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The map label for this gene is hisI

Identifier: 89054992

GI number: 89054992

Start: 2499498

End: 2499857

Strand: Reverse

Name: hisI

Synonym: Jann_2501

Alternate gene names: 89054992

Gene position: 2499857-2499498 (Counterclockwise)

Preceding gene: 89054994

Following gene: 89054981

Centisome position: 57.89

GC content: 60.83

Gene sequence:

>360_bases
ATGACCCAGTTTGATCCGGCGACACTTCGCTATGATGTGAACGGCTTGATCCCCTGTATTGCGCAGCAGGAGGGCACCGG
CGAGGTGCTGATGATGGCGTGGATGAATGCCGATTCTGTGGCCCGGACGTTAGAGAGCGGGCGAGTGACCTATTGGAGCC
GCTCTCGCCAGGCGTTCTGGGTGAAGGGGGAGACCAGCGGGCATGTGCAGGAACTGGTGGATCTGCGCGTGGATTGTGAT
CGGGATTGCCTTCTGGCCGTGGTCCGGCAAACCGGGCCCGCGTGTCACACGAACCGGCGCGTGTGTTTCTATACCTCGGT
CACAAGCGGTGAAGAGGTGGAGTTGATGGCGCCGGAATAG

Upstream 100 bases:

>100_bases
TCAGTATCGCTCGCCATCGCTTGCCTTTCGGGGCTTTGCCTTTCGGGTCCGTCCTGCCTTAAGTAGCGGCGCGTGAATGA
TTTGCAAAGAGGCACACCCG

Downstream 100 bases:

>100_bases
GGAGCGCTGCCCCCGTTCTGCGGCCTCCCCAGCCAAGATGGCGATAGCTCAAAGCCCGACCATGGCACGAACGTCGTCGG
GCGAGGCACCATCCGCACGG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 119; Mature: 118

Protein sequence:

>119_residues
MTQFDPATLRYDVNGLIPCIAQQEGTGEVLMMAWMNADSVARTLESGRVTYWSRSRQAFWVKGETSGHVQELVDLRVDCD
RDCLLAVVRQTGPACHTNRRVCFYTSVTSGEEVELMAPE

Sequences:

>Translated_119_residues
MTQFDPATLRYDVNGLIPCIAQQEGTGEVLMMAWMNADSVARTLESGRVTYWSRSRQAFWVKGETSGHVQELVDLRVDCD
RDCLLAVVRQTGPACHTNRRVCFYTSVTSGEEVELMAPE
>Mature_118_residues
TQFDPATLRYDVNGLIPCIAQQEGTGEVLMMAWMNADSVARTLESGRVTYWSRSRQAFWVKGETSGHVQELVDLRVDCDR
DCLLAVVRQTGPACHTNRRVCFYTSVTSGEEVELMAPE

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=90, Percent_Identity=46.6666666666667, Blast_Score=100, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319819, Length=75, Percent_Identity=40, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_JANSC (Q28PE4)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510443.1
- ProteinModelPortal:   Q28PE4
- SMR:   Q28PE4
- STRING:   Q28PE4
- GeneID:   3934960
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2501
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   CLSK933610
- BioCyc:   JSP290400:JANN_2501-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 13361; Mature: 13230

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
8.4 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQFDPATLRYDVNGLIPCIAQQEGTGEVLMMAWMNADSVARTLESGRVTYWSRSRQAFW
CCCCCCCEEEEECCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHCCCEEEEECCCEEEE
VKGETSGHVQELVDLRVDCDRDCLLAVVRQTGPACHTNRRVCFYTSVTSGEEVELMAPE
EECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEECCC
>Mature Secondary Structure 
TQFDPATLRYDVNGLIPCIAQQEGTGEVLMMAWMNADSVARTLESGRVTYWSRSRQAFW
CCCCCCEEEEECCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHCCCEEEEECCCEEEE
VKGETSGHVQELVDLRVDCDRDCLLAVVRQTGPACHTNRRVCFYTSVTSGEEVELMAPE
EECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA