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The map label for this gene is typA [H]

Identifier: 88657787

GI number: 88657787

Start: 701180

End: 703024

Strand: Reverse

Name: typA [H]

Synonym: ECH_0693

Alternate gene names: 88657787

Gene position: 703024-701180 (Counterclockwise)

Preceding gene: 88658112

Following gene: 88657963

Centisome position: 59.77

GC content: 35.07

Gene sequence:

>1845_bases
ATGTTGTCACAAGGTGATTATCAGTCGATATGTAATTTAGCAATTATTGCTCATGTTGATCATGGGAAAACAACGCTATT
AGATGGTATGTTAAAACAGAGTGGTACATTTAGAGAAAATCAAGATGTAGCTGAAAGGGTGATGGATAATAATGATTTGG
AACGTGAACGTGGTATTACCATTTTAGCAAAGTGTACATCTGTTATTTGGCAAGGTAAGAAAATTAATATAATTGATACT
CCAGGACATGCGGATTTTGGTGGAGAGGTAGAAAGAGTATTGTCAATGGCAGATGGAGTGTTACTGCTTGTTGATGCGTC
AGAGGGTCCTATGCCTCAGACTAAGTTTGTCTTATCAAAAGCATTGAAAGCTGGATTATTACCAATAGTGATTATAAATA
AAGTTGATAGGCCAGATAGTAGAGTAGATGAAGTACTAGATGAAGTGTATGAGTTATTTATCAATCTGGATGCTACTAGT
GAGCAATTGGATTTTCCAATATTATATGCATCAGGAAGAAATGGATGGTGTGTTAAAAATTTGTCTGATAATAGGGAAAG
TTTAGTACCATTATTTGAAGCGATTGTTGAATATGTAAAGCCTGTTTCTTATGATGCTAATGCACCATTTACTATGTTGT
TGACTTTATTAGAGTCGGACAAATTTTTAGGTAGAATATTAACGGGAAAAATATATACAGGTACAATACGGGTTAATGAC
AGTGTTAAAGTATTGAATTTATCTGGTGAAGTTGTTGAATATGGTAAACTTACAAAGCTTTTGGCATTTTCAGGGGTAAA
GCGTATCCCAATTAAAGAGGCAAAAGCTGGGGATATTATTGCTGTTGCAGGTCTTGAGAAGGCTTCTGTATCTGATAGTA
TTCTTGATAGTTCTATTAATTTTCCTATTACATCAACACCTGTTGATCCTCCAACTATGGCAGTAACTATTAGTGTGAAT
GACTCGCCATTTGCTGGTACGGAAGGAGTAAAATTGACATCGACTGTTATTAAAGCACGCCTTGTAGCTGAAGCTGAAAC
AAACGTTGCAATTACAGTTAAAGAGACAGAGCAGGGTGATGCATATGAGGTTGGTGGAAGAGGAGAACTACAGCTTGGAG
TGTTAATTGAGACTATGAGAAGGGAAGGTTTTGAACTATCTGTATCTAGACCTCGTGTTTTATTACGTAAAGATGATCAA
GGTCAAGTTTTAGAACCTATAGAAGAAGTTGTTATAGATGTAGATGAAGCATACAGCGGTGTGATTATGGAAAAATTAAG
TTTCCGTAAAGGTGATATGCGAGATTTACGTCCATCTGGAAAAGATAGAGTGAGAATGATATTTTTAGTTCCTTCACGTG
GTCTTATAGGGTATCAGGGAGAATTTTTAACAGACTCTCATGGTACTGGAATTATGAACCGGTTATTCCATAGTTATGCT
CCACATAAAGGTAATATTCCTACTAGAAATAATGGAGTTCTTATTTCTACTGATAAAGGTGATGCAGTAGCTTATGCAAT
ATTTAATTTGCAAGATCGGGGTATTATGTTTGTTAAACCTCAAGATAAAGTATATTGTGGAATGATTGTTGGGCTTCATA
ATCGTGAAAATGATATTGATGTTAATGTATTAAAGGGTAAACAATTAACTAATATAAGAGCAGCAGGTTCAGATGAAGCA
GTTAGGTTAGTTCCACCAAAAGTAATGACTTTAGAAGAAATGATAGCATTTATTAATGATGATGAATTAGTTGAATGTAC
ACCTAAATCTATCCGTTTGCGTAAAAAATATTTAGATCCTAATGAACGTAAACGTGCTTCCCGTGCTAGTAAGAATATGG
TCTAG

Upstream 100 bases:

>100_bases
TAAGTAAGATAGGTATCAATAATTGTTAAATCAGTGTTTGTTGATTAGTAACATGTGTGCTATAAGTTAATATATAGAGT
TTTAAAGTTTAAGAGATATT

Downstream 100 bases:

>100_bases
TTTAGGTTAAGTATTTAAAAATCATATAATTTTGGATATTTGATAAAGGTTGAGTTTTTATTAACTAAGTATCTTGGTAT
TTTATTATTAAGAAAAAAGG

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MLSQGDYQSICNLAIIAHVDHGKTTLLDGMLKQSGTFRENQDVAERVMDNNDLERERGITILAKCTSVIWQGKKINIIDT
PGHADFGGEVERVLSMADGVLLLVDASEGPMPQTKFVLSKALKAGLLPIVIINKVDRPDSRVDEVLDEVYELFINLDATS
EQLDFPILYASGRNGWCVKNLSDNRESLVPLFEAIVEYVKPVSYDANAPFTMLLTLLESDKFLGRILTGKIYTGTIRVND
SVKVLNLSGEVVEYGKLTKLLAFSGVKRIPIKEAKAGDIIAVAGLEKASVSDSILDSSINFPITSTPVDPPTMAVTISVN
DSPFAGTEGVKLTSTVIKARLVAEAETNVAITVKETEQGDAYEVGGRGELQLGVLIETMRREGFELSVSRPRVLLRKDDQ
GQVLEPIEEVVIDVDEAYSGVIMEKLSFRKGDMRDLRPSGKDRVRMIFLVPSRGLIGYQGEFLTDSHGTGIMNRLFHSYA
PHKGNIPTRNNGVLISTDKGDAVAYAIFNLQDRGIMFVKPQDKVYCGMIVGLHNRENDIDVNVLKGKQLTNIRAAGSDEA
VRLVPPKVMTLEEMIAFINDDELVECTPKSIRLRKKYLDPNERKRASRASKNMV

Sequences:

>Translated_614_residues
MLSQGDYQSICNLAIIAHVDHGKTTLLDGMLKQSGTFRENQDVAERVMDNNDLERERGITILAKCTSVIWQGKKINIIDT
PGHADFGGEVERVLSMADGVLLLVDASEGPMPQTKFVLSKALKAGLLPIVIINKVDRPDSRVDEVLDEVYELFINLDATS
EQLDFPILYASGRNGWCVKNLSDNRESLVPLFEAIVEYVKPVSYDANAPFTMLLTLLESDKFLGRILTGKIYTGTIRVND
SVKVLNLSGEVVEYGKLTKLLAFSGVKRIPIKEAKAGDIIAVAGLEKASVSDSILDSSINFPITSTPVDPPTMAVTISVN
DSPFAGTEGVKLTSTVIKARLVAEAETNVAITVKETEQGDAYEVGGRGELQLGVLIETMRREGFELSVSRPRVLLRKDDQ
GQVLEPIEEVVIDVDEAYSGVIMEKLSFRKGDMRDLRPSGKDRVRMIFLVPSRGLIGYQGEFLTDSHGTGIMNRLFHSYA
PHKGNIPTRNNGVLISTDKGDAVAYAIFNLQDRGIMFVKPQDKVYCGMIVGLHNRENDIDVNVLKGKQLTNIRAAGSDEA
VRLVPPKVMTLEEMIAFINDDELVECTPKSIRLRKKYLDPNERKRASRASKNMV
>Mature_614_residues
MLSQGDYQSICNLAIIAHVDHGKTTLLDGMLKQSGTFRENQDVAERVMDNNDLERERGITILAKCTSVIWQGKKINIIDT
PGHADFGGEVERVLSMADGVLLLVDASEGPMPQTKFVLSKALKAGLLPIVIINKVDRPDSRVDEVLDEVYELFINLDATS
EQLDFPILYASGRNGWCVKNLSDNRESLVPLFEAIVEYVKPVSYDANAPFTMLLTLLESDKFLGRILTGKIYTGTIRVND
SVKVLNLSGEVVEYGKLTKLLAFSGVKRIPIKEAKAGDIIAVAGLEKASVSDSILDSSINFPITSTPVDPPTMAVTISVN
DSPFAGTEGVKLTSTVIKARLVAEAETNVAITVKETEQGDAYEVGGRGELQLGVLIETMRREGFELSVSRPRVLLRKDDQ
GQVLEPIEEVVIDVDEAYSGVIMEKLSFRKGDMRDLRPSGKDRVRMIFLVPSRGLIGYQGEFLTDSHGTGIMNRLFHSYA
PHKGNIPTRNNGVLISTDKGDAVAYAIFNLQDRGIMFVKPQDKVYCGMIVGLHNRENDIDVNVLKGKQLTNIRAAGSDEA
VRLVPPKVMTLEEMIAFINDDELVECTPKSIRLRKKYLDPNERKRASRASKNMV

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=494, Percent_Identity=27.7327935222672, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI94966754, Length=138, Percent_Identity=39.1304347826087, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=39.4557823129252, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI4503483, Length=161, Percent_Identity=34.1614906832298, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI25306283, Length=160, Percent_Identity=38.125, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI19923640, Length=160, Percent_Identity=38.125, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI25306287, Length=160, Percent_Identity=38.125, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI34147630, Length=245, Percent_Identity=28.9795918367347, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI217272894, Length=134, Percent_Identity=35.8208955223881, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI217272892, Length=134, Percent_Identity=35.8208955223881, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI310132016, Length=116, Percent_Identity=36.2068965517241, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI310110807, Length=116, Percent_Identity=36.2068965517241, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI310123363, Length=116, Percent_Identity=36.2068965517241, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI94966752, Length=63, Percent_Identity=47.6190476190476, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI223555963, Length=268, Percent_Identity=26.865671641791, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI5729864, Length=268, Percent_Identity=26.865671641791, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI53729339, Length=229, Percent_Identity=29.2576419213974, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI53729337, Length=229, Percent_Identity=29.2576419213974, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI48994988, Length=606, Percent_Identity=52.1452145214521, Blast_Score=628, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=540, Percent_Identity=25.5555555555556, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI1789738, Length=147, Percent_Identity=36.734693877551, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789737, Length=279, Percent_Identity=27.5985663082437, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1790412, Length=279, Percent_Identity=27.5985663082437, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1790835, Length=144, Percent_Identity=29.8611111111111, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17557151, Length=242, Percent_Identity=32.6446280991736, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17556745, Length=140, Percent_Identity=40, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17533571, Length=174, Percent_Identity=38.5057471264368, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=37.6923076923077, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=37.6923076923077, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=192, Percent_Identity=32.2916666666667, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17506493, Length=174, Percent_Identity=32.183908045977, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17556456, Length=248, Percent_Identity=27.8225806451613, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994658, Length=129, Percent_Identity=35.6589147286822, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=399, Percent_Identity=30.0751879699248, Blast_Score=127, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6324707, Length=161, Percent_Identity=36.0248447204969, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320593, Length=161, Percent_Identity=36.0248447204969, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323098, Length=142, Percent_Identity=39.4366197183099, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324761, Length=237, Percent_Identity=27.8481012658228, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322359, Length=146, Percent_Identity=35.6164383561644, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324166, Length=175, Percent_Identity=33.7142857142857, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324550, Length=125, Percent_Identity=33.6, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI78706572, Length=409, Percent_Identity=28.361858190709, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24582462, Length=147, Percent_Identity=40.1360544217687, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28574573, Length=146, Percent_Identity=37.6712328767123, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585711, Length=166, Percent_Identity=33.7349397590361, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585713, Length=166, Percent_Identity=33.7349397590361, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585709, Length=166, Percent_Identity=33.7349397590361, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221458488, Length=160, Percent_Identity=37.5, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281363316, Length=272, Percent_Identity=28.3088235294118, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17864358, Length=272, Percent_Identity=28.3088235294118, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357743, Length=190, Percent_Identity=33.1578947368421, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921738, Length=248, Percent_Identity=29.4354838709677, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI28572034, Length=287, Percent_Identity=25.4355400696864, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67687; Mature: 67687

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSQGDYQSICNLAIIAHVDHGKTTLLDGMLKQSGTFRENQDVAERVMDNNDLERERGIT
CCCCCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHCCCE
ILAKCTSVIWQGKKINIIDTPGHADFGGEVERVLSMADGVLLLVDASEGPMPQTKFVLSK
EEEEHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
ALKAGLLPIVIINKVDRPDSRVDEVLDEVYELFINLDATSEQLDFPILYASGRNGWCVKN
HHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEECCCCCEEECC
LSDNRESLVPLFEAIVEYVKPVSYDANAPFTMLLTLLESDKFLGRILTGKIYTGTIRVND
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHEEECEEEEEEEEECC
SVKVLNLSGEVVEYGKLTKLLAFSGVKRIPIKEAKAGDIIAVAGLEKASVSDSILDSSIN
CEEEEECCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHCCCC
FPITSTPVDPPTMAVTISVNDSPFAGTEGVKLTSTVIKARLVAEAETNVAITVKETEQGD
CCEECCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHEEECCCCEEEEEEECCCCC
AYEVGGRGELQLGVLIETMRREGFELSVSRPRVLLRKDDQGQVLEPIEEVVIDVDEAYSG
CEEECCCCCEEHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHHHHEEHHHHHHH
VIMEKLSFRKGDMRDLRPSGKDRVRMIFLVPSRGLIGYQGEFLTDSHGTGIMNRLFHSYA
HHHHHHHCCCCCCHHCCCCCCCEEEEEEEECCCCCEECCCCEEECCCCCHHHHHHHHHCC
PHKGNIPTRNNGVLISTDKGDAVAYAIFNLQDRGIMFVKPQDKVYCGMIVGLHNRENDID
CCCCCCCCCCCCEEEECCCCCEEEEEEEEECCCCEEEECCCCCEEEEEEEEECCCCCCCE
VNVLKGKQLTNIRAAGSDEAVRLVPPKVMTLEEMIAFINDDELVECTPKSIRLRKKYLDP
EEEECCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCC
NERKRASRASKNMV
CHHHHHHHHHCCCC
>Mature Secondary Structure
MLSQGDYQSICNLAIIAHVDHGKTTLLDGMLKQSGTFRENQDVAERVMDNNDLERERGIT
CCCCCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHCCCE
ILAKCTSVIWQGKKINIIDTPGHADFGGEVERVLSMADGVLLLVDASEGPMPQTKFVLSK
EEEEHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
ALKAGLLPIVIINKVDRPDSRVDEVLDEVYELFINLDATSEQLDFPILYASGRNGWCVKN
HHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEECCCCCEEECC
LSDNRESLVPLFEAIVEYVKPVSYDANAPFTMLLTLLESDKFLGRILTGKIYTGTIRVND
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHEEECEEEEEEEEECC
SVKVLNLSGEVVEYGKLTKLLAFSGVKRIPIKEAKAGDIIAVAGLEKASVSDSILDSSIN
CEEEEECCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHCCCC
FPITSTPVDPPTMAVTISVNDSPFAGTEGVKLTSTVIKARLVAEAETNVAITVKETEQGD
CCEECCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHEEECCCCEEEEEEECCCCC
AYEVGGRGELQLGVLIETMRREGFELSVSRPRVLLRKDDQGQVLEPIEEVVIDVDEAYSG
CEEECCCCCEEHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHHHHEEHHHHHHH
VIMEKLSFRKGDMRDLRPSGKDRVRMIFLVPSRGLIGYQGEFLTDSHGTGIMNRLFHSYA
HHHHHHHCCCCCCHHCCCCCCCEEEEEEEECCCCCEECCCCEEECCCCCHHHHHHHHHCC
PHKGNIPTRNNGVLISTDKGDAVAYAIFNLQDRGIMFVKPQDKVYCGMIVGLHNRENDID
CCCCCCCCCCCCEEEECCCCCEEEEEEEEECCCCEEEECCCCCEEEEEEEEECCCCCCCE
VNVLKGKQLTNIRAAGSDEAVRLVPPKVMTLEEMIAFINDDELVECTPKSIRLRKKYLDP
EEEECCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCC
NERKRASRASKNMV
CHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]