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The map label for this gene is hmrR [H]

Identifier: 89054578

GI number: 89054578

Start: 2097240

End: 2097626

Strand: Direct

Name: hmrR [H]

Synonym: Jann_2087

Alternate gene names: 89054578

Gene position: 2097240-2097626 (Clockwise)

Preceding gene: 89054577

Following gene: 89054591

Centisome position: 48.57

GC content: 60.98

Gene sequence:

>387_bases
ATGAACATTAAATACGTGGCGCAAGCCACTAATATTCCAGCAAAAACGATCCGATACTATGAAGAAATTGGCCTGATCCG
GCCTGCGCGCGGGGCCAACGGATACCGCTCGTTCAGCGCGCAGGATCTGCACAAGCTGGCGTTTGTGGGGCGGGCGCGGG
CGTTGGGCTTCTCCATCGCCGATTGCCGCGTGTTACTGGCGCTGTATGAGGATGCCGGGCGATCGTCTGCGGAGGTGAAA
GCGGTGGCGCAGGCCCATCTGGCGGAGATCGACGCCAAGATTGCGGCCCTGACGGATATGCGCGCGACGTTGTCCCATCT
GGTGGAGACCTGTGCGGGCGACGCCCGGCCCGATTGCCCGATCCTCGCGTCACTTGCCAAAGATTAA

Upstream 100 bases:

>100_bases
CGCCCGCTTTTGCGGCGGGAGCGATGGCGTTGTCGAGTGTCTCCGTTCTGGGCAACGCGCTGCGGCTCAGGCGGATGGGC
CGCCGGCAGGGACAGGTATC

Downstream 100 bases:

>100_bases
CGCCCGAATAGCCGGGACGCGATGGGCGCGCCGATGATGACCGTGACGATCCGCAACAGATGGTGGGCGACAACGAAGGC
CACATCAGCGCCCGCGATCA

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 128; Mature: 128

Protein sequence:

>128_residues
MNIKYVAQATNIPAKTIRYYEEIGLIRPARGANGYRSFSAQDLHKLAFVGRARALGFSIADCRVLLALYEDAGRSSAEVK
AVAQAHLAEIDAKIAALTDMRATLSHLVETCAGDARPDCPILASLAKD

Sequences:

>Translated_128_residues
MNIKYVAQATNIPAKTIRYYEEIGLIRPARGANGYRSFSAQDLHKLAFVGRARALGFSIADCRVLLALYEDAGRSSAEVK
AVAQAHLAEIDAKIAALTDMRATLSHLVETCAGDARPDCPILASLAKD
>Mature_128_residues
MNIKYVAQATNIPAKTIRYYEEIGLIRPARGANGYRSFSAQDLHKLAFVGRARALGFSIADCRVLLALYEDAGRSSAEVK
AVAQAHLAEIDAKIAALTDMRATLSHLVETCAGDARPDCPILASLAKD

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=40.9448818897638, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI1789687, Length=129, Percent_Identity=34.1085271317829, Blast_Score=76, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 13776; Mature: 13776

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKYVAQATNIPAKTIRYYEEIGLIRPARGANGYRSFSAQDLHKLAFVGRARALGFSIA
CCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHH
DCRVLLALYEDAGRSSAEVKAVAQAHLAEIDAKIAALTDMRATLSHLVETCAGDARPDCP
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ILASLAKD
HHHHHCCC
>Mature Secondary Structure
MNIKYVAQATNIPAKTIRYYEEIGLIRPARGANGYRSFSAQDLHKLAFVGRARALGFSIA
CCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHH
DCRVLLALYEDAGRSSAEVKAVAQAHLAEIDAKIAALTDMRATLSHLVETCAGDARPDCP
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ILASLAKD
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]