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The map label for this gene is ldc [H]

Identifier: 89053292

GI number: 89053292

Start: 762453

End: 763622

Strand: Reverse

Name: ldc [H]

Synonym: Jann_0801

Alternate gene names: 89053292

Gene position: 763622-762453 (Counterclockwise)

Preceding gene: 89053293

Following gene: 89053286

Centisome position: 17.68

GC content: 65.21

Gene sequence:

>1170_bases
ATGACCGCTCCCTTTATCGCCCTTTCGGGCGCAGCTCCCGTATCTTCCTCCCGCGCGGAGGTCTATGCCCGCACCCATAC
GTTCGACCGCCCCACGCTGATCCTCGACGTCGACCGTGTGGCGCAGCACTACGACGCACTCTCCGCCGGTCTGGGTCAGG
CGCATATCCACTACGCCGTCAAAGCCAACCCCGCGCCTGAAATCCTCGCGCGCCTTGTCACTATGGGCTCGGGCTTCGAT
GCGGCATCAAAGGTGGAGATCCAGATGTGCCTCGATGCAGGCGCTGCCCCCTCGCACATCTCGTTCGGGAACACCGTCAA
GAAACCGTCAGACATCGCCTATGCGCATTCCGTCGGCGTGGACGTCTTCGCCGCCGATGCGTCTGAGGAACTGGACAAGA
TCGCCACCCACGCCCCCGGCGCGCAGGTCTACATCCGCCTGTTGGTGGAGGCGTCGGGCGCGGATTGGCCGCTCACCCGC
AAATTCGGCACCACCAAAGCCAACGCGCTGGACCTCATGGCCCACGCCCGTGCTCTGGGTCTGCGCCCGGTGGGCCTGTC
ATTCCACGTCGGCTCCCAAACCCGCGATCCTGCCATGTGGGGCCCGGTCCTCGATGGTATCGCGGACGTCTGGACCACGG
CCAAGACACTCGGCTTCCCGCTGGACCTCCTGAACATCGGCGGCGGCTTCCCCGCGTTCTACGGCGACGACATCCCGCAC
CCCACCGCCTATGCGGCCAACGTCATGGCGCAGGTCCACACCCGCTTCGGCGACGTGCCCCGGATCATGGCCGAACCCGG
TCGCGGTCTGGTGGCGGAGGCGGGCATGATCGCCGCCGAGGTCCTGCTGGTCGCCCGCAAATCCCCCGATGACCTACACC
GCTGGGTGTATCTGGATATCGGCAAATTCTCAGGCCTCGCGGAAACGATTGATGAGGCGATCCGCTACCAATTCGCCACC
GACCGCGATCATGAGGCGATGGGCCCCTGCATCCTCGCCGGCCCCTCCTGTGACAGCGCCGATGTCCTCTACGAAAAACG
CCCCATCGCCCTGCCCCTGGGCCTGAAATCCGGCGACCGCATCTGGATCCGCAATTGTGGCGCCTACACCACTACTTACG
CTTCCATCGGCTTCAACGGCTTCCCACCGCTGGATGTCGTGGTCCTCTGA

Upstream 100 bases:

>100_bases
TGGAGCGCTCCGGGATACCCATCGCAGTTACGTAGCGACGGTAACGTCTCCTCTTTGATCGAACCCCCCCCATGGGGCAT
CCGTCCACTTGGAGACCATG

Downstream 100 bases:

>100_bases
CAAGCAAGCGCGTTAGCCTCCCATTAAGGTTAACGCGCCACCGGGCCTGCGGGCACGCCGCTCCCTGTTTCATCTGGGCA
AATACAACTCATAGCGCGTC

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTAPFIALSGAAPVSSSRAEVYARTHTFDRPTLILDVDRVAQHYDALSAGLGQAHIHYAVKANPAPEILARLVTMGSGFD
AASKVEIQMCLDAGAAPSHISFGNTVKKPSDIAYAHSVGVDVFAADASEELDKIATHAPGAQVYIRLLVEASGADWPLTR
KFGTTKANALDLMAHARALGLRPVGLSFHVGSQTRDPAMWGPVLDGIADVWTTAKTLGFPLDLLNIGGGFPAFYGDDIPH
PTAYAANVMAQVHTRFGDVPRIMAEPGRGLVAEAGMIAAEVLLVARKSPDDLHRWVYLDIGKFSGLAETIDEAIRYQFAT
DRDHEAMGPCILAGPSCDSADVLYEKRPIALPLGLKSGDRIWIRNCGAYTTTYASIGFNGFPPLDVVVL

Sequences:

>Translated_389_residues
MTAPFIALSGAAPVSSSRAEVYARTHTFDRPTLILDVDRVAQHYDALSAGLGQAHIHYAVKANPAPEILARLVTMGSGFD
AASKVEIQMCLDAGAAPSHISFGNTVKKPSDIAYAHSVGVDVFAADASEELDKIATHAPGAQVYIRLLVEASGADWPLTR
KFGTTKANALDLMAHARALGLRPVGLSFHVGSQTRDPAMWGPVLDGIADVWTTAKTLGFPLDLLNIGGGFPAFYGDDIPH
PTAYAANVMAQVHTRFGDVPRIMAEPGRGLVAEAGMIAAEVLLVARKSPDDLHRWVYLDIGKFSGLAETIDEAIRYQFAT
DRDHEAMGPCILAGPSCDSADVLYEKRPIALPLGLKSGDRIWIRNCGAYTTTYASIGFNGFPPLDVVVL
>Mature_388_residues
TAPFIALSGAAPVSSSRAEVYARTHTFDRPTLILDVDRVAQHYDALSAGLGQAHIHYAVKANPAPEILARLVTMGSGFDA
ASKVEIQMCLDAGAAPSHISFGNTVKKPSDIAYAHSVGVDVFAADASEELDKIATHAPGAQVYIRLLVEASGADWPLTRK
FGTTKANALDLMAHARALGLRPVGLSFHVGSQTRDPAMWGPVLDGIADVWTTAKTLGFPLDLLNIGGGFPAFYGDDIPHP
TAYAANVMAQVHTRFGDVPRIMAEPGRGLVAEAGMIAAEVLLVARKSPDDLHRWVYLDIGKFSGLAETIDEAIRYQFATD
RDHEAMGPCILAGPSCDSADVLYEKRPIALPLGLKSGDRIWIRNCGAYTTTYASIGFNGFPPLDVVVL

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=372, Percent_Identity=31.4516129032258, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI22538418, Length=378, Percent_Identity=26.984126984127, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI21361583, Length=378, Percent_Identity=26.984126984127, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI16506287, Length=250, Percent_Identity=29.2, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562780, Length=373, Percent_Identity=30.0268096514745, Blast_Score=137, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6322664, Length=374, Percent_Identity=28.3422459893048, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24586472, Length=365, Percent_Identity=30.958904109589, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24586474, Length=333, Percent_Identity=30.3303303303303, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 41462; Mature: 41330

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPFIALSGAAPVSSSRAEVYARTHTFDRPTLILDVDRVAQHYDALSAGLGQAHIHYAV
CCCCEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCEEEEEEE
KANPAPEILARLVTMGSGFDAASKVEIQMCLDAGAAPSHISFGNTVKKPSDIAYAHSVGV
ECCCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHCCC
DVFAADASEELDKIATHAPGAQVYIRLLVEASGADWPLTRKFGTTKANALDLMAHARALG
EEEECCCHHHHHHHHHCCCCHHEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
LRPVGLSFHVGSQTRDPAMWGPVLDGIADVWTTAKTLGFPLDLLNIGGGFPAFYGDDIPH
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHCCCCCCCCCCCCCCCC
PTAYAANVMAQVHTRFGDVPRIMAEPGRGLVAEAGMIAAEVLLVARKSPDDLHRWVYLDI
CHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCHHHEEEEEEC
GKFSGLAETIDEAIRYQFATDRDHEAMGPCILAGPSCDSADVLYEKRPIALPLGLKSGDR
CCCCCHHHHHHHHHHHHCCCCCCCHHCCCEEEECCCCCCCCCEECCCCEEEEECCCCCCE
IWIRNCGAYTTTYASIGFNGFPPLDVVVL
EEEEECCCCEEEEEECCCCCCCCEEEEEC
>Mature Secondary Structure 
TAPFIALSGAAPVSSSRAEVYARTHTFDRPTLILDVDRVAQHYDALSAGLGQAHIHYAV
CCCEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCEEEEEEE
KANPAPEILARLVTMGSGFDAASKVEIQMCLDAGAAPSHISFGNTVKKPSDIAYAHSVGV
ECCCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHCCC
DVFAADASEELDKIATHAPGAQVYIRLLVEASGADWPLTRKFGTTKANALDLMAHARALG
EEEECCCHHHHHHHHHCCCCHHEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
LRPVGLSFHVGSQTRDPAMWGPVLDGIADVWTTAKTLGFPLDLLNIGGGFPAFYGDDIPH
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHCCCCCCCCCCCCCCCC
PTAYAANVMAQVHTRFGDVPRIMAEPGRGLVAEAGMIAAEVLLVARKSPDDLHRWVYLDI
CHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCHHHEEEEEEC
GKFSGLAETIDEAIRYQFATDRDHEAMGPCILAGPSCDSADVLYEKRPIALPLGLKSGDR
CCCCCHHHHHHHHHHHHCCCCCCCHHCCCEEEECCCCCCCCCEECCCCEEEEECCCCCCE
IWIRNCGAYTTTYASIGFNGFPPLDVVVL
EEEEECCCCEEEEEECCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]