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The map label for this gene is dht [H]

Identifier: 89055196

GI number: 89055196

Start: 2714936

End: 2716399

Strand: Reverse

Name: dht [H]

Synonym: Jann_2705

Alternate gene names: 89055196

Gene position: 2716399-2714936 (Counterclockwise)

Preceding gene: 89055197

Following gene: 89055195

Centisome position: 62.91

GC content: 61.2

Gene sequence:

>1464_bases
ATGAGCAAGGTGATCAAGGGCGGCACGATTGTGACCGCAGACCGTCAATGGCAGGCGGACGTGTTGATCGAGGGCGAAAA
GATTGCCGAGATCGGGGAGAACCTGCGCGGGGATGAGGTGATCGACGCGGAAGGCGCCTATGTGATCCCGGGCGGCATAG
ACCCCCACACGCATCTTGAGATGCCCTTCATGGGCACCACGGCGGCGGAGACGTTCGAGACGGGCACCTTTGCGGCGGCA
GCGGGCGGCACCACGATGCTGGTCGATTTCTGCCTTCCGGGCGAGGATGGCAGCCTTTTGTCCGCCATCGATGCCTGGGA
CGCCAAATCGAAGGATCAGATCTGCGTTGATATCTCCTACCACATGGCGATCACCGGCTGGTCGGAGAGCATTTTCAATG
AGATGGCGGACGTTGTTAATGTGCGCGGCATCAACACATTTAAGCATTTCATGGCCTATAAAGGCGCGCTGATGATCGAG
GATGACGAGATGTTTTCGTCGTTCAAGCGCTGCGCTGAATTGGGCGCGCTGCCGCTGGTCCATGCCGAAAACGGCGATAT
CGTCCAGGAGTTGCAACAGAAATACATGGCGATGGGCGTGACGGGGCCGGAGGGTCACGCATATTCCCGTCCGCCTGAGG
TCGAAGGGGAAGCCGCCAACCGCGCGATCATGATCGCCGACGCCGCTGGCACGCCGTTGTATATCGTCCATGTGTCGTGT
GAGCAGGCCCATGAGGCCATCCGCCGTGCCCGTCAGAAGGGGATGCGGGTCTTCGGGGAGCCACTGATCCAGCACCTGAC
GCTGGATGAGAGCGAGTATTTCAACAAGGATTGGCAATATGCGGCCCGCCGGGTCATGTCCCCGCCGTTTCGCAACAAAG
AGCATCAGGACGGTCTTTGGGCAGGTCTTGCCGCTGGGTCCTTGCAGGTTGTGGCCACGGACCACGCCGCCTTCACCGAC
GAGCAAAAGCGCATGGGCGTGGACAATTTCGGCATGATCCCCAACGGCACCGGCGGGCTTGAGGAGCGCATGGCAATGTT
GTGGACGCGCGGCGTGGAAACGGGCCGCCTGACGCCGGAAGAATTCGTTGCGGTGACGTCATCGAACATCGCCAAGATCC
TCAACATTTACCCAATGAAGGGTGGCATCAACGTCGGCGGCGACGCGGATATCGTGGTCTGGGACCCGAAACTGGGCCGC
ACGATCACGACGGCAACGGCGAAATCTATCCTTGATTACAATGTGTTCGAGGGAATGGAGGTGAGCGCCTCCCCCCGCTA
CACCCTGTCGCGCGGGGATGTGGTGTGGGCGGCGGGGCAAAACAGCCAGCCGCAACCGGGCCGTGGGAAATTCGTGAAAC
GGCCCCCGGCGGCGAGTGCGTCCCAGGCGCTGAGCAAGTGGAAGGCGTTGAACACGCCGCGCAAGATCGAGCGCGACCCG
ATGAACATTCCGGCGGGGGTTTGA

Upstream 100 bases:

>100_bases
AATGTGGTTGAGAGCGTCTACATCCCGCTCCTGACCCGCGACCAACGGATGATCTGCGTGACCGCGCAGTAGGATATCAT
ATGCAGATAGGGGGCTCTCG

Downstream 100 bases:

>100_bases
GTGGAGCTAGAGTTCCTACTTTTCGTGGTCCTTCTTCCGTTGGCTGCTGCAGGAGCAGTGACATTTGGTGTTTGGGTCAT
CCAACGTTACTGTGGTCGAA

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MSKVIKGGTIVTADRQWQADVLIEGEKIAEIGENLRGDEVIDAEGAYVIPGGIDPHTHLEMPFMGTTAAETFETGTFAAA
AGGTTMLVDFCLPGEDGSLLSAIDAWDAKSKDQICVDISYHMAITGWSESIFNEMADVVNVRGINTFKHFMAYKGALMIE
DDEMFSSFKRCAELGALPLVHAENGDIVQELQQKYMAMGVTGPEGHAYSRPPEVEGEAANRAIMIADAAGTPLYIVHVSC
EQAHEAIRRARQKGMRVFGEPLIQHLTLDESEYFNKDWQYAARRVMSPPFRNKEHQDGLWAGLAAGSLQVVATDHAAFTD
EQKRMGVDNFGMIPNGTGGLEERMAMLWTRGVETGRLTPEEFVAVTSSNIAKILNIYPMKGGINVGGDADIVVWDPKLGR
TITTATAKSILDYNVFEGMEVSASPRYTLSRGDVVWAAGQNSQPQPGRGKFVKRPPAASASQALSKWKALNTPRKIERDP
MNIPAGV

Sequences:

>Translated_487_residues
MSKVIKGGTIVTADRQWQADVLIEGEKIAEIGENLRGDEVIDAEGAYVIPGGIDPHTHLEMPFMGTTAAETFETGTFAAA
AGGTTMLVDFCLPGEDGSLLSAIDAWDAKSKDQICVDISYHMAITGWSESIFNEMADVVNVRGINTFKHFMAYKGALMIE
DDEMFSSFKRCAELGALPLVHAENGDIVQELQQKYMAMGVTGPEGHAYSRPPEVEGEAANRAIMIADAAGTPLYIVHVSC
EQAHEAIRRARQKGMRVFGEPLIQHLTLDESEYFNKDWQYAARRVMSPPFRNKEHQDGLWAGLAAGSLQVVATDHAAFTD
EQKRMGVDNFGMIPNGTGGLEERMAMLWTRGVETGRLTPEEFVAVTSSNIAKILNIYPMKGGINVGGDADIVVWDPKLGR
TITTATAKSILDYNVFEGMEVSASPRYTLSRGDVVWAAGQNSQPQPGRGKFVKRPPAASASQALSKWKALNTPRKIERDP
MNIPAGV
>Mature_486_residues
SKVIKGGTIVTADRQWQADVLIEGEKIAEIGENLRGDEVIDAEGAYVIPGGIDPHTHLEMPFMGTTAAETFETGTFAAAA
GGTTMLVDFCLPGEDGSLLSAIDAWDAKSKDQICVDISYHMAITGWSESIFNEMADVVNVRGINTFKHFMAYKGALMIED
DEMFSSFKRCAELGALPLVHAENGDIVQELQQKYMAMGVTGPEGHAYSRPPEVEGEAANRAIMIADAAGTPLYIVHVSCE
QAHEAIRRARQKGMRVFGEPLIQHLTLDESEYFNKDWQYAARRVMSPPFRNKEHQDGLWAGLAAGSLQVVATDHAAFTDE
QKRMGVDNFGMIPNGTGGLEERMAMLWTRGVETGRLTPEEFVAVTSSNIAKILNIYPMKGGINVGGDADIVVWDPKLGRT
ITTATAKSILDYNVFEGMEVSASPRYTLSRGDVVWAAGQNSQPQPGRGKFVKRPPAASASQALSKWKALNTPRKIERDPM
NIPAGV

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=486, Percent_Identity=44.8559670781893, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI190194363, Length=455, Percent_Identity=45.7142857142857, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI4503377, Length=457, Percent_Identity=44.6389496717724, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI4503051, Length=455, Percent_Identity=44.3956043956044, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI62422571, Length=455, Percent_Identity=44.3956043956044, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI4503379, Length=457, Percent_Identity=42.2319474835886, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI19923821, Length=483, Percent_Identity=40.1656314699793, Blast_Score=361, Evalue=1e-99,
Organism=Escherichia coli, GI87082175, Length=462, Percent_Identity=37.2294372294372, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI1786722, Length=466, Percent_Identity=29.6137339055794, Blast_Score=175, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17539558, Length=486, Percent_Identity=46.2962962962963, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71989490, Length=485, Percent_Identity=45.1546391752577, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI86575075, Length=457, Percent_Identity=32.1663019693654, Blast_Score=225, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6322218, Length=460, Percent_Identity=24.5652173913043, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221377917, Length=463, Percent_Identity=42.7645788336933, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI17137462, Length=461, Percent_Identity=42.7331887201735, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24644287, Length=294, Percent_Identity=42.1768707482993, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24644289, Length=258, Percent_Identity=42.2480620155039, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24642586, Length=426, Percent_Identity=26.5258215962441, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 53015; Mature: 52884

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVIKGGTIVTADRQWQADVLIEGEKIAEIGENLRGDEVIDAEGAYVIPGGIDPHTHLE
CCCEECCCEEEEECCCCCCEEEECCHHHHHHHCCCCCCEEEECCCCEEECCCCCCCCEEE
MPFMGTTAAETFETGTFAAAAGGTTMLVDFCLPGEDGSLLSAIDAWDAKSKDQICVDISY
CCCCCCCHHHHHCCCCEEEECCCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCEEEEEEE
HMAITGWSESIFNEMADVVNVRGINTFKHFMAYKGALMIEDDEMFSSFKRCAELGALPLV
EEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCEEE
HAENGDIVQELQQKYMAMGVTGPEGHAYSRPPEVEGEAANRAIMIADAAGTPLYIVHVSC
ECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECH
EQAHEAIRRARQKGMRVFGEPLIQHLTLDESEYFNKDWQYAARRVMSPPFRNKEHQDGLW
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCCCCCCCCCCCE
AGLAAGSLQVVATDHAAFTDEQKRMGVDNFGMIPNGTGGLEERMAMLWTRGVETGRLTPE
EEECCCCEEEEEECCHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHH
EFVAVTSSNIAKILNIYPMKGGINVGGDADIVVWDPKLGRTITTATAKSILDYNVFEGME
HHEEECCCCHHEEHEEEECCCCCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHCCCC
VSASPRYTLSRGDVVWAAGQNSQPQPGRGKFVKRPPAASASQALSKWKALNTPRKIERDP
CCCCCCEEECCCCEEEEECCCCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCCHHCCCCC
MNIPAGV
CCCCCCC
>Mature Secondary Structure 
SKVIKGGTIVTADRQWQADVLIEGEKIAEIGENLRGDEVIDAEGAYVIPGGIDPHTHLE
CCEECCCEEEEECCCCCCEEEECCHHHHHHHCCCCCCEEEECCCCEEECCCCCCCCEEE
MPFMGTTAAETFETGTFAAAAGGTTMLVDFCLPGEDGSLLSAIDAWDAKSKDQICVDISY
CCCCCCCHHHHHCCCCEEEECCCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCEEEEEEE
HMAITGWSESIFNEMADVVNVRGINTFKHFMAYKGALMIEDDEMFSSFKRCAELGALPLV
EEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCEEE
HAENGDIVQELQQKYMAMGVTGPEGHAYSRPPEVEGEAANRAIMIADAAGTPLYIVHVSC
ECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECH
EQAHEAIRRARQKGMRVFGEPLIQHLTLDESEYFNKDWQYAARRVMSPPFRNKEHQDGLW
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCCCCCCCCCCCE
AGLAAGSLQVVATDHAAFTDEQKRMGVDNFGMIPNGTGGLEERMAMLWTRGVETGRLTPE
EEECCCCEEEEEECCHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHH
EFVAVTSSNIAKILNIYPMKGGINVGGDADIVVWDPKLGRTITTATAKSILDYNVFEGME
HHEEECCCCHHEEHEEEECCCCCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHCCCC
VSASPRYTLSRGDVVWAAGQNSQPQPGRGKFVKRPPAASASQALSKWKALNTPRKIERDP
CCCCCCEEECCCCEEEEECCCCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCCHHCCCCC
MNIPAGV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]