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The map label for this gene is tkt [H]

Identifier: 88658548

GI number: 88658548

Start: 442242

End: 444233

Strand: Direct

Name: tkt [H]

Synonym: ECH_0465

Alternate gene names: 88658548

Gene position: 442242-444233 (Clockwise)

Preceding gene: 88658190

Following gene: 88658258

Centisome position: 37.6

GC content: 33.03

Gene sequence:

>1992_bases
ATGGACAACGAATATAATGATATGGTAAATATGGCTAATGCCATTAGGGTGTTATCAGTAGATGCTATACAGAAAGCTGC
GTCTGGACATCCAGGTATGCCTCTTGGAATGGCAGATGTTGCTACAGTATTGTTTGCAAAGTTTTTAAAATTTAATCCTA
AAGATCCTAATTGGTTTGATAGAGATAGATTTGTGTTATCAAATGGCCATGGATCTATGTTGCTGTATTCCATATTATAT
TTTTTAGGATGTTTAGATATAGAAGAAATAAAAAGATTTAGACAAATTCATTCTTTAACTCCTGGACACCCAGAATATGG
ATACACTCCTGGAGTAGATGCTACTACTGGCCCATTAGGTCAGGGTTTAGCGTGTGCAGTAGGTATGGCAATAGCAGAAA
AAATATTGTCTGAAAAATTTGGCAGTGAAATTGTAAATCATACTACTTATGTTATGGTTGGTGATGGATGCCTTATGGAA
GGCATTAGTCATGAAGCAGCATCTTTGGCAGGACATTTGCAGTTGAATAAATTGATAGTATTATTTGATGACAATAATAT
TTCAATAGATGGTCCAATTTCTTTATCTGTTTCAGATGATGTTAAAGCTAGGTTTTTGTCTTATCAGTGGGATGTTTTTG
AAATAGATGGGCATGATTTTGGTCAGATTGAATCTTCAATTAAAAATGCTCAGAAATCTGAAAAACCTTCTTTGATTTGT
TGTAAGACGGTTATTGGAAAGCATCTTTCTTCAAAAGAAAATACATGTGCTGCACATAGTTGGCCATTTTCAGAAGAAGA
AGTAATGTTGATGAAAGAGAAATTAAATTGGCAATGTAATCCATTTAATATACCAGAAGAAATTTTGCAGTTATGGAAGA
ATGTTTCTAGTAGATCAGAAGATGAATACAACATGTGGCTTGATAGGTCTGCGAAATATAGTAAAACTTTTGATGATTTT
GTAGATATGATGAAGGAAGGTGTTCCTGATTCAGTTTTTTTAGGTTTGAAAGAATTTAAAAAAGAACTTTATGCTTTAAA
CTTAAGTGAAGCAACTCGTAGGACTTCTGGTAGAGTATTAGAAGTTATAGCAAAGCATACAAGTAAATTAATAGGTGGAT
CTGCTGATCTTACTAATTCTAATAATACTAAACCACAGTTAATATCAATTATTAACAGAAGTAATTTTAATGGATCTTAT
TTGCATTATGGTATTAGAGAACATGCTATGGCAGGGTGTATGAATGGTATGGCATTGCATGGTGGAATGATTCCTTATGG
TGGAACATTTTTAGTTTTTTCTGATTATTGTAGACCAGCTATTAGATTGTCTGCATTGATGAAAAAACAAGTTATTTATG
TTATGACACATGATTCTATTGGAGTAGGAGAGGATGGGCCAACTCATCAACCTATAGAGCACTTATCATCTTTACGATCG
ATCCCTAATTTATATGTTTTTAGACCAGCTGATGCTATTGAAGTATTAGAATGTTGGGAAATTGCATTAAAGTTAACTAG
TTCTCCATCTGTGTTTATACTATCTAGACAAAATGTTGGCAGTGTTCGCAGTGTATCTGTTGATGAGAATTTATCTAATA
AAGGTGCATATGTTATACGTGAATATGAGAAGGATTTAGATGTTACCATTTTTGCCACAGGGTCTGAAGTGGAGATTGCA
CTAAAAGCATCTGATATTTTGAAAAGTAAAGGGTTAGGTACAAGAGTAGTATCTATTCCTTGCTGGGAGTTGTTTGTTCA
GCAAGATAAAAAGTATATATTCAATTTATTGAATAATAAAAGCATTAAAGCTGCGGTAGAAGCTGCAAGTTCTTTTGGAT
GGCATAGATACATAGGAGAAAATGGTATTTTTGTAGGTTTAGAGGATTTTGGGATATCTGCTCCATATAAGGATTTATAT
AAACATTTTGGAATCACTGCGGAAGGTTTAGTAAACAAGATACTTGATAAGTTGAAAATTAATACAAATTAG

Upstream 100 bases:

>100_bases
AATTTCTATAAAAATTATCTTACAAATAAGTATCTCAACATGTAGATCGTTGTATGTGTTTAGCTAAAGCTATGTATTGT
TAATTTAATGAGAATGAAAT

Downstream 100 bases:

>100_bases
ATGAATATAAGTAATCAATTTTATTAAATATTTGTAAACGAAATTTTTAAGCATTGTAGAACAAACTTTAATTGGTTTAA
TCTATTTTTTAGTATTGAAT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MDNEYNDMVNMANAIRVLSVDAIQKAASGHPGMPLGMADVATVLFAKFLKFNPKDPNWFDRDRFVLSNGHGSMLLYSILY
FLGCLDIEEIKRFRQIHSLTPGHPEYGYTPGVDATTGPLGQGLACAVGMAIAEKILSEKFGSEIVNHTTYVMVGDGCLME
GISHEAASLAGHLQLNKLIVLFDDNNISIDGPISLSVSDDVKARFLSYQWDVFEIDGHDFGQIESSIKNAQKSEKPSLIC
CKTVIGKHLSSKENTCAAHSWPFSEEEVMLMKEKLNWQCNPFNIPEEILQLWKNVSSRSEDEYNMWLDRSAKYSKTFDDF
VDMMKEGVPDSVFLGLKEFKKELYALNLSEATRRTSGRVLEVIAKHTSKLIGGSADLTNSNNTKPQLISIINRSNFNGSY
LHYGIREHAMAGCMNGMALHGGMIPYGGTFLVFSDYCRPAIRLSALMKKQVIYVMTHDSIGVGEDGPTHQPIEHLSSLRS
IPNLYVFRPADAIEVLECWEIALKLTSSPSVFILSRQNVGSVRSVSVDENLSNKGAYVIREYEKDLDVTIFATGSEVEIA
LKASDILKSKGLGTRVVSIPCWELFVQQDKKYIFNLLNNKSIKAAVEAASSFGWHRYIGENGIFVGLEDFGISAPYKDLY
KHFGITAEGLVNKILDKLKINTN

Sequences:

>Translated_663_residues
MDNEYNDMVNMANAIRVLSVDAIQKAASGHPGMPLGMADVATVLFAKFLKFNPKDPNWFDRDRFVLSNGHGSMLLYSILY
FLGCLDIEEIKRFRQIHSLTPGHPEYGYTPGVDATTGPLGQGLACAVGMAIAEKILSEKFGSEIVNHTTYVMVGDGCLME
GISHEAASLAGHLQLNKLIVLFDDNNISIDGPISLSVSDDVKARFLSYQWDVFEIDGHDFGQIESSIKNAQKSEKPSLIC
CKTVIGKHLSSKENTCAAHSWPFSEEEVMLMKEKLNWQCNPFNIPEEILQLWKNVSSRSEDEYNMWLDRSAKYSKTFDDF
VDMMKEGVPDSVFLGLKEFKKELYALNLSEATRRTSGRVLEVIAKHTSKLIGGSADLTNSNNTKPQLISIINRSNFNGSY
LHYGIREHAMAGCMNGMALHGGMIPYGGTFLVFSDYCRPAIRLSALMKKQVIYVMTHDSIGVGEDGPTHQPIEHLSSLRS
IPNLYVFRPADAIEVLECWEIALKLTSSPSVFILSRQNVGSVRSVSVDENLSNKGAYVIREYEKDLDVTIFATGSEVEIA
LKASDILKSKGLGTRVVSIPCWELFVQQDKKYIFNLLNNKSIKAAVEAASSFGWHRYIGENGIFVGLEDFGISAPYKDLY
KHFGITAEGLVNKILDKLKINTN
>Mature_663_residues
MDNEYNDMVNMANAIRVLSVDAIQKAASGHPGMPLGMADVATVLFAKFLKFNPKDPNWFDRDRFVLSNGHGSMLLYSILY
FLGCLDIEEIKRFRQIHSLTPGHPEYGYTPGVDATTGPLGQGLACAVGMAIAEKILSEKFGSEIVNHTTYVMVGDGCLME
GISHEAASLAGHLQLNKLIVLFDDNNISIDGPISLSVSDDVKARFLSYQWDVFEIDGHDFGQIESSIKNAQKSEKPSLIC
CKTVIGKHLSSKENTCAAHSWPFSEEEVMLMKEKLNWQCNPFNIPEEILQLWKNVSSRSEDEYNMWLDRSAKYSKTFDDF
VDMMKEGVPDSVFLGLKEFKKELYALNLSEATRRTSGRVLEVIAKHTSKLIGGSADLTNSNNTKPQLISIINRSNFNGSY
LHYGIREHAMAGCMNGMALHGGMIPYGGTFLVFSDYCRPAIRLSALMKKQVIYVMTHDSIGVGEDGPTHQPIEHLSSLRS
IPNLYVFRPADAIEVLECWEIALKLTSSPSVFILSRQNVGSVRSVSVDENLSNKGAYVIREYEKDLDVTIFATGSEVEIA
LKASDILKSKGLGTRVVSIPCWELFVQQDKKYIFNLLNNKSIKAAVEAASSFGWHRYIGENGIFVGLEDFGISAPYKDLY
KHFGITAEGLVNKILDKLKINTN

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=579, Percent_Identity=25.9067357512953, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI4507521, Length=579, Percent_Identity=25.9067357512953, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI133778974, Length=574, Percent_Identity=27.5261324041812, Blast_Score=176, Evalue=6e-44,
Organism=Escherichia coli, GI1788808, Length=655, Percent_Identity=47.6335877862595, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=45.9909228441755, Blast_Score=593, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI17539652, Length=577, Percent_Identity=26.3431542461005, Blast_Score=176, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6325331, Length=669, Percent_Identity=40.6576980568012, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6319593, Length=673, Percent_Identity=40.5646359583952, Blast_Score=459, Evalue=1e-130,
Organism=Drosophila melanogaster, GI45551847, Length=584, Percent_Identity=27.2260273972603, Blast_Score=183, Evalue=4e-46,
Organism=Drosophila melanogaster, GI45550715, Length=584, Percent_Identity=27.2260273972603, Blast_Score=183, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24666278, Length=584, Percent_Identity=25.513698630137, Blast_Score=168, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24645119, Length=548, Percent_Identity=27.007299270073, Blast_Score=159, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73705; Mature: 73705

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNEYNDMVNMANAIRVLSVDAIQKAASGHPGMPLGMADVATVLFAKFLKFNPKDPNWFD
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
RDRFVLSNGHGSMLLYSILYFLGCLDIEEIKRFRQIHSLTPGHPEYGYTPGVDATTGPLG
CCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
QGLACAVGMAIAEKILSEKFGSEIVNHTTYVMVGDGCLMEGISHEAASLAGHLQLNKLIV
CCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHCCCHHHHHHHHEEEEEEEEE
LFDDNNISIDGPISLSVSDDVKARFLSYQWDVFEIDGHDFGQIESSIKNAQKSEKPSLIC
EECCCCEEECCCEEEEECCCHHHHHHEEECEEEEECCCCHHHHHHHHHHHHHCCCCCEEE
CKTVIGKHLSSKENTCAAHSWPFSEEEVMLMKEKLNWQCNPFNIPEEILQLWKNVSSRSE
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
DEYNMWLDRSAKYSKTFDDFVDMMKEGVPDSVFLGLKEFKKELYALNLSEATRRTSGRVL
CCHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHH
EVIAKHTSKLIGGSADLTNSNNTKPQLISIINRSNFNGSYLHYGIREHAMAGCMNGMALH
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEECCHHHHHHHHHHCCCCCC
GGMIPYGGTFLVFSDYCRPAIRLSALMKKQVIYVMTHDSIGVGEDGPTHQPIEHLSSLRS
CCCCCCCCEEEEEHHHCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHC
IPNLYVFRPADAIEVLECWEIALKLTSSPSVFILSRQNVGSVRSVSVDENLSNKGAYVIR
CCCEEEECCCCHHHHHHHHHHHHEECCCCCEEEEECCCCCCEEEEECCCCCCCCCCEEEE
EYEKDLDVTIFATGSEVEIALKASDILKSKGLGTRVVSIPCWELFVQQDKKYIFNLLNNK
EECCCCCEEEEEECCEEEEEEEHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHCCC
SIKAAVEAASSFGWHRYIGENGIFVGLEDFGISAPYKDLYKHFGITAEGLVNKILDKLKI
HHHHHHHHHHHCCHHEEECCCCEEEEEHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC
NTN
CCC
>Mature Secondary Structure
MDNEYNDMVNMANAIRVLSVDAIQKAASGHPGMPLGMADVATVLFAKFLKFNPKDPNWFD
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
RDRFVLSNGHGSMLLYSILYFLGCLDIEEIKRFRQIHSLTPGHPEYGYTPGVDATTGPLG
CCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
QGLACAVGMAIAEKILSEKFGSEIVNHTTYVMVGDGCLMEGISHEAASLAGHLQLNKLIV
CCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHCCCHHHHHHHHEEEEEEEEE
LFDDNNISIDGPISLSVSDDVKARFLSYQWDVFEIDGHDFGQIESSIKNAQKSEKPSLIC
EECCCCEEECCCEEEEECCCHHHHHHEEECEEEEECCCCHHHHHHHHHHHHHCCCCCEEE
CKTVIGKHLSSKENTCAAHSWPFSEEEVMLMKEKLNWQCNPFNIPEEILQLWKNVSSRSE
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
DEYNMWLDRSAKYSKTFDDFVDMMKEGVPDSVFLGLKEFKKELYALNLSEATRRTSGRVL
CCHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHH
EVIAKHTSKLIGGSADLTNSNNTKPQLISIINRSNFNGSYLHYGIREHAMAGCMNGMALH
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEECCHHHHHHHHHHCCCCCC
GGMIPYGGTFLVFSDYCRPAIRLSALMKKQVIYVMTHDSIGVGEDGPTHQPIEHLSSLRS
CCCCCCCCEEEEEHHHCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHC
IPNLYVFRPADAIEVLECWEIALKLTSSPSVFILSRQNVGSVRSVSVDENLSNKGAYVIR
CCCEEEECCCCHHHHHHHHHHHHEECCCCCEEEEECCCCCCEEEEECCCCCCCCCCEEEE
EYEKDLDVTIFATGSEVEIALKASDILKSKGLGTRVVSIPCWELFVQQDKKYIFNLLNNK
EECCCCCEEEEEECCEEEEEEEHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHCCC
SIKAAVEAASSFGWHRYIGENGIFVGLEDFGISAPYKDLYKHFGITAEGLVNKILDKLKI
HHHHHHHHHHHCCHHEEECCCCEEEEEHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC
NTN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA