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The map label for this gene is dapB

Identifier: 88658614

GI number: 88658614

Start: 420651

End: 421454

Strand: Direct

Name: dapB

Synonym: ECH_0443

Alternate gene names: 88658614

Gene position: 420651-421454 (Clockwise)

Preceding gene: 88658132

Following gene: 88657871

Centisome position: 35.76

GC content: 35.7

Gene sequence:

>804_bases
ATGACACGAGTAAATATAGGTATAGTTGGTTGTTTGGGTAAACAAGGGAGAAGGTTGGTTAGTGAAATATCAGCGAGTCC
TTATGCTCAAGTAAGTGGGGGGCTTGTTCGTTCAGGAAATCCACATGTTGGGCAAATTTTAGGAGAAGTTGTAGGATGTG
ATTGTTCTGTCAAAATTACTGATTCTTTGGAACATCTTTTTGAAACTTCAGATATTGTTATAGAATTTACTAATCCTGAC
ATGTTATTAGAGTGTATCAAAATGGCTGAACAGAAGAAAAAGCCTTTATTAAGTGGTACTACTGGTCCAGCTGCTACAGA
AATGGTTTTTGAAGATTATATTAAGAGTATACCATTTTTATGGACTACAAATGTAAGTTTTGGTGTTAATATACTTGCAA
AATTGGTTCAAGAGGCTGCAAAGAAGCTGTTTGATTATGATATTGAAATATGGGAGATGCATCATAGATATAAGAAGGAT
TCTCCATCTGGTACATCTTTAATTTTAGGAAAAGCTGCAGCTAAGGGAAGAAATGTTCCTTTCCAAATGGCTCAATATGT
GAGAGGTACTCCACAGGAAGCTAGAAAAGATGTGAATACTATTGGATATTCTGTATCTAGAGGTGGTGCTGATTTAAGTG
ATCATAGAGTCATGTTTGTCAGTGATGAGGAAATGATAGACTTTAATCATAGAACGTTAAATAAAAACCTTTATGCAAAA
GGAGCTTTAAAAGCTGCATTATGGTTAGTCAAGCAACCTCCTGGTGTATACACAATGTCAGATATGATGGCTGCTGTAGA
GTAG

Upstream 100 bases:

>100_bases
AGATTATAGTTGGTGAGGTCATAAATTGTGCAAAACTAAATAATGATGATAAACCATTGGCGTACTACAAAGGTAAATAT
ATGGTTATAGGAGGTGTGTT

Downstream 100 bases:

>100_bases
TTATTTAATTAGGGTTAATATGTCACAACGAATTCATGCTTCAGCTAGAAATTTAAGTTTATGGTATGATACTAACCAAA
TTTTATATGATATAAATTTG

Product: dihydrodipicolinate reductase

Products: NA

Alternate protein names: DHPR

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MTRVNIGIVGCLGKQGRRLVSEISASPYAQVSGGLVRSGNPHVGQILGEVVGCDCSVKITDSLEHLFETSDIVIEFTNPD
MLLECIKMAEQKKKPLLSGTTGPAATEMVFEDYIKSIPFLWTTNVSFGVNILAKLVQEAAKKLFDYDIEIWEMHHRYKKD
SPSGTSLILGKAAAKGRNVPFQMAQYVRGTPQEARKDVNTIGYSVSRGGADLSDHRVMFVSDEEMIDFNHRTLNKNLYAK
GALKAALWLVKQPPGVYTMSDMMAAVE

Sequences:

>Translated_267_residues
MTRVNIGIVGCLGKQGRRLVSEISASPYAQVSGGLVRSGNPHVGQILGEVVGCDCSVKITDSLEHLFETSDIVIEFTNPD
MLLECIKMAEQKKKPLLSGTTGPAATEMVFEDYIKSIPFLWTTNVSFGVNILAKLVQEAAKKLFDYDIEIWEMHHRYKKD
SPSGTSLILGKAAAKGRNVPFQMAQYVRGTPQEARKDVNTIGYSVSRGGADLSDHRVMFVSDEEMIDFNHRTLNKNLYAK
GALKAALWLVKQPPGVYTMSDMMAAVE
>Mature_266_residues
TRVNIGIVGCLGKQGRRLVSEISASPYAQVSGGLVRSGNPHVGQILGEVVGCDCSVKITDSLEHLFETSDIVIEFTNPDM
LLECIKMAEQKKKPLLSGTTGPAATEMVFEDYIKSIPFLWTTNVSFGVNILAKLVQEAAKKLFDYDIEIWEMHHRYKKDS
PSGTSLILGKAAAKGRNVPFQMAQYVRGTPQEARKDVNTIGYSVSRGGADLSDHRVMFVSDEEMIDFNHRTLNKNLYAKG
ALKAALWLVKQPPGVYTMSDMMAAVE

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; second step. [C]

COG id: COG0289

COG function: function code E; Dihydrodipicolinate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydrodipicolinate reductase family

Homologues:

Organism=Escherichia coli, GI1786214, Length=263, Percent_Identity=31.5589353612167, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPB_EHRCR (Q2GH22)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_507261.1
- HSSP:   Q9X1K8
- ProteinModelPortal:   Q2GH22
- SMR:   Q2GH22
- STRING:   Q2GH22
- GeneID:   3927319
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_0443
- TIGR:   ECH_0443
- eggNOG:   COG0289
- HOGENOM:   HBG594002
- OMA:   GALKACE
- PhylomeDB:   Q2GH22
- ProtClustDB:   PRK00048
- BioCyc:   ECHA205920:ECH_0443-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00102
- InterPro:   IPR022663
- InterPro:   IPR000846
- InterPro:   IPR022664
- InterPro:   IPR011770
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR20836
- TIGRFAMs:   TIGR00036

Pfam domain/function: PF05173 DapB_C; PF01113 DapB_N

EC number: =1.3.1.26

Molecular weight: Translated: 29405; Mature: 29274

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS01298 DAPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVNIGIVGCLGKQGRRLVSEISASPYAQVSGGLVRSGNPHVGQILGEVVGCDCSVKIT
CCEEEEEEEECCCHHHHHHHHHHCCCCCHHHCCCEEECCCCHHHHHHHHHHCCCCEEEEH
DSLEHLFETSDIVIEFTNPDMLLECIKMAEQKKKPLLSGTTGPAATEMVFEDYIKSIPFL
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCEE
WTTNVSFGVNILAKLVQEAAKKLFDYDIEIWEMHHRYKKDSPSGTSLILGKAAAKGRNVP
EECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEECHHCCCCCCC
FQMAQYVRGTPQEARKDVNTIGYSVSRGGADLSDHRVMFVSDEEMIDFNHRTLNKNLYAK
HHHHHHHCCCHHHHHHHHHHHCCEECCCCCCCCCCEEEEEECCCCCCCCCHHHCCCHHHH
GALKAALWLVKQPPGVYTMSDMMAAVE
HHHHHHHHHHCCCCCCEEHHHHHHHCC
>Mature Secondary Structure 
TRVNIGIVGCLGKQGRRLVSEISASPYAQVSGGLVRSGNPHVGQILGEVVGCDCSVKIT
CEEEEEEEECCCHHHHHHHHHHCCCCCHHHCCCEEECCCCHHHHHHHHHHCCCCEEEEH
DSLEHLFETSDIVIEFTNPDMLLECIKMAEQKKKPLLSGTTGPAATEMVFEDYIKSIPFL
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCEE
WTTNVSFGVNILAKLVQEAAKKLFDYDIEIWEMHHRYKKDSPSGTSLILGKAAAKGRNVP
EECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEECHHCCCCCCC
FQMAQYVRGTPQEARKDVNTIGYSVSRGGADLSDHRVMFVSDEEMIDFNHRTLNKNLYAK
HHHHHHHCCCHHHHHHHHHHHCCEECCCCCCCCCCEEEEEECCCCCCCCCHHHCCCHHHH
GALKAALWLVKQPPGVYTMSDMMAAVE
HHHHHHHHHHCCCCCCEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA