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The map label for this gene is fabF [H]

Identifier: 89054120

GI number: 89054120

Start: 1615493

End: 1616749

Strand: Direct

Name: fabF [H]

Synonym: Jann_1629

Alternate gene names: 89054120

Gene position: 1615493-1616749 (Clockwise)

Preceding gene: 89054118

Following gene: 89054121

Centisome position: 37.41

GC content: 64.04

Gene sequence:

>1257_bases
ATGCGGCGAGTGGTTGTGACGGGGCTGGGGCTGGTGACGCCCTTGGCATCGGGCGTTGAAGAAACGTGGAGCCGCCTTCT
GGCGGGGCAATCAGGCGCGGGCCCGATCACACGGTTTGATGCAACGGGCTATGGCACGACCTATGCCTGCGAGCTGCCCC
GTGGCGACGGCAGCAACGGCACGTTCAACGCTGATGACTGGATGGACAGCAAGGAACAGCGCAAGGTCGACGAGTTCATC
CTTTACGGGATGGCGGCGGCTGTTCAGGCCGTGGAAGATGCCGGTTGGGCGCCCACCGATACCGAAAGCCTGGAACGCAC
GGGCTGCTTGATGGGCGCTGGCATCGGCGGTTTGTCGTCCATCGCAGATACGTCGTTGATCCTGAACGAGCGTGGGCCGC
GCCGCGTGTCGCCGTTCTTCGTTCCGGGGGCTTTGATCAACCTGATCTCGGGCCAGGTGTCTATTCGGTATGGGTTCAAG
GGGCCGAACCATTCGGTCGTGACGGCCTGTTCCACAGGTGCCCATGCGATTGGTGATGCGGCGCGGTTGATTGCCTTCGA
CGACGCCGATGTGATGATCGCGGGGGGGGCGGAAAGCCCGATCTGTAAGATCGGCATTGCGGGCTTCAATGCGTGCAAAG
CCCTGTCCACCAAGCGTGCCGACGAGCCGGAGAAGGCCTCGCGCCCCTGGGATAGCGACAGCGACGGTTTCGTGATGGGC
GAGGGCGGCGGTGTTGTCGTGCTGGAGGAATATGAGCACGCCAAGGCGCGGGGCGCGAAGATCTACGCCGAAATCCTGGG
GTATGGCCTGAGCGGCGACGCCCACCATATCACCGCCCCGCCGCCCGACCATGAAGGCGCGGAGCGGGCCATGCGGGCGG
CCTTGAAGCGTGCGGGCCTGCCGGTGACGGCGGTGGATTATGTCAACGCCCACGGCACATCGACCATGGCAGACACAATC
GAGTTGGGCGCGGTGGAGCGGCTGATGGGCGATCACGCGGAAAACCTGCGCATGTCGTCCACCAAGTCGATGACGGGGCA
CCTTCTGGGGGCGGCCGGCGCGATTGAGGCGATCTTCAGCATCCTGGCGATCCGGGACAATGTCGCGCCGCCGACGATTA
ACCTGGACAATCCCGCGGCGGAAACGCCGATCAACCTGTGTGCAAACGCCAAGCAGGAAGGCGAGATCAACATCGTACAG
TCCAATTCCTTCGGGTTCGGGGGCACGAATGCGTGCCTGATCATGGGGCGGGTGTAG

Upstream 100 bases:

>100_bases
CCCGAACGCGTCGGCGGGAAACAGCCGCGCTAAGCCATTGCACAGGGGCGGGTCTTTCCGGTAATTGAACCCGCGAGCGC
GAGACATAGGGGGCTGACGC

Downstream 100 bases:

>100_bases
CCTGAGATGTGGAAGCATATTGCCGCCAACGGAATTTCATTCCTGATCGTCGCCTTGATCGCCGCCGCGGTGGCGCTGGG
GTGGGGACAGCGGCAATGGA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MRRVVVTGLGLVTPLASGVEETWSRLLAGQSGAGPITRFDATGYGTTYACELPRGDGSNGTFNADDWMDSKEQRKVDEFI
LYGMAAAVQAVEDAGWAPTDTESLERTGCLMGAGIGGLSSIADTSLILNERGPRRVSPFFVPGALINLISGQVSIRYGFK
GPNHSVVTACSTGAHAIGDAARLIAFDDADVMIAGGAESPICKIGIAGFNACKALSTKRADEPEKASRPWDSDSDGFVMG
EGGGVVVLEEYEHAKARGAKIYAEILGYGLSGDAHHITAPPPDHEGAERAMRAALKRAGLPVTAVDYVNAHGTSTMADTI
ELGAVERLMGDHAENLRMSSTKSMTGHLLGAAGAIEAIFSILAIRDNVAPPTINLDNPAAETPINLCANAKQEGEINIVQ
SNSFGFGGTNACLIMGRV

Sequences:

>Translated_418_residues
MRRVVVTGLGLVTPLASGVEETWSRLLAGQSGAGPITRFDATGYGTTYACELPRGDGSNGTFNADDWMDSKEQRKVDEFI
LYGMAAAVQAVEDAGWAPTDTESLERTGCLMGAGIGGLSSIADTSLILNERGPRRVSPFFVPGALINLISGQVSIRYGFK
GPNHSVVTACSTGAHAIGDAARLIAFDDADVMIAGGAESPICKIGIAGFNACKALSTKRADEPEKASRPWDSDSDGFVMG
EGGGVVVLEEYEHAKARGAKIYAEILGYGLSGDAHHITAPPPDHEGAERAMRAALKRAGLPVTAVDYVNAHGTSTMADTI
ELGAVERLMGDHAENLRMSSTKSMTGHLLGAAGAIEAIFSILAIRDNVAPPTINLDNPAAETPINLCANAKQEGEINIVQ
SNSFGFGGTNACLIMGRV
>Mature_418_residues
MRRVVVTGLGLVTPLASGVEETWSRLLAGQSGAGPITRFDATGYGTTYACELPRGDGSNGTFNADDWMDSKEQRKVDEFI
LYGMAAAVQAVEDAGWAPTDTESLERTGCLMGAGIGGLSSIADTSLILNERGPRRVSPFFVPGALINLISGQVSIRYGFK
GPNHSVVTACSTGAHAIGDAARLIAFDDADVMIAGGAESPICKIGIAGFNACKALSTKRADEPEKASRPWDSDSDGFVMG
EGGGVVVLEEYEHAKARGAKIYAEILGYGLSGDAHHITAPPPDHEGAERAMRAALKRAGLPVTAVDYVNAHGTSTMADTI
ELGAVERLMGDHAENLRMSSTKSMTGHLLGAAGAIEAIFSILAIRDNVAPPTINLDNPAAETPINLCANAKQEGEINIVQ
SNSFGFGGTNACLIMGRV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=48.3253588516746, Blast_Score=370, Evalue=1e-103,
Organism=Homo sapiens, GI223972627, Length=188, Percent_Identity=41.4893617021277, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI41872631, Length=436, Percent_Identity=25.9174311926606, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1787337, Length=419, Percent_Identity=52.0286396181384, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1788663, Length=429, Percent_Identity=37.995337995338, Blast_Score=245, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI71983541, Length=422, Percent_Identity=37.2037914691943, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=41.8250950570342, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI212642053, Length=432, Percent_Identity=25, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=420, Percent_Identity=24.2857142857143, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=452, Percent_Identity=38.0530973451327, Blast_Score=284, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=45.0236966824645, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI221330659, Length=369, Percent_Identity=25.4742547425474, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19920632, Length=369, Percent_Identity=25.4742547425474, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24581345, Length=439, Percent_Identity=23.9179954441913, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43596; Mature: 43596

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGLVTPLASGVEETWSRLLAGQSGAGPITRFDATGYGTTYACELPRGDGSNG
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEECCCCCCCCC
TFNADDWMDSKEQRKVDEFILYGMAAAVQAVEDAGWAPTDTESLERTGCLMGAGIGGLSS
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEECCCCCHHH
IADTSLILNERGPRRVSPFFVPGALINLISGQVSIRYGFKGPNHSVVTACSTGAHAIGDA
HHHHHHEECCCCCCCCCCEECCHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCHHHCCC
ARLIAFDDADVMIAGGAESPICKIGIAGFNACKALSTKRADEPEKASRPWDSDSDGFVMG
EEEEEECCCCEEEECCCCCCEEEEECCCCHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEE
EGGGVVVLEEYEHAKARGAKIYAEILGYGLSGDAHHITAPPPDHEGAERAMRAALKRAGL
CCCCEEEEECCCCHHHCCHHEEHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
PVTAVDYVNAHGTSTMADTIELGAVERLMGDHAENLRMSSTKSMTGHLLGAAGAIEAIFS
CEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHH
ILAIRDNVAPPTINLDNPAAETPINLCANAKQEGEINIVQSNSFGFGGTNACLIMGRV
HHHHHCCCCCCEEECCCCCCCCCHHHHCCCCCCCCEEEEECCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MRRVVVTGLGLVTPLASGVEETWSRLLAGQSGAGPITRFDATGYGTTYACELPRGDGSNG
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEECCCCCCCCC
TFNADDWMDSKEQRKVDEFILYGMAAAVQAVEDAGWAPTDTESLERTGCLMGAGIGGLSS
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEECCCCCHHH
IADTSLILNERGPRRVSPFFVPGALINLISGQVSIRYGFKGPNHSVVTACSTGAHAIGDA
HHHHHHEECCCCCCCCCCEECCHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCHHHCCC
ARLIAFDDADVMIAGGAESPICKIGIAGFNACKALSTKRADEPEKASRPWDSDSDGFVMG
EEEEEECCCCEEEECCCCCCEEEEECCCCHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEE
EGGGVVVLEEYEHAKARGAKIYAEILGYGLSGDAHHITAPPPDHEGAERAMRAALKRAGL
CCCCEEEEECCCCHHHCCHHEEHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
PVTAVDYVNAHGTSTMADTIELGAVERLMGDHAENLRMSSTKSMTGHLLGAAGAIEAIFS
CEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHH
ILAIRDNVAPPTINLDNPAAETPINLCANAKQEGEINIVQSNSFGFGGTNACLIMGRV
HHHHHCCCCCCEEECCCCCCCCCHHHHCCCCCCCCEEEEECCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]