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The map label for this gene is ffh [H]

Identifier: 89053248

GI number: 89053248

Start: 720660

End: 722165

Strand: Reverse

Name: ffh [H]

Synonym: Jann_0757

Alternate gene names: 89053248

Gene position: 722165-720660 (Counterclockwise)

Preceding gene: 89053249

Following gene: 89053247

Centisome position: 16.72

GC content: 63.28

Gene sequence:

>1506_bases
ATGTTTGAGAACCTATCCGAGCGCCTTGGTGGCGTCTTTGACCGCCTCACCAAACAGGGCGCGCTGTCGGAGGATGACGT
TCGCACCGCGCTCCGCGAAGTGCGGGTCGCGCTGTTGGAGGCGGACGTCTCACTGCCCGTCGCACGGACCTTCATCAAGA
ACGTGGAAAAGAAGGCGACGGGGGCTGCCGTCACCAAGTCGATCACCCCCGGCCAGCAGGTCATCAAGATCGTCCATGAC
GAATTGATCGCCACCCTGCGCGGCGCGGATGATCCCGGCGTTTTGAAAATCGACAACCCGCCCGCGCCGATCCTGATGGT
CGGCCTTCAGGGCTCCGGTAAGACGACGACGACGGCGAAACTGGCCAAGCGGTTGAAGGACCGTGAGGGCAAGAAGGTGC
TTATGGCGTCTTTGGACACCAACCGTCCGGCGGCGATGGAGCAGTTGGCGATCCTCGGCACGCAGATCGGCGTGGACACC
CTGCCCATCGTGCCCGGTGAAGATCCCGTTCAGATCGCCAAGCGGGCGAAGACGCAGGCGTCTCTGGCCGGATATGACGT
CTATATGCTCGACACTGCGGGCCGGTTGCACATCGACGCAGAGCTGATCGCCCAGGCCGCTGCCGTACGTGACGTGGCCA
ACCCGCGTGAGACGCTGCTGGTCGTGGACGGCCTGACAGGTCAGGACGCGGTCAATGTCGCGACGGAATTCGATGACAAG
ATCGGCGTCTCGGGCGTTGTCCTGACCCGGATGGACGGCGACGGGCGCGGCGGTGCGGCGCTCTCGATGCGAGAGATCAC
TGGCAAGCCCATCCGCTTCGTCGGTCTCGGCGAGAAGATGGACGCGATCGAGACGTTCGAGCCCGAGCGCATCGCGGGCC
GCATCCTTGGCATGGGCGACATCGTGGCCCTGGTCGAGAAGGCGCAGGAGACGCTGGAGGCCGAACAGGCCGAGCGCATG
ATGAAGCGGTTCCAGAAGGGTCAGTTCAACATGAACGACCTGAAGGGCCAGCTTGAGCAGATGCAGAAGATGGGCGGCAT
GCAAGGCATGATGGGCATGATGCCCGGCATGGCCAAGATGTCAAAACAGATCGAAGAGGCCGGTTTTGACGACAAGGTTA
TTGTGCGTCAGGTGGCGCTGATCCAGTCGATGACCAAAAAGGAACGCGCCAATCCGGGCATGTTGCAGGCGTCCCGCAAG
AAGCGCATTGCCAAGGGCGCGGGGCAGGATGTGTCTGACCTCAATAAGCTGCTGAAGATGCACCGCCAGATGGCGGATGC
GATGAAGAAGATGGGCAAAATGGGCAAGAAAGGCCTGATGCGGGGCGGCCTCGGCGCGCTGATGGGCAAGGGCGGCGGTA
TGCCGGCTGGCATGGATGCGGCTGGCATGGGTGGCATGGACCCCAAGGCGCTGGAACGCGCGGCCAAGCAGATGGGTGCG
GGCGGCGGCGGGCTGCCCGGCTTGGGCGGCATGGGTGATCTGAGCGGGTTGGGTAAGAAGAAGTGA

Upstream 100 bases:

>100_bases
GAAACCAGACAAAGGGGCGTGTTGCGTCTCGGGACTTGGGAAATAAGGCACTGCCCCTTATCTGATTGGGGTATCCGAGA
TCGCGAAAGGGGCCACGCCC

Downstream 100 bases:

>100_bases
TCACCTGCACCGTCAGATATGAGATCGACCCCGACAAGCTTCCTGAGTTTGAGGTCTACGCCCGTGCGTGGATTCATCTG
GTGACGAAACTTGGCGGGAT

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MFENLSERLGGVFDRLTKQGALSEDDVRTALREVRVALLEADVSLPVARTFIKNVEKKATGAAVTKSITPGQQVIKIVHD
ELIATLRGADDPGVLKIDNPPAPILMVGLQGSGKTTTTAKLAKRLKDREGKKVLMASLDTNRPAAMEQLAILGTQIGVDT
LPIVPGEDPVQIAKRAKTQASLAGYDVYMLDTAGRLHIDAELIAQAAAVRDVANPRETLLVVDGLTGQDAVNVATEFDDK
IGVSGVVLTRMDGDGRGGAALSMREITGKPIRFVGLGEKMDAIETFEPERIAGRILGMGDIVALVEKAQETLEAEQAERM
MKRFQKGQFNMNDLKGQLEQMQKMGGMQGMMGMMPGMAKMSKQIEEAGFDDKVIVRQVALIQSMTKKERANPGMLQASRK
KRIAKGAGQDVSDLNKLLKMHRQMADAMKKMGKMGKKGLMRGGLGALMGKGGGMPAGMDAAGMGGMDPKALERAAKQMGA
GGGGLPGLGGMGDLSGLGKKK

Sequences:

>Translated_501_residues
MFENLSERLGGVFDRLTKQGALSEDDVRTALREVRVALLEADVSLPVARTFIKNVEKKATGAAVTKSITPGQQVIKIVHD
ELIATLRGADDPGVLKIDNPPAPILMVGLQGSGKTTTTAKLAKRLKDREGKKVLMASLDTNRPAAMEQLAILGTQIGVDT
LPIVPGEDPVQIAKRAKTQASLAGYDVYMLDTAGRLHIDAELIAQAAAVRDVANPRETLLVVDGLTGQDAVNVATEFDDK
IGVSGVVLTRMDGDGRGGAALSMREITGKPIRFVGLGEKMDAIETFEPERIAGRILGMGDIVALVEKAQETLEAEQAERM
MKRFQKGQFNMNDLKGQLEQMQKMGGMQGMMGMMPGMAKMSKQIEEAGFDDKVIVRQVALIQSMTKKERANPGMLQASRK
KRIAKGAGQDVSDLNKLLKMHRQMADAMKKMGKMGKKGLMRGGLGALMGKGGGMPAGMDAAGMGGMDPKALERAAKQMGA
GGGGLPGLGGMGDLSGLGKKK
>Mature_501_residues
MFENLSERLGGVFDRLTKQGALSEDDVRTALREVRVALLEADVSLPVARTFIKNVEKKATGAAVTKSITPGQQVIKIVHD
ELIATLRGADDPGVLKIDNPPAPILMVGLQGSGKTTTTAKLAKRLKDREGKKVLMASLDTNRPAAMEQLAILGTQIGVDT
LPIVPGEDPVQIAKRAKTQASLAGYDVYMLDTAGRLHIDAELIAQAAAVRDVANPRETLLVVDGLTGQDAVNVATEFDDK
IGVSGVVLTRMDGDGRGGAALSMREITGKPIRFVGLGEKMDAIETFEPERIAGRILGMGDIVALVEKAQETLEAEQAERM
MKRFQKGQFNMNDLKGQLEQMQKMGGMQGMMGMMPGMAKMSKQIEEAGFDDKVIVRQVALIQSMTKKERANPGMLQASRK
KRIAKGAGQDVSDLNKLLKMHRQMADAMKKMGKMGKKGLMRGGLGALMGKGGGMPAGMDAAGMGGMDPKALERAAKQMGA
GGGGLPGLGGMGDLSGLGKKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=449, Percent_Identity=30.7349665924276, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI226371618, Length=377, Percent_Identity=32.3607427055703, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=32.5, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI295424842, Length=303, Percent_Identity=29.3729372937294, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI23308697, Length=303, Percent_Identity=29.3729372937294, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1788963, Length=425, Percent_Identity=49.8823529411765, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1789874, Length=253, Percent_Identity=34.7826086956522, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17539958, Length=502, Percent_Identity=29.0836653386454, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI193206261, Length=303, Percent_Identity=29.3729372937294, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325345, Length=485, Percent_Identity=30.3092783505155, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320498, Length=265, Percent_Identity=29.0566037735849, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647949, Length=452, Percent_Identity=29.2035398230088, Blast_Score=188, Evalue=9e-48,
Organism=Drosophila melanogaster, GI24641198, Length=283, Percent_Identity=28.9752650176678, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 53218; Mature: 53218

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.2 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
7.2 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLSERLGGVFDRLTKQGALSEDDVRTALREVRVALLEADVSLPVARTFIKNVEKKAT
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GAAVTKSITPGQQVIKIVHDELIATLRGADDPGVLKIDNPPAPILMVGLQGSGKTTTTAK
CHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEECCCCCCHHHHH
LAKRLKDREGKKVLMASLDTNRPAAMEQLAILGTQIGVDTLPIVPGEDPVQIAKRAKTQA
HHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
SLAGYDVYMLDTAGRLHIDAELIAQAAAVRDVANPRETLLVVDGLTGQDAVNVATEFDDK
HHCCCEEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCHH
IGVSGVVLTRMDGDGRGGAALSMREITGKPIRFVGLGEKMDAIETFEPERIAGRILGMGD
CCCCEEEEEEECCCCCCCCEEEHHHHCCCCEEEEECCCHHHHHHHCCCHHHHHHHCCHHH
IVALVEKAQETLEAEQAERMMKRFQKGQFNMNDLKGQLEQMQKMGGMQGMMGMMPGMAKM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHH
SKQIEEAGFDDKVIVRQVALIQSMTKKERANPGMLQASRKKRIAKGAGQDVSDLNKLLKM
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
HRQMADAMKKMGKMGKKGLMRGGLGALMGKGGGMPAGMDAAGMGGMDPKALERAAKQMGA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
GGGGLPGLGGMGDLSGLGKKK
CCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFENLSERLGGVFDRLTKQGALSEDDVRTALREVRVALLEADVSLPVARTFIKNVEKKAT
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GAAVTKSITPGQQVIKIVHDELIATLRGADDPGVLKIDNPPAPILMVGLQGSGKTTTTAK
CHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEECCCCCCHHHHH
LAKRLKDREGKKVLMASLDTNRPAAMEQLAILGTQIGVDTLPIVPGEDPVQIAKRAKTQA
HHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
SLAGYDVYMLDTAGRLHIDAELIAQAAAVRDVANPRETLLVVDGLTGQDAVNVATEFDDK
HHCCCEEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCHH
IGVSGVVLTRMDGDGRGGAALSMREITGKPIRFVGLGEKMDAIETFEPERIAGRILGMGD
CCCCEEEEEEECCCCCCCCEEEHHHHCCCCEEEEECCCHHHHHHHCCCHHHHHHHCCHHH
IVALVEKAQETLEAEQAERMMKRFQKGQFNMNDLKGQLEQMQKMGGMQGMMGMMPGMAKM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHH
SKQIEEAGFDDKVIVRQVALIQSMTKKERANPGMLQASRKKRIAKGAGQDVSDLNKLLKM
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
HRQMADAMKKMGKMGKKGLMRGGLGALMGKGGGMPAGMDAAGMGGMDPKALERAAKQMGA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
GGGGLPGLGGMGDLSGLGKKK
CCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA