Click here to switch to the map view.

The map label for this gene is pleC [H]

Identifier: 88608782

GI number: 88608782

Start: 457473

End: 459203

Strand: Direct

Name: pleC [H]

Synonym: NSE_0531

Alternate gene names: 88608782

Gene position: 457473-459203 (Clockwise)

Preceding gene: 88608575

Following gene: 88608567

Centisome position: 53.26

GC content: 38.3

Gene sequence:

>1731_bases
TTGTATGACACAATTTACTTAGGAACAATGCCATTACTACACTGGCATCACCTATGCAAATCTCTTCTACTCCGTTGGAC
CTTTAAGCTACATAATTTAGCAAACTATCTATATTTTTCATTACATTTGGTTATTATAAGCAGAGAAAGCACCATATACA
GTGTATACAAAATGATCTTTCACAAATATGACCTCAAACCTGAAAGATACATTCGGTATGTTAAATTACTTCTTTCGGTT
CTTGCACTGGTCGGCTTTTATTTTTCTTTGACCTACAATAAAGATGCCATCACAAGCCATAACACAATCCGTTCTATTGA
GTCCTCTGTCATATTCAGTGTTGCACAGAACACAATAGAAAGTTTCTACTCGGCTGTACAGAACGAGATTTCCATTGTTC
GTTTCCTCGTTGAGGGCGGAATACCTCTCAGCTCAAACAGCAAGCACTTAAGCACGCTCCTTCAATATGGTGAATTCATC
GGGCTTGGTGAAAGTGGTAAGATAACTGGATATGAGTTCGGCCCAACACAGACAGAAATCTTTAAAGACGCGCCGGGTGA
ACTGGTTACAATCGAGAATATTTCCTTAAAAAACTCTTCGTGTCTTCAGCATAAAAATTTCGATCAATCAGGTGGCGAAG
TACGTCGCATGGTATATTACCTTCCGGCTGGGGCTCTTCTAGATAAACTAAAAGGAGCTTTGGTTAGGCTTGAAGGAAAA
CAAAATTTCTCCATCGTAGACAAAAACTATAATGAGATATATCGACCGAGTCATCACATCCAAGATAGAAGTATGAAGGA
ATGCAGAAGTATTTATTCCTACTTCGATAACGAGCTATACTTTTGTCAATACGGATCGAGTCACGTAACATATGGCAGTG
TCATTGCAAGGGTTATCAGTATTCTGCTGCCTTTGTGCGTTATTCTTTGGATATTTATCTTCCTGAAAAGGCTTGAGTTT
GCATTCGTAGGTAGCAAGGCGCGTGCTTCAAAAGGGCGGGAAACCAAAAACTCTTCGGTTCTGGATCAAATAGCGACGAA
CTCAAGTCATTTTATTTCTTGCATCACACATGAATTACGCACACCTCTAAATGTGATAATTGCATTTTCAGAGATGATAA
AAGATGAGTGCCTTGGAAGCATCACAAATAAAAAGTACGTGTGCTATGGAGAAGAAATTTATAAATTTGGGACGAGCCTA
CTCAGAACCGTTGATAACATAATAGATATAACGAAATCAAATAGCATGCTCATGACTCCAAAAAAGGATTATGTGAGTGT
CCAGCAAATAATAGCAGAAGCCGTAAGAAATTGCAGAACCTTTGCATTAACAAAAGAAATATCTCTTTGCAAAAGTATTG
ATGCAGATCTTCCGGAAATTTTTTTAGACCGTGATCAAGTCAAAAAGGCAATTTCTCATATCTTAAGCAATGCAATTAAA
TTCAGCGACAATGGCGCAACTGTTTCAATAAGGGCGTGTCAAAATTGTGAGGAAGGAAGCATTTCTATCACAATTGAAGA
TTCAGGAAGCGGAATGAAAGTTATCAATGGTGTACCACAGTTAGAAAATTTCCTAACAAAGAAGGCAGGTGGGTTGGGAA
TAGGGCTGTTGTTGTCAAGGAATATCATTCATCTCAACGATGGTTCTCTTGAGATATACTCTCAAGTTGGAAAAGGAACG
AAAACCACAATTACCTTCAACCAAAAGCAAGCAGATGAGGTAAAAAATTAG

Upstream 100 bases:

>100_bases
GGAACCTTTCCCAAACATTTTTTCAATTTGAACCACAACGCCCTTAAGCGCATCTTCCCTGTTCATTAAAATCAACTCGC
AACCCTCACGTTCCCAGACA

Downstream 100 bases:

>100_bases
CCTGTCCTTATAGCACGAATAGCAAAATGGGCAGAGATATTATACAATCCACACGGAAGGATGGCCGAGTGGTTGAAGGC
GCACGCTTGGAAAGCGTGTT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MYDTIYLGTMPLLHWHHLCKSLLLRWTFKLHNLANYLYFSLHLVIISRESTIYSVYKMIFHKYDLKPERYIRYVKLLLSV
LALVGFYFSLTYNKDAITSHNTIRSIESSVIFSVAQNTIESFYSAVQNEISIVRFLVEGGIPLSSNSKHLSTLLQYGEFI
GLGESGKITGYEFGPTQTEIFKDAPGELVTIENISLKNSSCLQHKNFDQSGGEVRRMVYYLPAGALLDKLKGALVRLEGK
QNFSIVDKNYNEIYRPSHHIQDRSMKECRSIYSYFDNELYFCQYGSSHVTYGSVIARVISILLPLCVILWIFIFLKRLEF
AFVGSKARASKGRETKNSSVLDQIATNSSHFISCITHELRTPLNVIIAFSEMIKDECLGSITNKKYVCYGEEIYKFGTSL
LRTVDNIIDITKSNSMLMTPKKDYVSVQQIIAEAVRNCRTFALTKEISLCKSIDADLPEIFLDRDQVKKAISHILSNAIK
FSDNGATVSIRACQNCEEGSISITIEDSGSGMKVINGVPQLENFLTKKAGGLGIGLLLSRNIIHLNDGSLEIYSQVGKGT
KTTITFNQKQADEVKN

Sequences:

>Translated_576_residues
MYDTIYLGTMPLLHWHHLCKSLLLRWTFKLHNLANYLYFSLHLVIISRESTIYSVYKMIFHKYDLKPERYIRYVKLLLSV
LALVGFYFSLTYNKDAITSHNTIRSIESSVIFSVAQNTIESFYSAVQNEISIVRFLVEGGIPLSSNSKHLSTLLQYGEFI
GLGESGKITGYEFGPTQTEIFKDAPGELVTIENISLKNSSCLQHKNFDQSGGEVRRMVYYLPAGALLDKLKGALVRLEGK
QNFSIVDKNYNEIYRPSHHIQDRSMKECRSIYSYFDNELYFCQYGSSHVTYGSVIARVISILLPLCVILWIFIFLKRLEF
AFVGSKARASKGRETKNSSVLDQIATNSSHFISCITHELRTPLNVIIAFSEMIKDECLGSITNKKYVCYGEEIYKFGTSL
LRTVDNIIDITKSNSMLMTPKKDYVSVQQIIAEAVRNCRTFALTKEISLCKSIDADLPEIFLDRDQVKKAISHILSNAIK
FSDNGATVSIRACQNCEEGSISITIEDSGSGMKVINGVPQLENFLTKKAGGLGIGLLLSRNIIHLNDGSLEIYSQVGKGT
KTTITFNQKQADEVKN
>Mature_576_residues
MYDTIYLGTMPLLHWHHLCKSLLLRWTFKLHNLANYLYFSLHLVIISRESTIYSVYKMIFHKYDLKPERYIRYVKLLLSV
LALVGFYFSLTYNKDAITSHNTIRSIESSVIFSVAQNTIESFYSAVQNEISIVRFLVEGGIPLSSNSKHLSTLLQYGEFI
GLGESGKITGYEFGPTQTEIFKDAPGELVTIENISLKNSSCLQHKNFDQSGGEVRRMVYYLPAGALLDKLKGALVRLEGK
QNFSIVDKNYNEIYRPSHHIQDRSMKECRSIYSYFDNELYFCQYGSSHVTYGSVIARVISILLPLCVILWIFIFLKRLEF
AFVGSKARASKGRETKNSSVLDQIATNSSHFISCITHELRTPLNVIIAFSEMIKDECLGSITNKKYVCYGEEIYKFGTSL
LRTVDNIIDITKSNSMLMTPKKDYVSVQQIIAEAVRNCRTFALTKEISLCKSIDADLPEIFLDRDQVKKAISHILSNAIK
FSDNGATVSIRACQNCEEGSISITIEDSGSGMKVINGVPQLENFLTKKAGGLGIGLLLSRNIIHLNDGSLEIYSQVGKGT
KTTITFNQKQADEVKN

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=239, Percent_Identity=28.0334728033473, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786600, Length=242, Percent_Identity=23.9669421487603, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=26.2931034482759, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789149, Length=223, Percent_Identity=24.6636771300448, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI48994928, Length=258, Percent_Identity=27.1317829457364, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786912, Length=275, Percent_Identity=21.8181818181818, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=23.2558139534884, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=23.394495412844, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1788393, Length=223, Percent_Identity=25.5605381165919, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65024; Mature: 65024

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDTIYLGTMPLLHWHHLCKSLLLRWTFKLHNLANYLYFSLHLVIISRESTIYSVYKMIF
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHHH
HKYDLKPERYIRYVKLLLSVLALVGFYFSLTYNKDAITSHNTIRSIESSVIFSVAQNTIE
HHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
SFYSAVQNEISIVRFLVEGGIPLSSNSKHLSTLLQYGEFIGLGESGKITGYEFGPTQTEI
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHH
FKDAPGELVTIENISLKNSSCLQHKNFDQSGGEVRRMVYYLPAGALLDKLKGALVRLEGK
HHCCCCCEEEEEEEECCCCCHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCEEEEECC
QNFSIVDKNYNEIYRPSHHIQDRSMKECRSIYSYFDNELYFCQYGSSHVTYGSVIARVIS
CCCEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
ILLPLCVILWIFIFLKRLEFAFVGSKARASKGRETKNSSVLDQIATNSSHFISCITHELR
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHC
TPLNVIIAFSEMIKDECLGSITNKKYVCYGEEIYKFGTSLLRTVDNIIDITKSNSMLMTP
CHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
KKDYVSVQQIIAEAVRNCRTFALTKEISLCKSIDADLPEIFLDRDQVKKAISHILSNAIK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHEE
FSDNGATVSIRACQNCEEGSISITIEDSGSGMKVINGVPQLENFLTKKAGGLGIGLLLSR
ECCCCCEEEEEECCCCCCCCEEEEEECCCCCCHHHCCCHHHHHHHHHCCCCCEEEHHHHC
NIIHLNDGSLEIYSQVGKGTKTTITFNQKQADEVKN
CEEEECCCCCHHHHHHCCCCEEEEEECCHHHHHCCC
>Mature Secondary Structure
MYDTIYLGTMPLLHWHHLCKSLLLRWTFKLHNLANYLYFSLHLVIISRESTIYSVYKMIF
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHHH
HKYDLKPERYIRYVKLLLSVLALVGFYFSLTYNKDAITSHNTIRSIESSVIFSVAQNTIE
HHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
SFYSAVQNEISIVRFLVEGGIPLSSNSKHLSTLLQYGEFIGLGESGKITGYEFGPTQTEI
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHH
FKDAPGELVTIENISLKNSSCLQHKNFDQSGGEVRRMVYYLPAGALLDKLKGALVRLEGK
HHCCCCCEEEEEEEECCCCCHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCEEEEECC
QNFSIVDKNYNEIYRPSHHIQDRSMKECRSIYSYFDNELYFCQYGSSHVTYGSVIARVIS
CCCEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
ILLPLCVILWIFIFLKRLEFAFVGSKARASKGRETKNSSVLDQIATNSSHFISCITHELR
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHC
TPLNVIIAFSEMIKDECLGSITNKKYVCYGEEIYKFGTSLLRTVDNIIDITKSNSMLMTP
CHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
KKDYVSVQQIIAEAVRNCRTFALTKEISLCKSIDADLPEIFLDRDQVKKAISHILSNAIK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHEE
FSDNGATVSIRACQNCEEGSISITIEDSGSGMKVINGVPQLENFLTKKAGGLGIGLLLSR
ECCCCCEEEEEECCCCCCCCEEEEEECCCCCCHHHCCCHHHHHHHHHCCCCCEEEHHHHC
NIIHLNDGSLEIYSQVGKGTKTTITFNQKQADEVKN
CEEEECCCCCHHHHHHCCCCEEEEEECCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]