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The map label for this gene is lon [H]

Identifier: 89055009

GI number: 89055009

Start: 2516483

End: 2518882

Strand: Reverse

Name: lon [H]

Synonym: Jann_2518

Alternate gene names: 89055009

Gene position: 2518882-2516483 (Counterclockwise)

Preceding gene: 89055010

Following gene: 89055008

Centisome position: 58.33

GC content: 60.5

Gene sequence:

>2400_bases
ATGTCCGAACAAACTATCTATCCCGTCCTGCCGCTGCGCGACATCGTGGTGTTCCCGCACATGGTGGTGCCGCTGTTCGT
GGGCCGCGAAAAATCCGTGCGTGCGCTGGAAGAGGTGATGCAGGACGACAAGCAGATCCTGCTGTCGTCGCAACGGGACC
CGGCGGAGGATGATCCCGGCACCGACGGCATCTTTGAAAACGGCGTGCTGGCCAATGTGCTGCAATTGCTGAAGCTGCCC
GATGGCACCGTGAAGGTGCTTGTCGAAGGCCGTCGCCGCGTGCGGATCGAGGAATACACGTCCACTGAGCCGTTCTTTGA
GGCGATTGCCGTCGAATTGTCCGAATCCACCGGCGATCTGGAAGCGATCACGGCGCTGACGCGGTCGGTGGCCGAAGAAT
TCGAGAAATACGCCAAGGTGAAGAAGAACGTGCCGGAAGAGGCGCTGACCTCTGTATCGGAAGCGCATGATCCGGCGAAG
CTGGCCGATCTTGTCTCCGGCCACCTGGGCATCGAGGTGGAGCAAAAGCAGGAGCTTCTTGAAACCCTCGAAGTCGCCGC
GCGGCTAGAGAAGGTCTATGGCCTAATGCAGGGCGAAATGTCCGTGCTGCAGGTGGAAAAGAAGATCAAGACCCGCGTGA
AGTCCCAGATGGAGCGGACCCAGCGCGAATATTACCTGAACGAACAGATGAAGGCGATCCAGCGGGAATTGGGCGATGGT
GAAGAGGGCGAGGGCGAAGTGGCCGAGCTGTCGGAGCGGATCGCCAGCACCAAGCTGAGCAAGGAGGCGCGCGAAAAGGC
CGATGCGGAGCTGAAGAAGCTCAAGAATATGTCGCCGATGAGCGCGGAAGCCACGGTTGTGCGCAACTACCTCGACTGGA
TGCTGTCGATCCCGTGGGGCACGAAATCCCGCGTGAAAAAGGATCTGGGGCGTGCCCAGAAGATCCTCGACGACGATCAC
TACAGCCTGGAGAAGGTGAAGGAGCGGATCGTTGAATATCTCGCGGTCCAGCAACGTTCCAAGAAGCTGAAGGGGCCGAT
CATGTGCCTCGTCGGCCCTCCCGGCGTGGGTAAGACCTCATTGGGCAAATCGGTGGCCAAGGCGACGGGGCGGGAGTTCA
TTCGGATTTCCCTCGGCGGCGTGCGCGATGAATCCGAGATCCGCGGCCATCGGCGCACCTATATCGGCTCCATGCCCGGC
AAGATCATCCAGGCGCTCAGGAAAGCGAAGACGACGAACCCGCTTATTCTGTTGGACGAGATCGACAAGATGGGGCAGGA
TTTCCGGGGCGATCCGGCATCCGCGATGCTGGAGGTGCTGGACCCCGAACAGAATGGCACCTTCGTGGATCACTATCTTG
AGGTGGAATACGACCTTTCGAACGTGATGTTCCTTACCACCGCGAACTCCTACAACATGCCGGGCCCGCTTCTGGACCGG
ATGGAGATCATTCCGCTGGCCGGCTACACCGAGGATGAAAAGGCCGAGATCGCCAATCGTCACCTCATCGCCAAGCAGGT
GAAGAACCACGGGCTGAAGAAGAACGAATTCACGCTGGAGCCCGAAGCGCTGCAAGAGATGATCCGCACCTATACCCGTG
AAGCGGGCGTGCGGAATCTGGAGCGGGAGATCGGGAAGCTCTGCCGCAAGGCGGTCACCAAGATCGTGCGCAAGGAGGTT
GAAGAAGTCGTTGTAACCCCCGAGAATCTAGACGATTTCCTTGGCGTGAAGAAGTATCGCTACGGGTTGGCAGAGGATGC
CGATGCCATCGGTGTTGTCACCGGCCTCGCCTATACGTCAGTGGGCGGCGACCTTCTGCATATCGAGGCGTTGAAGCTGC
CCGGTAAGGGGCGGATGAAAACGACGGGCAAGCTCGGCGATGTGATGAAGGAAAGCATCGACGCGGCGGCCAGCTACGTC
CGCTCCATCGCGCCAGAGATCGGGGTGAAGCCGCCTCGGTTTGACCGGATGGACATCCACGTCCACGTGCCCGATGGCGC
GACACCCAAGGACGGGCCGTCTGCCGGTCTGGCCATGGTGACGTCCATCGTGTCGGTCCTCACGGGCATTCCCGTGAAGC
GCGACATTGCGATGACGGGCGAGGTCAGCTTGCGCGGCAATGCGATGCCCATCGGCGGCTTGAAGGAAAAGCTGCTGGCT
GCCCTGCGCGGTGGGATCACCACAGTTCTCATCCCGCAAGAGAATGAGAAGGACCTGGTGGAGATCCCGGACAACGTGAA
GGACGGGCTGACCATCATCCCCGTGACCCATGTCTCGGAGGTTCTGGCCCATGCTCTGACAAGCAAACCCGAGCCAATCG
AATGGGATGAGGCCGCTGAAGAGGCCGCCGCCGCTGCGGCTGCGATCGCTCAAGGCGGTCAGGGTGCGACGGCCCATTAG

Upstream 100 bases:

>100_bases
CAAACACCCGCCCCACGTTAAGTTATCCTGAAGATGGAGAGGGCTAGGTTGCCGCCAAGCGGGGCCATGATCCTCTGCCT
AAGACCAAGGAAGTAGGCAT

Downstream 100 bases:

>100_bases
CACGTGTCGGACCGGGGCGGGACGTAAGCTCCGCCCCGCAAATGGCTGAAAAGAAATAAAAAAGGCCCGTAGCGTTTTTC
AGCTACGGGCCTTTTTATTG

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 799; Mature: 798

Protein sequence:

>799_residues
MSEQTIYPVLPLRDIVVFPHMVVPLFVGREKSVRALEEVMQDDKQILLSSQRDPAEDDPGTDGIFENGVLANVLQLLKLP
DGTVKVLVEGRRRVRIEEYTSTEPFFEAIAVELSESTGDLEAITALTRSVAEEFEKYAKVKKNVPEEALTSVSEAHDPAK
LADLVSGHLGIEVEQKQELLETLEVAARLEKVYGLMQGEMSVLQVEKKIKTRVKSQMERTQREYYLNEQMKAIQRELGDG
EEGEGEVAELSERIASTKLSKEAREKADAELKKLKNMSPMSAEATVVRNYLDWMLSIPWGTKSRVKKDLGRAQKILDDDH
YSLEKVKERIVEYLAVQQRSKKLKGPIMCLVGPPGVGKTSLGKSVAKATGREFIRISLGGVRDESEIRGHRRTYIGSMPG
KIIQALRKAKTTNPLILLDEIDKMGQDFRGDPASAMLEVLDPEQNGTFVDHYLEVEYDLSNVMFLTTANSYNMPGPLLDR
MEIIPLAGYTEDEKAEIANRHLIAKQVKNHGLKKNEFTLEPEALQEMIRTYTREAGVRNLEREIGKLCRKAVTKIVRKEV
EEVVVTPENLDDFLGVKKYRYGLAEDADAIGVVTGLAYTSVGGDLLHIEALKLPGKGRMKTTGKLGDVMKESIDAAASYV
RSIAPEIGVKPPRFDRMDIHVHVPDGATPKDGPSAGLAMVTSIVSVLTGIPVKRDIAMTGEVSLRGNAMPIGGLKEKLLA
ALRGGITTVLIPQENEKDLVEIPDNVKDGLTIIPVTHVSEVLAHALTSKPEPIEWDEAAEEAAAAAAAIAQGGQGATAH

Sequences:

>Translated_799_residues
MSEQTIYPVLPLRDIVVFPHMVVPLFVGREKSVRALEEVMQDDKQILLSSQRDPAEDDPGTDGIFENGVLANVLQLLKLP
DGTVKVLVEGRRRVRIEEYTSTEPFFEAIAVELSESTGDLEAITALTRSVAEEFEKYAKVKKNVPEEALTSVSEAHDPAK
LADLVSGHLGIEVEQKQELLETLEVAARLEKVYGLMQGEMSVLQVEKKIKTRVKSQMERTQREYYLNEQMKAIQRELGDG
EEGEGEVAELSERIASTKLSKEAREKADAELKKLKNMSPMSAEATVVRNYLDWMLSIPWGTKSRVKKDLGRAQKILDDDH
YSLEKVKERIVEYLAVQQRSKKLKGPIMCLVGPPGVGKTSLGKSVAKATGREFIRISLGGVRDESEIRGHRRTYIGSMPG
KIIQALRKAKTTNPLILLDEIDKMGQDFRGDPASAMLEVLDPEQNGTFVDHYLEVEYDLSNVMFLTTANSYNMPGPLLDR
MEIIPLAGYTEDEKAEIANRHLIAKQVKNHGLKKNEFTLEPEALQEMIRTYTREAGVRNLEREIGKLCRKAVTKIVRKEV
EEVVVTPENLDDFLGVKKYRYGLAEDADAIGVVTGLAYTSVGGDLLHIEALKLPGKGRMKTTGKLGDVMKESIDAAASYV
RSIAPEIGVKPPRFDRMDIHVHVPDGATPKDGPSAGLAMVTSIVSVLTGIPVKRDIAMTGEVSLRGNAMPIGGLKEKLLA
ALRGGITTVLIPQENEKDLVEIPDNVKDGLTIIPVTHVSEVLAHALTSKPEPIEWDEAAEEAAAAAAAIAQGGQGATAH
>Mature_798_residues
SEQTIYPVLPLRDIVVFPHMVVPLFVGREKSVRALEEVMQDDKQILLSSQRDPAEDDPGTDGIFENGVLANVLQLLKLPD
GTVKVLVEGRRRVRIEEYTSTEPFFEAIAVELSESTGDLEAITALTRSVAEEFEKYAKVKKNVPEEALTSVSEAHDPAKL
ADLVSGHLGIEVEQKQELLETLEVAARLEKVYGLMQGEMSVLQVEKKIKTRVKSQMERTQREYYLNEQMKAIQRELGDGE
EGEGEVAELSERIASTKLSKEAREKADAELKKLKNMSPMSAEATVVRNYLDWMLSIPWGTKSRVKKDLGRAQKILDDDHY
SLEKVKERIVEYLAVQQRSKKLKGPIMCLVGPPGVGKTSLGKSVAKATGREFIRISLGGVRDESEIRGHRRTYIGSMPGK
IIQALRKAKTTNPLILLDEIDKMGQDFRGDPASAMLEVLDPEQNGTFVDHYLEVEYDLSNVMFLTTANSYNMPGPLLDRM
EIIPLAGYTEDEKAEIANRHLIAKQVKNHGLKKNEFTLEPEALQEMIRTYTREAGVRNLEREIGKLCRKAVTKIVRKEVE
EVVVTPENLDDFLGVKKYRYGLAEDADAIGVVTGLAYTSVGGDLLHIEALKLPGKGRMKTTGKLGDVMKESIDAAASYVR
SIAPEIGVKPPRFDRMDIHVHVPDGATPKDGPSAGLAMVTSIVSVLTGIPVKRDIAMTGEVSLRGNAMPIGGLKEKLLAA
LRGGITTVLIPQENEKDLVEIPDNVKDGLTIIPVTHVSEVLAHALTSKPEPIEWDEAAEEAAAAAAAIAQGGQGATAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=695, Percent_Identity=41.4388489208633, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI31377667, Length=566, Percent_Identity=44.3462897526502, Blast_Score=499, Evalue=1e-141,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=59.3506493506494, Blast_Score=927, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=654, Percent_Identity=41.8960244648318, Blast_Score=509, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17556486, Length=543, Percent_Identity=39.5948434622468, Blast_Score=436, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319449, Length=446, Percent_Identity=43.7219730941704, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI221513036, Length=649, Percent_Identity=41.9106317411402, Blast_Score=517, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24666867, Length=649, Percent_Identity=41.9106317411402, Blast_Score=517, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87982; Mature: 87851

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQTIYPVLPLRDIVVFPHMVVPLFVGREKSVRALEEVMQDDKQILLSSQRDPAEDDPG
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TDGIFENGVLANVLQLLKLPDGTVKVLVEGRRRVRIEEYTSTEPFFEAIAVELSESTGDL
CCCCCCCCHHHHHHHHHHCCCCCEEHEECCCHHEEEHHCCCCCHHHHHHHHHHHCCCCHH
EAITALTRSVAEEFEKYAKVKKNVPEEALTSVSEAHDPAKLADLVSGHLGIEVEQKQELL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEHHHHHHH
ETLEVAARLEKVYGLMQGEMSVLQVEKKIKTRVKSQMERTQREYYLNEQMKAIQRELGDG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EEGEGEVAELSERIASTKLSKEAREKADAELKKLKNMSPMSAEATVVRNYLDWMLSIPWG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCC
TKSRVKKDLGRAQKILDDDHYSLEKVKERIVEYLAVQQRSKKLKGPIMCLVGPPGVGKTS
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
LGKSVAKATGREFIRISLGGVRDESEIRGHRRTYIGSMPGKIIQALRKAKTTNPLILLDE
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEHHH
IDKMGQDFRGDPASAMLEVLDPEQNGTFVDHYLEVEYDLSNVMFLTTANSYNMPGPLLDR
HHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCCCHHHHC
MEIIPLAGYTEDEKAEIANRHLIAKQVKNHGLKKNEFTLEPEALQEMIRTYTREAGVRNL
HHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHHH
EREIGKLCRKAVTKIVRKEVEEVVVTPENLDDFLGVKKYRYGLAEDADAIGVVTGLAYTS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
VGGDLLHIEALKLPGKGRMKTTGKLGDVMKESIDAAASYVRSIAPEIGVKPPRFDRMDIH
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
VHVPDGATPKDGPSAGLAMVTSIVSVLTGIPVKRDIAMTGEVSLRGNAMPIGGLKEKLLA
EECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCEEECCCCCCCCHHHHHHHH
ALRGGITTVLIPQENEKDLVEIPDNVKDGLTIIPVTHVSEVLAHALTSKPEPIEWDEAAE
HHHCCCEEEEECCCCCCCHHCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCHHHHHH
EAAAAAAAIAQGGQGATAH
HHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SEQTIYPVLPLRDIVVFPHMVVPLFVGREKSVRALEEVMQDDKQILLSSQRDPAEDDPG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TDGIFENGVLANVLQLLKLPDGTVKVLVEGRRRVRIEEYTSTEPFFEAIAVELSESTGDL
CCCCCCCCHHHHHHHHHHCCCCCEEHEECCCHHEEEHHCCCCCHHHHHHHHHHHCCCCHH
EAITALTRSVAEEFEKYAKVKKNVPEEALTSVSEAHDPAKLADLVSGHLGIEVEQKQELL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEHHHHHHH
ETLEVAARLEKVYGLMQGEMSVLQVEKKIKTRVKSQMERTQREYYLNEQMKAIQRELGDG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EEGEGEVAELSERIASTKLSKEAREKADAELKKLKNMSPMSAEATVVRNYLDWMLSIPWG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCC
TKSRVKKDLGRAQKILDDDHYSLEKVKERIVEYLAVQQRSKKLKGPIMCLVGPPGVGKTS
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
LGKSVAKATGREFIRISLGGVRDESEIRGHRRTYIGSMPGKIIQALRKAKTTNPLILLDE
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEHHH
IDKMGQDFRGDPASAMLEVLDPEQNGTFVDHYLEVEYDLSNVMFLTTANSYNMPGPLLDR
HHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCCCHHHHC
MEIIPLAGYTEDEKAEIANRHLIAKQVKNHGLKKNEFTLEPEALQEMIRTYTREAGVRNL
HHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHHH
EREIGKLCRKAVTKIVRKEVEEVVVTPENLDDFLGVKKYRYGLAEDADAIGVVTGLAYTS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
VGGDLLHIEALKLPGKGRMKTTGKLGDVMKESIDAAASYVRSIAPEIGVKPPRFDRMDIH
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
VHVPDGATPKDGPSAGLAMVTSIVSVLTGIPVKRDIAMTGEVSLRGNAMPIGGLKEKLLA
EECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCEEECCCCCCCCHHHHHHHH
ALRGGITTVLIPQENEKDLVEIPDNVKDGLTIIPVTHVSEVLAHALTSKPEPIEWDEAAE
HHHCCCEEEEECCCCCCCHHCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCHHHHHH
EAAAAAAAIAQGGQGATAH
HHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10762258; 11481430 [H]