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The map label for this gene is ald [H]

Identifier: 89052949

GI number: 89052949

Start: 459549

End: 460667

Strand: Reverse

Name: ald [H]

Synonym: Jann_0458

Alternate gene names: 89052949

Gene position: 460667-459549 (Counterclockwise)

Preceding gene: 89052951

Following gene: 89052947

Centisome position: 10.67

GC content: 63.9

Gene sequence:

>1119_bases
ATGCATATCGGATGCCCCACAGAGATCAAACCGCAGGAATTTCGTGTCGGGATCACGCCCGCCGCCGCGCGCGAGGCCGT
CGTTCACGGCCACCGGGTGACCATGCAGGCCGGGGCTGGCACGGGCGCTGGCTTCACGGATGAGGATTACACCGCAGCAG
GGGCAGAGATCGCCGCCACGGCCAAGGACGTTTTCGCCGCGGCCCAGATGATCGTTAAGGTCAAGGAACCCCAAGCCGTT
GAACGCGCCATGCTGCGTAAGGGTCAGATCCTGTTCACTTACCTCCACCTTGCGCCCGATCCCGACCAAACCGCCGACCT
TCTGCAAAGCGGCGTCACGGCCATCGCCTATGAAACGGTGACGGACCGCACCGGCGGCCTGCCCCTGCTGGCCCCTATGT
CGGAGGTCGCGGGACGGTTGGCACCTCAGGTTGGGTCCTGGGCGCTGCAAAAGGCCAACGGGGGGGGCGGCGTGCTGATG
GGCGGTGTCCCCGGGGTTGGTCCGGCGGAGGTCGTCGTGATTGGCGGCGGCGTTGTCGGCACGCAGGCAGCGCGTGTGGC
GGCCGGTATGGGCGCGGATGTTACCATCCTTGATCGCTCGCTCCCACGTCTGCGGTATCTGGATGATGCCTATCGCGGTG
CGTTCAAGACGCGTTACGCCAGCGCCGATGCAACAGCGCAACTGATCACGACAGCGGATATGGTCATCGGTGCGGTTCTG
ATCCCCGGAGCTGCGGCGCCCAAACTGGTGACGAAGGACCAACTGTCGACGATGAACCCGGGCGCTGTCATCGTCGACGT
CGCCATCGATCAGGGTGGATGCTTTGAGACGTCGAAGGCCACCACCCATCAAGACCCGATCTATGAGGTCGATGGCGTCG
TCCACTATTGTGTTGCCAACATGCCCGGTGCAGTGGCCCGGACCTCAACGCTTGCGCTTGGCAATGCCACCATGCCCTTC
ATGCTGGCGCTGGCCGATAAGGGTTGGAAACAGGCCTGCGCCGATGATCCGCATCTGCTGGAGGGTCTGAACACCCATGA
GGGCAAGCTGACCAACTACGCCGTGGGCATGGCCCTGGGGCTTGATGTGCTATCCCCGTCACTCGCGATCAAAGGCTAG

Upstream 100 bases:

>100_bases
CTTGCGTGTTATCGCTCACACGCGCGCGACGTTTCAAAGCAATTCCACGTGGCCGGGCGTATTTTCCGCTCAGATGGTTC
GTGTTCGGGAGGAACAACAC

Downstream 100 bases:

>100_bases
CGCGCCGATGGGGCCGAGGTGTCACACCCTCGGCCCCGTCGCGTCTTGAACGGACGGTTGTTAGCCGCGGGCCTTCAAGC
CATCGCGGATCTCGATCAGC

Product: L-alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MHIGCPTEIKPQEFRVGITPAAAREAVVHGHRVTMQAGAGTGAGFTDEDYTAAGAEIAATAKDVFAAAQMIVKVKEPQAV
ERAMLRKGQILFTYLHLAPDPDQTADLLQSGVTAIAYETVTDRTGGLPLLAPMSEVAGRLAPQVGSWALQKANGGGGVLM
GGVPGVGPAEVVVIGGGVVGTQAARVAAGMGADVTILDRSLPRLRYLDDAYRGAFKTRYASADATAQLITTADMVIGAVL
IPGAAAPKLVTKDQLSTMNPGAVIVDVAIDQGGCFETSKATTHQDPIYEVDGVVHYCVANMPGAVARTSTLALGNATMPF
MLALADKGWKQACADDPHLLEGLNTHEGKLTNYAVGMALGLDVLSPSLAIKG

Sequences:

>Translated_372_residues
MHIGCPTEIKPQEFRVGITPAAAREAVVHGHRVTMQAGAGTGAGFTDEDYTAAGAEIAATAKDVFAAAQMIVKVKEPQAV
ERAMLRKGQILFTYLHLAPDPDQTADLLQSGVTAIAYETVTDRTGGLPLLAPMSEVAGRLAPQVGSWALQKANGGGGVLM
GGVPGVGPAEVVVIGGGVVGTQAARVAAGMGADVTILDRSLPRLRYLDDAYRGAFKTRYASADATAQLITTADMVIGAVL
IPGAAAPKLVTKDQLSTMNPGAVIVDVAIDQGGCFETSKATTHQDPIYEVDGVVHYCVANMPGAVARTSTLALGNATMPF
MLALADKGWKQACADDPHLLEGLNTHEGKLTNYAVGMALGLDVLSPSLAIKG
>Mature_372_residues
MHIGCPTEIKPQEFRVGITPAAAREAVVHGHRVTMQAGAGTGAGFTDEDYTAAGAEIAATAKDVFAAAQMIVKVKEPQAV
ERAMLRKGQILFTYLHLAPDPDQTADLLQSGVTAIAYETVTDRTGGLPLLAPMSEVAGRLAPQVGSWALQKANGGGGVLM
GGVPGVGPAEVVVIGGGVVGTQAARVAAGMGADVTILDRSLPRLRYLDDAYRGAFKTRYASADATAQLITTADMVIGAVL
IPGAAAPKLVTKDQLSTMNPGAVIVDVAIDQGGCFETSKATTHQDPIYEVDGVVHYCVANMPGAVARTSTLALGNATMPF
MLALADKGWKQACADDPHLLEGLNTHEGKLTNYAVGMALGLDVLSPSLAIKG

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=346, Percent_Identity=29.7687861271676, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI122939153, Length=346, Percent_Identity=29.7687861271676, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1787887, Length=303, Percent_Identity=31.023102310231, Blast_Score=111, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17550456, Length=349, Percent_Identity=27.2206303724928, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38325; Mature: 38325

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00837 ALADH_PNT_2 ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGCPTEIKPQEFRVGITPAAAREAVVHGHRVTMQAGAGTGAGFTDEDYTAAGAEIAAT
CCCCCCCCCCCCCEEEECCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHH
AKDVFAAAQMIVKVKEPQAVERAMLRKGQILFTYLHLAPDPDQTADLLQSGVTAIAYETV
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHCCCCEEEEEEC
TDRTGGLPLLAPMSEVAGRLAPQVGSWALQKANGGGGVLMGGVPGVGPAEVVVIGGGVVG
CCCCCCCEEECCHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCCEEEEECCCEEC
TQAARVAAGMGADVTILDRSLPRLRYLDDAYRGAFKTRYASADATAQLITTADMVIGAVL
HHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
IPGAAAPKLVTKDQLSTMNPGAVIVDVAIDQGGCFETSKATTHQDPIYEVDGVVHYCVAN
CCCCCCCCCEEHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
MPGAVARTSTLALGNATMPFMLALADKGWKQACADDPHLLEGLNTHEGKLTNYAVGMALG
CCCCHHHCEEEEECCCCHHHHEEECCCCHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHH
LDVLSPSLAIKG
HHHHCCCEECCC
>Mature Secondary Structure
MHIGCPTEIKPQEFRVGITPAAAREAVVHGHRVTMQAGAGTGAGFTDEDYTAAGAEIAAT
CCCCCCCCCCCCCEEEECCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHH
AKDVFAAAQMIVKVKEPQAVERAMLRKGQILFTYLHLAPDPDQTADLLQSGVTAIAYETV
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHCCCCEEEEEEC
TDRTGGLPLLAPMSEVAGRLAPQVGSWALQKANGGGGVLMGGVPGVGPAEVVVIGGGVVG
CCCCCCCEEECCHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCCEEEEECCCEEC
TQAARVAAGMGADVTILDRSLPRLRYLDDAYRGAFKTRYASADATAQLITTADMVIGAVL
HHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
IPGAAAPKLVTKDQLSTMNPGAVIVDVAIDQGGCFETSKATTHQDPIYEVDGVVHYCVAN
CCCCCCCCCEEHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
MPGAVARTSTLALGNATMPFMLALADKGWKQACADDPHLLEGLNTHEGKLTNYAVGMALG
CCCCHHHCEEEEECCCCHHHHEEECCCCHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHH
LDVLSPSLAIKG
HHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]