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The map label for this gene is 89053927

Identifier: 89053927

GI number: 89053927

Start: 1403871

End: 1405121

Strand: Reverse

Name: 89053927

Synonym: Jann_1436

Alternate gene names: NA

Gene position: 1405121-1403871 (Counterclockwise)

Preceding gene: 89053928

Following gene: 89053926

Centisome position: 32.54

GC content: 65.87

Gene sequence:

>1251_bases
ATGTCCGACCTGATCAAAAGCTGGCTCCCCTCCGCCAACACCGCCACGACCGAATTTCCCCTCAACAACCTGCCCTACGG
CGTCTTTTCCGCGGGCGACGGGGACCTGCGCTGTGGGGTGGCCATTGGCGACCGGATCGTGGATGTCACGGGGCTGGAGG
CGGCGGGCCACCTGCGCGCGGATCCCGACGCCGATGTGCTGGATGCGCCTTACTGGAACGACTTCATGGAACTCGGCCCC
GTCGTCTGGCAGGCCTACCGGCTGGCGCTGACCGCGATCCTGGCCGAGGATGCCAGCGATGAAGTCCAGGACCTGATCAC
CACCTTCTCCGTGCCGATGGCCCAGGCGACCCTGCACATGCCCTTCAAGGTCGCGGAATACACCGACTTCTACGCCGGTC
GCCACCACGCCACCAATGTCGGCACCATGTTCCGGGGCGCGGAAAACGCGCTGCCGCCCAATTGGCTGCACATGCCCATC
GGCTACAATGGGCGTGCGTCCTCGGTCGTCGTCTCCGGCACCGACATCCGCCGCCCTTGGGGGCAGTTGAAAGCGCCCGA
CGCGGACCTGCCAATCTTCGCGCCCTCCAAACGCTTCGATATCGAGCTGGAACTGGGTGCCATCGTGGGCACCGCTTCCG
ACGGTCCCCTCACCGTCGATCAGGCGTTCGACAATATCTTCGGCTATGTGCTGCTCAACGATTGGTCCGCGCGCGATATT
CAGGCCTGGGAATACCAGCCCCTTGGACCGTTCCAAGCCAAGGCCACCGCCACAACCATCAGCCCCTGGATCGTTCCAGC
CGAGGCGCTGGCCCCCTTCCGCACCGCCACGCCCGCCCGCGAACACGCGCTGCTGCCGCACCTCGCCGACACCACACCGA
TGAACCACGACATCACCCTGTCCGTGACCCTCAACGGCGCGGAAATCGCGCAGACCAACGCCAATGAGCTTTACTATTCC
GCCGCCCAGCAGCTGGCCCACCACGCCACCGCGGGCGGCCCGATGCGCACCGGCGATCTTCTGGGCTCCGGCACCATCTC
CGGCCCCGAAAAACGCAATCGCGGCTCGCTTCTGGAACTCTCCTGGGGCGGGAAAGAGCCTCTGGACACCGCCTCCGGCC
CCCGCTCCTTCATTGAAGACGGCGACACCCTCGCCCTGCACGGTGCGTCCAAAGGCGACGGCTATCAGATCGGCTTCGGC
CCCTGCATCGGCACGGTTCTGCCTGCCCTCGACGATCCCTTCCAGACCTAA

Upstream 100 bases:

>100_bases
CCCGACGCACCCTAACCCGCCCGTCCTCTTGCCCAAAACGCGCCCCGCCGTCCCCGGATATGGGGCGCCGATCCGCCACA
CGCCCTAACGAAAGCCCGAC

Downstream 100 bases:

>100_bases
GCCCTTTCCCCGTTCTTCAAATATCCCCGCCGGAGGCTCCGACACCTCCCACGGGACCGACCCTCAAAGGAAAACACACC
ATGGCCAAAGCCTTCGCCTC

Product: fumarylacetoacetate hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSDLIKSWLPSANTATTEFPLNNLPYGVFSAGDGDLRCGVAIGDRIVDVTGLEAAGHLRADPDADVLDAPYWNDFMELGP
VVWQAYRLALTAILAEDASDEVQDLITTFSVPMAQATLHMPFKVAEYTDFYAGRHHATNVGTMFRGAENALPPNWLHMPI
GYNGRASSVVVSGTDIRRPWGQLKAPDADLPIFAPSKRFDIELELGAIVGTASDGPLTVDQAFDNIFGYVLLNDWSARDI
QAWEYQPLGPFQAKATATTISPWIVPAEALAPFRTATPAREHALLPHLADTTPMNHDITLSVTLNGAEIAQTNANELYYS
AAQQLAHHATAGGPMRTGDLLGSGTISGPEKRNRGSLLELSWGGKEPLDTASGPRSFIEDGDTLALHGASKGDGYQIGFG
PCIGTVLPALDDPFQT

Sequences:

>Translated_416_residues
MSDLIKSWLPSANTATTEFPLNNLPYGVFSAGDGDLRCGVAIGDRIVDVTGLEAAGHLRADPDADVLDAPYWNDFMELGP
VVWQAYRLALTAILAEDASDEVQDLITTFSVPMAQATLHMPFKVAEYTDFYAGRHHATNVGTMFRGAENALPPNWLHMPI
GYNGRASSVVVSGTDIRRPWGQLKAPDADLPIFAPSKRFDIELELGAIVGTASDGPLTVDQAFDNIFGYVLLNDWSARDI
QAWEYQPLGPFQAKATATTISPWIVPAEALAPFRTATPAREHALLPHLADTTPMNHDITLSVTLNGAEIAQTNANELYYS
AAQQLAHHATAGGPMRTGDLLGSGTISGPEKRNRGSLLELSWGGKEPLDTASGPRSFIEDGDTLALHGASKGDGYQIGFG
PCIGTVLPALDDPFQT
>Mature_415_residues
SDLIKSWLPSANTATTEFPLNNLPYGVFSAGDGDLRCGVAIGDRIVDVTGLEAAGHLRADPDADVLDAPYWNDFMELGPV
VWQAYRLALTAILAEDASDEVQDLITTFSVPMAQATLHMPFKVAEYTDFYAGRHHATNVGTMFRGAENALPPNWLHMPIG
YNGRASSVVVSGTDIRRPWGQLKAPDADLPIFAPSKRFDIELELGAIVGTASDGPLTVDQAFDNIFGYVLLNDWSARDIQ
AWEYQPLGPFQAKATATTISPWIVPAEALAPFRTATPAREHALLPHLADTTPMNHDITLSVTLNGAEIAQTNANELYYSA
AQQLAHHATAGGPMRTGDLLGSGTISGPEKRNRGSLLELSWGGKEPLDTASGPRSFIEDGDTLALHGASKGDGYQIGFGP
CIGTVLPALDDPFQT

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=420, Percent_Identity=48.5714285714286, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17568863, Length=409, Percent_Identity=46.6992665036675, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24657182, Length=405, Percent_Identity=45.679012345679, Blast_Score=348, Evalue=3e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 44596; Mature: 44465

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLIKSWLPSANTATTEFPLNNLPYGVFSAGDGDLRCGVAIGDRIVDVTGLEAAGHLRA
CHHHHHHHCCCCCCCEEECCCCCCCCCEEECCCCCEEEEEEECCEEEEEECCCCCCCCCC
DPDADVLDAPYWNDFMELGPVVWQAYRLALTAILAEDASDEVQDLITTFSVPMAQATLHM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHEEEC
PFKVAEYTDFYAGRHHATNVGTMFRGAENALPPNWLHMPIGYNGRASSVVVSGTDIRRPW
CEEEHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCC
GQLKAPDADLPIFAPSKRFDIELELGAIVGTASDGPLTVDQAFDNIFGYVLLNDWSARDI
CCCCCCCCCCCEECCCCCEEEEEEEEEEEECCCCCCEEHHHHHHHHEEEEEEECCCCCCC
QAWEYQPLGPFQAKATATTISPWIVPAEALAPFRTATPAREHALLPHLADTTPMNHDITL
CCCCCCCCCCCCCCCEEEECCCCEECHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCEEE
SVTLNGAEIAQTNANELYYSAAQQLAHHATAGGPMRTGDLLGSGTISGPEKRNRGSLLEL
EEEECCHHEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
SWGGKEPLDTASGPRSFIEDGDTLALHGASKGDGYQIGFGPCIGTVLPALDDPFQT
ECCCCCCCCCCCCCHHHHCCCCEEEEECCCCCCCEEEECHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDLIKSWLPSANTATTEFPLNNLPYGVFSAGDGDLRCGVAIGDRIVDVTGLEAAGHLRA
HHHHHHHCCCCCCCEEECCCCCCCCCEEECCCCCEEEEEEECCEEEEEECCCCCCCCCC
DPDADVLDAPYWNDFMELGPVVWQAYRLALTAILAEDASDEVQDLITTFSVPMAQATLHM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHEEEC
PFKVAEYTDFYAGRHHATNVGTMFRGAENALPPNWLHMPIGYNGRASSVVVSGTDIRRPW
CEEEHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCC
GQLKAPDADLPIFAPSKRFDIELELGAIVGTASDGPLTVDQAFDNIFGYVLLNDWSARDI
CCCCCCCCCCCEECCCCCEEEEEEEEEEEECCCCCCEEHHHHHHHHEEEEEEECCCCCCC
QAWEYQPLGPFQAKATATTISPWIVPAEALAPFRTATPAREHALLPHLADTTPMNHDITL
CCCCCCCCCCCCCCCEEEECCCCEECHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCEEE
SVTLNGAEIAQTNANELYYSAAQQLAHHATAGGPMRTGDLLGSGTISGPEKRNRGSLLEL
EEEECCHHEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
SWGGKEPLDTASGPRSFIEDGDTLALHGASKGDGYQIGFGPCIGTVLPALDDPFQT
ECCCCCCCCCCCCCHHHHCCCCEEEEECCCCCCCEEEECHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA