEEEEEEEECCHHHHHHH
ILPLVEDTGADGIELNFGCPHGMSERGMGAAVGQVPEYIEMVTRWCKQYYSKPVIVKLTP
HHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
NITDITKPAAAAKRGGADAVSLINTINSITSVNLDTMSPEPSIDGKGSHGGYCGPAVKPI
CCHHHCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
AMSMVSEIARSPETHGLPISGIGGVTTWRDAAEFMTLGAGNVQVCTAAMTYGFKIVEEMI
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
SGLSQFLDEKGMTLDDLVGRAVPNVTDWQYLNLNYVAKAQINQDDCIKCGRCYAACEDTS
HHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEEEEECCCHHHHHHHCCHHHHCCCCC
HQAISMSADRVFEVIDAECVACNLCVNVCPVENCITMVEMDAGEVDPRTGKPVEPDYANW
CCEEECCHHHHHHHHHHHHHEEEHHHHHCCHHHHHEEEEECCCCCCCCCCCCCCCCCCCC
TTHPNNPGRVEAAE
CCCCCCCCCEECCC
>Mature Secondary Structure 
ADLTSNFIGITSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGSEGPPVVNVNGP
CCCCCCEEEECCCCCEEEECCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCEEEECCC
RYGAIYGADRRLLGLNNIELITDRDLYTNLEEIKRVKADYPDRAIIVSIMVPCEEAAWKA
CEEEEECCCCEEECCCCEEEEECCHHHCCHHHHHHHHCCCCCCEEEEEEEECCHHHHHHH
ILPLVEDTGADGIELNFGCPHGMSERGMGAAVGQVPEYIEMVTRWCKQYYSKPVIVKLTP
HHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
NITDITKPAAAAKRGGADAVSLINTINSITSVNLDTMSPEPSIDGKGSHGGYCGPAVKPI
CCHHHCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
AMSMVSEIARSPETHGLPISGIGGVTTWRDAAEFMTLGAGNVQVCTAAMTYGFKIVEEMI
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
SGLSQFLDEKGMTLDDLVGRAVPNVTDWQYLNLNYVAKAQINQDDCIKCGRCYAACEDTS
HHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEEEEECCCHHHHHHHCCHHHHCCCCC
HQAISMSADRVFEVIDAECVACNLCVNVCPVENCITMVEMDAGEVDPRTGKPVEPDYANW
CCEEECCHHHHHHHHHHHHHEEEHHHHHCCHHHHHEEEEECCCCCCCCCCCCCCCCCCCC
TTHPNNPGRVEAAE
CCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]