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The map label for this gene is purQ [H]

Identifier: 88657958

GI number: 88657958

Start: 351149

End: 351952

Strand: Direct

Name: purQ [H]

Synonym: ECH_0362

Alternate gene names: 88657958

Gene position: 351149-351952 (Clockwise)

Preceding gene: 88657744

Following gene: 88658095

Centisome position: 29.85

GC content: 33.08

Gene sequence:

>804_bases
ATGAAAAAAATGAAGGTCATTGTATTATCTGGATATGGTTTAAATTGTGAAGAAGAAACCCTGTTTGCTTTTGTTAAGGC
AGGAGAGTTATTGTCATGTGATGTGCAGGGAAAAATAGTGCATATTAATGAAGTAATATCATGTCCTAATTTGTTGCGAG
ATTATAATGTACTTGCAATTCCTGGAGGTTTTTCCTATGGAGATGATACTGGTGCTGGAAATGCTTTCGCATTGAGAATT
TTTCATAACTTAAGAGAAGAAATATCAGAGTTTTTGGCTGGTGATAAATTAGTAATTGGTATATGTAATGGATGTCAGAT
ACTGATGAGATTAATATCAGATTTTGCGTGTATAACACTTTTAAATAATTCTGTTCGACAATATCAGTGTAGATGGGTGA
AAGTGAAAGTGAATTTATCAAATAATTCACCATGGTTAAAAGGATTAAATGAATTATATATTCCAGTTGCGCATGGAGAG
GGAAGGTTTTTTGTAGAAAATGTCTCTGTCATTTCTTCTATTGAGAAGAATATTGCGTTCAGGTATATTAACAATGAAGG
TAATTATGCGAATCAAGAATTTCCTTGTAATCCTAATGGGTCAGTTGCCGATATTGCTGCACTGTCTGACAATAGTGGTA
AAGTATTGGTTATGATGCCACATCCAGAGAGAGCAATGTTTTTCACACAGCAGGATAACTGGACACAGATAAAAGAACAA
TGTTTAAGATCTAATATTGCTTATCCTACTTATGGAGATGGAATGAAGATTTTTTGTAATGCTGTGAAATATTTTTGCAA
ATGA

Upstream 100 bases:

>100_bases
AGATGTTATATCTAAAAGTTGAGGACTTGTTTACATGATTTTCAATAAATGGAGTTTAAGTGTTTACTTTTTGTGTTAAG
CTAATAGTTTATATATTTTG

Downstream 100 bases:

>100_bases
TCTAAAAGGTATTTTGTAAGTTTTAATGTTGTTGAGTTTTATCAGGTTTATCATTTTATTACTTTTATGTTTTTGGTATT
ACTGCATATAAAATATAAAC

Product: putative phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MKKMKVIVLSGYGLNCEEETLFAFVKAGELLSCDVQGKIVHINEVISCPNLLRDYNVLAIPGGFSYGDDTGAGNAFALRI
FHNLREEISEFLAGDKLVIGICNGCQILMRLISDFACITLLNNSVRQYQCRWVKVKVNLSNNSPWLKGLNELYIPVAHGE
GRFFVENVSVISSIEKNIAFRYINNEGNYANQEFPCNPNGSVADIAALSDNSGKVLVMMPHPERAMFFTQQDNWTQIKEQ
CLRSNIAYPTYGDGMKIFCNAVKYFCK

Sequences:

>Translated_267_residues
MKKMKVIVLSGYGLNCEEETLFAFVKAGELLSCDVQGKIVHINEVISCPNLLRDYNVLAIPGGFSYGDDTGAGNAFALRI
FHNLREEISEFLAGDKLVIGICNGCQILMRLISDFACITLLNNSVRQYQCRWVKVKVNLSNNSPWLKGLNELYIPVAHGE
GRFFVENVSVISSIEKNIAFRYINNEGNYANQEFPCNPNGSVADIAALSDNSGKVLVMMPHPERAMFFTQQDNWTQIKEQ
CLRSNIAYPTYGDGMKIFCNAVKYFCK
>Mature_267_residues
MKKMKVIVLSGYGLNCEEETLFAFVKAGELLSCDVQGKIVHINEVISCPNLLRDYNVLAIPGGFSYGDDTGAGNAFALRI
FHNLREEISEFLAGDKLVIGICNGCQILMRLISDFACITLLNNSVRQYQCRWVKVKVNLSNNSPWLKGLNELYIPVAHGE
GRFFVENVSVISSIEKNIAFRYINNEGNYANQEFPCNPNGSVADIAALSDNSGKVLVMMPHPERAMFFTQQDNWTQIKEQ
CLRSNIAYPTYGDGMKIFCNAVKYFCK

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=248, Percent_Identity=29.4354838709677, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI48994899, Length=241, Percent_Identity=34.8547717842324, Blast_Score=127, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17553022, Length=254, Percent_Identity=28.740157480315, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321498, Length=241, Percent_Identity=35.2697095435685, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24582111, Length=239, Percent_Identity=33.8912133891213, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24582109, Length=239, Percent_Identity=33.8912133891213, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17137292, Length=239, Percent_Identity=33.8912133891213, Blast_Score=121, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075 [H]

Pfam domain/function: PF07685 GATase_3 [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 29910; Mature: 29910

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKMKVIVLSGYGLNCEEETLFAFVKAGELLSCDVQGKIVHINEVISCPNLLRDYNVLAI
CCCEEEEEEECCCCCCCHHHHEEEEECCCEEEECCCCEEEEEHHHHCCHHHHHCCCEEEE
PGGFSYGDDTGAGNAFALRIFHNLREEISEFLAGDKLVIGICNGCQILMRLISDFACITL
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHH
LNNSVRQYQCRWVKVKVNLSNNSPWLKGLNELYIPVAHGEGRFFVENVSVISSIEKNIAF
HHCCHHEEEEEEEEEEEEECCCCHHHCCCCCEEEEEEECCCEEEEEHHHHHHHHHHCEEE
RYINNEGNYANQEFPCNPNGSVADIAALSDNSGKVLVMMPHPERAMFFTQQDNWTQIKEQ
EEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCEEEEEECCCHHHHHHH
CLRSNIAYPTYGDGMKIFCNAVKYFCK
HHHCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKKMKVIVLSGYGLNCEEETLFAFVKAGELLSCDVQGKIVHINEVISCPNLLRDYNVLAI
CCCEEEEEEECCCCCCCHHHHEEEEECCCEEEECCCCEEEEEHHHHCCHHHHHCCCEEEE
PGGFSYGDDTGAGNAFALRIFHNLREEISEFLAGDKLVIGICNGCQILMRLISDFACITL
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHH
LNNSVRQYQCRWVKVKVNLSNNSPWLKGLNELYIPVAHGEGRFFVENVSVISSIEKNIAF
HHCCHHEEEEEEEEEEEEECCCCHHHCCCCCEEEEEEECCCEEEEEHHHHHHHHHHCEEE
RYINNEGNYANQEFPCNPNGSVADIAALSDNSGKVLVMMPHPERAMFFTQQDNWTQIKEQ
EEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCEEEEEECCCHHHHHHH
CLRSNIAYPTYGDGMKIFCNAVKYFCK
HHHCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA