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The map label for this gene is gcp

Identifier: 88657692

GI number: 88657692

Start: 648209

End: 649258

Strand: Reverse

Name: gcp

Synonym: ECH_0644

Alternate gene names: 88657692

Gene position: 649258-648209 (Counterclockwise)

Preceding gene: 88658051

Following gene: 88657839

Centisome position: 55.2

GC content: 33.33

Gene sequence:

>1050_bases
GTGGATAAATTAAAAATAGTATTAGGTATAGAAACAAGTTGTGATGAAACTGCTGTTGCTATTGTAAATAGTAATAAGGA
GGTTTTATCACATAAAATTCTTTCACAGCAGGAACATGCAGCATATGGTGGAGTTGTTCCGGAAATTGCTTCTCGTGCTC
ATATTAATTATTTATATGAGTTAGTTGGTAGTTGTATAGAGGAGTCGCAACTTTGTTTTAATGATATTGATGCTATTGCT
GTTACTGCAGGTCCTGGTCTTATTGGTGGTTTAATAGTTGGCATAATGATGGCTAAAGCAATTTCCAGTGTTACTGGTAA
GCCTATTATTGAAATTAATCATTTAGAGGCTCATGCTTTAATTATTCGTATGTTTTATGAAATAGATTTTCCATTCTTAT
TGTTAATAATGTCTGGAGGGCATTGTCAGTTCTTGGTAGCTTACGATGTAAGGTGTTATTATAAGTTAGGTTCTTCTTTG
GATGATTCTTTAGGTGAAGTATTTGATAAAGTAGCAAGAATGTTAAATCTTGGGTATCCTGGGGGGCCAATTATTGAAGA
GAAGTCTTTGTTAGGTGATAGTGGAAGTTTTACTTTACCACGAGCATTAACTAACCGTCCTGGATGTGATTTTTCGTTTT
CTGGACTTAAAACTGCTGTGAGAAATATTATTGCAGGTCAGAAGTGTATAAATCATGAGTTGGTATGTAATATTTCAGCA
TCTTTCCAAGATTGTGTTGGTGATATATTGGTAAACAGGATTAACAACGCGATTGTAATGTCAAAAGATATAGATCACAG
GATTAATAAGTTAGTAGTAACTGGTGGTGTTGCAGCTAATAAATTATTACGTAATCGTATGTCAGTATGTGCAAATGATA
ATGGTTTTGAAATATTGTATCCTCCAAGTAAGTTATGTACTGATAATGGAGTTATGATAGGATGGGCTGGTATTGAAAAT
TTAGCAAAGGGTTATGTTTCAAATTTAAATTTTTTTCCAAGAGCAAGGTGGCCTTTAGAAAATTTGAGGTTTGATATACT
AAGAAAGTAG

Upstream 100 bases:

>100_bases
AACTCTTACTGTGCAAGATATGGCAAAGTCAAGTATTACTCCTATGCATGATGGTGCTGAACGTTATTATAAAGAAATTG
GAGCTATAAAATAAGAAAGT

Downstream 100 bases:

>100_bases
ATGAAAGCTTGACTGGCATAAAATATTTATCAAGAACATTTTTATAATTATAGATTAGTTTTTAGTAGTACTAGTAAAGA
ATTATCTAGAAAATGTGTTT

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MDKLKIVLGIETSCDETAVAIVNSNKEVLSHKILSQQEHAAYGGVVPEIASRAHINYLYELVGSCIEESQLCFNDIDAIA
VTAGPGLIGGLIVGIMMAKAISSVTGKPIIEINHLEAHALIIRMFYEIDFPFLLLIMSGGHCQFLVAYDVRCYYKLGSSL
DDSLGEVFDKVARMLNLGYPGGPIIEEKSLLGDSGSFTLPRALTNRPGCDFSFSGLKTAVRNIIAGQKCINHELVCNISA
SFQDCVGDILVNRINNAIVMSKDIDHRINKLVVTGGVAANKLLRNRMSVCANDNGFEILYPPSKLCTDNGVMIGWAGIEN
LAKGYVSNLNFFPRARWPLENLRFDILRK

Sequences:

>Translated_349_residues
MDKLKIVLGIETSCDETAVAIVNSNKEVLSHKILSQQEHAAYGGVVPEIASRAHINYLYELVGSCIEESQLCFNDIDAIA
VTAGPGLIGGLIVGIMMAKAISSVTGKPIIEINHLEAHALIIRMFYEIDFPFLLLIMSGGHCQFLVAYDVRCYYKLGSSL
DDSLGEVFDKVARMLNLGYPGGPIIEEKSLLGDSGSFTLPRALTNRPGCDFSFSGLKTAVRNIIAGQKCINHELVCNISA
SFQDCVGDILVNRINNAIVMSKDIDHRINKLVVTGGVAANKLLRNRMSVCANDNGFEILYPPSKLCTDNGVMIGWAGIEN
LAKGYVSNLNFFPRARWPLENLRFDILRK
>Mature_349_residues
MDKLKIVLGIETSCDETAVAIVNSNKEVLSHKILSQQEHAAYGGVVPEIASRAHINYLYELVGSCIEESQLCFNDIDAIA
VTAGPGLIGGLIVGIMMAKAISSVTGKPIIEINHLEAHALIIRMFYEIDFPFLLLIMSGGHCQFLVAYDVRCYYKLGSSL
DDSLGEVFDKVARMLNLGYPGGPIIEEKSLLGDSGSFTLPRALTNRPGCDFSFSGLKTAVRNIIAGQKCINHELVCNISA
SFQDCVGDILVNRINNAIVMSKDIDHRINKLVVTGGVAANKLLRNRMSVCANDNGFEILYPPSKLCTDNGVMIGWAGIEN
LAKGYVSNLNFFPRARWPLENLRFDILRK

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=338, Percent_Identity=38.4615384615385, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI8923380, Length=333, Percent_Identity=27.027027027027, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789445, Length=339, Percent_Identity=41.0029498525074, Blast_Score=272, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17557464, Length=327, Percent_Identity=32.7217125382263, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71995670, Length=333, Percent_Identity=29.4294294294294, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320099, Length=368, Percent_Identity=30.7065217391304, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322891, Length=292, Percent_Identity=26.7123287671233, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI20129063, Length=343, Percent_Identity=36.1516034985423, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI21357207, Length=329, Percent_Identity=27.6595744680851, Blast_Score=111, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_EHRCR (Q2GGH9)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_507454.1
- STRING:   Q2GGH9
- MEROPS:   M22.001
- GeneID:   3927736
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_0644
- TIGR:   ECH_0644
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   Q2GGH9
- ProtClustDB:   PRK09604
- BioCyc:   ECHA205920:ECH_0644-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 38157; Mature: 38157

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLKIVLGIETSCDETAVAIVNSNKEVLSHKILSQQEHAAYGGVVPEIASRAHINYLYE
CCCEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LVGSCIEESQLCFNDIDAIAVTAGPGLIGGLIVGIMMAKAISSVTGKPIIEINHLEAHAL
HHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHH
IIRMFYEIDFPFLLLIMSGGHCQFLVAYDVRCYYKLGSSLDDSLGEVFDKVARMLNLGYP
HHHHHHHCCCHHEEEEECCCCEEEEEEECCEEEEHHCCCCCHHHHHHHHHHHHHHHCCCC
GGPIIEEKSLLGDSGSFTLPRALTNRPGCDFSFSGLKTAVRNIIAGQKCINHELVCNISA
CCCCCCCHHHCCCCCCEECCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECC
SFQDCVGDILVNRINNAIVMSKDIDHRINKLVVTGGVAANKLLRNRMSVCANDNGFEILY
CHHHHHHHHHHHHCCCEEEEECCHHHHHCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEE
PPSKLCTDNGVMIGWAGIENLAKGYVSNLNFFPRARWPLENLRFDILRK
CCHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDKLKIVLGIETSCDETAVAIVNSNKEVLSHKILSQQEHAAYGGVVPEIASRAHINYLYE
CCCEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LVGSCIEESQLCFNDIDAIAVTAGPGLIGGLIVGIMMAKAISSVTGKPIIEINHLEAHAL
HHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHH
IIRMFYEIDFPFLLLIMSGGHCQFLVAYDVRCYYKLGSSLDDSLGEVFDKVARMLNLGYP
HHHHHHHCCCHHEEEEECCCCEEEEEEECCEEEEHHCCCCCHHHHHHHHHHHHHHHCCCC
GGPIIEEKSLLGDSGSFTLPRALTNRPGCDFSFSGLKTAVRNIIAGQKCINHELVCNISA
CCCCCCCHHHCCCCCCEECCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECC
SFQDCVGDILVNRINNAIVMSKDIDHRINKLVVTGGVAANKLLRNRMSVCANDNGFEILY
CHHHHHHHHHHHHCCCEEEEECCHHHHHCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEE
PPSKLCTDNGVMIGWAGIENLAKGYVSNLNFFPRARWPLENLRFDILRK
CCHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA