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The map label for this gene is nuoN [H]

Identifier: 88657884

GI number: 88657884

Start: 172216

End: 173691

Strand: Direct

Name: nuoN [H]

Synonym: ECH_0179

Alternate gene names: 88657884

Gene position: 172216-173691 (Clockwise)

Preceding gene: 88657681

Following gene: 88657867

Centisome position: 14.64

GC content: 29.81

Gene sequence:

>1476_bases
ATGATTAGTTCGTTACCTGTTTTACAGGTTGTTATACCTTTACTTTCTGCGATAGGATGTGCATTGTTAAAAGATGCTAG
ATTAGTCAAGATTATATCAGCTATTGTAGTGTTAATATCTTCCGCTATTGCAGTAGTGCTATTTTTTCAAGTATATCATG
GTGGTGTTATTAAATATAGCATAGGAGGGTGGATAGTACCTTATGGAATAGAACTTAAGGTAAATGTCTTTAATTCGATG
ATGCTTGTTTTAGTTGGGTTTGTTGCTATGATGAGTATTGTATATGGTATCTACCCTAATACCAAAGAAATAAATGTACG
TACAATACCAAGTTTTTATTCTGTATTTTTGTTATGTTTTAGTGGCTTTTTAGGAATATTAGTTTCAAATGATGTTTTTA
ATATTTATGTTTTTCTAGAAATATCATCAATTTCTTCATATATCTTAGTTGCAATGGGTAATAACAGGAATGCATTGATA
GCTGCATTTGATTACTTAGTAATAGGTACCATTGGTGCAACGTTTTATTTAATAGGAGTAGGGTTTTTATATGCTATTAC
TGGAACTTTAAATGTTGGAAATTTGTTTTTAATAGTTCAAGATAAATCTTTAACGACAAATAGGGCTATACAAGTTGGGT
TGTTGTTCATAATGTTAGGTTTGTTTATTAAAGCAGCACTATTTCCATTTCATAAATGGTTAATTCAAGCATATAATTAT
GCACCTACTTTTATTTCGGTATTCTTCTCTGGTGTTTCTACTAAAGTAATGATCTACCTTATAATAAAAGTAATATATGA
TGTTTTTAAAGCTGAATTAGTACTGTTAACTTTACCTTTTAATATTGTATTTATGAGTTTTGCTGCATTATCAGTGATTT
CTGCATCTATTCTTGCAATGCTGAGTAGTAATATGAAGAGAATTTTTGCATACTCAAGTGTAGCACATCTAGGATATATT
ATATTTGCTGTAGGTTTGAATACTTACTATGGTTTAGTGGCTGCTGTAACTTATATAATTAACCATAGTTTAGTGAAATC
AGCATTATTTATGGTCATGGGTAGTATTTCTTACAATTGTGGTAGTCTTGAGCTTAAAGATTGTACAAATATTTGGAAAA
ATATGCCAAAGATTGCGTTACCATTTGTTATTTTATGTATAAGCCTTATTGGAATGCCAATAACTTCAGGATTTATTTCT
AAGTGGTATGTTTTTGATGCGGCAATTAAAACGAATTTTTGGTTGGGTGTAATTGTTTTACTTATAGGATCAGGTCTATC
TGTGGTGTATGTGTGGAATATAATAGAAGCAACATGTTTTAAGCCATCTGATAAACAAGTGAAGAAATTGTTTGAAGTTC
CTAATGTTATGGTGTTATGTATTTGGGTAATGGCTATTTCATCTATTATTCTTGGGTTATATCCAGTACCTTTAATGATG
ATTTCTAATAAAATAGCGGAATCACTGTTATATTAA

Upstream 100 bases:

>100_bases
TCAATTAATTATTGCTATTTTACAATAAAGGCGCTTGCCTTTTTGGTAATATTTTAGTAGGTTTGTCAATCATATATTAT
TGAATTTATGGGTATATGTG

Downstream 100 bases:

>100_bases
ATTAGTGGGTAAAGTTTTTGGTGCATTTGTAATTTTTGGAAGGGATACCTTGATATATTTTTCGTGAATTGACTTTTATA
TCTTCAAGGTATTTAATAAA

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MISSLPVLQVVIPLLSAIGCALLKDARLVKIISAIVVLISSAIAVVLFFQVYHGGVIKYSIGGWIVPYGIELKVNVFNSM
MLVLVGFVAMMSIVYGIYPNTKEINVRTIPSFYSVFLLCFSGFLGILVSNDVFNIYVFLEISSISSYILVAMGNNRNALI
AAFDYLVIGTIGATFYLIGVGFLYAITGTLNVGNLFLIVQDKSLTTNRAIQVGLLFIMLGLFIKAALFPFHKWLIQAYNY
APTFISVFFSGVSTKVMIYLIIKVIYDVFKAELVLLTLPFNIVFMSFAALSVISASILAMLSSNMKRIFAYSSVAHLGYI
IFAVGLNTYYGLVAAVTYIINHSLVKSALFMVMGSISYNCGSLELKDCTNIWKNMPKIALPFVILCISLIGMPITSGFIS
KWYVFDAAIKTNFWLGVIVLLIGSGLSVVYVWNIIEATCFKPSDKQVKKLFEVPNVMVLCIWVMAISSIILGLYPVPLMM
ISNKIAESLLY

Sequences:

>Translated_491_residues
MISSLPVLQVVIPLLSAIGCALLKDARLVKIISAIVVLISSAIAVVLFFQVYHGGVIKYSIGGWIVPYGIELKVNVFNSM
MLVLVGFVAMMSIVYGIYPNTKEINVRTIPSFYSVFLLCFSGFLGILVSNDVFNIYVFLEISSISSYILVAMGNNRNALI
AAFDYLVIGTIGATFYLIGVGFLYAITGTLNVGNLFLIVQDKSLTTNRAIQVGLLFIMLGLFIKAALFPFHKWLIQAYNY
APTFISVFFSGVSTKVMIYLIIKVIYDVFKAELVLLTLPFNIVFMSFAALSVISASILAMLSSNMKRIFAYSSVAHLGYI
IFAVGLNTYYGLVAAVTYIINHSLVKSALFMVMGSISYNCGSLELKDCTNIWKNMPKIALPFVILCISLIGMPITSGFIS
KWYVFDAAIKTNFWLGVIVLLIGSGLSVVYVWNIIEATCFKPSDKQVKKLFEVPNVMVLCIWVMAISSIILGLYPVPLMM
ISNKIAESLLY
>Mature_491_residues
MISSLPVLQVVIPLLSAIGCALLKDARLVKIISAIVVLISSAIAVVLFFQVYHGGVIKYSIGGWIVPYGIELKVNVFNSM
MLVLVGFVAMMSIVYGIYPNTKEINVRTIPSFYSVFLLCFSGFLGILVSNDVFNIYVFLEISSISSYILVAMGNNRNALI
AAFDYLVIGTIGATFYLIGVGFLYAITGTLNVGNLFLIVQDKSLTTNRAIQVGLLFIMLGLFIKAALFPFHKWLIQAYNY
APTFISVFFSGVSTKVMIYLIIKVIYDVFKAELVLLTLPFNIVFMSFAALSVISASILAMLSSNMKRIFAYSSVAHLGYI
IFAVGLNTYYGLVAAVTYIINHSLVKSALFMVMGSISYNCGSLELKDCTNIWKNMPKIALPFVILCISLIGMPITSGFIS
KWYVFDAAIKTNFWLGVIVLLIGSGLSVVYVWNIIEATCFKPSDKQVKKLFEVPNVMVLCIWVMAISSIILGLYPVPLMM
ISNKIAESLLY

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=370, Percent_Identity=23.5135135135135, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1788827, Length=370, Percent_Identity=27.2972972972973, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788831, Length=397, Percent_Identity=26.448362720403, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1788829, Length=414, Percent_Identity=26.0869565217391, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI145693160, Length=382, Percent_Identity=25.130890052356, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788613, Length=508, Percent_Identity=21.6535433070866, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI2367154, Length=330, Percent_Identity=21.8181818181818, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788614, Length=447, Percent_Identity=23.2662192393736, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54106; Mature: 54106

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISSLPVLQVVIPLLSAIGCALLKDARLVKIISAIVVLISSAIAVVLFFQVYHGGVIKYS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
IGGWIVPYGIELKVNVFNSMMLVLVGFVAMMSIVYGIYPNTKEINVRTIPSFYSVFLLCF
CCCEEEEECEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHH
SGFLGILVSNDVFNIYVFLEISSISSYILVAMGNNRNALIAAFDYLVIGTIGATFYLIGV
HHHHHHHHCCCEEEEEEEEEEECCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHH
GFLYAITGTLNVGNLFLIVQDKSLTTNRAIQVGLLFIMLGLFIKAALFPFHKWLIQAYNY
HHHHHHHCCEEECEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APTFISVFFSGVSTKVMIYLIIKVIYDVFKAELVLLTLPFNIVFMSFAALSVISASILAM
CHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHH
LSSNMKRIFAYSSVAHLGYIIFAVGLNTYYGLVAAVTYIINHSLVKSALFMVMGSISYNC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GSLELKDCTNIWKNMPKIALPFVILCISLIGMPITSGFISKWYVFDAAIKTNFWLGVIVL
CCEEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGSGLSVVYVWNIIEATCFKPSDKQVKKLFEVPNVMVLCIWVMAISSIILGLYPVPLMM
HHCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ISNKIAESLLY
HHHHHHHHHCC
>Mature Secondary Structure
MISSLPVLQVVIPLLSAIGCALLKDARLVKIISAIVVLISSAIAVVLFFQVYHGGVIKYS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
IGGWIVPYGIELKVNVFNSMMLVLVGFVAMMSIVYGIYPNTKEINVRTIPSFYSVFLLCF
CCCEEEEECEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHH
SGFLGILVSNDVFNIYVFLEISSISSYILVAMGNNRNALIAAFDYLVIGTIGATFYLIGV
HHHHHHHHCCCEEEEEEEEEEECCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHH
GFLYAITGTLNVGNLFLIVQDKSLTTNRAIQVGLLFIMLGLFIKAALFPFHKWLIQAYNY
HHHHHHHCCEEECEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APTFISVFFSGVSTKVMIYLIIKVIYDVFKAELVLLTLPFNIVFMSFAALSVISASILAM
CHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHH
LSSNMKRIFAYSSVAHLGYIIFAVGLNTYYGLVAAVTYIINHSLVKSALFMVMGSISYNC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GSLELKDCTNIWKNMPKIALPFVILCISLIGMPITSGFISKWYVFDAAIKTNFWLGVIVL
CCEEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGSGLSVVYVWNIIEATCFKPSDKQVKKLFEVPNVMVLCIWVMAISSIILGLYPVPLMM
HHCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ISNKIAESLLY
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA