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The map label for this gene is 89054765

Identifier: 89054765

GI number: 89054765

Start: 2280311

End: 2281318

Strand: Direct

Name: 89054765

Synonym: Jann_2274

Alternate gene names: NA

Gene position: 2280311-2281318 (Clockwise)

Preceding gene: 89054753

Following gene: 89054766

Centisome position: 52.81

GC content: 62.0

Gene sequence:

>1008_bases
ATGACACCAAAAGCCGCGACCGCTGACGTCATCGACGTCCACGCCCATATTGTGCTGGCCGAGACCTTTGGCGCGGCGGG
CACGGCGCTTGGGCCGGAGATGGGGGGGCAGGACGGCGACAGGCCGTGGTTTCGCGTGGGCGACTATCGTCTGGACGGGG
TCCGCTACCAGGGCAGTGCATTCATGGACGCTGGTTTGCGGCTGGCTCGTATGGAGGAGGCGGGCATCGACTATCAGCTG
CTGTCGCCCAACCCGCTCACCTTTCTGCACTTTGTGGATGCGCCACTGGCCATCGACTTCTGCACGATTCACAACAACGC
CTTGTCATCGCTTGTGCGGAGCCATGCCGATCACCTTGGCGGCTGCGCGGCCTTGCCGATGCAGGATATCGGTGCGGCGA
TTGAAGAATTGGAACGCGGCGTGCGCGATCTGGGTTTGATGGGCGGCTACATCGGAACGGATCAGACCCAGCGGCTCGAT
GCGCCCGAGATGGATCGGTTCTATGCGACCTGCGTGCGGCTGAATGTGCCTGTGTTCCTGCACCCACAACCGGCCGGGAT
CGATGGGCCGGCGGGCGACGCCAACCTTGGGTATTATGACCTCGATGTCGTGATTGGTTTTGCCGCGCAGGAGGCGCTGG
CGGTTGCACGGCTCATCTATGGCGGCGTCCTGGATCGGCACCCTGATCTGGATGTCTGCGTCAGCCATGGTGGTGGCTCT
ACCGGATATTTGTTTGGCCGTATGGCAATGGCGGCGCGCAAACGACCTTGGGCCAGCGGCGCCCTCAAGGCCGATGGGGC
GTTCGAGGAACGCCTTTCACGGATCTGGTTTGACAATCATTTGAACTCGGATGGCGCATTGGACCTGCTGACCGGGCTTG
TCGGCGATGACCGGCTGGTCTTTGGAACGAATTTTTCAGGCTGGGATGCGCCTGATGATCTGGCCGCGCACAAACCTCAC
CCCAAGCTTGCCGATAACGCGCGCCGATTGCTGCGCATCACCCAATAG

Upstream 100 bases:

>100_bases
TGCACCCTCGCATAAACGGTTGCGTTTCCAAATCCCAGCGCGTTGACTAGATACATTGATATCGATCATATTCAAAACGC
AATGAGTCCGAGGTGCGATG

Downstream 100 bases:

>100_bases
GAGCAGACCTTTGACCGACTTGATCATCGAAAATGGACGCATCATTGACGGCACCGGTGCGCCCGCTTTTGAAGGCTCGG
TCCTTGTCCGGGACGGCAAG

Product: amidohydrolase 2

Products: 2-aminomuconate semialdehyde; CO2

Alternate protein names: Amidohydrolase; Amidohydrolase/Decarboxylase; Amidohydrolase Family Protein; 2-Amino-3-Carboxylmuconate-6-Semialdehyde Decarboxylase; O-Pyrocatechuate Decarboxylase; 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase; Hydrolase; 2-Amino-3-Carboxymuconate-6- Semialdehyde Decarboxylase; Metal-Dependent Hydrolase; Tryptophan 2 3-Dioxygenase; Decarboxylase; 2 3-Dihydroxybenzoic Acid Decarboxylase; Amidohydrolase Family; 2-Amino-3-Carboxymuconate 6-Semialdehyde Decarboxylase; Amidase; Metal Dependent Hydrolase; 5-Carboxy-2-Hydroxymuconate-6-Semialdehyde Decarboxylase

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTPKAATADVIDVHAHIVLAETFGAAGTALGPEMGGQDGDRPWFRVGDYRLDGVRYQGSAFMDAGLRLARMEEAGIDYQL
LSPNPLTFLHFVDAPLAIDFCTIHNNALSSLVRSHADHLGGCAALPMQDIGAAIEELERGVRDLGLMGGYIGTDQTQRLD
APEMDRFYATCVRLNVPVFLHPQPAGIDGPAGDANLGYYDLDVVIGFAAQEALAVARLIYGGVLDRHPDLDVCVSHGGGS
TGYLFGRMAMAARKRPWASGALKADGAFEERLSRIWFDNHLNSDGALDLLTGLVGDDRLVFGTNFSGWDAPDDLAAHKPH
PKLADNARRLLRITQ

Sequences:

>Translated_335_residues
MTPKAATADVIDVHAHIVLAETFGAAGTALGPEMGGQDGDRPWFRVGDYRLDGVRYQGSAFMDAGLRLARMEEAGIDYQL
LSPNPLTFLHFVDAPLAIDFCTIHNNALSSLVRSHADHLGGCAALPMQDIGAAIEELERGVRDLGLMGGYIGTDQTQRLD
APEMDRFYATCVRLNVPVFLHPQPAGIDGPAGDANLGYYDLDVVIGFAAQEALAVARLIYGGVLDRHPDLDVCVSHGGGS
TGYLFGRMAMAARKRPWASGALKADGAFEERLSRIWFDNHLNSDGALDLLTGLVGDDRLVFGTNFSGWDAPDDLAAHKPH
PKLADNARRLLRITQ
>Mature_334_residues
TPKAATADVIDVHAHIVLAETFGAAGTALGPEMGGQDGDRPWFRVGDYRLDGVRYQGSAFMDAGLRLARMEEAGIDYQLL
SPNPLTFLHFVDAPLAIDFCTIHNNALSSLVRSHADHLGGCAALPMQDIGAAIEELERGVRDLGLMGGYIGTDQTQRLDA
PEMDRFYATCVRLNVPVFLHPQPAGIDGPAGDANLGYYDLDVVIGFAAQEALAVARLIYGGVLDRHPDLDVCVSHGGGST
GYLFGRMAMAARKRPWASGALKADGAFEERLSRIWFDNHLNSDGALDLLTGLVGDDRLVFGTNFSGWDAPDDLAAHKPHP
KLADNARRLLRITQ

Specific function: Unknown

COG id: COG2159

COG function: function code R; Predicted metal-dependent hydrolase of the TIM-barrel fold

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI109715856, Length=307, Percent_Identity=29.3159609120521, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71995651, Length=312, Percent_Identity=27.2435897435897, Blast_Score=103, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.45

Molecular weight: Translated: 36078; Mature: 35947

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPKAATADVIDVHAHIVLAETFGAAGTALGPEMGGQDGDRPWFRVGDYRLDGVRYQGSA
CCCCCCCCCEEEHEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCEEECCEEECCCH
FMDAGLRLARMEEAGIDYQLLSPNPLTFLHFVDAPLAIDFCTIHNNALSSLVRSHADHLG
HHHHCCCEEHHHHCCCCEEEECCCCEEEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHC
GCAALPMQDIGAAIEELERGVRDLGLMGGYIGTDQTQRLDAPEMDRFYATCVRLNVPVFL
CEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHEECCCEEE
HPQPAGIDGPAGDANLGYYDLDVVIGFAAQEALAVARLIYGGVLDRHPDLDVCVSHGGGS
CCCCCCCCCCCCCCCCCEEEEHHEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
TGYLFGRMAMAARKRPWASGALKADGAFEERLSRIWFDNHLNSDGALDLLTGLVGDDRLV
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEE
FGTNFSGWDAPDDLAAHKPHPKLADNARRLLRITQ
EECCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECC
>Mature Secondary Structure 
TPKAATADVIDVHAHIVLAETFGAAGTALGPEMGGQDGDRPWFRVGDYRLDGVRYQGSA
CCCCCCCCEEEHEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCEEECCEEECCCH
FMDAGLRLARMEEAGIDYQLLSPNPLTFLHFVDAPLAIDFCTIHNNALSSLVRSHADHLG
HHHHCCCEEHHHHCCCCEEEECCCCEEEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHC
GCAALPMQDIGAAIEELERGVRDLGLMGGYIGTDQTQRLDAPEMDRFYATCVRLNVPVFL
CEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHEECCCEEE
HPQPAGIDGPAGDANLGYYDLDVVIGFAAQEALAVARLIYGGVLDRHPDLDVCVSHGGGS
CCCCCCCCCCCCCCCCCEEEEHHEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
TGYLFGRMAMAARKRPWASGALKADGAFEERLSRIWFDNHLNSDGALDLLTGLVGDDRLV
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEE
FGTNFSGWDAPDDLAAHKPHPKLADNARRLLRITQ
EECCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate

Specific reaction: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate = 2-aminomuconate semialdehyde + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA