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The map label for this gene is ribA

Identifier: 88608776

GI number: 88608776

Start: 664568

End: 665629

Strand: Reverse

Name: ribA

Synonym: NSE_0745

Alternate gene names: 88608776

Gene position: 665629-664568 (Counterclockwise)

Preceding gene: 88608003

Following gene: 88608672

Centisome position: 77.49

GC content: 44.54

Gene sequence:

>1062_bases
ATGTCTTTGTCTCCTGAGCGTCAAGCGGCTTTTGCTTTGTGCGCGTTCAAAGCCGGTATCCCGGTGATTTTTTGCAGTTT
CTCTAAAGTCGTTGTTGCGGCTCCACGTGAGTCATGCGATGTAGAAGGGTTCTTTAGGAATTACGGAAAAGTAGGAGTCT
CACTTTTGTTGTCTGCTGAGCGCATTGGTTTTCATTCGGGCAGTTCAAATAATCAAAGTGTGAGATTGTCTCTAAAAGTA
GTTGAAGAACTTAGGTTAGGGTTGGAATTGTTGATAAGGTTAGCAGAGACTATTCCTGCTAGTGAGGAAGAGGAGCTGCT
AGTAGTGCTTGCAAAGATGGCTGAGCTTCTGCCAGAGGTCCTTGTTTCCACACTCGAATTCCAGGAACGCACAGATATGT
TGAATTTTGCCTTTTCCAACGGGTTGCAGGTAATGGATTTGGATGCCATATCGAGAGGGCTGGTGCAGCAACATATTACC
CGCGTCTCAGAAGCAAAAATACGGATAAGAGAGAACGTGGATTCCTACATGGTATGTTACCGGTCAATCTTGAAAGAGCA
CTATGCAATTATTATAGGTGACCCTTTGAGTTCAAAGGAGCCGCTTGTTAGGGTGCACTCTTCCTGTTATACAGGGGACC
TGCTGGGTAGTCTATCGTGTGACTGCAGGGATCAACTACACGATACAGTTAAGAAGATTGCTGAGGATCCAGCGGGTGGA
ATAATACTGTATCTTTCGCAAGAAGGTAGGGGTATAGGATTACCGAACAAAATACGTGCATATAATCTGCAAGAAGATAA
GGGTCTTGACACAGTTGAAGCAAACCTCTGTCTTGGTTTTAAGGATGACGAGCGTGATTTTAGAGTGGTAAGGCTTATTC
TAAAAGATCTTGGTGTCCAAAAAGTTAGACTCATTACAAATAACCCGGAGAAGATCCGTCAACTCAGTTCCGCAGGGGTA
GACGTTGCGTCTCGTGTGCCAATCTTGATGAGGAGCAATCCCTACAATCACAAGTACCTTCAAACGAAATCTGAGAAGCT
TGGGCATATCTTTATCGCTTAG

Upstream 100 bases:

>100_bases
TGCGGTAACATTTGCGTTGTGCCGATTGTTGATCAACAGTTCCTAGATAGTATATAGATGAAGTAGTTTTTCTTCGTTCT
AGCCTTTCTTTTTGTTTCTG

Downstream 100 bases:

>100_bases
GTTTTTAACCTTTTTGAAATTAAGTCAGGGTTACTTTACGTTCTTTGTAGTCTTTTTTGTGCGATTGCTGTGACCTGTTT
CTTTGCTTATGTAGCATCTT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSLSPERQAAFALCAFKAGIPVIFCSFSKVVVAAPRESCDVEGFFRNYGKVGVSLLLSAERIGFHSGSSNNQSVRLSLKV
VEELRLGLELLIRLAETIPASEEEELLVVLAKMAELLPEVLVSTLEFQERTDMLNFAFSNGLQVMDLDAISRGLVQQHIT
RVSEAKIRIRENVDSYMVCYRSILKEHYAIIIGDPLSSKEPLVRVHSSCYTGDLLGSLSCDCRDQLHDTVKKIAEDPAGG
IILYLSQEGRGIGLPNKIRAYNLQEDKGLDTVEANLCLGFKDDERDFRVVRLILKDLGVQKVRLITNNPEKIRQLSSAGV
DVASRVPILMRSNPYNHKYLQTKSEKLGHIFIA

Sequences:

>Translated_353_residues
MSLSPERQAAFALCAFKAGIPVIFCSFSKVVVAAPRESCDVEGFFRNYGKVGVSLLLSAERIGFHSGSSNNQSVRLSLKV
VEELRLGLELLIRLAETIPASEEEELLVVLAKMAELLPEVLVSTLEFQERTDMLNFAFSNGLQVMDLDAISRGLVQQHIT
RVSEAKIRIRENVDSYMVCYRSILKEHYAIIIGDPLSSKEPLVRVHSSCYTGDLLGSLSCDCRDQLHDTVKKIAEDPAGG
IILYLSQEGRGIGLPNKIRAYNLQEDKGLDTVEANLCLGFKDDERDFRVVRLILKDLGVQKVRLITNNPEKIRQLSSAGV
DVASRVPILMRSNPYNHKYLQTKSEKLGHIFIA
>Mature_352_residues
SLSPERQAAFALCAFKAGIPVIFCSFSKVVVAAPRESCDVEGFFRNYGKVGVSLLLSAERIGFHSGSSNNQSVRLSLKVV
EELRLGLELLIRLAETIPASEEEELLVVLAKMAELLPEVLVSTLEFQERTDMLNFAFSNGLQVMDLDAISRGLVQQHITR
VSEAKIRIRENVDSYMVCYRSILKEHYAIIIGDPLSSKEPLVRVHSSCYTGDLLGSLSCDCRDQLHDTVKKIAEDPAGGI
ILYLSQEGRGIGLPNKIRAYNLQEDKGLDTVEANLCLGFKDDERDFRVVRLILKDLGVQKVRLITNNPEKIRQLSSAGVD
VASRVPILMRSNPYNHKYLQTKSEKLGHIFIA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=195, Percent_Identity=49.2307692307692, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319438, Length=176, Percent_Identity=42.6136363636364, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 39295; Mature: 39164

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSPERQAAFALCAFKAGIPVIFCSFSKVVVAAPRESCDVEGFFRNYGKVGVSLLLSAE
CCCCCHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
RIGFHSGSSNNQSVRLSLKVVEELRLGLELLIRLAETIPASEEEELLVVLAKMAELLPEV
HHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LVSTLEFQERTDMLNFAFSNGLQVMDLDAISRGLVQQHITRVSEAKIRIRENVDSYMVCY
HHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
RSILKEHYAIIIGDPLSSKEPLVRVHSSCYTGDLLGSLSCDCRDQLHDTVKKIAEDPAGG
HHHHHHCCEEEEECCCCCCCCHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCC
IILYLSQEGRGIGLPNKIRAYNLQEDKGLDTVEANLCLGFKDDERDFRVVRLILKDLGVQ
EEEEEECCCCCCCCCCCCEEECCCCCCCCCEEECCEEECCCCCCHHHHHHHHHHHHCCCE
KVRLITNNPEKIRQLSSAGVDVASRVPILMRSNPYNHKYLQTKSEKLGHIFIA
EEEEEECCHHHHHHHHHCCCCHHHCCCEEEECCCCCCHHHHCHHHCCCEEEEC
>Mature Secondary Structure 
SLSPERQAAFALCAFKAGIPVIFCSFSKVVVAAPRESCDVEGFFRNYGKVGVSLLLSAE
CCCCHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
RIGFHSGSSNNQSVRLSLKVVEELRLGLELLIRLAETIPASEEEELLVVLAKMAELLPEV
HHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LVSTLEFQERTDMLNFAFSNGLQVMDLDAISRGLVQQHITRVSEAKIRIRENVDSYMVCY
HHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
RSILKEHYAIIIGDPLSSKEPLVRVHSSCYTGDLLGSLSCDCRDQLHDTVKKIAEDPAGG
HHHHHHCCEEEEECCCCCCCCHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCC
IILYLSQEGRGIGLPNKIRAYNLQEDKGLDTVEANLCLGFKDDERDFRVVRLILKDLGVQ
EEEEEECCCCCCCCCCCCEEECCCCCCCCCEEECCEEECCCCCCHHHHHHHHHHHHCCCE
KVRLITNNPEKIRQLSSAGVDVASRVPILMRSNPYNHKYLQTKSEKLGHIFIA
EEEEEECCHHHHHHHHHCCCCHHHCCCEEEECCCCCCHHHHCHHHCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA