Click here to switch to the map view.

The map label for this gene is tetA [H]

Identifier: 89054152

GI number: 89054152

Start: 1644460

End: 1645680

Strand: Reverse

Name: tetA [H]

Synonym: Jann_1661

Alternate gene names: 89054152

Gene position: 1645680-1644460 (Counterclockwise)

Preceding gene: 89054153

Following gene: 89054143

Centisome position: 38.11

GC content: 66.5

Gene sequence:

>1221_bases
ATGCGCCTGCCCACCCTCTTCATCCTGATCACGGTCACCATCGACGCGATGGGCATCGGCCTGATCCTGCCCGTCATGCC
CGACCTGATCACCGAGGTGCGCGGCGCGGGTCTTGCCAACGCGGCCCTTTGGGGCGGCCTCCTATCCACCACCTACGCGG
TAATGCAATTCCTCTGCTCCCCCACCCTCGGCAACCTGTCGGACAGGTTTGGCCGCCGCCCCATCCTCCTGATATCGCTG
GCGGTTCTCGCCGCCGACTACGTCGTGATGAGCCTCGCCCACACCATCTGGATCCTGATCGCGGGCCGCATCGTGGCGGG
CATCGCGGCGGGCACGCACGCCACGGCGCTGGCCTATATGGCCGACATCTCTCCGCCCGAAAAACGCGCCCAGAACTTCG
GCCTGATCTCTGCGGGTTTCGGCATAGGCTTCGTCCTCGGTCCCCTCGTCGCAGCGTTTCTGGGCGAGTTCGACCCGCGC
GCGCCCTTTGTGGCCGCTGCGTGCCTGGCCGCTGCCAACTTCGCGTTCGGATACTTCATCCTGCCCGAAAGCCTGCCCAA
GGATCGCCGCCGCCCGTTCCAGTGGCGCCGTGCCAACCCGGCGGGCGGGCTTTTGCAAATTGGCGCTCTGCCCGGCGTGC
GCCTGTTGCTGATGGTGATGCTGGCCTACCAGATCGCCAACTTCGTCTACCCCGCAATCTGGGCCTATTACGGCCAGGCA
GCGTTTGGCTGGACGTCACGCATGATCGGCCTGTCGCTGACCGTCTACGGGATTTCGATGGCCGTCGTGCAGGGCGGGCT
GATCCGCCTGGTCCTCCCGCGATTGGGCGAGACGCGAACAGTCTATTGGGGCCTGATCCTCAATGTGTGCTGCCTGATCT
GCTATGGCCTGGCGACCGAGGCCTGGATGATCTGGGCCCTGATCCCGGTCTCCGCGATGGGTGCAGTGGTCGCCCCGGCC
ATGCAAGGCGTGATGAGCCGGGCGGCAGGGGCCGACCAGCAGGGAGAGCTTCAGGGCGTCCTCGCCTCCATTTCATCCCT
GTCGATGATCCTCAGCCCGATCGTCATGACGCAGGCCTTCTTCTGGTTCACCCGGGACGAGGCCATTCTGCGCCTGCCCG
GCGCGCCGTTTCTTGTGGCCGCCGTCCTCATGGCCGGTGCCTTCGCCATCTTCGCCATCCGCCACGGACGCGCTCGCCCG
ACCCCGCGAGAGGCCGCCTAG

Upstream 100 bases:

>100_bases
CCCGCAGGGCATCAAGCAGGCGCGAAGCGCCGCCCCCTTTCCCCCTTGCACGCCCTAATCTGTCAACCTACCCTGACACA
TCGTCGTCAGGATCCACCAC

Downstream 100 bases:

>100_bases
CCCTCGGCCTCCGCCACGATCTGCGCGAATACTCCCAGGTCCACATTCCCCCCCGACAGCGTCGCAATAACCGGTCCGTC
GGCCAACGCATCGCCATGGT

Product: major facilitator transporter

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MRLPTLFILITVTIDAMGIGLILPVMPDLITEVRGAGLANAALWGGLLSTTYAVMQFLCSPTLGNLSDRFGRRPILLISL
AVLAADYVVMSLAHTIWILIAGRIVAGIAAGTHATALAYMADISPPEKRAQNFGLISAGFGIGFVLGPLVAAFLGEFDPR
APFVAAACLAAANFAFGYFILPESLPKDRRRPFQWRRANPAGGLLQIGALPGVRLLLMVMLAYQIANFVYPAIWAYYGQA
AFGWTSRMIGLSLTVYGISMAVVQGGLIRLVLPRLGETRTVYWGLILNVCCLICYGLATEAWMIWALIPVSAMGAVVAPA
MQGVMSRAAGADQQGELQGVLASISSLSMILSPIVMTQAFFWFTRDEAILRLPGAPFLVAAVLMAGAFAIFAIRHGRARP
TPREAA

Sequences:

>Translated_406_residues
MRLPTLFILITVTIDAMGIGLILPVMPDLITEVRGAGLANAALWGGLLSTTYAVMQFLCSPTLGNLSDRFGRRPILLISL
AVLAADYVVMSLAHTIWILIAGRIVAGIAAGTHATALAYMADISPPEKRAQNFGLISAGFGIGFVLGPLVAAFLGEFDPR
APFVAAACLAAANFAFGYFILPESLPKDRRRPFQWRRANPAGGLLQIGALPGVRLLLMVMLAYQIANFVYPAIWAYYGQA
AFGWTSRMIGLSLTVYGISMAVVQGGLIRLVLPRLGETRTVYWGLILNVCCLICYGLATEAWMIWALIPVSAMGAVVAPA
MQGVMSRAAGADQQGELQGVLASISSLSMILSPIVMTQAFFWFTRDEAILRLPGAPFLVAAVLMAGAFAIFAIRHGRARP
TPREAA
>Mature_406_residues
MRLPTLFILITVTIDAMGIGLILPVMPDLITEVRGAGLANAALWGGLLSTTYAVMQFLCSPTLGNLSDRFGRRPILLISL
AVLAADYVVMSLAHTIWILIAGRIVAGIAAGTHATALAYMADISPPEKRAQNFGLISAGFGIGFVLGPLVAAFLGEFDPR
APFVAAACLAAANFAFGYFILPESLPKDRRRPFQWRRANPAGGLLQIGALPGVRLLLMVMLAYQIANFVYPAIWAYYGQA
AFGWTSRMIGLSLTVYGISMAVVQGGLIRLVLPRLGETRTVYWGLILNVCCLICYGLATEAWMIWALIPVSAMGAVVAPA
MQGVMSRAAGADQQGELQGVLASISSLSMILSPIVMTQAFFWFTRDEAILRLPGAPFLVAAVLMAGAFAIFAIRHGRARP
TPREAA

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=339, Percent_Identity=30.0884955752212, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI94721311, Length=387, Percent_Identity=28.6821705426357, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI225703104, Length=357, Percent_Identity=28.8515406162465, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI225703102, Length=357, Percent_Identity=28.8515406162465, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI217416366, Length=187, Percent_Identity=26.7379679144385, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081738, Length=176, Percent_Identity=32.3863636363636, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71996331, Length=340, Percent_Identity=27.6470588235294, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17551570, Length=344, Percent_Identity=22.093023255814, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357569, Length=331, Percent_Identity=29.0030211480363, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI161080926, Length=334, Percent_Identity=28.7425149700599, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI161080924, Length=334, Percent_Identity=28.7425149700599, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24656463, Length=334, Percent_Identity=28.7425149700599, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24656468, Length=334, Percent_Identity=28.7425149700599, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17738085, Length=342, Percent_Identity=25.1461988304094, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI221513297, Length=365, Percent_Identity=25.7534246575342, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24667557, Length=160, Percent_Identity=28.125, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24667561, Length=164, Percent_Identity=27.4390243902439, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43361; Mature: 43361

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPTLFILITVTIDAMGIGLILPVMPDLITEVRGAGLANAALWGGLLSTTYAVMQFLCS
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
PTLGNLSDRFGRRPILLISLAVLAADYVVMSLAHTIWILIAGRIVAGIAAGTHATALAYM
CCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ADISPPEKRAQNFGLISAGFGIGFVLGPLVAAFLGEFDPRAPFVAAACLAAANFAFGYFI
HCCCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEE
LPESLPKDRRRPFQWRRANPAGGLLQIGALPGVRLLLMVMLAYQIANFVYPAIWAYYGQA
CCCCCCCHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AFGWTSRMIGLSLTVYGISMAVVQGGLIRLVLPRLGETRTVYWGLILNVCCLICYGLATE
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
AWMIWALIPVSAMGAVVAPAMQGVMSRAAGADQQGELQGVLASISSLSMILSPIVMTQAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FWFTRDEAILRLPGAPFLVAAVLMAGAFAIFAIRHGRARPTPREAA
HHEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRLPTLFILITVTIDAMGIGLILPVMPDLITEVRGAGLANAALWGGLLSTTYAVMQFLCS
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
PTLGNLSDRFGRRPILLISLAVLAADYVVMSLAHTIWILIAGRIVAGIAAGTHATALAYM
CCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ADISPPEKRAQNFGLISAGFGIGFVLGPLVAAFLGEFDPRAPFVAAACLAAANFAFGYFI
HCCCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEE
LPESLPKDRRRPFQWRRANPAGGLLQIGALPGVRLLLMVMLAYQIANFVYPAIWAYYGQA
CCCCCCCHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AFGWTSRMIGLSLTVYGISMAVVQGGLIRLVLPRLGETRTVYWGLILNVCCLICYGLATE
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
AWMIWALIPVSAMGAVVAPAMQGVMSRAAGADQQGELQGVLASISSLSMILSPIVMTQAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FWFTRDEAILRLPGAPFLVAAVLMAGAFAIFAIRHGRARPTPREAA
HHEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]