Click here to switch to the map view.

The map label for this gene is fumC

Identifier: 89054885

GI number: 89054885

Start: 2394989

End: 2396377

Strand: Direct

Name: fumC

Synonym: Jann_2394

Alternate gene names: 89054885

Gene position: 2394989-2396377 (Clockwise)

Preceding gene: 89054883

Following gene: 89054886

Centisome position: 55.47

GC content: 63.07

Gene sequence:

>1389_bases
ATGACCGCAACCCGCACCGAGACCGACAGCTTTGGCCCGCTGGACGTGCCCTCCGACAAATATTGGGGCGCACAGACCCA
GCGCTCGATCCTGAATTTCCCGATTGGGTGGGAGAAGCAGCCCGTGGCCGTCGTGCGGGCTTTGGGCGTCATCAAACGGG
CCTGCGCGGAGGCGAACATCGCCCGCGGCAAGCTGGATGGCATCGGTGACGCGGTGCTGGAGGCGGCGCAAGAGGTCATC
GACGGAAAGCTGGACGACAACTTCCCGCTGGTAGTCTGGCAGACCGGATCGGGCACCCAATCCAACATGAACGCCAATGA
GGTCATCGCCAACCGCGCGATCGAGATCCTGGGCGGCGAGATCGGGTCTAAGACGCCCGTCCATCCCAACGATCACTGCA
ATATGGGGCAATCGTCCAACGACACGTTTCCCACGGCCATGCATATCGCCACCGCCATGACCGCCCGCGACGTGACCCTG
CCCGGCCTGCGCAAACTGCACGCGGCGCTGGAAGATAAGGTCGCAGCGTTCCAGGGCATCATCAAGATTGGCCGCACCCA
CACGATGGACGCCACGCCCCTGACCCTGGCGCAGGAGTTTGGCGGCTATGCCCATCAGGTCCTGAAAAGCATTGCCCGGA
TCGAGACGGCCCTTGGCGATATCTATGAGCTGGCCCAGGGCGGCACGGCGGTGGGCACCGGACTGAACACGCCCGAAGGT
TGGGGCGAAGAGGTCGCGGGCCACATGGCGCGGATCACCGGCCTGCCATTCGTCACCGCCCCCAACAAGTTCGAGGCCTT
GGCCGCCCACGATGCCATGGTCGCCATATCGGGCGCGATGAAGACCACTGCCGCGTCGCTGTTCAAGATCGCCAACGATA
TCCGGCTGCTCGGCTCCGGCCCCCGCTGCGGGTTGGGAGAGTTGATGCTGCCCGAAAACGAACCCGGCTCCTCCATCATG
CCCGGCAAGGTGAACCCGACCCAATGCGAAGCGATGACCCAGGTCTGCGCCCATGTCATCGGCAACGACGCCGCCGTGGG
CTTTGCGGGCAGCCAGGGGCATTTTGAGTTGAACGTCTACAAGCCGATGATGGCGTATAACGTGCTGCAGTCCATGCAGC
TGGTGGGCGATGCCTGCGTGGCGTTTACCGACAATTGCGTGGTGGGTATCAAGGCCGATGTCGTGCGGATCGAGAAGATC
ATGAATGAGTCGCTTATGCTGGTCACTGCGCTGGCCCCCACCATCGGCTATGACAACGCCACGACGGTCGCCAAGACCGC
CCACAAGAACGGCACCACCCTGAAAGAAGAGGCCATAGGTCTGGGGTTTGTCGATGAGGAGACGTTCAACCGCGTCGTGC
GGCCCGAGACGATGATCGGTCCGAAATGA

Upstream 100 bases:

>100_bases
GGCCGTGCCCGACGGCGGGGCGCGTCCCCTGCGGCCATTGCGACACGCGCCGCCGTGCGCTACTGCGCAGGTGTAATTTC
AGCGACCGGGAGACACCCCA

Downstream 100 bases:

>100_bases
GCGGCACCGCACGATGACCGATGGGCCGATCAACCTCAACCGCGTGCGCAAGGCCCGCGCGCGCGATGCCGCACGGGTCC
GGGCCGATGAAAATGCCGCA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTATRTETDSFGPLDVPSDKYWGAQTQRSILNFPIGWEKQPVAVVRALGVIKRACAEANIARGKLDGIGDAVLEAAQEVI
DGKLDDNFPLVVWQTGSGTQSNMNANEVIANRAIEILGGEIGSKTPVHPNDHCNMGQSSNDTFPTAMHIATAMTARDVTL
PGLRKLHAALEDKVAAFQGIIKIGRTHTMDATPLTLAQEFGGYAHQVLKSIARIETALGDIYELAQGGTAVGTGLNTPEG
WGEEVAGHMARITGLPFVTAPNKFEALAAHDAMVAISGAMKTTAASLFKIANDIRLLGSGPRCGLGELMLPENEPGSSIM
PGKVNPTQCEAMTQVCAHVIGNDAAVGFAGSQGHFELNVYKPMMAYNVLQSMQLVGDACVAFTDNCVVGIKADVVRIEKI
MNESLMLVTALAPTIGYDNATTVAKTAHKNGTTLKEEAIGLGFVDEETFNRVVRPETMIGPK

Sequences:

>Translated_462_residues
MTATRTETDSFGPLDVPSDKYWGAQTQRSILNFPIGWEKQPVAVVRALGVIKRACAEANIARGKLDGIGDAVLEAAQEVI
DGKLDDNFPLVVWQTGSGTQSNMNANEVIANRAIEILGGEIGSKTPVHPNDHCNMGQSSNDTFPTAMHIATAMTARDVTL
PGLRKLHAALEDKVAAFQGIIKIGRTHTMDATPLTLAQEFGGYAHQVLKSIARIETALGDIYELAQGGTAVGTGLNTPEG
WGEEVAGHMARITGLPFVTAPNKFEALAAHDAMVAISGAMKTTAASLFKIANDIRLLGSGPRCGLGELMLPENEPGSSIM
PGKVNPTQCEAMTQVCAHVIGNDAAVGFAGSQGHFELNVYKPMMAYNVLQSMQLVGDACVAFTDNCVVGIKADVVRIEKI
MNESLMLVTALAPTIGYDNATTVAKTAHKNGTTLKEEAIGLGFVDEETFNRVVRPETMIGPK
>Mature_461_residues
TATRTETDSFGPLDVPSDKYWGAQTQRSILNFPIGWEKQPVAVVRALGVIKRACAEANIARGKLDGIGDAVLEAAQEVID
GKLDDNFPLVVWQTGSGTQSNMNANEVIANRAIEILGGEIGSKTPVHPNDHCNMGQSSNDTFPTAMHIATAMTARDVTLP
GLRKLHAALEDKVAAFQGIIKIGRTHTMDATPLTLAQEFGGYAHQVLKSIARIETALGDIYELAQGGTAVGTGLNTPEGW
GEEVAGHMARITGLPFVTAPNKFEALAAHDAMVAISGAMKTTAASLFKIANDIRLLGSGPRCGLGELMLPENEPGSSIMP
GKVNPTQCEAMTQVCAHVIGNDAAVGFAGSQGHFELNVYKPMMAYNVLQSMQLVGDACVAFTDNCVVGIKADVVRIEKIM
NESLMLVTALAPTIGYDNATTVAKTAHKNGTTLKEEAIGLGFVDEETFNRVVRPETMIGPK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=67.3913043478261, Blast_Score=623, Evalue=1e-178,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=50.6493506493506, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=55.531453362256, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=37.0932754880694, Blast_Score=300, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17553882, Length=464, Percent_Identity=64.2241379310345, Blast_Score=617, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=65.2439024390244, Blast_Score=440, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6324993, Length=464, Percent_Identity=62.2844827586207, Blast_Score=575, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=63.9913232104121, Blast_Score=607, Evalue=1e-174,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=63.9913232104121, Blast_Score=605, Evalue=1e-173,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=62.2030237580993, Blast_Score=582, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=58.6580086580087, Blast_Score=560, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=51.8358531317495, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 48969; Mature: 48837

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATRTETDSFGPLDVPSDKYWGAQTQRSILNFPIGWEKQPVAVVRALGVIKRACAEANI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ARGKLDGIGDAVLEAAQEVIDGKLDDNFPLVVWQTGSGTQSNMNANEVIANRAIEILGGE
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
IGSKTPVHPNDHCNMGQSSNDTFPTAMHIATAMTARDVTLPGLRKLHAALEDKVAAFQGI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
IKIGRTHTMDATPLTLAQEFGGYAHQVLKSIARIETALGDIYELAQGGTAVGTGLNTPEG
HHHCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCC
WGEEVAGHMARITGLPFVTAPNKFEALAAHDAMVAISGAMKTTAASLFKIANDIRLLGSG
HHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHEECCC
PRCGLGELMLPENEPGSSIMPGKVNPTQCEAMTQVCAHVIGNDAAVGFAGSQGHFELNVY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEC
KPMMAYNVLQSMQLVGDACVAFTDNCVVGIKADVVRIEKIMNESLMLVTALAPTIGYDNA
CHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCHHEEHHHHHHHCCCCCC
TTVAKTAHKNGTTLKEEAIGLGFVDEETFNRVVRPETMIGPK
HHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TATRTETDSFGPLDVPSDKYWGAQTQRSILNFPIGWEKQPVAVVRALGVIKRACAEANI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ARGKLDGIGDAVLEAAQEVIDGKLDDNFPLVVWQTGSGTQSNMNANEVIANRAIEILGGE
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
IGSKTPVHPNDHCNMGQSSNDTFPTAMHIATAMTARDVTLPGLRKLHAALEDKVAAFQGI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
IKIGRTHTMDATPLTLAQEFGGYAHQVLKSIARIETALGDIYELAQGGTAVGTGLNTPEG
HHHCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCC
WGEEVAGHMARITGLPFVTAPNKFEALAAHDAMVAISGAMKTTAASLFKIANDIRLLGSG
HHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHEECCC
PRCGLGELMLPENEPGSSIMPGKVNPTQCEAMTQVCAHVIGNDAAVGFAGSQGHFELNVY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEC
KPMMAYNVLQSMQLVGDACVAFTDNCVVGIKADVVRIEKIMNESLMLVTALAPTIGYDNA
CHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCHHEEHHHHHHHCCCCCC
TTVAKTAHKNGTTLKEEAIGLGFVDEETFNRVVRPETMIGPK
HHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]