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The map label for this gene is ctaDII [H]

Identifier: 89053741

GI number: 89053741

Start: 1204641

End: 1206527

Strand: Reverse

Name: ctaDII [H]

Synonym: Jann_1250

Alternate gene names: 89053741

Gene position: 1206527-1204641 (Counterclockwise)

Preceding gene: 89053742

Following gene: 89053740

Centisome position: 27.94

GC content: 61.69

Gene sequence:

>1887_bases
ATGGCAGACGCCACCCTCACAGGGAATGACGGCCACGACCGGCCCGGGTTCTTCACCCGTTGGTTCATGTCGACCAACCA
CAAAGACATCGGCATCCTTTATCTGTTCACCGCAGGCCTTGTGGGCCTCGTCTCGGTGGCCTTCACCGTTTACATGCGGA
TGGAGCTGATGGAGCCGGGCGTGCAGTACATGTACGACGCCTTTGCTGCTTCCCCTGAGGGTATCTCGGCGCTCTTTGAA
CGTCTGGGTGAGGCTCTGGCCGCCGCCGGTGGCGGGACCAATGCCTTCGCTGATCAACTGGCGACAATGGAAAGCACCCT
GACCGCTGCCGGGGGTGAAACCATTGAAATCACGGGTGGAATGCGCGCCGATATGGTCGCCGGGTTCGAATCTATGCTCG
CCACCGCCAACCCGGCCGAGGCTCAGGCCCTGTTGGGCACAATGGACCAGCTGGACGGCAACCCCGATGGCCATCTGTGG
AACGTTCTGATCACCGGTCACGGCGTGTTGATGATGTTCTTCGTCGTCATCCCGGCGCTGTTCGGCGGCTTCGGCAACTA
CTTCATGCCGCTGATGATCGGCGCACCGGACATGGCGTTCCCGCGCCTCAACAACCTCTCCTACTGGATGTATGTCGCGG
GCACCTGCCTCGCCTTCTGCTCCGTCATGATTGACGGTGGCGCGGGTCCGGGCTGGACGTTCTACCCGCCGATTTCCGCG
CAGGGCGTTGAAACCTCCCGCGCCGTGGACTTCGCGATCTTCGCCGTCCACGTCTCGGGCGCCTCGTCGATCCTCGGCTC
GATCAACTTCATCACGACCTTCCTGAACATGCGCGCGCCCGGCATGACGCTGCACAAGGTGCCGCTTTTCGCCTGGTCCG
TGTTCGTGACCGCCTGGTTGCTTCTGCTGTCCCTGCCGGTTCTGGCCGGGGCCATCACCATGCTGCTGACGGATCGCAAC
TTCGGCACCACTTTCTTCGACCCCGCCGGGGGCGGTGACCCGATCCTGTTCCAGCACATCTTCTGGTTCTTCGGCCACCC
CGAGGTTTACATCGTGATCCTACCCGCCTTTGGCGTGATCTCCCACATCGTGGCGACCTTTTCCAAGAAGCCGATCTTCG
GCTATCTGCCGATGGTCTACGCGCTGGTGGCCATCGGGGGTCTGGGCTTCGTCGTCTGGGCGCACCACATGTACACGGTG
GGCATGACGCTGACGCAGCAGGCCTATTTCATGGTGGCCACAATGGTGATCGCGGTGCCCACGGGCATCAAGATCTTCTC
CTGGATCGCGACGATGTGGATGGGGTCGATCAGCTTCAAGACCCCGATGATGTTCGCCCTTGGCTTCATCTTCCTCTTCA
CCCTCGGCGGCACGACGGGCATCATCCTGTCGCAAGCCGGTGTGGACCGCGCCTACCACGACACCTATTACGTCGTCGCG
CACTTCCACTATGTGATGAGCCTTGGGGCCGTCTTCGGGATCTTCGCCGCCGTCTACTACTGGATCGGCAAGATGTCGGG
CCGCCAATACCCGGAATGGGCCGGACAAGTTCACTTCTGGGTGTTTTTCATCGGCACCAACATCACCTTCTTCCCGCAGC
ACTTCCTGGGCCGCCAGGGCATGCCGCGCCGCTATATCGACTACCCGGATGCCTTCGCGCTCTGGAACTATGTGTCGTCC
ATCGGTGCGTTCATCTCCTTTGCATCGTTCCTCTTCTTCATCGGCATCGTGTTCTACACGCTCTTCGCCGGGAAGCGCGT
CACCCAGCCCGCCTATTGGGGCGAGCATGCCGACACGCTGGAATGGACCCTGCCCAACCCGCCCCCGGAGCACACGTTTG
AGGAGCTTCCCACCCGCGAGATGTGGGACAAGCAACCGGGTCACTGA

Upstream 100 bases:

>100_bases
CGCTGCGCACTACACCCTCATCAGGACAAAGATTTCGACCTCCGATTCAAGGGGTCGTGCGTGACGCTAGACGCGCTTAA
GACGCGAACAGGAGACGACC

Downstream 100 bases:

>100_bases
CCACTGTCATGCGCTGGTATGACTGGCTGATCCTGACAACGATAGGCGCCCTCCTCGGGGGCGCCTATTTTCGATTCTGG
CCCTCGCAGCGGATCGCCCT

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1-beta; Cytochrome c oxidase polypeptide I-beta [H]

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MADATLTGNDGHDRPGFFTRWFMSTNHKDIGILYLFTAGLVGLVSVAFTVYMRMELMEPGVQYMYDAFAASPEGISALFE
RLGEALAAAGGGTNAFADQLATMESTLTAAGGETIEITGGMRADMVAGFESMLATANPAEAQALLGTMDQLDGNPDGHLW
NVLITGHGVLMMFFVVIPALFGGFGNYFMPLMIGAPDMAFPRLNNLSYWMYVAGTCLAFCSVMIDGGAGPGWTFYPPISA
QGVETSRAVDFAIFAVHVSGASSILGSINFITTFLNMRAPGMTLHKVPLFAWSVFVTAWLLLLSLPVLAGAITMLLTDRN
FGTTFFDPAGGGDPILFQHIFWFFGHPEVYIVILPAFGVISHIVATFSKKPIFGYLPMVYALVAIGGLGFVVWAHHMYTV
GMTLTQQAYFMVATMVIAVPTGIKIFSWIATMWMGSISFKTPMMFALGFIFLFTLGGTTGIILSQAGVDRAYHDTYYVVA
HFHYVMSLGAVFGIFAAVYYWIGKMSGRQYPEWAGQVHFWVFFIGTNITFFPQHFLGRQGMPRRYIDYPDAFALWNYVSS
IGAFISFASFLFFIGIVFYTLFAGKRVTQPAYWGEHADTLEWTLPNPPPEHTFEELPTREMWDKQPGH

Sequences:

>Translated_628_residues
MADATLTGNDGHDRPGFFTRWFMSTNHKDIGILYLFTAGLVGLVSVAFTVYMRMELMEPGVQYMYDAFAASPEGISALFE
RLGEALAAAGGGTNAFADQLATMESTLTAAGGETIEITGGMRADMVAGFESMLATANPAEAQALLGTMDQLDGNPDGHLW
NVLITGHGVLMMFFVVIPALFGGFGNYFMPLMIGAPDMAFPRLNNLSYWMYVAGTCLAFCSVMIDGGAGPGWTFYPPISA
QGVETSRAVDFAIFAVHVSGASSILGSINFITTFLNMRAPGMTLHKVPLFAWSVFVTAWLLLLSLPVLAGAITMLLTDRN
FGTTFFDPAGGGDPILFQHIFWFFGHPEVYIVILPAFGVISHIVATFSKKPIFGYLPMVYALVAIGGLGFVVWAHHMYTV
GMTLTQQAYFMVATMVIAVPTGIKIFSWIATMWMGSISFKTPMMFALGFIFLFTLGGTTGIILSQAGVDRAYHDTYYVVA
HFHYVMSLGAVFGIFAAVYYWIGKMSGRQYPEWAGQVHFWVFFIGTNITFFPQHFLGRQGMPRRYIDYPDAFALWNYVSS
IGAFISFASFLFFIGIVFYTLFAGKRVTQPAYWGEHADTLEWTLPNPPPEHTFEELPTREMWDKQPGH
>Mature_627_residues
ADATLTGNDGHDRPGFFTRWFMSTNHKDIGILYLFTAGLVGLVSVAFTVYMRMELMEPGVQYMYDAFAASPEGISALFER
LGEALAAAGGGTNAFADQLATMESTLTAAGGETIEITGGMRADMVAGFESMLATANPAEAQALLGTMDQLDGNPDGHLWN
VLITGHGVLMMFFVVIPALFGGFGNYFMPLMIGAPDMAFPRLNNLSYWMYVAGTCLAFCSVMIDGGAGPGWTFYPPISAQ
GVETSRAVDFAIFAVHVSGASSILGSINFITTFLNMRAPGMTLHKVPLFAWSVFVTAWLLLLSLPVLAGAITMLLTDRNF
GTTFFDPAGGGDPILFQHIFWFFGHPEVYIVILPAFGVISHIVATFSKKPIFGYLPMVYALVAIGGLGFVVWAHHMYTVG
MTLTQQAYFMVATMVIAVPTGIKIFSWIATMWMGSISFKTPMMFALGFIFLFTLGGTTGIILSQAGVDRAYHDTYYVVAH
FHYVMSLGAVFGIFAAVYYWIGKMSGRQYPEWAGQVHFWVFFIGTNITFFPQHFLGRQGMPRRYIDYPDAFALWNYVSSI
GAFISFASFLFFIGIVFYTLFAGKRVTQPAYWGEHADTLEWTLPNPPPEHTFEELPTREMWDKQPGH

Specific function: Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across th

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=485, Percent_Identity=55.4639175257732, Blast_Score=510, Evalue=1e-144,
Organism=Escherichia coli, GI1786634, Length=464, Percent_Identity=40.301724137931, Blast_Score=329, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6226519, Length=509, Percent_Identity=53.2416502946955, Blast_Score=534, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6226524, Length=274, Percent_Identity=61.6788321167883, Blast_Score=356, Evalue=6e-99,
Organism=Saccharomyces cerevisiae, GI6226523, Length=193, Percent_Identity=56.4766839378238, Blast_Score=216, Evalue=7e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 69111; Mature: 68980

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADATLTGNDGHDRPGFFTRWFMSTNHKDIGILYLFTAGLVGLVSVAFTVYMRMELMEPG
CCCCEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
VQYMYDAFAASPEGISALFERLGEALAAAGGGTNAFADQLATMESTLTAAGGETIEITGG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCC
MRADMVAGFESMLATANPAEAQALLGTMDQLDGNPDGHLWNVLITGHGVLMMFFVVIPAL
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHH
FGGFGNYFMPLMIGAPDMAFPRLNNLSYWMYVAGTCLAFCSVMIDGGAGPGWTFYPPISA
HCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
QGVETSRAVDFAIFAVHVSGASSILGSINFITTFLNMRAPGMTLHKVPLFAWSVFVTAWL
CCCCCHHHHEEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
LLLSLPVLAGAITMLLTDRNFGTTFFDPAGGGDPILFQHIFWFFGHPEVYIVILPAFGVI
HHHHHHHHHHHHHHHEECCCCCCCEECCCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHH
SHIVATFSKKPIFGYLPMVYALVAIGGLGFVVWAHHMYTVGMTLTQQAYFMVATMVIAVP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGIKIFSWIATMWMGSISFKTPMMFALGFIFLFTLGGTTGIILSQAGVDRAYHDTYYVVA
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHCCHHHHHH
HFHYVMSLGAVFGIFAAVYYWIGKMSGRQYPEWAGQVHFWVFFIGTNITFFPQHFLGRQG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCEECCHHHHCCCC
MPRRYIDYPDAFALWNYVSSIGAFISFASFLFFIGIVFYTLFAGKRVTQPAYWGEHADTL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
EWTLPNPPPEHTFEELPTREMWDKQPGH
EEECCCCCCCCHHHHCCCHHHCCCCCCC
>Mature Secondary Structure 
ADATLTGNDGHDRPGFFTRWFMSTNHKDIGILYLFTAGLVGLVSVAFTVYMRMELMEPG
CCCEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
VQYMYDAFAASPEGISALFERLGEALAAAGGGTNAFADQLATMESTLTAAGGETIEITGG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCC
MRADMVAGFESMLATANPAEAQALLGTMDQLDGNPDGHLWNVLITGHGVLMMFFVVIPAL
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHH
FGGFGNYFMPLMIGAPDMAFPRLNNLSYWMYVAGTCLAFCSVMIDGGAGPGWTFYPPISA
HCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
QGVETSRAVDFAIFAVHVSGASSILGSINFITTFLNMRAPGMTLHKVPLFAWSVFVTAWL
CCCCCHHHHEEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
LLLSLPVLAGAITMLLTDRNFGTTFFDPAGGGDPILFQHIFWFFGHPEVYIVILPAFGVI
HHHHHHHHHHHHHHHEECCCCCCCEECCCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHH
SHIVATFSKKPIFGYLPMVYALVAIGGLGFVVWAHHMYTVGMTLTQQAYFMVATMVIAVP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGIKIFSWIATMWMGSISFKTPMMFALGFIFLFTLGGTTGIILSQAGVDRAYHDTYYVVA
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHCCHHHHHH
HFHYVMSLGAVFGIFAAVYYWIGKMSGRQYPEWAGQVHFWVFFIGTNITFFPQHFLGRQG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCEECCHHHHCCCC
MPRRYIDYPDAFALWNYVSSIGAFISFASFLFFIGIVFYTLFAGKRVTQPAYWGEHADTL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
EWTLPNPPPEHTFEELPTREMWDKQPGH
EEECCCCCCCCHHHHCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2155830; 7651515; 9380672; 10338009; 8794157 [H]