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The map label for this gene is hmgA [H]

Identifier: 89053930

GI number: 89053930

Start: 1406329

End: 1407711

Strand: Reverse

Name: hmgA [H]

Synonym: Jann_1439

Alternate gene names: 89053930

Gene position: 1407711-1406329 (Counterclockwise)

Preceding gene: 89053931

Following gene: 89053929

Centisome position: 32.6

GC content: 62.18

Gene sequence:

>1383_bases
ATGAACGAACAAGCCACACGCAGACCGATGATCCAGGCCCCCAGCCACCCCGGCCCCCATGACGGCTATATGCCGGGCTT
CGGCAATGACTTTGAGACAGAGGCGCTGCCGGGTGCGCTGCCGCAGGGGATGAACTCGCCCCAGAAGGTAAATTACGGCC
TCTACGGCGAACAGCTCTCCGGCACCGCCTTCACCGATGTGCGGCCTGAGCGGACGTGGTGTTACCGCATCCGTCCCTCC
GTCAAGCACTCACACCGTTACTCCAAGATCGACCTGCCCTACTGGCACTCCGCGCCGACCATTGACCCCGATGTGATCTC
ACTAGGTCAGTACCGCTGGGACCCTGTTCCCCATTCCGACACGCCGCTGACCTGGCTCACCGGCATGCGCACCATGACCA
GCGCGGGGGATGTGAACACGCAGGTCGGCATGGCGACCCATGTCTATCTGGTCACGCAAAGCATGGTGGACGATTATTTC
TACTCCGCTGACAGTGAGATGCTGGTTGTCCCGCAGGAGGGCCGCCTGCGCTTCTGCACCGAGCTTGGCATCATCGACGT
GGAGCCGCAGGAGATCGCCATTCTGCCACGCGGTCTTGTGTACCGGGTGGAGGTGCTGGACGGCCCCGCGCGCGGCTTTG
TTTGCGAAAACTACGGCGCGAAGTTTGACCTTCCGGGGCGCGGCCCCATTGGCGCGAACTGCATGGCCAACCCGCGCGAC
TTCAAGGCCCCCGTCGCGGCCTATGAGGACCGCGAAGTGCCGTCCACAATCACGATCAAATGGTGCGGCCAGTTCCACAC
GTCGAAGATCGCGCAGAGCCCGCTGGATGTCGTGGCCTGGCACGGCAATTACGCGCCCTACAAATACGATCTGAAGACCT
ATTGCCCCGTCGGCGCGATCCTGTTCGACCACCCGGACCCGTCGATCTTCACGGTGCTGACCGCGCCATCGGGCCAACCG
GGCGTCGCCAACATCGACTTCGTGCTGTTCCGCGAGCGCTGGATGGTGGCCGAAAACACGTTCCGCCCGCCGTGGTATCA
CAAGAACATCATGTCCGAACTGATGGGCAACATCTACGGCCAATATGACGCCAAGCCCAAGGGGTTCGTGCCCGGCGGTA
TCTCCCTGCACAACATGATGATCCCCCACGGCCCCGACAAAAACGCCTTCGAGGGCGCGTCAAACGCCGACCTTCAGCCG
CAGAAGCTCGATAACACAATGTCCTTCATGTTCGAGACCCGCTTCCCCCAACACCTCACGGCCTTTGCGGCGAATGAGGC
CCCGTTGCAGGACGACTACATCGACTGCTGGGAAACGCTGGAGAAGAAGTTTGATCCCTCGCAGCGCCCCGATGCGGGTC
ACGGGACGCCGGGCAAAAAATGA

Upstream 100 bases:

>100_bases
CCTGGGCATCTCGGCCGCCAATTGACCGATCCGGTGACGGGTTCCCCTTGTTAGTTACAAAAGCAACCGTTATCCCTCCT
TCCAAACGGAGGGCGCTGCC

Downstream 100 bases:

>100_bases
CCGCGTCGGTGTGGATTATACTGGCGGTCGTCATCGTGGTATCCTGCGCGGCACCGGCCCTGATCCTGCATGTCACATGG
CGCGCAGGCCAGCGCGCCGA

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNEQATRRPMIQAPSHPGPHDGYMPGFGNDFETEALPGALPQGMNSPQKVNYGLYGEQLSGTAFTDVRPERTWCYRIRPS
VKHSHRYSKIDLPYWHSAPTIDPDVISLGQYRWDPVPHSDTPLTWLTGMRTMTSAGDVNTQVGMATHVYLVTQSMVDDYF
YSADSEMLVVPQEGRLRFCTELGIIDVEPQEIAILPRGLVYRVEVLDGPARGFVCENYGAKFDLPGRGPIGANCMANPRD
FKAPVAAYEDREVPSTITIKWCGQFHTSKIAQSPLDVVAWHGNYAPYKYDLKTYCPVGAILFDHPDPSIFTVLTAPSGQP
GVANIDFVLFRERWMVAENTFRPPWYHKNIMSELMGNIYGQYDAKPKGFVPGGISLHNMMIPHGPDKNAFEGASNADLQP
QKLDNTMSFMFETRFPQHLTAFAANEAPLQDDYIDCWETLEKKFDPSQRPDAGHGTPGKK

Sequences:

>Translated_460_residues
MNEQATRRPMIQAPSHPGPHDGYMPGFGNDFETEALPGALPQGMNSPQKVNYGLYGEQLSGTAFTDVRPERTWCYRIRPS
VKHSHRYSKIDLPYWHSAPTIDPDVISLGQYRWDPVPHSDTPLTWLTGMRTMTSAGDVNTQVGMATHVYLVTQSMVDDYF
YSADSEMLVVPQEGRLRFCTELGIIDVEPQEIAILPRGLVYRVEVLDGPARGFVCENYGAKFDLPGRGPIGANCMANPRD
FKAPVAAYEDREVPSTITIKWCGQFHTSKIAQSPLDVVAWHGNYAPYKYDLKTYCPVGAILFDHPDPSIFTVLTAPSGQP
GVANIDFVLFRERWMVAENTFRPPWYHKNIMSELMGNIYGQYDAKPKGFVPGGISLHNMMIPHGPDKNAFEGASNADLQP
QKLDNTMSFMFETRFPQHLTAFAANEAPLQDDYIDCWETLEKKFDPSQRPDAGHGTPGKK
>Mature_460_residues
MNEQATRRPMIQAPSHPGPHDGYMPGFGNDFETEALPGALPQGMNSPQKVNYGLYGEQLSGTAFTDVRPERTWCYRIRPS
VKHSHRYSKIDLPYWHSAPTIDPDVISLGQYRWDPVPHSDTPLTWLTGMRTMTSAGDVNTQVGMATHVYLVTQSMVDDYF
YSADSEMLVVPQEGRLRFCTELGIIDVEPQEIAILPRGLVYRVEVLDGPARGFVCENYGAKFDLPGRGPIGANCMANPRD
FKAPVAAYEDREVPSTITIKWCGQFHTSKIAQSPLDVVAWHGNYAPYKYDLKTYCPVGAILFDHPDPSIFTVLTAPSGQP
GVANIDFVLFRERWMVAENTFRPPWYHKNIMSELMGNIYGQYDAKPKGFVPGGISLHNMMIPHGPDKNAFEGASNADLQP
QKLDNTMSFMFETRFPQHLTAFAANEAPLQDDYIDCWETLEKKFDPSQRPDAGHGTPGKK

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=438, Percent_Identity=46.8036529680365, Blast_Score=394, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17507969, Length=430, Percent_Identity=50, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24583650, Length=438, Percent_Identity=44.7488584474886, Blast_Score=360, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 51545; Mature: 51545

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQATRRPMIQAPSHPGPHDGYMPGFGNDFETEALPGALPQGMNSPQKVNYGLYGEQLS
CCCCHHCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCC
GTAFTDVRPERTWCYRIRPSVKHSHRYSKIDLPYWHSAPTIDPDVISLGQYRWDPVPHSD
CCEEECCCCCCEEEEEECCCCHHCCCCCEECCCCCCCCCCCCHHHHHCCCEECCCCCCCC
TPLTWLTGMRTMTSAGDVNTQVGMATHVYLVTQSMVDDYFYSADSEMLVVPQEGRLRFCT
CCCHHHHCCHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHCCCCCEEEECCCCCEEEEE
ELGIIDVEPQEIAILPRGLVYRVEVLDGPARGFVCENYGAKFDLPGRGPIGANCMANPRD
ECCEEECCCCEEEEECCCEEEEEEEECCCCCCEEECCCCCEECCCCCCCCCCCCCCCCHH
FKAPVAAYEDREVPSTITIKWCGQFHTSKIAQSPLDVVAWHGNYAPYKYDLKTYCPVGAI
CCCCHHCCCCCCCCCEEEEEECCCHHHHHHHCCCCEEEEECCCCCCEEECCCCCCCCCEE
LFDHPDPSIFTVLTAPSGQPGVANIDFVLFRERWMVAENTFRPPWYHKNIMSELMGNIYG
EEECCCCCEEEEEECCCCCCCCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCC
QYDAKPKGFVPGGISLHNMMIPHGPDKNAFEGASNADLQPQKLDNTMSFMFETRFPQHLT
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
AFAANEAPLQDDYIDCWETLEKKFDPSQRPDAGHGTPGKK
HHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNEQATRRPMIQAPSHPGPHDGYMPGFGNDFETEALPGALPQGMNSPQKVNYGLYGEQLS
CCCCHHCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCC
GTAFTDVRPERTWCYRIRPSVKHSHRYSKIDLPYWHSAPTIDPDVISLGQYRWDPVPHSD
CCEEECCCCCCEEEEEECCCCHHCCCCCEECCCCCCCCCCCCHHHHHCCCEECCCCCCCC
TPLTWLTGMRTMTSAGDVNTQVGMATHVYLVTQSMVDDYFYSADSEMLVVPQEGRLRFCT
CCCHHHHCCHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHCCCCCEEEECCCCCEEEEE
ELGIIDVEPQEIAILPRGLVYRVEVLDGPARGFVCENYGAKFDLPGRGPIGANCMANPRD
ECCEEECCCCEEEEECCCEEEEEEEECCCCCCEEECCCCCEECCCCCCCCCCCCCCCCHH
FKAPVAAYEDREVPSTITIKWCGQFHTSKIAQSPLDVVAWHGNYAPYKYDLKTYCPVGAI
CCCCHHCCCCCCCCCEEEEEECCCHHHHHHHCCCCEEEEECCCCCCEEECCCCCCCCCEE
LFDHPDPSIFTVLTAPSGQPGVANIDFVLFRERWMVAENTFRPPWYHKNIMSELMGNIYG
EEECCCCCEEEEEECCCCCCCCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCC
QYDAKPKGFVPGGISLHNMMIPHGPDKNAFEGASNADLQPQKLDNTMSFMFETRFPQHLT
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
AFAANEAPLQDDYIDCWETLEKKFDPSQRPDAGHGTPGKK
HHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10220173; 11481430 [H]