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The map label for this gene is ubiA [H]

Identifier: 88657627

GI number: 88657627

Start: 419238

End: 420113

Strand: Direct

Name: ubiA [H]

Synonym: ECH_0441

Alternate gene names: 88657627

Gene position: 419238-420113 (Clockwise)

Preceding gene: 88658084

Following gene: 88658132

Centisome position: 35.64

GC content: 29.0

Gene sequence:

>876_bases
TTGTGTAAAATAAAGGATATTATATCTAATTTCAGGAAATATCATTTGCTATTGAGGTTACATAGTGTAGAAATAATTTT
ATTATTGATATTTCCTAGTTTAGCTAGTATAGCCCTAGTATCTCATAGTGTATTACGTGCTTGTGGTTATATGTTTTTAT
GTTCCATAGGAGCATTTATTATGAGACCAGCTGGGTGTATAATTAATGATATTTTTGATAGAAAAATAGATTCAGAGGTA
AAAAGGACACAAAATAGGCCATTGGCAAATAATAGTTTAAGTGTTTTTCAAGCATTGAAAATATTAGCAATACTTTTATT
GTGTGCGTGTGTATTACTTGTGTTGACTAATATGTATACTATTAAAATTGCTATTGTATCAATGGTATTGATTGTTTTAT
ATCCGTTAGCTAAGAGATATTTTGCTTGGCCACAGTTATTGCTTGGAATAGTCTTTAATACTGGAATATTGATGGGATGT
ACTATGACTGTTGGTCATTTAACATTAAGTTGTGTACTACTTTATATAGGATGTATTTTTTGGACGGTAGGTTATGATAC
TATATATGCTGCGCAAGATAAGGAGTATGATATAAAATTAGGATTGCAATCTACTGCAATAAAATTTGGTAATGATATTC
GATTATGGATTGGACGGCTATATATGATTACTGTTACAATGTGGCTTTCTGCTGGAATAATTGCTGTGTTGCATCCTATT
TTTTATCTAGCAATTCTGATTATTGCTGCAATTTTTTATTATCAGTATAAAAAATCAGATTTTGACAACCCAGAAAAATG
TATGTATATGTTTAAAGTAAATATATATGTAGGGTTGATTTTATTTTTAGGCACTGTGTTTGGTAGAATATTATAA

Upstream 100 bases:

>100_bases
TAATGGTACTATAATTTTTTTTATTTTTGTTAAAGTGGTAGTGTGCGTATAGTTACGCATGTTGCTACTTCTATGTCTGG
TCATATTAGGAGGATGTATG

Downstream 100 bases:

>100_bases
GCAATGTGAAATAGTGCTGTAGTTGTGTGGTGGGTAATTTAAATAAATGCAGATTGGTGATTGGTCTAAAACTCATATAA
AATCTTGTTTCAGTGAGTTT

Product: 4-hydroxybenzoate polyprenyltransferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MCKIKDIISNFRKYHLLLRLHSVEIILLLIFPSLASIALVSHSVLRACGYMFLCSIGAFIMRPAGCIINDIFDRKIDSEV
KRTQNRPLANNSLSVFQALKILAILLLCACVLLVLTNMYTIKIAIVSMVLIVLYPLAKRYFAWPQLLLGIVFNTGILMGC
TMTVGHLTLSCVLLYIGCIFWTVGYDTIYAAQDKEYDIKLGLQSTAIKFGNDIRLWIGRLYMITVTMWLSAGIIAVLHPI
FYLAILIIAAIFYYQYKKSDFDNPEKCMYMFKVNIYVGLILFLGTVFGRIL

Sequences:

>Translated_291_residues
MCKIKDIISNFRKYHLLLRLHSVEIILLLIFPSLASIALVSHSVLRACGYMFLCSIGAFIMRPAGCIINDIFDRKIDSEV
KRTQNRPLANNSLSVFQALKILAILLLCACVLLVLTNMYTIKIAIVSMVLIVLYPLAKRYFAWPQLLLGIVFNTGILMGC
TMTVGHLTLSCVLLYIGCIFWTVGYDTIYAAQDKEYDIKLGLQSTAIKFGNDIRLWIGRLYMITVTMWLSAGIIAVLHPI
FYLAILIIAAIFYYQYKKSDFDNPEKCMYMFKVNIYVGLILFLGTVFGRIL
>Mature_291_residues
MCKIKDIISNFRKYHLLLRLHSVEIILLLIFPSLASIALVSHSVLRACGYMFLCSIGAFIMRPAGCIINDIFDRKIDSEV
KRTQNRPLANNSLSVFQALKILAILLLCACVLLVLTNMYTIKIAIVSMVLIVLYPLAKRYFAWPQLLLGIVFNTGILMGC
TMTVGHLTLSCVLLYIGCIFWTVGYDTIYAAQDKEYDIKLGLQSTAIKFGNDIRLWIGRLYMITVTMWLSAGIIAVLHPI
FYLAILIIAAIFYYQYKKSDFDNPEKCMYMFKVNIYVGLILFLGTVFGRIL

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate [H]

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI260656052, Length=282, Percent_Identity=36.8794326241135, Blast_Score=175, Evalue=4e-44,
Organism=Escherichia coli, GI1790473, Length=274, Percent_Identity=35.7664233576642, Blast_Score=157, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17553718, Length=284, Percent_Identity=38.7323943661972, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32565247, Length=285, Percent_Identity=37.5438596491228, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17553720, Length=341, Percent_Identity=32.258064516129, Blast_Score=150, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI32565245, Length=141, Percent_Identity=41.8439716312057, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32565243, Length=140, Percent_Identity=41.4285714285714, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324370, Length=272, Percent_Identity=33.4558823529412, Blast_Score=138, Evalue=8e-34,
Organism=Drosophila melanogaster, GI21355567, Length=290, Percent_Identity=37.9310344827586, Blast_Score=190, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006370
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 33018; Mature: 33018

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCKIKDIISNFRKYHLLLRLHSVEIILLLIFPSLASIALVSHSVLRACGYMFLCSIGAFI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRPAGCIINDIFDRKIDSEVKRTQNRPLANNSLSVFQALKILAILLLCACVLLVLTNMYT
HCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKIAIVSMVLIVLYPLAKRYFAWPQLLLGIVFNTGILMGCTMTVGHLTLSCVLLYIGCIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WTVGYDTIYAAQDKEYDIKLGLQSTAIKFGNDIRLWIGRLYMITVTMWLSAGIIAVLHPI
HHHCCHHEEECCCCCCEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYLAILIIAAIFYYQYKKSDFDNPEKCMYMFKVNIYVGLILFLGTVFGRIL
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MCKIKDIISNFRKYHLLLRLHSVEIILLLIFPSLASIALVSHSVLRACGYMFLCSIGAFI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRPAGCIINDIFDRKIDSEVKRTQNRPLANNSLSVFQALKILAILLLCACVLLVLTNMYT
HCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKIAIVSMVLIVLYPLAKRYFAWPQLLLGIVFNTGILMGCTMTVGHLTLSCVLLYIGCIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WTVGYDTIYAAQDKEYDIKLGLQSTAIKFGNDIRLWIGRLYMITVTMWLSAGIIAVLHPI
HHHCCHHEEECCCCCCEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYLAILIIAAIFYYQYKKSDFDNPEKCMYMFKVNIYVGLILFLGTVFGRIL
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA