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The map label for this gene is zitB [H]

Identifier: 88658657

GI number: 88658657

Start: 60648

End: 61568

Strand: Direct

Name: zitB [H]

Synonym: ECH_0067

Alternate gene names: 88658657

Gene position: 60648-61568 (Clockwise)

Preceding gene: 88657935

Following gene: 88658044

Centisome position: 5.16

GC content: 31.38

Gene sequence:

>921_bases
ATGTCGCTTATTCATAAAAATAAGCCTTCCAACCATGAAAATAAGCTAATATATGCTATTTTTATTATTATCATTACGAT
GGTTGTAGAAGTAGTTGGGGGGATAATATCAAATTCTTTGGCATTGCTTTCAGATGCTGGACATATGTTTACTGATTTTA
TTTCTTTGTTATTAAGTTGGTTAGCATATAAAGTTGCTATGAAAAAATCAGATTCATGTCGTTCCTATGGTTATCATAGA
TTTCAAGTTGTTGCTGCTTTTATTAATGGACTCACTTTGTTTGGTATAGCCATTTTAATTATCTTGGAGTCGATAAAGCG
CTTTTTTTCTCCAGAAGAAGTTTGCTGGGAAATTATGATGTCTGTTGCAATATTAGGATTGATAGCAAATGTTGTATCAT
TTTTTCTACTGTATAGAAAAAATGAGAGTAATTTGAACCTTAAAAGTGCAGTTCTGCATGTTGTTGGTGACTTGTTAGGG
TCAGTTGCAGCGATTGTTGCTTCTGTTGTGATTATGTTTACTTCATGGCAGATAGTGGATCCTCTTTTATCAGTATTTGT
CAGTATTATAATACTTGGTGGTGCATATAGGATTATTAAGAATTCTGGTCACATTTTACTTGAAGGTACTCCAGATAATA
TAGATCCGGATAAGATTAGAAAAACTGTTTCTGAAAACATTGCTGAAGTTTTGGATATACATCATATTCATATTTGGTCA
TTAACTACAGATCATCCAATTATGACAATGCATGTTAAACTTGATAAGGCAGCTGTAACTGATAATTTAAAGTATAGTCA
AGTATTAGTATCTATCAAAAAATTACTGAGCAGAGATTTTGGTATTATTCATGTTACTATTGAAGCTGAATACGATAATT
GTGCTGATGATAGTGTTATGATTAAGACAGCTCATAATTAA

Upstream 100 bases:

>100_bases
GGGTAATTAGCTCATTTGGTTAGAGCACTTGCTTGACGTGCAAGAGGTGACTGGTTCGAATCCAGTATTGCCCACTGGTC
TGACGTAATTTGGTTATAAA

Downstream 100 bases:

>100_bases
ATTAACAGTATGGACTGTAATTAAGTGACTAACAATTATTTGATAGGTTAGTATCTTTATTATGTTTTTCTTGATTGAGA
TCTTTAAAATGTTAAACGGT

Product: cation diffusion facilitator transporter family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSLIHKNKPSNHENKLIYAIFIIIITMVVEVVGGIISNSLALLSDAGHMFTDFISLLLSWLAYKVAMKKSDSCRSYGYHR
FQVVAAFINGLTLFGIAILIILESIKRFFSPEEVCWEIMMSVAILGLIANVVSFFLLYRKNESNLNLKSAVLHVVGDLLG
SVAAIVASVVIMFTSWQIVDPLLSVFVSIIILGGAYRIIKNSGHILLEGTPDNIDPDKIRKTVSENIAEVLDIHHIHIWS
LTTDHPIMTMHVKLDKAAVTDNLKYSQVLVSIKKLLSRDFGIIHVTIEAEYDNCADDSVMIKTAHN

Sequences:

>Translated_306_residues
MSLIHKNKPSNHENKLIYAIFIIIITMVVEVVGGIISNSLALLSDAGHMFTDFISLLLSWLAYKVAMKKSDSCRSYGYHR
FQVVAAFINGLTLFGIAILIILESIKRFFSPEEVCWEIMMSVAILGLIANVVSFFLLYRKNESNLNLKSAVLHVVGDLLG
SVAAIVASVVIMFTSWQIVDPLLSVFVSIIILGGAYRIIKNSGHILLEGTPDNIDPDKIRKTVSENIAEVLDIHHIHIWS
LTTDHPIMTMHVKLDKAAVTDNLKYSQVLVSIKKLLSRDFGIIHVTIEAEYDNCADDSVMIKTAHN
>Mature_305_residues
SLIHKNKPSNHENKLIYAIFIIIITMVVEVVGGIISNSLALLSDAGHMFTDFISLLLSWLAYKVAMKKSDSCRSYGYHRF
QVVAAFINGLTLFGIAILIILESIKRFFSPEEVCWEIMMSVAILGLIANVVSFFLLYRKNESNLNLKSAVLHVVGDLLGS
VAAIVASVVIMFTSWQIVDPLLSVFVSIIILGGAYRIIKNSGHILLEGTPDNIDPDKIRKTVSENIAEVLDIHHIHIWSL
TTDHPIMTMHVKLDKAAVTDNLKYSQVLVSIKKLLSRDFGIIHVTIEAEYDNCADDSVMIKTAHN

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=296, Percent_Identity=26.0135135135135, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI21359890, Length=303, Percent_Identity=27.3927392739274, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI64762489, Length=287, Percent_Identity=29.2682926829268, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI289803013, Length=287, Percent_Identity=29.2682926829268, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI289803009, Length=287, Percent_Identity=29.2682926829268, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI289803007, Length=287, Percent_Identity=29.2682926829268, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI289803003, Length=287, Percent_Identity=29.2682926829268, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI21361112, Length=306, Percent_Identity=25.1633986928105, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI20070323, Length=319, Percent_Identity=25.0783699059561, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI14210520, Length=222, Percent_Identity=23.8738738738739, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI222080086, Length=109, Percent_Identity=37.6146788990826, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI40255009, Length=109, Percent_Identity=37.6146788990826, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI52351208, Length=161, Percent_Identity=29.8136645962733, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI52352803, Length=131, Percent_Identity=29.7709923664122, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI169162025, Length=128, Percent_Identity=32.03125, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI169162520, Length=128, Percent_Identity=32.03125, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI169161196, Length=128, Percent_Identity=32.03125, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786966, Length=285, Percent_Identity=41.0526315789474, Blast_Score=197, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI193210990, Length=285, Percent_Identity=32.6315789473684, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17555794, Length=306, Percent_Identity=25.8169934640523, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17555796, Length=305, Percent_Identity=25.5737704918033, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI32564488, Length=317, Percent_Identity=26.813880126183, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17550442, Length=207, Percent_Identity=25.6038647342995, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17550440, Length=207, Percent_Identity=25.6038647342995, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320411, Length=180, Percent_Identity=31.1111111111111, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323899, Length=139, Percent_Identity=31.6546762589928, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=130, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24656728, Length=343, Percent_Identity=25.9475218658892, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656724, Length=343, Percent_Identity=25.9475218658892, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656720, Length=343, Percent_Identity=25.9475218658892, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656715, Length=343, Percent_Identity=25.9475218658892, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21357035, Length=343, Percent_Identity=25.9475218658892, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24583858, Length=325, Percent_Identity=25.5384615384615, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24585900, Length=125, Percent_Identity=30.4, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585898, Length=125, Percent_Identity=30.4, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585896, Length=125, Percent_Identity=30.4, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921672, Length=125, Percent_Identity=30.4, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24645863, Length=107, Percent_Identity=41.1214953271028, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24584409, Length=121, Percent_Identity=33.8842975206612, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574430, Length=121, Percent_Identity=33.8842975206612, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34048; Mature: 33916

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIHKNKPSNHENKLIYAIFIIIITMVVEVVGGIISNSLALLSDAGHMFTDFISLLLSW
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LAYKVAMKKSDSCRSYGYHRFQVVAAFINGLTLFGIAILIILESIKRFFSPEEVCWEIMM
HHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SVAILGLIANVVSFFLLYRKNESNLNLKSAVLHVVGDLLGSVAAIVASVVIMFTSWQIVD
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLLSVFVSIIILGGAYRIIKNSGHILLEGTPDNIDPDKIRKTVSENIAEVLDIHHIHIWS
HHHHHHHHHHHHCCHHEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEE
LTTDHPIMTMHVKLDKAAVTDNLKYSQVLVSIKKLLSRDFGIIHVTIEAEYDNCADDSVM
EECCCCEEEEEEEECHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEE
IKTAHN
EEECCC
>Mature Secondary Structure 
SLIHKNKPSNHENKLIYAIFIIIITMVVEVVGGIISNSLALLSDAGHMFTDFISLLLSW
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LAYKVAMKKSDSCRSYGYHRFQVVAAFINGLTLFGIAILIILESIKRFFSPEEVCWEIMM
HHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SVAILGLIANVVSFFLLYRKNESNLNLKSAVLHVVGDLLGSVAAIVASVVIMFTSWQIVD
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLLSVFVSIIILGGAYRIIKNSGHILLEGTPDNIDPDKIRKTVSENIAEVLDIHHIHIWS
HHHHHHHHHHHHCCHHEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEE
LTTDHPIMTMHVKLDKAAVTDNLKYSQVLVSIKKLLSRDFGIIHVTIEAEYDNCADDSVM
EECCCCEEEEEEEECHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEE
IKTAHN
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]