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The map label for this gene is uppS [H]

Identifier: 89054948

GI number: 89054948

Start: 2451060

End: 2451785

Strand: Reverse

Name: uppS [H]

Synonym: Jann_2457

Alternate gene names: 89054948

Gene position: 2451785-2451060 (Counterclockwise)

Preceding gene: 89054949

Following gene: 89054947

Centisome position: 56.78

GC content: 62.26

Gene sequence:

>726_bases
ATGCCCACGCAATCCGAAACATCCAATGCCCCAAAGCATGTCGCCATCATCATGGACGGCAACGGGCGGTGGGCGCAGAT
GCGCCACCGGCCAAGGCTGGTGGGTCACCATGCTGGCGCCAAGCGGGTACGGGAAATCGTGCGCGCGGCCCCTGATCACG
GCGTGAAATACCTGACGATTTTTGCCTTCTCGACCGAGAACTGGAAGCGCACGCAGACCGAAGTGGCGGGGCTGATGAAG
CTGTTCAAGCGCTATATCCGGCGCGAGGCGCAGAACCTGCTGGACGAAGGCGTGTGCGTGCGCTTCATCGGCGACCGCGT
GCGGCTGGAGCCTGCGCTGGTCGATCTGATGGACGGGCTGGAGCTTCTGACCGCCGACAATGACAAGGTGCATCTGACCA
TCGCACTCAACTATGGCGGCCGGGACGAGGTTGCGCGCGCCGCCAAGCGCATGGCCTACGATGTGTCCATGGGCAAGCTG
AACCCGCGCGATGTGTGTGACGAGACATTCCCCAAATACCTCGACACCCACGTTCTGCCGGACCCGGATCTGGTGATCCG
CACCAGCGGCGAGGCGCGGATTTCCAACTTCCTGCTCTGGCAATCGGCCTATGCGGAATATGAGTTCATCGACACGCTCT
GGCCTGATTTCACGGCGGACGTCTTCGCCAGTGTTCTTGGCCGCTTTGGCGCGCGCGACCGTCGTTTCGGCGCTGTGAAA
GCCTAA

Upstream 100 bases:

>100_bases
GATCGATCCGCGCGCCGCTGGGGCAACCGGAGGATTTCCGGCCTTGCCCCGCAGCGGATCGACACATCATTTCCGGACGT
GCCTTGAAAGGACAGTCCCT

Downstream 100 bases:

>100_bases
GCGCCGCCATGGCTGCGGGTCCCAAAACAGCATCTGGCCCGAAATTCGCGGATCTGCTTCCGCGCATCGCGTCCGCCTTT
GTGTTGCTGAGCGTTGCGGG

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MPTQSETSNAPKHVAIIMDGNGRWAQMRHRPRLVGHHAGAKRVREIVRAAPDHGVKYLTIFAFSTENWKRTQTEVAGLMK
LFKRYIRREAQNLLDEGVCVRFIGDRVRLEPALVDLMDGLELLTADNDKVHLTIALNYGGRDEVARAAKRMAYDVSMGKL
NPRDVCDETFPKYLDTHVLPDPDLVIRTSGEARISNFLLWQSAYAEYEFIDTLWPDFTADVFASVLGRFGARDRRFGAVK
A

Sequences:

>Translated_241_residues
MPTQSETSNAPKHVAIIMDGNGRWAQMRHRPRLVGHHAGAKRVREIVRAAPDHGVKYLTIFAFSTENWKRTQTEVAGLMK
LFKRYIRREAQNLLDEGVCVRFIGDRVRLEPALVDLMDGLELLTADNDKVHLTIALNYGGRDEVARAAKRMAYDVSMGKL
NPRDVCDETFPKYLDTHVLPDPDLVIRTSGEARISNFLLWQSAYAEYEFIDTLWPDFTADVFASVLGRFGARDRRFGAVK
A
>Mature_240_residues
PTQSETSNAPKHVAIIMDGNGRWAQMRHRPRLVGHHAGAKRVREIVRAAPDHGVKYLTIFAFSTENWKRTQTEVAGLMKL
FKRYIRREAQNLLDEGVCVRFIGDRVRLEPALVDLMDGLELLTADNDKVHLTIALNYGGRDEVARAAKRMAYDVSMGKLN
PRDVCDETFPKYLDTHVLPDPDLVIRTSGEARISNFLLWQSAYAEYEFIDTLWPDFTADVFASVLGRFGARDRRFGAVKA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=220, Percent_Identity=38.1818181818182, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI45580738, Length=220, Percent_Identity=38.1818181818182, Blast_Score=162, Evalue=4e-40,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=46.2882096069869, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71993029, Length=212, Percent_Identity=36.3207547169811, Blast_Score=147, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6319474, Length=229, Percent_Identity=33.6244541484716, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323748, Length=216, Percent_Identity=34.2592592592593, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18857969, Length=231, Percent_Identity=36.3636363636364, Blast_Score=134, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27363; Mature: 27231

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTQSETSNAPKHVAIIMDGNGRWAQMRHRPRLVGHHAGAKRVREIVRAAPDHGVKYLTI
CCCCCCCCCCCCEEEEEECCCCCEEHHHCCCCHHCCCCCHHHHHHHHHHCCCCCCEEEEE
FAFSTENWKRTQTEVAGLMKLFKRYIRREAQNLLDEGVCVRFIGDRVRLEPALVDLMDGL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHEECHHHHHHHCCH
ELLTADNDKVHLTIALNYGGRDEVARAAKRMAYDVSMGKLNPRDVCDETFPKYLDTHVLP
HEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCC
DPDLVIRTSGEARISNFLLWQSAYAEYEFIDTLWPDFTADVFASVLGRFGARDRRFGAVK
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCC
A
C
>Mature Secondary Structure 
PTQSETSNAPKHVAIIMDGNGRWAQMRHRPRLVGHHAGAKRVREIVRAAPDHGVKYLTI
CCCCCCCCCCCEEEEEECCCCCEEHHHCCCCHHCCCCCHHHHHHHHHHCCCCCCEEEEE
FAFSTENWKRTQTEVAGLMKLFKRYIRREAQNLLDEGVCVRFIGDRVRLEPALVDLMDGL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHEECHHHHHHHCCH
ELLTADNDKVHLTIALNYGGRDEVARAAKRMAYDVSMGKLNPRDVCDETFPKYLDTHVLP
HEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCC
DPDLVIRTSGEARISNFLLWQSAYAEYEFIDTLWPDFTADVFASVLGRFGARDRRFGAVK
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]