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The map label for this gene is nuoF

Identifier: 88608878

GI number: 88608878

Start: 633479

End: 634720

Strand: Direct

Name: nuoF

Synonym: NSE_0714

Alternate gene names: 88608878

Gene position: 633479-634720 (Clockwise)

Preceding gene: 88608252

Following gene: 88608813

Centisome position: 73.75

GC content: 44.12

Gene sequence:

>1242_bases
ATGCTCAAACCAGAAGATAGAATCTTTAGTAATATACAAAAAAGAGAAGGTATCACGTTAAGTGAGGCGCTCAGACGTGG
TGATTGGAAGGACACCAAAAAATTTCTTGATAAGGAGCCTGAATGGATCGTAGAAGAAATTAAAAAATCCGGTCTAAGGG
GAAGAGGAGGTGCAGGTTTCCCAACAGGAATAAAGTGGAGCTTCATGCCAAAAGAGAAAGAGGCTGGCAAACCGTCGTAC
CTAGTAGTAAATGCAGACGAATCGGAGCCAGGCACATGTAAAGATAGAGACATAATACGGTTCGAGCCACATAAACTCAT
CGAAGGAATAGTATTAGCAAGTCATGCGATGCGCATAGACGTATCGTATATTTACATACGCGGGGAGTTCTACAACGAAT
CTCTTGTTCTAGAAAAGGTCATACAGGAAGCGATGGATGCGCATCTTATTCCTGAGCAACTCAAGATTTTCGTTCATAGA
GGCGCTGGAGCTTACATCTGTGGTGAAGAAACAGCTTTACTCGAATCACTTGAAGGAAAGCGAGGCATGCCGAGAATGAA
ACCTCCTTTCCCTGCTGGATGTGGGCTATATGGCAAGCCCACCACAATAAATAACGTGGAAAGTATTGCATCGGTCCCTA
CAATACTCAGTAGGGGAAGCGATTGGTTTGCAAATCTTGGCGTCAAAAATAGCTGTGGTACAAAAATATTTTGCATCTCC
GGTCACGTAAACAAGCCGTGTAACGTCGAAGAGGCATTGGGAATACCACTAAAATTTCTTATTGAAGAATACGCAGGTGG
TGTCATAGGTGGCTGGGACAACCTTCTTGCAGTGATACCAGGCGGATCATCAGTACCAATGATCACTAAGGAAGTTGCAG
AAACAGTCACGATGGATTTCGATTCCCTAAGAGCAGTAGGCTCCTCCCTTGGGACTGGCGGCATAATCGTAATGAACAAA
GAAACTGACATAATACGTGCCATAGAGAGACTTTCACATTTCTACATGCACGAATCATGCGGTCAGTGCACACCGTGCCG
GGAGGGTACGGGCTGGCTATGGAGCATAATGAAACAATTAAGTGAAGGTAAGGGAAAAAAATCCGATGTTGATTTTTTAT
TGCAGCTCACAAAACAAATCGAGGGAAATACCATATGCGCACTAGGTGATGCGGCTGCTTGGCCTATACAAGGTCTTATA
AAAAACTTCAGGGACGAGATAGAAGCACGTCAAAAAGGGTGA

Upstream 100 bases:

>100_bases
ATCACCTTCTTCGCCCCGACACTGAACATAAAAAAGACATTTGATGTTATGACTTTCTCTCTAACCTTTTGTATAATCTC
GCTGTAAAACAAAGAGAATC

Downstream 100 bases:

>100_bases
TATTACCTGTTTGCTCAGAGATAATAGGGGGGACCAGTCACTTTATTCGAGAGAAGCAGCTTAACAGAGACAGCCCTCGA
TCTCACCATAACTGCAGATG

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MLKPEDRIFSNIQKREGITLSEALRRGDWKDTKKFLDKEPEWIVEEIKKSGLRGRGGAGFPTGIKWSFMPKEKEAGKPSY
LVVNADESEPGTCKDRDIIRFEPHKLIEGIVLASHAMRIDVSYIYIRGEFYNESLVLEKVIQEAMDAHLIPEQLKIFVHR
GAGAYICGEETALLESLEGKRGMPRMKPPFPAGCGLYGKPTTINNVESIASVPTILSRGSDWFANLGVKNSCGTKIFCIS
GHVNKPCNVEEALGIPLKFLIEEYAGGVIGGWDNLLAVIPGGSSVPMITKEVAETVTMDFDSLRAVGSSLGTGGIIVMNK
ETDIIRAIERLSHFYMHESCGQCTPCREGTGWLWSIMKQLSEGKGKKSDVDFLLQLTKQIEGNTICALGDAAAWPIQGLI
KNFRDEIEARQKG

Sequences:

>Translated_413_residues
MLKPEDRIFSNIQKREGITLSEALRRGDWKDTKKFLDKEPEWIVEEIKKSGLRGRGGAGFPTGIKWSFMPKEKEAGKPSY
LVVNADESEPGTCKDRDIIRFEPHKLIEGIVLASHAMRIDVSYIYIRGEFYNESLVLEKVIQEAMDAHLIPEQLKIFVHR
GAGAYICGEETALLESLEGKRGMPRMKPPFPAGCGLYGKPTTINNVESIASVPTILSRGSDWFANLGVKNSCGTKIFCIS
GHVNKPCNVEEALGIPLKFLIEEYAGGVIGGWDNLLAVIPGGSSVPMITKEVAETVTMDFDSLRAVGSSLGTGGIIVMNK
ETDIIRAIERLSHFYMHESCGQCTPCREGTGWLWSIMKQLSEGKGKKSDVDFLLQLTKQIEGNTICALGDAAAWPIQGLI
KNFRDEIEARQKG
>Mature_413_residues
MLKPEDRIFSNIQKREGITLSEALRRGDWKDTKKFLDKEPEWIVEEIKKSGLRGRGGAGFPTGIKWSFMPKEKEAGKPSY
LVVNADESEPGTCKDRDIIRFEPHKLIEGIVLASHAMRIDVSYIYIRGEFYNESLVLEKVIQEAMDAHLIPEQLKIFVHR
GAGAYICGEETALLESLEGKRGMPRMKPPFPAGCGLYGKPTTINNVESIASVPTILSRGSDWFANLGVKNSCGTKIFCIS
GHVNKPCNVEEALGIPLKFLIEEYAGGVIGGWDNLLAVIPGGSSVPMITKEVAETVTMDFDSLRAVGSSLGTGGIIVMNK
ETDIIRAIERLSHFYMHESCGQCTPCREGTGWLWSIMKQLSEGKGKKSDVDFLLQLTKQIEGNTICALGDAAAWPIQGLI
KNFRDEIEARQKG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=418, Percent_Identity=59.5693779904306, Blast_Score=518, Evalue=1e-147,
Organism=Homo sapiens, GI260656005, Length=418, Percent_Identity=59.5693779904306, Blast_Score=518, Evalue=1e-147,
Organism=Escherichia coli, GI1788620, Length=404, Percent_Identity=40.8415841584158, Blast_Score=310, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17531727, Length=416, Percent_Identity=60.8173076923077, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI19920794, Length=418, Percent_Identity=60.2870813397129, Blast_Score=522, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550452, Length=418, Percent_Identity=58.8516746411483, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24653819, Length=413, Percent_Identity=45.2784503631961, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24653817, Length=413, Percent_Identity=41.8886198547215, Blast_Score=327, Evalue=9e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 45596; Mature: 45596

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKPEDRIFSNIQKREGITLSEALRRGDWKDTKKFLDKEPEWIVEEIKKSGLRGRGGAGF
CCCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCC
PTGIKWSFMPKEKEAGKPSYLVVNADESEPGTCKDRDIIRFEPHKLIEGIVLASHAMRID
CCCCEEEECCCHHCCCCCCEEEEECCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHEEEE
VSYIYIRGEFYNESLVLEKVIQEAMDAHLIPEQLKIFVHRGAGAYICGEETALLESLEGK
EEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHEEEECCCCEEEECCHHHHHHHHCCC
RGMPRMKPPFPAGCGLYGKPTTINNVESIASVPTILSRGSDWFANLGVKNSCGTKIFCIS
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCEEEEEE
GHVNKPCNVEEALGIPLKFLIEEYAGGVIGGWDNLLAVIPGGSSVPMITKEVAETVTMDF
CCCCCCCCHHHHHCCCHHHHHHHHCCCEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCH
DSLRAVGSSLGTGGIIVMNKETDIIRAIERLSHFYMHESCGQCTPCREGTGWLWSIMKQL
HHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
SEGKGKKSDVDFLLQLTKQIEGNTICALGDAAAWPIQGLIKNFRDEIEARQKG
HHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKPEDRIFSNIQKREGITLSEALRRGDWKDTKKFLDKEPEWIVEEIKKSGLRGRGGAGF
CCCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCC
PTGIKWSFMPKEKEAGKPSYLVVNADESEPGTCKDRDIIRFEPHKLIEGIVLASHAMRID
CCCCEEEECCCHHCCCCCCEEEEECCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHEEEE
VSYIYIRGEFYNESLVLEKVIQEAMDAHLIPEQLKIFVHRGAGAYICGEETALLESLEGK
EEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHEEEECCCCEEEECCHHHHHHHHCCC
RGMPRMKPPFPAGCGLYGKPTTINNVESIASVPTILSRGSDWFANLGVKNSCGTKIFCIS
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCEEEEEE
GHVNKPCNVEEALGIPLKFLIEEYAGGVIGGWDNLLAVIPGGSSVPMITKEVAETVTMDF
CCCCCCCCHHHHHCCCHHHHHHHHCCCEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCH
DSLRAVGSSLGTGGIIVMNKETDIIRAIERLSHFYMHESCGQCTPCREGTGWLWSIMKQL
HHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
SEGKGKKSDVDFLLQLTKQIEGNTICALGDAAAWPIQGLIKNFRDEIEARQKG
HHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA