Click here to switch to the map view.

The map label for this gene is metA

Identifier: 89054842

GI number: 89054842

Start: 2357389

End: 2358330

Strand: Direct

Name: metA

Synonym: Jann_2351

Alternate gene names: 89054842

Gene position: 2357389-2358330 (Clockwise)

Preceding gene: 89054840

Following gene: 89054843

Centisome position: 54.59

GC content: 59.55

Gene sequence:

>942_bases
ATGCCGATCAAACTGCCCGATACCCTGCCCGCCTATGACATCCTTTCCCGCGAGGGGGTGATGGTGATGCCCGAGGATGG
CGCTGCCAAGCAGGACATTCGCCCCCTGCGTATCGGGCTGCTGAACCTGATGCCCAAGAAGATCCAGACCGAGACGCAAT
TCGCGCGTCTCATCGGCGCATCGCCTTTGCAGATCGAGCTGTCGCTGATCCGCATGTCAGACCACGAATCCAAGAACACC
TCTGCCGCGCATATGGACGAATTCTACCGCACGTTCTCGGAGGTACAGGCGACGGGCGAGAAATTCGATGGCCTCCTGAT
CACCGGCGCGCCGATTGAGCATCTGCCGTTTGAGGACGTCACCTATTGGGACGAGTTGATCCAGGTAATGGACTGGACCC
AGACCAACGTCCATTCCACCTTCGGGATCTGCTGGGGCGGCATGGCCATGGCCTACCACTTCCACGGGATCAAGAAACAC
ATGTTGGACGCCAAGGCGTTCGGGTGCTTCCGCCATGTGAACCAGGCCCCGGCCTCGCCATATCTGCGCGGCTTCTCCGA
CGACGTTCTGATGCCCGTGTCGCGCTGGACGGAAGTGCGCTCGGATGAAATCGCGGCGGCGGGTCTCTCCACGCTGATCG
GATCCGATGACGTGGGGCCCGCGCTGGTGGAGGATGCCGATCACCGCGCGCTTTATGTGTTCAACCACTTTGAATACGAC
AGTGAGACGCTTAAGCAGGAATATGACCGCGATGCCGATGCAGGCGCGCCGATCAACGTGCCGGTGAATTACTACCCGGG
CGATGACCCCACAGCCACGCCGATGAACCGCTGGCGATCCCATGCGCATCTTCTCTACGGCAATTGGGTGAGTGAACTTT
ACCTCACAACCCCTTATGATATCGAACAAATCGGCCTGGCGTCCACGGATCTGCGCAAATGA

Upstream 100 bases:

>100_bases
GCGATCAAGGGACACGTTGGCGTGTCCGCACCTGCGCCCGGTTGTGTCCCCGCGCGTTCCCACATATTTCAAAGGTCCGA
GTTCAAGGACCCCGCGCGCC

Downstream 100 bases:

>100_bases
AGATCGTCGTTACCGTCCTTGCGCTGCTGGTGATCTTCGCGGCCGTCACGATGTGGCGCGCCGCGCGCAATGAGGCGCAG
GCCGAGGCCGAGTATCCCCC

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MPIKLPDTLPAYDILSREGVMVMPEDGAAKQDIRPLRIGLLNLMPKKIQTETQFARLIGASPLQIELSLIRMSDHESKNT
SAAHMDEFYRTFSEVQATGEKFDGLLITGAPIEHLPFEDVTYWDELIQVMDWTQTNVHSTFGICWGGMAMAYHFHGIKKH
MLDAKAFGCFRHVNQAPASPYLRGFSDDVLMPVSRWTEVRSDEIAAAGLSTLIGSDDVGPALVEDADHRALYVFNHFEYD
SETLKQEYDRDADAGAPINVPVNYYPGDDPTATPMNRWRSHAHLLYGNWVSELYLTTPYDIEQIGLASTDLRK

Sequences:

>Translated_313_residues
MPIKLPDTLPAYDILSREGVMVMPEDGAAKQDIRPLRIGLLNLMPKKIQTETQFARLIGASPLQIELSLIRMSDHESKNT
SAAHMDEFYRTFSEVQATGEKFDGLLITGAPIEHLPFEDVTYWDELIQVMDWTQTNVHSTFGICWGGMAMAYHFHGIKKH
MLDAKAFGCFRHVNQAPASPYLRGFSDDVLMPVSRWTEVRSDEIAAAGLSTLIGSDDVGPALVEDADHRALYVFNHFEYD
SETLKQEYDRDADAGAPINVPVNYYPGDDPTATPMNRWRSHAHLLYGNWVSELYLTTPYDIEQIGLASTDLRK
>Mature_312_residues
PIKLPDTLPAYDILSREGVMVMPEDGAAKQDIRPLRIGLLNLMPKKIQTETQFARLIGASPLQIELSLIRMSDHESKNTS
AAHMDEFYRTFSEVQATGEKFDGLLITGAPIEHLPFEDVTYWDELIQVMDWTQTNVHSTFGICWGGMAMAYHFHGIKKHM
LDAKAFGCFRHVNQAPASPYLRGFSDDVLMPVSRWTEVRSDEIAAAGLSTLIGSDDVGPALVEDADHRALYVFNHFEYDS
ETLKQEYDRDADAGAPINVPVNYYPGDDPTATPMNRWRSHAHLLYGNWVSELYLTTPYDIEQIGLASTDLRK

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=307, Percent_Identity=41.3680781758958, Blast_Score=251, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_JANSC (Q28PU4)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510293.1
- HSSP:   Q72X44
- ProteinModelPortal:   Q28PU4
- SMR:   Q28PU4
- STRING:   Q28PU4
- GeneID:   3934807
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2351
- eggNOG:   COG1897
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- PhylomeDB:   Q28PU4
- ProtClustDB:   PRK05368
- BioCyc:   JSP290400:JANN_2351-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 35254; Mature: 35123

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: ACT_SITE 144-144

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKLPDTLPAYDILSREGVMVMPEDGAAKQDIRPLRIGLLNLMPKKIQTETQFARLIGA
CCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCC
SPLQIELSLIRMSDHESKNTSAAHMDEFYRTFSEVQATGEKFDGLLITGAPIEHLPFEDV
CCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHH
TYWDELIQVMDWTQTNVHSTFGICWGGMAMAYHFHGIKKHMLDAKAFGCFRHVNQAPASP
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
YLRGFSDDVLMPVSRWTEVRSDEIAAAGLSTLIGSDDVGPALVEDADHRALYVFNHFEYD
HHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEECCCCC
SETLKQEYDRDADAGAPINVPVNYYPGDDPTATPMNRWRSHAHLLYGNWVSELYLTTPYD
HHHHHHHHCCCCCCCCCEECCEEEECCCCCCCCHHHHHHHHCEEEECCHHHHEEEECCCC
IEQIGLASTDLRK
HHHHCCCCCCCCC
>Mature Secondary Structure 
PIKLPDTLPAYDILSREGVMVMPEDGAAKQDIRPLRIGLLNLMPKKIQTETQFARLIGA
CCCCCCCCCHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCC
SPLQIELSLIRMSDHESKNTSAAHMDEFYRTFSEVQATGEKFDGLLITGAPIEHLPFEDV
CCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHH
TYWDELIQVMDWTQTNVHSTFGICWGGMAMAYHFHGIKKHMLDAKAFGCFRHVNQAPASP
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
YLRGFSDDVLMPVSRWTEVRSDEIAAAGLSTLIGSDDVGPALVEDADHRALYVFNHFEYD
HHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEECCCCC
SETLKQEYDRDADAGAPINVPVNYYPGDDPTATPMNRWRSHAHLLYGNWVSELYLTTPYD
HHHHHHHHCCCCCCCCCEECCEEEECCCCCCCCHHHHHHHHCEEEECCHHHHEEEECCCC
IEQIGLASTDLRK
HHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA