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The map label for this gene is fabB [H]

Identifier: 89054147

GI number: 89054147

Start: 1639749

End: 1640978

Strand: Direct

Name: fabB [H]

Synonym: Jann_1656

Alternate gene names: 89054147

Gene position: 1639749-1640978 (Clockwise)

Preceding gene: 89054146

Following gene: 89054148

Centisome position: 37.97

GC content: 62.68

Gene sequence:

>1230_bases
ATGAGACGTGTCGTCGTGACAGGGTTGGGCATCGTATCCCCCATCGGAAACAATGCCGCCGAGGTGGTGGAGAGCCTCAA
GGCCGGGCGGTCCGGGATCGAAAGTTCGCCCGAGATGGTCGAACATGGCTTCCGCAGCCAGGTGGCAGGGACGCTGAAAA
TCGACGTGGCCGAGCATGTGGACAAGCGCGCGTTGCGGTTCATGGGGCCGGGCGCGGCCTATGCCCATATCGCGATGGGT
CAGGCGATTGCCGATGCCGGGTTGGAGGAGAGCGACGTTATCAATGAGCGCACGGGCCTGATCGCGGGCTCTGGCGGGCC
GTCGACCTCTGCCATGTTCGCCGCCCATCAGACCGTTCTGGAGAAGGGTGCGCCCAAGCGGATCGGGCCCTTCGCCGTGC
CCAAATGCATGTCGTCGACGATCAGCGCGAACCTCAGCACCGCGTATAAGATTAAGGGCATTAACTATTCGATCACGAGC
GCCTGTTCCACGAGCCTGCATTGCATCGGGTCGGCGGCAGAGCAGATCATGATGGGCAAGCAGGACGTGATGTTCGCAGG
CGGCGCAGAGGAGTTGGACTGGACGCTGAGCTGTCTGTTCGATGCCATGGGCGCGATGAGCAGCAAGTATAACGACACGC
CGCAGCGTGCGAGCCGCGCGTTTGATGCGGACCGCGACGGGTTTGTCATCGGCGGCGGTGGCGCGATCCTGGTGCTGGAA
GAGATGGACCGTGCCGTGGCGCGCGGCGCGAAGATCTATGCGGAAGTCACTGGGTTTGCAGCGACATCTGACGGCCACGA
TATGGTGGCCCCCAGCGGTGAAGGCGGTGAGCGGGCCATGCGTCTGGCGATGCAAACCCTGCCCGAAGGTCGCAAAGTCG
GCTACATAAACGCCCATGGCACCTCCACCCCCGTGGGCGATGTGGGAGAGGTCGAAGCGGTGCGCCGGGTGTTTGGAGAG
GGCAACACACCGCCGATTTCCTCAACAAAATCAATGACGGGGCATGCCCAAGGCGCGGCGGGGGCGTTGGAGGCAACGTT
TTGCCTACTGATGCTGGACGGCGATTTCATCACCCCGTCGATCAACGTGGAAACGCTGGATCCGGCGTTGAACCCGGCGG
AGATCGCGACCGCGTTCAAGGCCGATGCGGGCCTCGACACCGTGATGACGAATTCCTTTGGCTTTGGCGGCACGAATGGC
TCGATGCTGCTGAGCCGATTTGAGAAGTGA

Upstream 100 bases:

>100_bases
CGCTAATTGGTTGCGCCAAGTGGGGGCGAATGCCTAGATACCCGGTAAGAGGCAGCTAGATGCGCGTGCCATGCGGCCGC
GTCAAACCAGAGGTTTGCAC

Downstream 100 bases:

>100_bases
GACGGACGACATGGCAGATCTGATGAAGGGCAAGCGGGGCCTGGTGATGGGGGTCGCGAACGAGCGGTCCATCGCCTGGG
GCATCGCAAAAGCACTGCAC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRRVVVTGLGIVSPIGNNAAEVVESLKAGRSGIESSPEMVEHGFRSQVAGTLKIDVAEHVDKRALRFMGPGAAYAHIAMG
QAIADAGLEESDVINERTGLIAGSGGPSTSAMFAAHQTVLEKGAPKRIGPFAVPKCMSSTISANLSTAYKIKGINYSITS
ACSTSLHCIGSAAEQIMMGKQDVMFAGGAEELDWTLSCLFDAMGAMSSKYNDTPQRASRAFDADRDGFVIGGGGAILVLE
EMDRAVARGAKIYAEVTGFAATSDGHDMVAPSGEGGERAMRLAMQTLPEGRKVGYINAHGTSTPVGDVGEVEAVRRVFGE
GNTPPISSTKSMTGHAQGAAGALEATFCLLMLDGDFITPSINVETLDPALNPAEIATAFKADAGLDTVMTNSFGFGGTNG
SMLLSRFEK

Sequences:

>Translated_409_residues
MRRVVVTGLGIVSPIGNNAAEVVESLKAGRSGIESSPEMVEHGFRSQVAGTLKIDVAEHVDKRALRFMGPGAAYAHIAMG
QAIADAGLEESDVINERTGLIAGSGGPSTSAMFAAHQTVLEKGAPKRIGPFAVPKCMSSTISANLSTAYKIKGINYSITS
ACSTSLHCIGSAAEQIMMGKQDVMFAGGAEELDWTLSCLFDAMGAMSSKYNDTPQRASRAFDADRDGFVIGGGGAILVLE
EMDRAVARGAKIYAEVTGFAATSDGHDMVAPSGEGGERAMRLAMQTLPEGRKVGYINAHGTSTPVGDVGEVEAVRRVFGE
GNTPPISSTKSMTGHAQGAAGALEATFCLLMLDGDFITPSINVETLDPALNPAEIATAFKADAGLDTVMTNSFGFGGTNG
SMLLSRFEK
>Mature_409_residues
MRRVVVTGLGIVSPIGNNAAEVVESLKAGRSGIESSPEMVEHGFRSQVAGTLKIDVAEHVDKRALRFMGPGAAYAHIAMG
QAIADAGLEESDVINERTGLIAGSGGPSTSAMFAAHQTVLEKGAPKRIGPFAVPKCMSSTISANLSTAYKIKGINYSITS
ACSTSLHCIGSAAEQIMMGKQDVMFAGGAEELDWTLSCLFDAMGAMSSKYNDTPQRASRAFDADRDGFVIGGGGAILVLE
EMDRAVARGAKIYAEVTGFAATSDGHDMVAPSGEGGERAMRLAMQTLPEGRKVGYINAHGTSTPVGDVGEVEAVRRVFGE
GNTPPISSTKSMTGHAQGAAGALEATFCLLMLDGDFITPSINVETLDPALNPAEIATAFKADAGLDTVMTNSFGFGGTNG
SMLLSRFEK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=425, Percent_Identity=35.2941176470588, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI41872631, Length=426, Percent_Identity=25.5868544600939, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI223972627, Length=170, Percent_Identity=35.8823529411765, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1788663, Length=410, Percent_Identity=55.1219512195122, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=39.8058252427184, Blast_Score=263, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=33.4128878281623, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=37.8378378378378, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI212642053, Length=360, Percent_Identity=28.3333333333333, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17550940, Length=276, Percent_Identity=28.9855072463768, Blast_Score=112, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=30.2222222222222, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=38.479809976247, Blast_Score=248, Evalue=5e-66,
Organism=Drosophila melanogaster, GI221330659, Length=421, Percent_Identity=26.1282660332542, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19920632, Length=421, Percent_Identity=26.1282660332542, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24581345, Length=428, Percent_Identity=24.0654205607477, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42443; Mature: 42443

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGIVSPIGNNAAEVVESLKAGRSGIESSPEMVEHGFRSQVAGTLKIDVAEHV
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEHHHHH
DKRALRFMGPGAAYAHIAMGQAIADAGLEESDVINERTGLIAGSGGPSTSAMFAAHQTVL
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCEEECCCCCCCHHHHHHHHHHH
EKGAPKRIGPFAVPKCMSSTISANLSTAYKIKGINYSITSACSTSLHCIGSAAEQIMMGK
HCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCC
QDVMFAGGAEELDWTLSCLFDAMGAMSSKYNDTPQRASRAFDADRDGFVIGGGGAILVLE
CCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCCEEEEEH
EMDRAVARGAKIYAEVTGFAATSDGHDMVAPSGEGGERAMRLAMQTLPEGRKVGYINAHG
HHHHHHHCCCEEEEEEECEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
TSTPVGDVGEVEAVRRVFGEGNTPPISSTKSMTGHAQGAAGALEATFCLLMLDGDFITPS
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEEECCCEECCC
INVETLDPALNPAEIATAFKADAGLDTVMTNSFGFGGTNGSMLLSRFEK
CCEEECCCCCCHHHHHHHHHCCCCCHHHEECCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MRRVVVTGLGIVSPIGNNAAEVVESLKAGRSGIESSPEMVEHGFRSQVAGTLKIDVAEHV
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEHHHHH
DKRALRFMGPGAAYAHIAMGQAIADAGLEESDVINERTGLIAGSGGPSTSAMFAAHQTVL
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCEEECCCCCCCHHHHHHHHHHH
EKGAPKRIGPFAVPKCMSSTISANLSTAYKIKGINYSITSACSTSLHCIGSAAEQIMMGK
HCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCC
QDVMFAGGAEELDWTLSCLFDAMGAMSSKYNDTPQRASRAFDADRDGFVIGGGGAILVLE
CCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCCEEEEEH
EMDRAVARGAKIYAEVTGFAATSDGHDMVAPSGEGGERAMRLAMQTLPEGRKVGYINAHG
HHHHHHHCCCEEEEEEECEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
TSTPVGDVGEVEAVRRVFGEGNTPPISSTKSMTGHAQGAAGALEATFCLLMLDGDFITPS
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEEECCCEECCC
INVETLDPALNPAEIATAFKADAGLDTVMTNSFGFGGTNGSMLLSRFEK
CCEEECCCCCCHHHHHHHHHCCCCCHHHEECCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]