Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 88658075

GI number: 88658075

Start: 1136453

End: 1137901

Strand: Reverse

Name: icd [H]

Synonym: ECH_1114

Alternate gene names: 88658075

Gene position: 1137901-1136453 (Counterclockwise)

Preceding gene: 88658311

Following gene: 88657805

Centisome position: 96.74

GC content: 32.78

Gene sequence:

>1449_bases
ATGTCAATTCCAATAACAGTTGCTTATGGAGATGGTATTGGCCCAGAAATTATGGAAGCTGTACTATTGATCTTGAGTGA
AGCAGAATCAGGTCTAGTTGTAGAAACTATAGAGGTGGGACACAATTTATATAAAAAAGAATGGTCTTCTGGTATTGCGC
CTTCATCTTGGGATTCTATTTATAGAACGAAAGTACTGCTTAAGTCTCCTACCATGACTCCACAAGGTCGTGGGCATAAA
AGTCTTAATGTTACGTTGAGAAAGAGATTAGGGTTGTATGCAAATATTAGGCCATGTATTTCTTATCATCCTGTGATAAA
GACAAGGTATCCTAATCTCAATGTAGTGATAGTTCGAGAAAATGAGGAAGATACATATACTGGTATAGAACATAGGCTGA
CTAATGATACGTATCAATGCTCAAAAGTTATTACGAGATCAGGTTCAGAAAGAATATGTGATTATGCATTTCACTATGCT
AAGGTTCATAATAGGAAGAGAGTTACTTGCTTGATAAAAGATAATATTATGAAAATGACAGATGGAATTTTTCATAAGTC
TTTTTCAAAGATTGCAGAGAATTATCCTGACATTGAATCAGATCATTATATTGTTGATATTGGAATGGCAAAAGTGGCTT
CTAACCCTGAAAATTTTGATGTTATAGTTACTACTAATCTTTATGGTGATATAGTGTCTGATATAGTTGCTGAATTATCA
GGGTCTATAGGCCTTGCAGGTAGTGCTAATATAGGGAATAATTATGCAATGTTTGAAGCTGTTCATGGTTCAGCTCCAGA
TATAGCTGGAAAGAACATAGCAAATCCTTCTGGATTACTTAATGCAGCTATACAAATGTTGATGTATTTAAAACAGTTTG
ACAAGGCACAGCTAATTTATAATGCATTTCTTAAAACTTTAGAAGATGGTATTCATACAGCAGATATTTACCAAAGTCAG
GTTAGCAAGAAAAAAGTTTCTACAATGGATTTTGCTAAGGCTGTTGTTGAAAATTTTGGACAATCTCCATCTCAATTACC
AAAATCAATGTTTCAGGATAATGTAGATAGGACGGGTGTATCTTATACATATGAACCATCTTATGTTACTAGAGTTCTTG
TAGGAGTGGATATTACTATTGGTTGTGATGGTGTAGGACTAGATTTTAAGCAGTTAATTAATAATCTTCAAAATATTACA
CATGATAAACTGGAGCTTGTGCTAATTCATAATAAAGGATTAGAAATTTGGCCTGATGAATCTGTGAGTGTAAATCTTTC
TTATATGGATCAGGTATGTTGTAGGTTTTACATGAAAAGTAAAGATGATAAAATCATGAATGAGCATATTAATCAGTTGC
TTTTTGACATAGAGCAAAAGAAAATAGATGTAGTAAAAATGGAAAAATTATACTTATATAATGATCAACCTGGCTTTTTT
ACTATGTAA

Upstream 100 bases:

>100_bases
TTGATATATTTTTGTTGTTTTTAATATTATATTGTCTATATAATCAAATTTTTTAGTCTGGAAGATATACTATATTATTG
TTGAAAATGGAAGAAGTATA

Downstream 100 bases:

>100_bases
TGATTGTTGTTATACGTGTTGCTTTTAACCTAGATTAAAAAATAAGTTAGTAGCTTGTTAATGTAATATGAATTTCTTTT
TAGTAAGAAATAATTAGCAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSIPITVAYGDGIGPEIMEAVLLILSEAESGLVVETIEVGHNLYKKEWSSGIAPSSWDSIYRTKVLLKSPTMTPQGRGHK
SLNVTLRKRLGLYANIRPCISYHPVIKTRYPNLNVVIVRENEEDTYTGIEHRLTNDTYQCSKVITRSGSERICDYAFHYA
KVHNRKRVTCLIKDNIMKMTDGIFHKSFSKIAENYPDIESDHYIVDIGMAKVASNPENFDVIVTTNLYGDIVSDIVAELS
GSIGLAGSANIGNNYAMFEAVHGSAPDIAGKNIANPSGLLNAAIQMLMYLKQFDKAQLIYNAFLKTLEDGIHTADIYQSQ
VSKKKVSTMDFAKAVVENFGQSPSQLPKSMFQDNVDRTGVSYTYEPSYVTRVLVGVDITIGCDGVGLDFKQLINNLQNIT
HDKLELVLIHNKGLEIWPDESVSVNLSYMDQVCCRFYMKSKDDKIMNEHINQLLFDIEQKKIDVVKMEKLYLYNDQPGFF
TM

Sequences:

>Translated_482_residues
MSIPITVAYGDGIGPEIMEAVLLILSEAESGLVVETIEVGHNLYKKEWSSGIAPSSWDSIYRTKVLLKSPTMTPQGRGHK
SLNVTLRKRLGLYANIRPCISYHPVIKTRYPNLNVVIVRENEEDTYTGIEHRLTNDTYQCSKVITRSGSERICDYAFHYA
KVHNRKRVTCLIKDNIMKMTDGIFHKSFSKIAENYPDIESDHYIVDIGMAKVASNPENFDVIVTTNLYGDIVSDIVAELS
GSIGLAGSANIGNNYAMFEAVHGSAPDIAGKNIANPSGLLNAAIQMLMYLKQFDKAQLIYNAFLKTLEDGIHTADIYQSQ
VSKKKVSTMDFAKAVVENFGQSPSQLPKSMFQDNVDRTGVSYTYEPSYVTRVLVGVDITIGCDGVGLDFKQLINNLQNIT
HDKLELVLIHNKGLEIWPDESVSVNLSYMDQVCCRFYMKSKDDKIMNEHINQLLFDIEQKKIDVVKMEKLYLYNDQPGFF
TM
>Mature_481_residues
SIPITVAYGDGIGPEIMEAVLLILSEAESGLVVETIEVGHNLYKKEWSSGIAPSSWDSIYRTKVLLKSPTMTPQGRGHKS
LNVTLRKRLGLYANIRPCISYHPVIKTRYPNLNVVIVRENEEDTYTGIEHRLTNDTYQCSKVITRSGSERICDYAFHYAK
VHNRKRVTCLIKDNIMKMTDGIFHKSFSKIAENYPDIESDHYIVDIGMAKVASNPENFDVIVTTNLYGDIVSDIVAELSG
SIGLAGSANIGNNYAMFEAVHGSAPDIAGKNIANPSGLLNAAIQMLMYLKQFDKAQLIYNAFLKTLEDGIHTADIYQSQV
SKKKVSTMDFAKAVVENFGQSPSQLPKSMFQDNVDRTGVSYTYEPSYVTRVLVGVDITIGCDGVGLDFKQLINNLQNITH
DKLELVLIHNKGLEIWPDESVSVNLSYMDQVCCRFYMKSKDDKIMNEHINQLLFDIEQKKIDVVKMEKLYLYNDQPGFFT
M

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=310, Percent_Identity=42.258064516129, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI4758582, Length=316, Percent_Identity=38.6075949367089, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI28178838, Length=308, Percent_Identity=38.3116883116883, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI28178821, Length=305, Percent_Identity=35.4098360655738, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI28178816, Length=305, Percent_Identity=35.4098360655738, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI28178819, Length=154, Percent_Identity=40.2597402597403, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1788101, Length=337, Percent_Identity=32.9376854599407, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1787381, Length=391, Percent_Identity=29.923273657289, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI87081683, Length=342, Percent_Identity=29.5321637426901, Blast_Score=131, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71986051, Length=306, Percent_Identity=40.5228758169935, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI25144293, Length=343, Percent_Identity=38.7755102040816, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17505779, Length=313, Percent_Identity=38.3386581469649, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17550882, Length=346, Percent_Identity=33.5260115606936, Blast_Score=168, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6324709, Length=341, Percent_Identity=40.7624633431085, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6324291, Length=338, Percent_Identity=37.2781065088757, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6322097, Length=337, Percent_Identity=33.2344213649852, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319830, Length=272, Percent_Identity=28.6764705882353, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24643270, Length=306, Percent_Identity=43.7908496732026, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24643268, Length=313, Percent_Identity=43.4504792332268, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24661184, Length=342, Percent_Identity=40.9356725146199, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI161078635, Length=315, Percent_Identity=36.8253968253968, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161078637, Length=315, Percent_Identity=36.8253968253968, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI161078633, Length=315, Percent_Identity=36.8253968253968, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24650122, Length=315, Percent_Identity=36.8253968253968, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI161078639, Length=323, Percent_Identity=35.9133126934984, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI281362242, Length=343, Percent_Identity=33.8192419825073, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24648872, Length=343, Percent_Identity=33.8192419825073, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20130355, Length=335, Percent_Identity=28.3582089552239, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45550436, Length=216, Percent_Identity=21.7592592592593, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR014273 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 54139; Mature: 54007

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPITVAYGDGIGPEIMEAVLLILSEAESGLVVETIEVGHNLYKKEWSSGIAPSSWDSI
CCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHH
YRTKVLLKSPTMTPQGRGHKSLNVTLRKRLGLYANIRPCISYHPVIKTRYPNLNVVIVRE
HHHEEEEECCCCCCCCCCCCCEEEEHHHHCCCCCCCCHHHCCCCEEEEECCCEEEEEEEC
NEEDTYTGIEHRLTNDTYQCSKVITRSGSERICDYAFHYAKVHNRKRVTCLIKDNIMKMT
CCCCCCCCHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCHHHHH
DGIFHKSFSKIAENYPDIESDHYIVDIGMAKVASNPENFDVIVTTNLYGDIVSDIVAELS
HHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHC
GSIGLAGSANIGNNYAMFEAVHGSAPDIAGKNIANPSGLLNAAIQMLMYLKQFDKAQLIY
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NAFLKTLEDGIHTADIYQSQVSKKKVSTMDFAKAVVENFGQSPSQLPKSMFQDNVDRTGV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
SYTYEPSYVTRVLVGVDITIGCDGVGLDFKQLINNLQNITHDKLELVLIHNKGLEIWPDE
EEEECCHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCEECCCC
SVSVNLSYMDQVCCRFYMKSKDDKIMNEHINQLLFDIEQKKIDVVKMEKLYLYNDQPGFF
CCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCC
TM
CC
>Mature Secondary Structure 
SIPITVAYGDGIGPEIMEAVLLILSEAESGLVVETIEVGHNLYKKEWSSGIAPSSWDSI
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHH
YRTKVLLKSPTMTPQGRGHKSLNVTLRKRLGLYANIRPCISYHPVIKTRYPNLNVVIVRE
HHHEEEEECCCCCCCCCCCCCEEEEHHHHCCCCCCCCHHHCCCCEEEEECCCEEEEEEEC
NEEDTYTGIEHRLTNDTYQCSKVITRSGSERICDYAFHYAKVHNRKRVTCLIKDNIMKMT
CCCCCCCCHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCHHHHH
DGIFHKSFSKIAENYPDIESDHYIVDIGMAKVASNPENFDVIVTTNLYGDIVSDIVAELS
HHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHC
GSIGLAGSANIGNNYAMFEAVHGSAPDIAGKNIANPSGLLNAAIQMLMYLKQFDKAQLIY
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NAFLKTLEDGIHTADIYQSQVSKKKVSTMDFAKAVVENFGQSPSQLPKSMFQDNVDRTGV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
SYTYEPSYVTRVLVGVDITIGCDGVGLDFKQLINNLQNITHDKLELVLIHNKGLEIWPDE
EEEECCHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCEECCCC
SVSVNLSYMDQVCCRFYMKSKDDKIMNEHINQLLFDIEQKKIDVVKMEKLYLYNDQPGFF
CCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCC
TM
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA