Click here to switch to the map view.

The map label for this gene is nrdR

Identifier: 88657867

GI number: 88657867

Start: 175498

End: 175959

Strand: Direct

Name: nrdR

Synonym: ECH_0185

Alternate gene names: 88657867

Gene position: 175498-175959 (Clockwise)

Preceding gene: 88657884

Following gene: 88658025

Centisome position: 14.92

GC content: 27.06

Gene sequence:

>462_bases
ATGAAATGTCCTTTTTGTAATAGTACTGATACTCAAGTTAAAGATTCAAGGTCTATAGAAAATGACATGTTGATTAGAAG
AAGAAGAGTATGTCTTGTATGTCACTCTAGGTTTACAACAACTGAAAAATTACTTCTTAGATCGTTTATGGTTGTAAAAA
AAAATGGTGAAACTGAACTATTTAATAAACAAAAGTTACTTTCTTCGATTTTGATAGCGACAAAAAAACGTCCTGTAAGT
CATGAAGGGATAAATATGATGGTGAATAATATTTTTTATGAGCTTGAAGGAAAAAAAGAAAATGCTATTCCGACTAATGT
TATTGGAAAAATGGTTATGGATAATCTTTTTAAGTTAGATAAAGTAGCATATGTTAGATTTGCTTCTGTATATATGAATT
TTAGAAATATAAATGACTTTAGTAATATAATTGCGAAAATAATTAGTGAAAAGACTCCTTAA

Upstream 100 bases:

>100_bases
ATCAGTATAATAGTTATGGTAATACAATACAACTATTAACTAGATATTTAGTTAATATTTTATGTAATAATTAGCTTAAA
GTGATAATATGTAAGTAATT

Downstream 100 bases:

>100_bases
TGCATCTCAATAATTATATTATGATTGATTATTATTCTTGAATTGTTAATAAGCTTGTGCTATGTATTTTGGAGGTTATT
TAGTAGTAACGTTATCTCGC

Product: transcriptional regulator NrdR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MKCPFCNSTDTQVKDSRSIENDMLIRRRRVCLVCHSRFTTTEKLLLRSFMVVKKNGETELFNKQKLLSSILIATKKRPVS
HEGINMMVNNIFYELEGKKENAIPTNVIGKMVMDNLFKLDKVAYVRFASVYMNFRNINDFSNIIAKIISEKTP

Sequences:

>Translated_153_residues
MKCPFCNSTDTQVKDSRSIENDMLIRRRRVCLVCHSRFTTTEKLLLRSFMVVKKNGETELFNKQKLLSSILIATKKRPVS
HEGINMMVNNIFYELEGKKENAIPTNVIGKMVMDNLFKLDKVAYVRFASVYMNFRNINDFSNIIAKIISEKTP
>Mature_153_residues
MKCPFCNSTDTQVKDSRSIENDMLIRRRRVCLVCHSRFTTTEKLLLRSFMVVKKNGETELFNKQKLLSSILIATKKRPVS
HEGINMMVNNIFYELEGKKENAIPTNVIGKMVMDNLFKLDKVAYVRFASVYMNFRNINDFSNIIAKIISEKTP

Specific function: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes

COG id: COG1327

COG function: function code K; Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain

Homologues:

Organism=Escherichia coli, GI1786615, Length=147, Percent_Identity=48.2993197278912, Blast_Score=139, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NRDR_EHRCR (Q2GHS3)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_507010.1
- STRING:   Q2GHS3
- GeneID:   3927548
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_0185
- TIGR:   ECH_0185
- eggNOG:   COG1327
- HOGENOM:   HBG351755
- OMA:   FASVYRD
- PhylomeDB:   Q2GHS3
- ProtClustDB:   PRK00464
- BioCyc:   ECHA205920:ECH_0185-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00440
- InterPro:   IPR005144
- InterPro:   IPR003796
- TIGRFAMs:   TIGR00244

Pfam domain/function: PF03477 ATP-cone

EC number: NA

Molecular weight: Translated: 17746; Mature: 17746

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCPFCNSTDTQVKDSRSIENDMLIRRRRVCLVCHSRFTTTEKLLLRSFMVVKKNGETEL
CCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHH
FNKQKLLSSILIATKKRPVSHEGINMMVNNIFYELEGKKENAIPTNVIGKMVMDNLFKLD
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHH
KVAYVRFASVYMNFRNINDFSNIIAKIISEKTP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKCPFCNSTDTQVKDSRSIENDMLIRRRRVCLVCHSRFTTTEKLLLRSFMVVKKNGETEL
CCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHH
FNKQKLLSSILIATKKRPVSHEGINMMVNNIFYELEGKKENAIPTNVIGKMVMDNLFKLD
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHH
KVAYVRFASVYMNFRNINDFSNIIAKIISEKTP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA