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The map label for this gene is gltR [H]

Identifier: 89054405

GI number: 89054405

Start: 1903682

End: 1904584

Strand: Direct

Name: gltR [H]

Synonym: Jann_1914

Alternate gene names: 89054405

Gene position: 1903682-1904584 (Clockwise)

Preceding gene: 89054403

Following gene: 89054406

Centisome position: 44.09

GC content: 66.89

Gene sequence:

>903_bases
ATGAATTGGGATGACCTGCGGATCTTCCTTGCGACCGCCCGCGCGGAAAGCCTGACGGCGGCGCGCGGCAGCCTGCGCAT
GGACCCCGCCACCATTGCGCGCCGCATCGCCCGGCTGGAGGGCGTGGCAGGCGCGGCGCTGTTCCTGAAATCGCCCCAAG
GATATCGGTTGACGGAGGCCGGTCTGCGACTTCTCGCCCATGCCGAAGCGGCCGAGGCGGCGCTGTCCCGCGGCATGGGG
GCGCTGACTGGCAGCGCGGAGGACCTGTCTGGCACCATCCGCATCGGCGCGCCCGATGGCTGCGCCACCTATCTGCTGCC
GCAGGTCTGCGCCCGGATCGCAGACGCGCATCCGGGCCTTGATCTGCAAATCCTCGCCCTGCCGCGCATCGTAAACCTCT
CGCGGCGCGAGGCGGATTTGGCGATCACCGTAAGCCAGCCGAAAACCCAGCGCCTCCGTGGCGAACGGTTGAGCGATTAT
CGCCTCTCGCTCGCGGCCTCAACGGACTGGCTTGATGCCCATGGTGTCCCCACATCCGTGAATGATCTCAAAGACATGCG
GATGATTGGCTATATCCCCGACATGATCTTTGACGCGGAGTTGGACTACCTGTCTGCGCTGGGTGTGACCCGCGTGCCGC
TGGCCTCAACCTCGGTCTCCGTGCAATTGCAGATGGCGCGGGCGGGGGGCGGATTGGCGGTGGTGCACGACTTTGCATTG
CCCACGGCGCCGGAGCTGGTCCGGGTCTTGCCAAATAAGGTGTCGCTGACGCGGACGTTCTGGCTGACGACCCATGCAGG
CCCCCGGGACGCCCGGCTGGACCGGATCACAACGCTTCTGCGCGACGGCCTGCGGGCCGAGATCGCGCGGCTGGAGGCGT
CCTCTCTGCCCCGAATTCCTTGA

Upstream 100 bases:

>100_bases
TCCAGTTTGCGCGGACAATAGCCTTGCATTTGTGCCGGGAAAAGAGACAGGTTCGCAGGGTCATTTTGCAAAAATAGGCG
TATGATGAGTTGGTCCAACA

Downstream 100 bases:

>100_bases
CAGGTCGCCCATCGTGGGGCGACGTTGGCCCGATAACGTCGATGTGAAGGAGGCCCGCCATGCTCGTGCAACAGATCCTC
AAGGACAAAGCGCAGGGGGA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MNWDDLRIFLATARAESLTAARGSLRMDPATIARRIARLEGVAGAALFLKSPQGYRLTEAGLRLLAHAEAAEAALSRGMG
ALTGSAEDLSGTIRIGAPDGCATYLLPQVCARIADAHPGLDLQILALPRIVNLSRREADLAITVSQPKTQRLRGERLSDY
RLSLAASTDWLDAHGVPTSVNDLKDMRMIGYIPDMIFDAELDYLSALGVTRVPLASTSVSVQLQMARAGGGLAVVHDFAL
PTAPELVRVLPNKVSLTRTFWLTTHAGPRDARLDRITTLLRDGLRAEIARLEASSLPRIP

Sequences:

>Translated_300_residues
MNWDDLRIFLATARAESLTAARGSLRMDPATIARRIARLEGVAGAALFLKSPQGYRLTEAGLRLLAHAEAAEAALSRGMG
ALTGSAEDLSGTIRIGAPDGCATYLLPQVCARIADAHPGLDLQILALPRIVNLSRREADLAITVSQPKTQRLRGERLSDY
RLSLAASTDWLDAHGVPTSVNDLKDMRMIGYIPDMIFDAELDYLSALGVTRVPLASTSVSVQLQMARAGGGLAVVHDFAL
PTAPELVRVLPNKVSLTRTFWLTTHAGPRDARLDRITTLLRDGLRAEIARLEASSLPRIP
>Mature_300_residues
MNWDDLRIFLATARAESLTAARGSLRMDPATIARRIARLEGVAGAALFLKSPQGYRLTEAGLRLLAHAEAAEAALSRGMG
ALTGSAEDLSGTIRIGAPDGCATYLLPQVCARIADAHPGLDLQILALPRIVNLSRREADLAITVSQPKTQRLRGERLSDY
RLSLAASTDWLDAHGVPTSVNDLKDMRMIGYIPDMIFDAELDYLSALGVTRVPLASTSVSVQLQMARAGGGLAVVHDFAL
PTAPELVRVLPNKVSLTRTFWLTTHAGPRDARLDRITTLLRDGLRAEIARLEASSLPRIP

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=258, Percent_Identity=22.4806201550388, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081978, Length=181, Percent_Identity=27.6243093922652, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI145693193, Length=230, Percent_Identity=25.6521739130435, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789440, Length=259, Percent_Identity=24.7104247104247, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32331; Mature: 32331

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWDDLRIFLATARAESLTAARGSLRMDPATIARRIARLEGVAGAALFLKSPQGYRLTEA
CCCCCEEEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHH
GLRLLAHAEAAEAALSRGMGALTGSAEDLSGTIRIGAPDGCATYLLPQVCARIADAHPGL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCC
DLQILALPRIVNLSRREADLAITVSQPKTQRLRGERLSDYRLSLAASTDWLDAHGVPTSV
CEEEEECCHHHCCCCCCCCEEEEECCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCH
NDLKDMRMIGYIPDMIFDAELDYLSALGVTRVPLASTSVSVQLQMARAGGGLAVVHDFAL
HHHHHHHHHHHCCHHHHHCCHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCC
PTAPELVRVLPNKVSLTRTFWLTTHAGPRDARLDRITTLLRDGLRAEIARLEASSLPRIP
CCHHHHHHHCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNWDDLRIFLATARAESLTAARGSLRMDPATIARRIARLEGVAGAALFLKSPQGYRLTEA
CCCCCEEEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHH
GLRLLAHAEAAEAALSRGMGALTGSAEDLSGTIRIGAPDGCATYLLPQVCARIADAHPGL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCC
DLQILALPRIVNLSRREADLAITVSQPKTQRLRGERLSDYRLSLAASTDWLDAHGVPTSV
CEEEEECCHHHCCCCCCCCEEEEECCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCH
NDLKDMRMIGYIPDMIFDAELDYLSALGVTRVPLASTSVSVQLQMARAGGGLAVVHDFAL
HHHHHHHHHHHCCHHHHHCCHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCC
PTAPELVRVLPNKVSLTRTFWLTTHAGPRDARLDRITTLLRDGLRAEIARLEASSLPRIP
CCHHHHHHHCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]